Review on fate and mechanism of removal of pharmaceutical pollutants from wastewater using biological approach

Bioresource Technology

Volumn 224, Issue , 2017, Pages 1-12

  Tiwari, Bhagyashree ^a   Sellamuthu, Balasubramanian ^b   Ouarda, Yassine ^a   Drogui, Patrick ^a   Tyagi, Rajeshwar D ^a   Buelna, Gerardo ^c  

^a CENTRE EAU TERRE ENVIRONNEMENT   (Canada)

^b INRS INSTITUT ARMAND FRAPPIER   (Canada)

^c Centre de Recherche Industrielle du Quebec   (Canada)

Author keywords

Eco toxic; Fate; Pharmaceuticals; Wastewater treatment plant

Indexed keywords

DRUG; GROUND WATER; WASTE WATER; WATER POLLUTANT;

ANALYSIS; CHEMISTRY; ENVIRONMENTAL MONITORING; HUMAN; WASTE WATER; WATER MANAGEMENT; WATER POLLUTANT; WATER QUALITY;

ENVIRONMENTAL MONITORING; GROUNDWATER; HUMANS; PHARMACEUTICAL PREPARATIONS; WASTE WATER; WATER POLLUTANTS, CHEMICAL; WATER PURIFICATION; WATER QUALITY;

EID: 85006507416     PISSN: 09608524     EISSN: 18732976     Source Type: Journal    
DOI: 10.1016/j.biortech.2016.11.042     Document Type: Review

References (104)

