Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 51, 2016, Pages E8316-E8325

  Lalancette Hebert, Melanie ^a   Sharma, Aarti ^a   Lyashchenko, Alexander K ^a   Shneider, Neil A ^a  

^a Columbia University ^*  (United States)

Author keywords

ALS; Fusimotor; Gamma motor neuron; Motor neuron disease

Indexed keywords

CHOLINE ACETYLTRANSFERASE; COPPER ZINC SUPEROXIDE DISMUTASE; EARLY GROWTH RESPONSE FACTOR 3; GFR ALPHA1 PROTEIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; SOD1 PROTEIN, MOUSE; SUPEROXIDE DISMUTASE;

ALLELE; ALPHA NERVE FIBER; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXON; CELL SURVIVAL; CONTROLLED STUDY; FAST MUSCLE; FEMALE; FUNCTIONAL CONNECTIVITY; GAMMA MOTONEURON; HISTOGRAM; INTRAFUSAL MUSCLE FIBER; MALE; MOUSE; MUSCLE INNERVATION; MUSCLE SPINDLE; NERVE CELL DEGENERATION; NERVE CELL DIFFERENTIATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROPRIOCEPTION; SENSORY NERVE; SENSORY NERVE ENDING; SENSORY STIMULATION; SIGNAL TRANSDUCTION; SPINAL CORD VENTRAL HORN; SYNAPSE; WILD TYPE; ANIMAL; CYTOLOGY; DISEASE MODEL; GENETICS; GENOTYPE; INNERVATION; METABOLISM; MOTONEURON; MUSCLE; MUTATION; PATHOLOGY; SENSORY NERVE CELL; SPINAL CORD; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FEMALE; GENOTYPE; MALE; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MOTOR NEURONS, GAMMA; MUSCLES; MUTATION; NEURONS, AFFERENT; PROPRIOCEPTION; SPINAL CORD; SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE-1; SYNAPSES;

EID: 85006386936     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1605210113     Document Type: Article

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