An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

Cell

Volumn 167, Issue 7, 2016, Pages 1705-1718.e13

  Wu, Lianfeng ^a,b,c   Zhou, Ben ^a,b,c   Oshiro Rapley, Noriko ^a   Li, Man ^a   Paulo, Joao A ^b   Webster, Christopher M ^a,b,c   Mou, Fan ^a   Kacergis, Michael C ^a   Talkowski, Michael E ^a   Carr, Christopher E ^a,d   Gygi, Steven P ^b   Zheng, Bin ^a   Soukas, Alexander A ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

ACAD10; acyl CoA dehydrogenase family member 10; C. elegans; cancer; diabetes; growth; lifespan; mechanistic target of rapamycin complex 1; Metformin; mitochondrial respiratory capacity; mTORC1; NPC; nuclear pore complex; nuclear transport; RagC GTPase

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; BIGUANIDE; GUANOSINE TRIPHOSPHATASE; HETERODIMER; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; METFORMIN; RAGA PROTEIN; RAGC PROTEIN; UNCLASSIFIED DRUG; ACAD-10 PROTEIN, C ELEGANS; CAENORHABDITIS ELEGANS PROTEIN; DNA BINDING PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MULTIPROTEIN COMPLEX; SKN-1 PROTEIN, C ELEGANS; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

ADULT; ARTICLE; CAENORHABDITIS ELEGANS; CELL KILLING; DNA RESPONSIVE ELEMENT; DRUG MECHANISM; GENE INACTIVATION; GENETIC SCREENING; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIFE EXTENSION; MALIGNANT NEOPLASM; MELANOMA; NONHUMAN; NUCLEAR PORE; NUCLEAR PORE COMPLEX; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; PRIORITY JOURNAL; UPREGULATION; AGING; ANIMAL; BODY SIZE; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; LONGEVITY; METABOLISM; MITOCHONDRION; NEOPLASMS; OXIDATIVE PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ACYL-COA DEHYDROGENASE; AGING; ANIMALS; BODY SIZE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; HUMANS; LONGEVITY; METFORMIN; MITOCHONDRIA; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; NEOPLASMS; NUCLEAR PORE; OXIDATIVE PHOSPHORYLATION; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 85006307149     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.11.055     Document Type: Article

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