1. Ahmad, M.S., Zafar, S., Yousuf, S., Choudhary, M.I., Biotransformation of 6-dehydroprogesterone with Aspergillus niger and Gibberella fujikuroi. Steroids 112 (2016), 62–67.
2. Arya, V., Philip, L., Murty Bhallamudi, S., Performance of suspended and attached growth bioreactors for the removal of cationic and anionic pharmaceuticals. Chem. Eng. J. 284 (2016), 1295–1307.
3. Bank, D., 2012. Open data drug & drug target database. Consultada en la página < http://www. drugbank. ca/drugs/DB00073>.
4. Baronti, C., Curini, R., D'Ascenzo, G., Di Corcia, A., Gentili, A., Samperi, R., Monitoring natural and synthetic estrogens at activated sludge sewage treatment plants and in a receiving river water. Environ. Sci. Technol. 34:24 (2000), 5059–5066.
5. Baydoun, E., Wahab, A.T., Shoaib, N., Ahmad, M.S., Abdel-Massih, R., Smith, C., Naveed, N., Choudhary, M.I., Microbial transformation of contraceptive drug etonogestrel into new metabolites with Cunninghamella blakesleeana and Cunninghamella echinulata. Steroids 115 (2016), 56–61.
6. Behera, S.K., Kim, H.W., Oh, J.-E., Park, H.-S., Occurrence and removal of antibiotics, hormones and several other pharmaceuticals in wastewater treatment plants of the largest industrial city of Korea. Sci. Total Environ. 409:20 (2011), 4351–4360.
7. Benotti, M.J., Stanford, B.D., Wert, E.C., Snyder, S.A., Evaluation of a photocatalytic reactor membrane pilot system for the removal of pharmaceuticals and endocrine disrupting compounds from water. Water Res. 43:6 (2009), 1513–1522.
8. Bernhard, M., Müller, J., Knepper, T.P., Biodegradation of persistent polar pollutants in wastewater: comparison of an optimised lab-scale membrane bioreactor and activated sludge treatment. Water Res. 40:18 (2006), 3419–3428.
9. Bright, T.V., Clark, B.R., O'Brien, E., Murphy, C.D., Bacterial production of hydroxylated and amidated metabolites of flurbiprofen. J. Mol. Catal. B Enzym. 72:3 (2011), 116–121.
10. Brooks, B.W., Chambliss, C.K., Stanley, J.K., Ramirez, A., Banks, K.E., Johnson, R.D., Lewis, R.J., Determination of select antidepressants in fish from an effluent-dominated stream. Environ. Toxicol. Chem. 24:2 (2005), 464–469.
11. Byrns, G., The fate of xenobiotic organic compounds in wastewater treatment plants. Water Res. 35:10 (2001), 2523–2533.
12. Carballa, M., Fink, G., Omil, F., Lema, J.M., Ternes, T., Determination of the solid–water distribution coefficient (K d) for pharmaceuticals, estrogens and musk fragrances in digested sludge. Water Res. 42:1 (2008), 287–295.
13. Carballa, M., Omil, F., Lema, J.M., Llompart, M.A., Garcı́a-Jares, C., Rodrı́guez, I., Gomez, M., Ternes, T., Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant. Water Res. 38:12 (2004), 2918–2926.
14. Castiglioni, S., Bagnati, R., Fanelli, R., Pomati, F., Calamari, D., Zuccato, E., Removal of pharmaceuticals in sewage treatment plants in Italy. Environ. Sci. Technol. 40:1 (2006), 357–363.
15. Chitnis, V., Chitnis, S., Vaidya, K., Ravikant, S., Patil, S., Chitnis, D.S., Bacterial population changes in hospital effluent treatment plant in central India. Water Res. 38:2 (2004), 441–447.
16. Dawas-Massalha, A., Gur-Reznik, S., Lerman, S., Sabbah, I., Dosoretz, C.G., Co-metabolic oxidation of pharmaceutical compounds by a nitrifying bacterial enrichment. Bioresour. Technol. 167 (2014), 336–342.
17. De Gusseme, B., Pycke, B., Hennebel, T., Marcoen, A., Vlaeminck, S.E., Noppe, H., Boon, N., Verstraete, W., Biological removal of 17α-ethinylestradiol by a nitrifier enrichment culture in a membrane bioreactor. Water Res. 43:9 (2009), 2493–2503.
