Microbial transformation of contraceptive drug etonogestrel into new metabolites with Cunninghamella blakesleeana and Cunninghamella echinulata

Steroids

Volumn 115, Issue , 2016, Pages 56-61

  Baydoun, Elias ^a   Wahab, Atia tul ^b   Shoaib, Nayab ^b   Ahmad, Malik Shoaib ^b   Abdel Massih, Roula ^c   Smith, Colin ^a   Naveed, Nimra ^b   Choudhary, M Iqbal ^b,d  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b UNIVERSITY OF KARACHI   (Pakistan)

^c UNIVERSITY OF BALAMAND   (Lebanon)

^d KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Biotransformation; Colon cancer; Contraceptive; Cunninghamella blakesleeana; Cunninghamella echinulata; Etonogestrel; Glucuronidase inhibition

Indexed keywords

10BETA HYDROXY ETONOGESTREL; 11,22 EPOXY ETONOGESTREL; 14ALPHA HYDROXY ETONOGESTREL; 6BETA HYDROXY 11,22 EPOXY ETONOGESTREL; 6BETA HYDROXY ETONOGESTREL; BETA GLUCURONIDASE; ETONOGESTREL; GLUCURONIC ACID; SACCHAROLACTONE; TOXIC SUBSTANCE; UNCLASSIFIED DRUG; CONTRACEPTIVE AGENT; DESOGESTREL;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; BIOTRANSFORMATION; CONTROLLED STUDY; CUNNINGHAMELLA BLAKESLEEANA; CUNNINGHAMELLA ECHINULATA; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST CULTURE; FUNGUS CULTURE; FUNGUS ISOLATION; HYDROLYSIS; IC50; INTESTINE FLORA; METABOLITE; MOUSE; NONHUMAN; 3T3 CELL LINE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CUNNINGHAMELLA; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

3T3 CELLS; ANIMALS; CONTRACEPTIVE AGENTS; CUNNINGHAMELLA; DESOGESTREL; GLUCURONIDASE; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR STRUCTURE;

EID: 84983233979     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2016.08.003     Document Type: Article

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