Determination of selected pharmaceuticals and caffeine in sewage and seawater from Tromsø/Norway with emphasis on ibuprofen and its metabolites

Chemosphere

Volumn 56, Issue 6, 2004, Pages 583-592

  Weigel, Stefan ^a   Berger, Urs ^b   Jensen, Einar ^c   Kallenborn, Roland ^b   Thoresen, Hilde ^c   Hühnerfuss, Heinrich ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b NORWEGIAN INSTITUTE FOR AIR RESEARCH   (Norway)

^c UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Carboxy ibuprofen; Drugs; Hydroxy ibuprofen; Triclosan

Indexed keywords

DRUG PRODUCTS; EFFLUENTS; ORGANIC COMPOUNDS; SEAWATER; SEWAGE TREATMENT;

ANALGESICS; CAFFEINE;

WATER POLLUTION CONTROL;

CAFFEINE; CARBAMAZEPINE; CARBOXYIBUPROFEN; CLOFIBRIC ACID; DICLOFENAC; DIETHYLTOLUAMIDE; FLUOXETINE; HYDROXYIBUPROFEN; IBUPROFEN; IBUPROFEN DERIVATIVE; METOPROLOL; PAROXETINE; PROPRANOLOL; SEA WATER; SERTRALINE; TRICLOSAN; UNCLASSIFIED DRUG;

ANTHROPOGENIC SOURCE; ORGANIC COMPOUND; SEWAGE OUTFALL; WATER POLLUTION;

ACCURACY; ANALYTIC METHOD; ARTICLE; DRUG DETERMINATION; GAS CHROMATOGRAPHY; GEOGRAPHIC DISTRIBUTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NORWAY; QUANTITATIVE ANALYSIS; SEA POLLUTION; SEWAGE EFFLUENT; SEWAGE TREATMENT; VALIDATION PROCESS;

EURASIA; EUROPE; NORTHERN EUROPE; NORWAY; SCANDINAVIA; TROMS; TROMSO;

BACTERIA (MICROORGANISMS); INSECTA;

EID: 2942718830     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2004.04.015     Document Type: Article

References (29)