18. Deloffre-Bonnamour, N., Wastes Rejects from Health Establishments: Liquid Effluents to Solid Wastes. Master's Thesis, 1995, Department of Environment and Ecodevelopment, University Claude Bernard-Lyon 1, Institut Universitaire Professionnalisé, Lyon, 75.
19. Evgenidou, E.N., Konstantinou, I.K., Lambropoulou, D.A., Occurrence and removal of transformation products of PPCPs and illicit drugs in wastewaters: a review. Sci. Total Environ. 505 (2015), 905–926.
20. Fernandes, J.P., Almeida, C.M.R., Pereira, A.C., Ribeiro, I.L., Reis, I., Carvalho, P., Basto, M.C.P., Mucha, A.P., Microbial community dynamics associated with veterinary antibiotics removal in constructed wetlands microcosms. Bioresour. Technol. 182 (2015), 26–33.
21. Ferrando-Climent, L., Rodriguez-Mozaz, S., Barceló, D., Incidence of anticancer drugs in an aquatic urban system: from hospital effluents through urban wastewater to natural environment. Environ. Pollut. 193 (2014), 216–223.
22. Fick, J., Lindberg, R.H., Fång, J., Magnér, J., Kaj, L., Brorström-Lundén, E., Screening 2014: Analysis of Pharmaceuticals and Hormones in Samples from WWTPs and Receiving Waters. 2015, IVL Swedish Environmental Research Institute C135.
23. Galvin, S., Boyle, F., Hickey, P., Vellinga, A., Morris, D., Cormican, M., Enumeration and characterization of antimicrobial-resistant Escherichia coli bacteria in effluent from municipal, hospital, and secondary treatment facility sources. Appl. Environ. Microbiol. 76:14 (2010), 4772–4779.
24. Garcia Martin, H., Ivanova, N., Kunin, V., Warnecke, F., Barry, K.W., McHardy, A.C., Yeates, C., He, S., Salamov, A.A., Szeto, E., Dalin, E., Putnam, N.H., Shapiro, H.J., Pangilinan, J.L., Rigoutsos, I., Kyrpides, N.C., Blackall, L.L., McMahon, K.D., Hugenholtz, P., Metagenomic analysis of two enhanced biological phosphorus removal (EBPR) sludge communities. Nat. Biotechnol. 24:10 (2006), 1263–1269.
25. Gautam, A.K., Kumar, S., Sabumon, P., Preliminary study of physico-chemical treatment options for hospital wastewater. J. Environ. Manage. 83:3 (2007), 298–306.
26. Gelbrand, H., Miller-Petrie, M., Pant, S., Gandra, S., Levinson, J., Barter, D., White, A., Laxminarayan, R., Ganguly, N., Kariuki, S., The State of the World's Antibiotics 2015. Wound Healing Southern Africa 8:2 (2015), 30–34.
27. Gross-Sorokin, M.Y., Roast, S.D., Brighty, G.C., Assessment of feminization of male fish in English rivers by the Environment Agency of England and Wales. Environ. Health Perspect. 114:S-1 (2005), 147–151.
28. Haroune, L., Saibi, S., Bellenger, J.-P., Cabana, H., Evaluation of the efficiency of Trametes hirsuta for the removal of multiple pharmaceutical compounds under low concentrations relevant to the environment. Bioresour. Technol. 171 (2014), 199–202.
29. Hata, T., Kawai, S., Okamura, H., Nishida, T., Removal of diclofenac and mefenamic acid by the white rot fungus Phanerochaete sordida YK-624 and identification of their metabolites after fungal transformation. Biodegradation 21:5 (2010), 681–689.
30. Heberer, T., Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol. Lett. 131:1 (2002), 5–17.
31. Hu, M., Wang, X., Wen, X., Xia, Y., Microbial community structures in different wastewater treatment plants as revealed by 454-pyrosequencing analysis. Bioresour. Technol. 117 (2012), 72–79.
32. Huang, L., Lee, D.J., Membrane bioreactor: a mini review on recent R&D works. Bioresour. Technol. 194 (2015), 383–388.
33. Ibarbalz, F.M., Figuerola, E.L., Erijman, L., Industrial activated sludge exhibit unique bacterial community composition at high taxonomic ranks. Water Res. 47:11 (2013), 3854–3864.
34. Indicators, O. 2015. Health at a Glance 2015.
35. Ismail, M.M., Essam, T.M., Ragab, Y.M., Mourad, F.E., Biodegradation of ketoprofen using a microalgal–bacterial consortium. Biotechnol. Lett. 38:9 (2016), 1493–1502.
