Imbalanced excitatory to inhibitory synaptic input precedes motor neuron degeneration in an animal model of amyotrophic lateral sclerosis

Neurobiology of Disease

Volumn 20, Issue 1, 2005, Pages 131-140

  Schütz, Burkhard ^a,b  

^a Clinic and Polyclinic for Psychiatry and Psychotherapy   (Germany)

^b Institute for Anatomy and Cell Biology   (Germany)

Author keywords

Motor neuron; Neurodegeneration; Superoxide dismutase; Synaptic; Vesicular transporter

Indexed keywords

AMINO ACID TRANSPORTER; COPPER ZINC SUPEROXIDE DISMUTASE; NEUROTRANSMITTER; VESICULAR ACETYLCHOLINE TRANSPORTER; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR GLUTAMATE TRANSPORTER 2;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CHEMICAL COMPOSITION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; IMMUNOREACTIVITY; MALE; MOTONEURON; MOUSE; NERVE CELL DEGENERATION; NEUROCHEMISTRY; NEUROPATHOLOGY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; SPINAL CORD MOTONEURON; SYNAPTIC INHIBITION; SYNAPTIC POTENTIAL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL SURVIVAL; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; NERVE DEGENERATION; NEURAL INHIBITION; NEURAL PATHWAYS; PRESYNAPTIC TERMINALS; SPINAL CORD; SUPEROXIDE DISMUTASE; SYNAPTIC TRANSMISSION; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1; VESICULAR GLUTAMATE TRANSPORT PROTEIN 2;

EID: 24044448620     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.02.006     Document Type: Article

References (24)

1. L.I. Bruijn, T.M. Miller, and D.W. Cleveland Unraveling the mechanisms involved in motor neuron degeneration in Als Annu. Rev. Neurosci. 27 2004 723 749
2. D.W. Cleveland, and J.D. Rothstein From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS Nat. Rev., Neurosci. 2 2001 806 819
3. J.N. Crawley, J.K. Belknap, A. Collins, J.C. Crabbe, W. Frankel, N. Henderson, R.J. Hitzemann, S.C. Maxson, L.L. Miner, A.J. Silva, J.M. Wehner, A. Wynshaw-Boris, and R. Paylor Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies Psychopharmacology (Berlin) 132 1997 107 124
4. F.F. Cruz-Sanchez, A. Moral, M.L. Rossi, L. Quinto, C. Castejon, E. Tolosa, and J. de Belleroche Synaptophysin in spinal anterior horn in aging and ALS: an immunohistological study J. Neural Transm. 103 1996 1317 1329
5. M.C. Dal Canto Comparison of pathological alterations in ALS and a murine transgenic model: pathogenetic implications Clin. Neurosci. 3 1995 332 337
6. M.C. Dal Canto, and M.E. Gurney Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS) Brain Res. 676 1995 25 40
7. M.E. Gurney, H. Pu, A.Y. Chiu, M.C. Dal Canto, C.Y. Polchow, D.D. Alexander, J. Caliendo, A. Hentati, Y.W. Kwon, and H.X. Deng Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation Science 264 1994 1772 1775
8. P.R. Heath, and P.J. Shaw Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis Muscle Nerve 26 2002 438 458
9. E. Herzog, M. Landry, E. Buhler, R. Bouali-Benazzouz, C. Legay, C.E. Henderson, F. Nagy, P. Dreyfus, B. Giros, and S. El Mestikawy Expression of vesicular glutamate transporters, VGLUT1 and VGLUT2, in cholinergic spinal motoneurons Eur. J. Neurosci. 20 2004 1752 1760
10. A. Ikemoto, T. Kawanami, J.F. Llena, and A. Hirano Immunocytochemical studies on synaptophysin in the anterior horn of lower motor neuron disease J. Neuropathol. Exp. Neurol. 53 1994 196 201
11. A. Ikemoto, S. Nakamura, I. Akiguchi, and A. Hirano Differential expression between synaptic vesicle proteins and presynaptic plasma membrane proteins in the anterior horn of amyotrophic lateral sclerosis Acta Neuropathol. (Berlin) 103 2002 179 187
12. P.G. Ince, J. Slade, R.M. Chinnery, J. McKenzie, C. Royston, G.W. Roberts, and P.J. Shaw Quantitative study of synaptophysin immunoreactivity of cerebral cortex and spinal cord in motor neuron disease J. Neuropathol. Exp. Neurol. 54 1995 673 679
13. S. Matsumoto, S. Goto, H. Kusaka, H. Ito, and T. Imai Synaptic pathology of spinal anterior horn cells in amyotrophic lateral sclerosis: an immunohistochemical study J. Neurol. Sci. 125 1994 180 185
14. M. Nagao, H. Misawa, S. Kato, and S. Hirai Loss of cholinergic synapses on the spinal motor neurons of amyotrophic lateral sclerosis J. Neuropathol. Exp. Neurol. 57 1998 329 333
15. A.L. Oliveira, F. Hydling, E. Olsson, T. Shi, R.H. Edwards, F. Fujiyama, T. Kaneko, T. Hokfelt, S. Cullheim, and B. Meister Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia Synapse 50 2003 117 129
16. D.R. Rosen, T. Siddique, D. Patterson, D.A. Figlewicz, P. Sapp, A. Hentati, D. Donaldson, J. Goto, J.P. O'Regan, and H.X. Deng Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362 1993 59 62
17. S. Sasaki, and S. Maruyama Decreased synaptophysin immunoreactivity of the anterior horns in motor neuron disease Acta Neuropathol. (Berlin) 87 1994 125 128
18. D. Schiffer, S. Cordera, M.T. Giordana, A. Attanasio, and T. Pezzulo Synaptic vesicle proteins, synaptophysin and chromogranin A in amyotrophic lateral sclerosis J. Neurol. Sci. 129 1995 68 74
19. B. Schutz, L. Chen, M.K. Schafer, E. Weihe, and L.E. Eiden Somatomotor neuron-specific expression of the human cholinergic gene locus in transgenic mice Neuroscience 96 2000 707 722
20. H. Varoqui, M.K. Schafer, H. Zhu, E. Weihe, and J.D. Erickson Identification of the differentiation-associated Na+/PI transporter as a novel vesicular glutamate transporter expressed in a distinct set of glutamatergic synapses J. Neurosci. 22 2002 142 155
21. E. Weihe, and L.E. Eiden Chemical neuroanatomy of the vesicular amine transporters FASEB J. 14 2000 2435 2449
22. E. Weihe, J.H. Tao-Cheng, M.K. Schafer, J.D. Erickson, and L.E. Eiden Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles Proc. Natl. Acad. Sci. U. S. A. 93 1996 3547 3552
23. P. Weydt, S.Y. Hong, M. Kliot, and T. Moller Assessing disease onset and progression in the SOD1 mouse model of ALS NeuroReport 14 2003 1051 1054
24. P.C. Wong, C.A. Pardo, D.R. Borchelt, M.K. Lee, N.G. Copeland, N.A. Jenkins, S.S. Sisodia, D.W. Cleveland, and D.L. Price An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria Neuron 14 1995 1105 1116