Investigation of the behavior and metabolism of pharmaceutical residues during purification of contaminated ground water used for drinking water supply

Chemosphere

Volumn 69, Issue 11, 2007, Pages 1673-1680

  Zuehlke, Sebastian ^a,b   Duennbier, Uwe ^b   Heberer, Thomas ^c  

^a TU DORTMUND UNIVERSITY   (Germany)

^b Berlin Water Company   (Germany)

^c FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

Degradation; Drinking water treatment; Drug residues; Metabolites; Phenazone

Indexed keywords

CONTAMINATION; DRUG PRODUCTS; FILTRATION; GROUNDWATER; METABOLITES; PURIFICATION;

BIOLOGICAL TRANSFORMATION; FILTER MATERIAL; PROPYPHENAZONE;

WATER TREATMENT;

1 ACETYL 1 METHYL 2 DIMETHYLOXAMOYL 2 PHENYLHYDRAZIDE; 1 ACETYL 1 METHYL 2 PHENYLHYDRAZIDE; 1,5 DIMETHYL 1,2 DEHYDRO 3 PYRAZOLONE; 4 (2 METHYLETHYL) 1,5 DIMETHYL 1,2 DEHYDRO 3 PYRAZOLONE; ACETOAMINOANTIPYRINE; AMINOPHENAZONE; DRINKING WATER; FORMYLAMINOANTIPYRINE; GROUND WATER; HYDRAZIDE DERIVATIVE; PHENAZONE; PHENAZONE DERIVATIVE; PROPYPHENAZONE; PYRAZOLONE; UNCLASSIFIED DRUG;

CONTAMINATION; DRUG PRODUCTS; FILTRATION; GROUNDWATER; METABOLITES; PURIFICATION; WATER TREATMENT;

BIOTRANSFORMATION; DRINKING WATER; DRUG; GROUNDWATER POLLUTION; METABOLISM; METABOLITE; WATER SUPPLY; WATER TREATMENT;

ARTICLE; CHEMICAL STRUCTURE; FILTRATION; MEDICAL CARE; VELOCITY; WATER CONTAMINATION; WATER MANAGEMENT; WATER METABOLISM; WATER POLLUTION; WATER SUPPLY;

BERLIN; CENTRAL EUROPE; EURASIA; EUROPE; GERMANY;

EID: 35448954016     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2007.06.020     Document Type: Article

References (19)

1. Boyd G.R., Zhang S.Y., and Grimm D.A. Naproxen removal from water by chlorination and biofilm processes. Water Res. 39 (2005) 668-676
2. Daughton C.G., and Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ. Health. Persp. 107 (1999) 907-938
3. Heberer Th., Duennbier U., Reilich Ch., and Stan H.J. Detection of drugs and drug metabolites in groundwater samples of a drinking water treatment plant. Fresen. Environ. Bull. 6 (1997) 438-443
4. Heberer Th. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol. Lett. 131 (2002) 5-17
5. Kümmerer K. Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources. Chemosphere 45 (2001) 957-969
6. Lingens F., Blecher R., Blecher H., Blobel F., and Eberspaecher J. Phenylobacterium immobile gen. nov., sp. nov., a gram-negative bacterium that degrades the herbicide chloridazon. Int. J. Syst. Bacteriol. 35 (1985) 26-39
7. OECD, 1997. OECD Guidelines for testing of chemicals, proposal for updating guideline 106. OECD, Paris, France.
8. Reddersen K., Heberer Th., and Duennbier U. Identification and significance of phenazone drugs and their metabolites in ground- and drinking water. Chemosphere 49 (2002) 539-544
9. Sauber K., Müller R., Keller E., Eberspaecher J., and Lingens F. Degradation of antipyrin by pyrazon-degrading bacteria. Z. Naturforsch. 32 (1977) 557-562
10. Schmidt R., and Brockmeyer R. Occurrence and behavior of expectorants, analgesics, xylometazoline and their metabolites in water and during bank filtration. Vom Wasser 98 (2002) 37-54
11. Ternes T.A. Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 32 (1998) 3245-3260
12. Ternes T.A., Stumpf M., Mueller J., Haberer K., Wilken R.-D., and Servos M. Behavior and occurrence of estrogens in municipal sewage treatment plants. Sci. Total Environ. 225 (1999) 81-90
13. Ternes T., Bonerz M., and Schmidt T. Determination of neutral pharmaceuticals in wastewater and rivers by liquid chromatography-electrospray tandem mass spectrometry. J. Chromatogr. A 938 (2001) 175-185
14. Vieno N., Tuhkanen T., and Kronberg L. Removal of pharmaceuticals in drinking water treatment: effect of chemical coagulation. Environ. Technol. 27 (2006) 183-192
15. Westerhoff P., Yoon Y., Snyder S., and Wert E. Fate of endocrine-disruptor, pharmaceutical, and personal care product chemicals during simulated drinking water treatment processes. Environ. Sci. Technol. 39 (2005) 6649-6663
16. Yu J.T., Bouwer E.J., and Coelhan M. Occurrence and biodegradability studies of selected pharmaceuticals and personal care products in sewage effluent. Agr. Water Manage. 86 (2006) 72-80
17. Zuehlke S., Duennbier U., and Heberer Th. Detection and identification of phenazone-type drugs and their microbial metabolites in ground- and drinking water applying solid-phase extraction and gas chromatography with mass spectrometric detection. J. Chromotogr. A. 1050 (2004) 201-209
18. Zuehlke S., Duennbier U., and Heberer Th. Determining polar drug residues in sewage and surface water applying liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Anal. Chem. 76 (2004) 6548-6554
19. Zuehlke S., Duennbier U., Gnirss R., Lesjean B., and Buisson H. Long term comparison of trace organics removal performances between conventional and membrane activated sludge processes. Water Environ. Res. 78 (2006) 2480-2486