36. Jelic, A., Gros, M., Ginebreda, A., Cespedes-Sanchez, R., Ventura, F., Petrovic, M., Barcelo, D., Occurrence, partition and removal of pharmaceuticals in sewage water and sludge during wastewater treatment. Water Res. 45:3 (2011), 1165–1176.
37. Jiang, B., Li, A., Cui, D., Cai, R., Ma, F., Wang, Y., Biodegradation and metabolic pathway of sulfamethoxazole by Pseudomonas psychrophila HA-4, a newly isolated cold-adapted sulfamethoxazole-degrading bacterium. Appl. Microbiol. Biotechnol. 98:10 (2014), 4671–4681.
38. Johnson, A.C., Williams, R.J., A model to estimate influent and effluent concentrations of estradiol, estrone, and ethinylestradiol at sewage treatment works. Environ. Sci. Technol. 38:13 (2004), 3649–3658.
39. Jones, O.A.H., Voulvoulis, N., Lester, J.N., Human pharmaceuticals in the aquatic environment a review. Environ. Technol. 22:12 (2001), 1383–1394.
40. Joss, A., Andersen, H., Ternes, T., Richle, P.R., Siegrist, H., Removal of estrogens in municipal wastewater treatment under aerobic and anaerobic conditions: consequences for plant optimization. Environ. Sci. Technol. 38:11 (2004), 3047–3055.
41. Joss, A., Zabczynski, S., Gobel, A., Hoffmann, B., Loffler, D., McArdell, C.S., Ternes, T.A., Thomsen, A., Siegrist, H., Biological degradation of pharmaceuticals in municipal wastewater treatment: proposing a classification scheme. Water Res. 40:8 (2006), 1686–1696.
42. Jukosky, J.A., Watzin, M.C., Leiter, J.C., The effects of environmentally relevant mixtures of estrogens on Japanese medaka (Oryzias latipes) reproduction. Aquat. Toxicol. 86:2 (2008), 323–331.
43. Kim, M., Guerra, P., Shah, A., Parsa, M., Alaee, M., Smyth, S.A., Removal of pharmaceuticals and personal care products in a membrane bioreactor wastewater treatment plant. Water Sci. Technol. 69:11 (2014), 2221–2229.
44. Kim, D.W., Heinze, T.M., Kim, B.S., Schnackenberg, L.K., Woodling, K.A., Sutherland, J.B., Modification of norfloxacin by a Microbacterium sp. strain isolated from a wastewater treatment plant. Appl. Environ. Microb. 77:17 (2011), 6100–6108.
45. Kimura, K., Hara, H., Watanabe, Y., Removal of pharmaceutical compounds by submerged membrane bioreactors (MBRs). Desalination 178:1 (2005), 135–140.
46. Klausen, M.M., Thomsen, T.R., Nielsen, J.L., Mikkelsen, L.H., Nielsen, P.H., Variations in microcolony strength of probe-defined bacteria in activated sludge flocs. FEMS Microbiol. Ecol. 50:2 (2004), 123–132.
47. Kruglova, A., Kråkström, M., Riska, M., Mikola, A., Rantanen, P., Vahala, R., Kronberg, L., Comparative study of emerging micro-pollutants removal by aerobic activated sludge of large laboratory-scale membrane bioreactors and sequencing batch reactors under low-temperature conditions. Bioresour. Technol. 214 (2016), 81–88.
48. Krustok, I., Odlare, M., Truu, J., Nehrenheim, E., Inhibition of nitrification in municipal wastewater-treating photobioreactors: Effect on algal growth and nutrient uptake. Bioresour. Technol. 202 (2016), 238–243.
49. Kwon, S., Kim, T.-S., Yu, G.H., Jung, J.-H., Park, H.-D., Bacterial community composition and diversity of a full-scale integrated fixed-film activated sludge system as investigated by pyrosequencing. J. Microbiol. Biotechnol. 20:12 (2010), 1717–1723.
50. Lemmer, H., Lind, G., Müller, E., Schade, M., Ziegelmayer, B., Scum in activated sludge plants: impact of non-filamentous and filamentous bacteria. Acta Hydrochim. Hydrobiol. 28:1 (2000), 34–40.
51. Lesjean, B., Rosenberger, S., Laabs, C., Jekel, M., Gnirss, R., Amy, G., Correlation between membrane fouling and soluble/colloidal organic substances in membrane bioreactors for municipal wastewater treatment. Water Sci. Technol. 51:6–7 (2005), 1–8.
