Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 34, 2008, Pages 12599-12604

  Ilieva, Hristelina S ^a   Yamanaka, Koji ^a,e   Malkmus, Shelle ^b   Kakinohana, Osamu ^b   Yaksh, Tony ^b   Marsala, Martin ^b   Cleveland, Don W ^a,c,d,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^f LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

Author keywords

Cytoplasmic dynein; Excitotoxicity; Noncell autonomous; Sensory neurons

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; SUPEROXIDE DISMUTASE;

ALPHA NERVE FIBER; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; EXCITOTOXICITY; LOA; MOTONEURON; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROPRIOCEPTION; SENSORY NERVE CELL; WILD TYPE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AXONS; CELL DEATH; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DYNEIN ATPASE; MICE; MOTOR NEURONS; MUTATION; SUPEROXIDE DISMUTASE;

ANIMALIA;

EID: 50449101429     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0805422105     Document Type: Article

References (20)

1. Rosen DR, et al. (1993) Mutations in Cu/Zn dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362:59-62.
2. Clement AM, et al. (2003) Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 302:113-117.
3. Boillee S, et al. (2006) Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312:1389-1392.
4. Yamanaka K, et al. (2008) Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 11:251-253.
5. Beers DR, et al. (2006) Wild-type microglia extend survival in PU. 1 knockout mice with familial amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 103:16021-16026.
6. Ahmad-Annuar A, et al. (2003) No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders. Amyotroph Lateral Scler Other Motor Neuron Disord 4:150-157.
7. Shah PR, et al. (2006) No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: A tagging SNP approach. Amyotroph Lateral Scler 7:46-56.
8. Kieran, D, et al. (2005) A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice. J Cell Biol 169:561-567.
9. Teuchert M, et al. (2006) A dynein mutation attenuates motor neuron degeneration in SOD1(G93A) mice. Exp Neurol 198:271-274.
10. Hafezparast M, et al. (2003) Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science 300:808-812.
11. Dib M, et al. (1987) The C57BL mice: An animal model for inflammatory demyelinating polyneuropathy. J Neurol Sci 81:101-111.
12. Guyton AC, Hall JE (2006) Textbook of Medical Physiology (Elsevier Saunders, Philadelphia).
13. Ernfors P, Lee KF, Kucera J, Jaenisch R (1994) Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77:503-512.
14. Chen XJ, et al. (2007) Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene. J Neurosci 27:14515-14524.
15. Rothstein JD, Van Kammen M, Levey AI, Martin LJ, Kuncl RW (1995) Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol 38:73-84.
16. Howland DS, et al. (2002) Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci USA 99:1604-1609.
17. Roy J, Minotti S, Dong L, Figlewicz DA, Durham HD (1998) Glutamate potentiates the toxicity of mutant Cu/Zn-superoxide dismutase in motor neurons by postsynaptic calcium-dependent mechanisms. J Neurosci 18:9673-9684.
18. Pasinelli P, Borchelt DR, Houseweart MK, Cleveland DW, Brown RH, Jr (1998) Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proc Natl Acad Sci USA 95:15763-15768.
19. Lobsiger CS, Garcia ML, Ward CM, Cleveland DW (2005) Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS. Proc Natl Acad Sci USA 102:10351-10356.
20. Achilli F, et al. (2005) The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12. Amyotroph Lateral Scler Other Motor Neuron Disord 6:111-114.