Increased Intracellular Reactive Oxygen Species Mediates the Anti-Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer Cells

Prostate

Volumn 77, Issue 5, 2017, Pages 489-504

  Chen, Minxiao ^a,b   Zhou, Bin ^c   Zhong, Peng ^a   Rajamanickam, Vinothkumar ^a   Dai, Xuanxuan ^b   Karvannan, Kanchana ^a   Zhou, Huiping ^a   Zhang, Xiuhua ^b   Liang, Guang ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; calcium; curcumin analog; mitochondria; prostate cancer; ROS

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM ION; CASPASE 3; CASPASE 9; CURCUMIN; CYTOCHROME C; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; WZ 35;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER INHIBITION; CANCER TISSUE; CELL CYCLE DISTRIBUTION; CELL CYCLE PARAMETERS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; DU145 CELL LINE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRIAL APOPTOSIS PATHWAY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MTT ASSAY; NONHUMAN; NUDE MOUSE; OXIDATIVE STRESS; PROSTATE CANCER; PROSTATE CANCER CELL LINE; RAT; RM 1 CELL LINE; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; INTRACELLULAR FLUID; METABOLISM; MITOCHONDRION; PHYSIOLOGY; PROCEDURES; PROSTATIC NEOPLASMS; TREATMENT OUTCOME; TUMOR CELL LINE; TUMOR MICROENVIRONMENT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTRACELLULAR FLUID; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; PROSTATIC NEOPLASMS; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; TUMOR MICROENVIRONMENT; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85007019364     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.23287     Document Type: Article

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