52. Li, X., Hai, F.I., Nghiem, L.D., Simultaneous activated carbon adsorption within a membrane bioreactor for an enhanced micro-pollutant removal. Bioresour. Technol. 102:9 (2011), 5319–5324.
53. Lin, A.Y.C., Plumlee, M.H., Reinhard, M., Natural attenuation of pharmaceuticals and alkylphenol polyethoxylate metabolites during river transport: photochemical and biological transformation. Environ. Toxicol. Chem. 25:6 (2006), 1458–1464.
54. Lin, B., Lyu, J., Lyu, X.J., Yu, H.Q., Hu, Z., Lam, J.C., Lam, P.K., Characterization of cefalexin degradation capabilities of two Pseudomonas strains isolated from activated sludge. J. Hazard. Mater. 282 (2015), 158–164.
55. Ma, C., Yu, S., Shi, W., Tian, W., Heijman, S.G.J., Rietveld, L.C., High concentration powdered activated carbon-membrane bioreactor (PAC-MBR) for slightly polluted surface water treatment at low temperature. Bioresour. Technol. 113 (2012), 136–142.
56. Marco-Urrea, E., Pérez-Trujillo, M., Vicent, T., Caminal, G., Ability of white-rot fungi to remove selected pharmaceuticals and identification of degradation products of ibuprofen by Trametes versicolor. Chemosphere 74:6 (2009), 765–772.
57. Margiotta-Casaluci, L., Hannah, R.E., Sumpter, J.P., Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study. Aquat. Toxicol. 128–129 (2013), 113–123.
58. Marques, C.R., Abrantes, N., Goncalves, F., Life-history traits of standard and autochthonous cladocerans: II. Acute and chronic effects of acetylsalicylic acid metabolites. Environ. Toxicol. 19:5 (2004), 527–540.
59. Miao, X.-S., Koenig, B.G., Metcalfe, C.D., Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography–electrospray ionization tandem mass spectrometry. J. Chromatogr. A 952:1 (2002), 139–147.
60. Nakada, N., Kiri, K., Shinohara, H., Harada, A., Kuroda, K., Takizawa, S., Takada, H., Evaluation of pharmaceuticals and personal care products as water-soluble molecular markers of sewage. Environ. Sci. Technol. 42:17 (2008), 6347–6353.
61. Ng, K.K., Shi, X., Ong, S.L., Ng, H.Y., Pyrosequencing reveals microbial community profile in anaerobic bio-entrapped membrane reactor for pharmaceutical wastewater treatment. Bioresour. Technol. 200 (2016), 1076–1079.
62. Ng, A.S., Stenstrom, M.K., Nitrification in powdered activated carbon activated sludge process. J. Environ. Eng. 113:6 (1987), 1285–1301.
63. Oaks, J.L., Gilbert, M., Virani, M.Z., Watson, R.T., Meteyer, C.U., Rideout, B.A., Shivaprasad, H., Ahmed, S., Chaudhry, M.J.I., Arshad, M., Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 427:6975 (2004), 630–633.
64. Osorio-Lozada, A., Surapaneni, S., Skiles, G.L., Subramanian, R., Biosynthesis of drug metabolites using microbes in hollow fiber cartridge reactors: case study of diclofenac metabolism by Actinoplanes species. Drug Metab. Dispos. 36:2 (2008), 234–240.
65. Ozdemir, G., Aydin, E., Topuz, E., Yangin-Gomec, C., Tas, D.O., Acute and chronic responses of denitrifying culture to diclofenac. Bioresour. Technol. 176 (2015), 112–120.
66. Paris-Nord, C.C.L.I.N., 1999. Elimination of liquid effluents in hospital establishments—recommendations, Institute of biomedical, Cordeliers, Paris, p. 74. Available on: < http://web. ccr. jussieu. fr/guide_effluents_liquides. pdf>, 20(09), 2001.
67. Pauwels, B., Verstraete, W., The treatment of hospital wastewater: an appraisal. J. Water Health 4:4 (2006), 405–416.
68. Popa Ungureanu, C., Favier, L., Bahrim, G., Screening of soil bacteria as potential agents for drugs biodegradation: a case study with clofibric acid. J. Chem. Technol. Biotechnol. 91:6 (2016), 1646–1653.
69. Quinlan, E.L., Nietch, C.T., Blocksom, K., Lazorchak, J.M., Batt, A.L., Griffiths, R., Klemm, D.J., Temporal dynamics of periphyton exposed to tetracycline in stream mesocosms. Environ. Sci. Technol. 45:24 (2011), 10684–10690.
