Illegitimate translation causes unexpected gene expression from on-target out-of-frame alleles created by CRISPR-Cas9

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Makino, Shigeru ^a   Fukumura, Ryutaro ^a   Gondo, Yoichi ^a  

^a RIKEN BIORESOURCE CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLI3 PROTEIN, HUMAN; GLI3 PROTEIN, MOUSE; NERVE PROTEIN; TRANSCRIPTIONAL ACTIVATOR GLI3;

ALLELE; ANIMAL; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CRISPR CAS SYSTEM; DNA SEQUENCE; FRAMESHIFT MUTATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; GENE VECTOR; GENETICS; GENOME; HEK293 CELL LINE; HOMOZYGOTE; HUMAN; MOUSE; MUTATION; NIH 3T3 CELL LINE; OPEN READING FRAME; PROTEIN SYNTHESIS; READING FRAME; TRANSGENIC MOUSE;

ALLELES; ANIMALS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; FRAMESHIFT MUTATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC VECTORS; GENOME; HEK293 CELLS; HOMOZYGOTE; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NIH 3T3 CELLS; OPEN READING FRAMES; PROTEIN BIOSYNTHESIS; READING FRAMES; SEQUENCE ANALYSIS, DNA; ZINC FINGER PROTEIN GLI3;

EID: 85006973031     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep39608     Document Type: Article

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