Interplay of reactive oxygen species, intracellular Ca2+ and mitochondrial homeostasis in the apoptosis of prostate cancer cells by deoxypodophyllotoxin

Journal of Cellular Biochemistry

Volumn 114, Issue 5, 2013, Pages 1124-1134

  Kim, Kwang Youn ^a   Cho, Hyo Jin ^b   Yu, Sun Nyoung ^a   Kim, Sang Hun ^a   Yu, Hak Sun ^a   Park, Yeong Min ^a   Mirkheshti, Nooshin ^c   Kim, So Young ^c   Song, Chung Seog ^c   Chatterjee, Bandana ^c,d   Ahn, Soon Cheol ^a,c,e  

^a Pusan National University School of Medicine   (South Korea)

^b Ajou University School of Medicine   (South Korea)

^c Mays Cancer Center at UT Health San Antonio   (United States)

^d SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^e Pusan National University   (South Korea)

Author keywords

apoptosis; Ca2+ overload; deoxypodophyllotoxin (DPT); mitochondrial membrane potential (MMP); reactive oxygen species (ROS)

Indexed keywords

ACETYLCYSTEINE; CALCIUM ION; CASPASE 3; CYTOCHROME C; DEOXYPODOPHYLLOTOXIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CANCER CELL; CANCER MODEL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; G2 PHASE CELL CYCLE CHECKPOINT; HOMEOSTASIS; HUMAN; HUMAN CELL; HYPERPOLARIZATION; M PHASE CELL CYCLE CHECKPOINT; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROSTATE CANCER;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CALCIUM; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOCHROMES C; DRUG SCREENING ASSAYS, ANTITUMOR; EGTAZIC ACID; ENZYME ACTIVATION; G2 PHASE CELL CYCLE CHECKPOINTS; HOMEOSTASIS; HUMANS; INTRACELLULAR SPACE; M PHASE CELL CYCLE CHECKPOINTS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MODELS, BIOLOGICAL; PODOPHYLLOTOXIN; PROSTATIC NEOPLASMS; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES;

EID: 84875190063     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24455     Document Type: Article

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