70. Quintana, J.B., Weiss, S., Reemtsma, T., Pathways and metabolites of microbial degradation of selected acidic pharmaceutical and their occurrence in municipal wastewater treated by a membrane bioreactor. Water Res. 39:12 (2005), 2654–2664.
71. Radjenović, J., Petrović, M., Barceló, D., Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment. Water Res. 43:3 (2009), 831–841.
72. Rodarte-Morales, A., Feijoo, G., Moreira, M., Lema, J., Biotransformation of three pharmaceutical active compounds by the fungus Phanerochaete chrysosporium in a fed batch stirred reactor under air and oxygen supply. Biodegradation 23:1 (2012), 145–156.
73. Rogers, H.R., Sources, behaviour and fate of organic contaminants during sewage treatment and in sewage sludges. Sci. Total Environ. 185:1 (1996), 3–26.
74. Samaras, V.G., Stasinakis, A.S., Mamais, D., Thomaidis, N.S., Lekkas, T.D., Fate of selected pharmaceuticals and synthetic endocrine disrupting compounds during wastewater treatment and sludge anaerobic digestion. J. Hazard. Mater. 244 (2013), 259–267.
75. Schwarzenbach, R.P., Gschwend, P.M., Imboden, D.M., Environmental Organic Chemistry. 2005, John Wiley & Sons.
76. Serrano, D., Suarez, S., Lema, J.M., Omil, F., Removal of persistent pharmaceutical micropollutants from sewage by addition of PAC in a sequential membrane bioreactor. Water Res. 45:16 (2011), 5323–5333.
77. Seung, H., Aerobic and Anaerobic Membrane Bioreactors (MBRs) for Dilute Municipal Wastewater Treatment. PhD Thesis, 2004, Illinois Institute of Technology, Chicago.
78. Sipma, J., Osuna, B., Collado, N., Monclús, H., Ferrero, G., Comas, J., Rodriguez-Roda, I., Comparison of removal of pharmaceuticals in MBR and activated sludge systems. Desalination 250:2 (2010), 653–659.
79. Sneader, W.E., Drug Discovery (The History). 2005, John Wiley & Sons Inc.
80. Snyder, S.A., Adham, S., Redding, A.M., Cannon, F.S., DeCarolis, J., Oppenheimer, J., Wert, E.C., Yoon, Y., Role of membranes and activated carbon in the removal of endocrine disruptors and pharmaceuticals. Desalination 202:1 (2007), 156–181.
81. Suarez, S., Lema, J.M., Omil, F., Removal of pharmaceutical and personal care products (PPCPs) under nitrifying and denitrifying conditions. Water Res. 44:10 (2010), 3214–3224.
82. Tadkaew, N., Sivakumar, M., Khan, S.J., McDonald, J.A., Nghiem, L.D., Effect of mixed liquor pH on the removal of trace organic contaminants in a membrane bioreactor. Bioresour. Technol. 101:5 (2010), 1494–1500.
83. Ternes, T., Janex-Habibi, M., Knacker, T., Kreuzinger, N., Siegrist, H. 2004. Assessment of technologies for the removal of pharmaceuticals and personal care products in sewage and drinking water facilities to improve the indirect potable water reuse. Contract No. EVK1-CT-2000-00047.
84. Ternes, T.A., Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 32:11 (1998), 3245–3260.
85. Ternes, T.A., Joss, A., Human Pharmaceuticals, Hormones and Fragrances: The Challenge of Micro-Pollutants in Urban Water Management. 2006, IWA publishing.
86. Thuy, Q.T.T., Visvanathan, C., Removal of inhibitory phenolic compounds by biological activated carbon coupled membrane bioreactor. Water Wastewater Manage. Sustainable Dev. Chem. Ind. 53:11 (2006), 89–97.
87. Topp, E., Chapman, R., Devers-Lamrani, M., Hartmann, A., Marti, R., Martin-Laurent, F., Sabourin, L., Scott, A., Sumarah, M., Accelerated biodegradation of veterinary antibiotics in agricultural soil following long-term exposure, and isolation of a sulfamethazine-degrading sp. J. Environ. Qual. 42:1 (2013), 173–178.
