Bacterial production of hydroxylated and amidated metabolites of flurbiprofen

Journal of Molecular Catalysis B: Enzymatic

Volumn 72, Issue 3-4, 2011, Pages 116-121

  Bright, Tara V ^a   Clark, Benjamin R ^a   O'Brien, Eimear ^a   Murphy, Cormac D ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Biotransformation; F 19 NMR; Fluorometabolite

Indexed keywords

AMIDATION REACTION; ANTI-INFLAMMATORY DRUGS; BACILLUS MEGATERIUM; BACILLUS SPP; BACILLUS STRAIN; BACILLUS SUBTILIS; BACTERIAL PRODUCTION; BIOTRANSFORMATION; F-19 NMR; FLUORINE-19; FLUOROMETABOLITE; FLURBIPROFEN; HYDROXYLATED METABOLITES; MEGATERIUM; METHOXY; NMR ANALYSIS; RESTING CELLS; STREPTOMYCES GRISEUS; STREPTOMYCES RIMOSUS; SUPERNATANTS;

AMINO ACIDS; BACILLI; BACTERIOLOGY; BIOMOLECULES; CELL CULTURE; FLUORINE; HYDROXYLATION; MAMMALS; METABOLISM; METABOLITES; RESONANCE;

NUCLEAR MAGNETIC RESONANCE;

3' METHOXY, 4' HYDROXYFLURBIPROFEN; 3',4' DIHYDROXYFLURBIPROFEN; 4' HYDROXYFLURBIPROFEN; 7 HYDROXYFLURBIPROFENAMIDE; DRUG METABOLITE; FLURBIPROFEN; FLURBIPROFENAMIDE; NITROGEN; UNCLASSIFIED DRUG;

AMIDATION; ARTICLE; BACILLUS; BACILLUS MEGATERIUM; BACILLUS SUBTILIS; DRUG HYDROXYLATION; DRUG TRANSFORMATION; FLUORINE NUCLEAR MAGNETIC RESONANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; STREPTOMYCES; STREPTOMYCES GRISEUS; STREPTOMYCES LAVENDULIGRISEUS; STREPTOMYCES RIMOSUS; STREPTOMYCES SUBRUTILIS;

BACILLUS (BACTERIUM); BACILLUS MEGATERIUM; BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); MAMMALIA; STREPTOMYCES; STREPTOMYCES GRISEUS; STREPTOMYCES LAVENDULIGRISEUS; STREPTOMYCES RIMOSUS; STREPTOMYCES SUBRUTILUS;

EID: 80052272688     PISSN: 13811177     EISSN: 18733158     Source Type: Journal    
DOI: 10.1016/j.molcatb.2011.05.008     Document Type: Article

References (27)

1. R. Azerad Advances in Biochemical Engineering/Biotechnology 63 1999 169 218
2. S.G. Jezequel Journal of Molecular Catalysis B: Enzymatic 5 1998 371 377
3. A. Osorio-Lozada, S. Surapaneni, G.L. Skiles, and R. Subramanian Drug Metabolism and Disposition 36 2008 234 240
4. S. Asha, and M. Vidyavathi Biotechnology Advances 27 2009 16 29
5. M. Taylor, D.C. Lamb, R. Cannell, M. Dawson, and S.L. Kelly Biochemical and Biophysical Research Communications 263 1999 838 842
6. D.H. Kim, K.H. Kim, D. Kim, H.C. Jung, J.G. Pan, Y.T. Chi, T. Ahn, and C.H. Yun Journal of Molecular Catalysis B: Enzymatic 63 2010 179 187
7. V. Alexandre, S. Ladril, M. Maurs, and R. Azerad Journal of Molecular Catalysis B: Enzymatic 29 2004 173 179
8. S. Pospisil, V. Prikrylova, J. Nemecek, and J. Spizek Canadian Journal of Microbiology 42 1996 867 869
9. C.D. Murphy, B.R. Clark, and J. Amadio Applied Microbiology and Biotechnology 84 2009 617 629
10. Y. Chen, J.P.N. Rosazza, C.P. Reese, H.Y. Chang, M.A. Nowakowski, and J.P. Kiplinger Journal of Industrial Microbiology & Biotechnology 19 1997 378 384
11. W. Herath, and I.A. Khan Chemical & Pharmaceutical Bulletin 58 2010 562 564
12. C.D. Murphy Omics: A Journal of Integrative Biology 11 2007 314 324
13. O. Corcoran, J.C. Lindon, R. Hall, I.M. Ismail, and J.K. Nicholson Analyst 126 2001 2103 2106
14. J. Amadio, K. Gordon, and C.D. Murphy Applied and Environmental Microbiology 2010 6299 6303
15. J. Amadio, and C.D. Murphy Biotechnology Letters 33 2011 321 326
16. D.A. Griffiths, D.J. Best, and S.G. Jezequel Applied Microbiology and Biotechnology 35 1991 373 381
17. F.S. Sariaslani, and D.A. Kunz Biochemical and Biophysical Research Communications 141 1986 405 410
18. C. Tsitsimpikou, M.H.E. Spyridaki, I. Georgoulakis, D. Kouretas, M. Konstantinidou, and C.G. Georgakopoulos Talanta 55 2001 1173 1180
19. K. Dhar, and J.P.N. Rosazza Applied and Environmental Microbiology 66 2000 4877 4882
20. D.C. Lamb, T. Skaug, H.-L. Song, C.J. Jackson, L.M. Podust, M.R. Waterman, D.B. Kell, D.E. Kelly, and S.L. Kelly Journal of Biological Chemistry 277 2002 24000 24005
21. C.H. Yun, K.H. Kim, D.H. Kim, H.C. Jung, and J.G. Pan Trends in Biotechnology 25 2007 289 298
22. E.V. Bellale, D.S. Bhalerao, and K.G. Akamanchi Journal of Organic Chemistry 73 2008 9473 9475
23. B. Clark, R.J. Capon, E. Lacey, S. Tennant, and J.H. Gill Organic & Biomolecular Chemistry 4 2006 1512 1519
24. A. Kergomard, and M.F. Renard Agricultural and Biological Chemistry 50 1986 2913 2914
25. M. Brunati, F. Marinelli, C. Bertolini, R. Gandolfi, D. Daffonchio, and F. Molinari Enzyme and Microbial Technology 34 2004 3 9
26. R. Maruyama, A. Kawata, S. Ono, M. Nishizawa, S. Ito, and M. Inoue Bioscience Biotechnology and Biochemistry 65 2001 1761 1765
27. R. Maruyama, S. Ono, and M. Inoue Tetrahedron Letters 41 2000 5229 5232