1. Buerge I.J., Poiger T., Müller M.D., Buser H.-R. Caffeine, an anthropogenic marker for wastewater contamination of surface waters. Environ. Sci. Technol. 37:2003;691-700
2. Buser H.-R., Müller M.D., Theobald N. Occurrence of the pharmaceutical drug clofibric acid and the herbicide mecoprop in various Swiss lakes and in the North Sea. Environ. Sci. Technol. 32:1998;188-192
3. Buser H.-R., Poiger T., Müller M.D. Occurrence and environmental behavior of the chiral pharmaceutical drug ibuprofen in surface waters and in wastewater. Environ. Sci. Technol. 33:1999;2529-2535
4. Caccia S. Metabolism of the newer antidepressants. An overview of the pharmacological and pharmacokinetic implications. Clin. Pharmacokinet. 34:1998;281-302
5. Daughton C.G., Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ. Health Perspect. 107(Suppl. 6):1999;907-938
6. Fong P.P. Zebra mussel spawning is induced in low concentrations of putative serotonin reuptake inhibitors. Biol. Bull. 194:1998;143-149
7. Halling-Sørensen B., Nors Nielsen S., Lanzky P.F., Ingerslev F., Holten Lützhøft H.C., Jørgensen S.E. Occurrence, fate and effects of pharmaceutical substances in the environment - a review. Chemosphere. 36:1998;357-393
8. Heberer T., Stan H.-J. Determination of clofibric acid and N-(phenylsulfonyl)-sarcosine in sewage, river and drinking water. Int. J. Environ. Anal. Chem. 67:1997;113-124
9. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.R., Buxton H.T. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ. Sci. Technol. 36:2002;1202-1211
10. Kuhlmann, J., Hühnerfuss, H., Weigel, S., 2003. Solid-phase extraction, sequential elution and derivatisation of acidic pharmaceuticals and estrogens from water samples for GC/MS-determination. Poster, SETAC Europe 13th Annual Meeting, Hamburg, Germany, 27 April-1 May
11. Kümmerer K. Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources - a review. Chemosphere. 45:2001;957-969
12. Kurtz R.R., Houser D.J. A 1, 6-eliminative epoxide cleavage in the synthesis of an ibuprofen metabolite. J. Org. Chem. 46:1981;202-203
13. Mills R.F.N., Adams S.S., Cliffe E.E., Dickinson W., Nicholson J.S. Xenobiotica. 3:1973;589-598
14. Paxéus N. Organic pollutants in the effluents of large wastewater treatment plants in Sweden. Water Res. 30:1996;1115-1122
15. Øydvin K. Drug consumption in Norway (1993-1997). 1998;NMD, Oslo
16. Sacher F., Lange F.T., Brauch H.J., Blankenhorn I. Pharmaceuticals in groundwaters Analytical methods and results of a monitoring program in Baden-Württemberg, Germany. J. Chromatogr. A. 938:2001;199-210
17. Schwabe U., Paffrath D. Arzneiverordnungsreport 2001. 2001;Springer-Verlag, Berlin
18. Seiler R.L., Zaugg S.D., Thomas J.M., Howcroft D.L. Caffeine and pharmaceuticals as indicators of waste water contamination in wells. Ground Water. 37:1999;405-410
19. Siegener R., Chen R.F. Caffeine in Boston Harbour seawater. Mar. Pollut. Bull. 44:2002;383-387
20. Stumpf M., Ternes T.A., Haberer K., Baumann W. Isolierung von Ibuprofen-Metaboliten und deren Bedeutung als Kontaminanten der aquatischen Umwelt. Vom Wasser. 91:1998;291-303
21. Tan S.C., Baker J.A., Stevens N., de Biasi V., Salter C., Chalaux M., Afarinkia V., Hutt A.J. Synthesis, chromatographic resolution and chiroptical properties of carboxyibuprofen stereoisomers: Major metabolites of ibuprofen in man. Chirality. 9:1997;75-87
22. Ternes T.A. Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 32:1998;3245-3260
23. Ternes T., Bonerz M., Schmidt T. Determination of neutral pharmaceuticals in wastewater and rivers by liquid chromatography-electrospray tandem mass spectrometry. J. Chromatogr. A. 938:2001;175-185
24. von Bruchhausen F., Dannhardt G., Ebel S., Frahm A.W., Holzgrabe U. Hagers Handbuch der Pharmazeutischen Praxis, 5th ed. vol. 7-9:1994;Springer- Verlag, Berlin
25. Weigel S., Bester K., Hühnerfuss H. New method for rapid solid-phase extraction of large-volume water samples and its application to non-target screening of North Sea water for organic contaminants by gas chromatography-mass spectrometry. J. Chromatogr. A. 912:2001;151-161
26. Weigel S., Kuhlmann V., Hühnerfuss H. Drugs and personal care products as ubiquitous pollutants: occurrence and distribution of clofibric acid, caffeine and DEET in the North Sea. Sci. Tot. Environ. 295:2002;131-141
27. Weigel S., Kallenborn R., Hühnerfuss H. Simultaneous solid-phase extraction of acidic, neutral and basic pharmaceuticals from aqueous samples at ambient (neutral) pH and their determination by gas chromatography-mass spectrometry. J. Chromatogr. A. 1023:2004;183-195
28. Winkler M., Lawrence J.R., Neu T.R. Selective degradation of ibuprofen and clofibric acid in two model river biofilm systems. Water Res. 35:2001;3197-3205
29. Zwiener C., Seeger S., Glauner T., Frimmel F.H. Metabolites from biodegradation of pharmaceutical residues of ibuprofen in biofilm reactors and batch experiments. Anal. Bioanal. Chem. 372:2002;569-575