88. Valcarcel, Y., Alonso, S.G., Rodriguez-Gil, J.L., Maroto, R.R., Gil, A., Catala, M., Analysis of the presence of cardiovascular and analgesic/anti-inflammatory/antipyretic pharmaceuticals in river- and drinking-water of the Madrid Region in Spain. Chemosphere 82:7 (2011), 1062–1071.
89. Vasskog, T., Anderssen, T., Pedersen-Bjergaard, S., Kallenborn, R., Jensen, E., Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway. J. Chromatogr. A 1185:2 (2008), 194–205.
90. Verlicchi, P., Al Aukidy, M., Galletti, A., Petrovic, M., Barceló, D., Hospital effluent: investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment. Sci. Total Environ. 430 (2012), 109–118.
91. Vieno, N.M., Härkki, H., Tuhkanen, T., Kronberg, L., Occurrence of pharmaceuticals in river water and their elimination in a pilot-scale drinking water treatment plant. Environ. Sci. Technol. 41:14 (2007), 5077–5084.
92. Wei, X., Li, B., Zhao, S., Wang, L., Zhang, H., Li, C., Wang, S., Mixed pharmaceutical wastewater treatment by integrated membrane-aerated biofilm reactor (MABR) system – a pilot-scale study. Bioresour. Technol. 122 (2012), 189–195.
93. Weigel, S., Berger, U., Jensen, E., Kallenborn, R., Thoresen, H., Hühnerfuss, H., Determination of selected pharmaceuticals and caffeine in sewage and seawater from Tromsø/Norway with emphasis on ibuprofen and its metabolites. Chemosphere 56:6 (2004), 583–592.
94. Wells, G.F., Park, H.D., Yeung, C.H., Eggleston, B., Francis, C.A., Criddle, C.S., Ammonia-oxidizing communities in a highly aerated full-scale activated sludge bioreactor: betaproteobacterial dynamics and low relative abundance of Crenarchaea. Environ. Microbiol. 11:9 (2009), 2310–2328.
95. Wen, X., Ding, H., Huang, X., Liu, R., Treatment of hospital wastewater using a submerged membrane bioreactor. Process Biochem. 39:11 (2004), 1427–1431.
96. Wijekoon, K.C., Hai, F.I., Kang, J., Price, W.E., Guo, W., Ngo, H.H., Nghiem, L.D., The fate of pharmaceuticals, steroid hormones, phytoestrogens, UV-filters and pesticides during MBR treatment. Bioresour. Technol. 144 (2013), 247–254.
97. Yan, C., Yang, Y., Zhou, J., Liu, M., Nie, M., Shi, H., Gu, L., Antibiotics in the surface water of the Yangtze Estuary: occurrence, distribution and risk assessment. Environ. Pollut. 175 (2013), 22–29.
98. Yang, S., Hai, F.I., Nghiem, L.D., Price, W.E., Roddick, F., Moreira, M.T., Magram, S.F., Understanding the factors controlling the removal of trace organic contaminants by white-rot fungi and their lignin modifying enzymes: a critical review. Bioresour. Technol. 141 (2013), 97–108.
99. Yu, Y., Wu, L., Chang, A.C., Seasonal variation of endocrine disrupting compounds, pharmaceuticals and personal care products in wastewater treatment plants. Sci. Total Environ. 442 (2013), 310–316.
100. Zhang, P., Huang, H.H., Zhong, D.F., Biotransformation of indomethacin by the fungus Cunninghamella blakesleeana1. Acta Pharmacol. Sin. 27:8 (2006), 1097–1102.
101. Zhang, Y., Geißen, S.U., Elimination of carbamazepine in a non-sterile fungal bioreactor. Bioresour. Technol. 112 (2012), 221–227.
102. Zhao, X., Chen, Z., Wang, X., Li, J., Shen, J., Xu, H., Remediation of pharmaceuticals and personal care products using an aerobic granular sludge sequencing bioreactor and microbial community profiling using Solexa sequencing technology analysis. Bioresour. Technol. 179 (2015), 104–112.
103. Zhou, S., Chan, E., Duan, W., Huang, M., Chen, Y.-Z., Drug bioactivation covalent binding to target proteins and toxicity relevance. Drug Metab. Rev. 37:1 (2005), 41–213.
104. Zuehlke, S., Duennbier, U., Heberer, T., Investigation of the behavior and metabolism of pharmaceutical residues during purification of contaminated ground water used for drinking water supply. Chemosphere 69:11 (2007), 1673–1680.