Biotransformation of indomethacin by the fungus Cunninghamella blakesleeana

Acta Pharmacologica Sinica

Volumn 27, Issue 8, 2006, Pages 1097-1102

  Zhang, Peng ^a   Lin, Li Hong ^a   Huang, Hai Hua ^b   Xu, Hai Yan ^a   Zhong, Da Fang ^a,b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cunninghamella blakesleeana; Indomethacin; Liquid chromatography; Mass spectrometry; Microbial transformation

Indexed keywords

DRUG METABOLITE; INDOMETACIN; N DESCHLOROBENZOYLINDOMETHACIN; NONSTEROID ANTIINFLAMMATORY AGENT; NOR N DESCHLOROBENZOYLINDOMETHACIN; NORINDOMETACIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CUNNINGHAMELLA; CUNNINGHAMELLA BLAKESLEEANA; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; FUNGAL STRAIN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCUBATION TIME; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; SEPARATION TECHNIQUE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; CUNNINGHAMELLA; INDOLEACETIC ACIDS; INDOMETHACIN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY;

EID: 33746416272     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00350.x     Document Type: Article

References (12)

1. O'Brien WM. Indomethacin: a survey of clinical trials. Clin Pharmacol Ther 1968; 9: 94-107.
2. Helleberg L. Clinical pharmacokinetics of indomethacin. Clin Pharmacokin 1981; 6: 245-58.
3. Goodson JM, Dewhirst FE, Brunetti A. Prostaglandin E2 levels, and human periodontal disease. Prostaglandins 1974; 6: 81-5.
4. Harman RE, Meisinger MAP, Davis GE, Kuehl FA Jr. The metabolism of indomethacin, a new anti-inflammatory drug. J Pharmacol Exp Ther 1964; 143: 215-20.
5. Duggan DE, Hogans AF, Kwan KC, McMahon FG. The metabolism of indomethacin in man. J Pharmacol Exp Ther 1972; 181: 563-75.
6. Vree TB, van den Biggelaar-Martea M, Verwey-van Wissen CP. Determination of indomethacin, its metabolites and their glucuronides in human plasma and urine by means of direct gradient high-performance liquid cromatographic analysis. Preliminary pharmacokinetics and effect of probenecid. J Chromatogr 1993; 616: 271-82.
7. Srisilam K, Veeresham C. Biotransformation of drugs by microbial cultures for predicting mammalian drug metabolism. Biotechnol Adv 2003; 21: 3-39.
8. Abourashed EA, Clark AM, Hufford CD. Microbial models of mammalian metabolism of xenobiotics: an updated review. Curr Med Chem 1999; 6: 359-64.
9. Zhong DF, Sun L, Liu L, Huang HH. Microbial transformation of naproxen by Cunninghamella species. Acta Pharmacol Sin 2003; 24: 442-7.
10. Sun L, Liu L, Huang HH, Zhong DF. Transformation of verapamil by Cunninghamella blakesleeana. Appl Environ Microbiol 2004: 70: 2722-7.
11. Cerniglia CE, Freeman JP, Mitchum RK. Glucuronide and sulfate conjugation in the fungal metabolism of aromatic hydrocarbons. Appl Environ Microbiol 1982; 43: 1070-5.
12. Chatterjee P, Pezzuto JM, Kouzi SA. Glucosidation of betulinic acid by Cunninghamella species. J Nat Prod 1999; 62: 761-3.