TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells

Radiotherapy and Oncology

Volumn 101, Issue 1, 2011, Pages 132-139

  Peña Rico, Miguel A ^a   Calvo Vidal, María Nieves ^a   Villalonga Planells, Ruth ^a   Martínez Soler, Fina ^a   Giménez Bonafé, Pepita ^a   Navarro Sabaté, Àurea ^a   Tortosa, Avelina ^a   Bartrons, Ramon ^a   Manzano, Anna ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

DNA repair; Oxidative stress; Radiotherapy; Senescence; TIGAR

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; FRUCTOSE 2,6 BISPHOSPHATASE; GLUTATHIONE; LACTIC ACID; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TIGAR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CELL DAMAGE; CELL GROWTH; DNA REPAIR; GENE SILENCING; GENOME; GLIOBLASTOMA; GLIOMA; GLIOMA CELL; GLYCOLYSIS; HUMAN; HUMAN CELL; IRRADIATION; METABOLIC REGULATION; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; RADIOSENSITIZATION; SENESCENCE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; DOWN-REGULATION; FLUORESCENT ANTIBODY TECHNIQUE; GLIOBLASTOMA; GLYCOLYSIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; RADIATION TOLERANCE; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SENSITIVITY AND SPECIFICITY; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80655124584     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.07.002     Document Type: Article

References (53)

1. K. Bensaad, A. Tsuruta, and M.A. Selak TIGAR, a p53-inducible regulator of glycolysis and apoptosis Cell 126 2006 107 120 (Pubitemid 44040989)
2. S. Li, H. Ouellet, D.H. Sherman, and L.M. Podust Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae J Biol Chem 284 2009 5723 5730
3. D.A. Okar, A. Manzano, and A. Navarro-Sabate PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate Trends Biochem Sci 26 2001 30 35 (Pubitemid 32124707)
4. M. Obach, A. Navarro-Sabate, and J. Caro 6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia J Biol Chem 279 2004 53562 53570 (Pubitemid 40051863)
5. K. Bensaad, E.C. Cheung, and K.H. Vousden Modulation of intracellular ROS levels by TIGAR controls autophagy Embo J 28 2009 3015 3026
6. H. Hasegawa, Y. Yamada, and H. Iha Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells Leukemia 23 2009 2090 2101
7. J.L. Martindale, and N.J. Holbrook Cellular response to oxidative stress: signaling for suicide and survival J Cell Physiol 192 2002 1 15 (Pubitemid 34587382)
8. T. Iida, A. Furuta, and M. Kawashima Accumulation of 8-oxo-2′- deoxyguanosine and increased expression of hMTH1 protein in brain tumors Neuro Oncol 3 2001 73 81 (Pubitemid 33691764)
9. M.H. Barcellos-Hoff, E.W. Newcomb, D. Zagzag, and A. Narayana Therapeutic targets in malignant glioblastoma microenvironment Semin Radiat Oncol 19 2009 163 170
10. C. Adamson, O.O. Kanu, and A.I. Mehta Glioblastoma multiforme: a review of where we have been and where we are going Expert Opin Investig Drugs 18 2009 1061 1083
11. O.O. Kanu, B. Hughes, and C. Di Glioblastoma multiforme oncogenomics and signaling pathways Clin Med Oncol 3 2009 39 52
12. S. Sathornsumetee, D.A. Reardon, and A. Desjardins Molecularly targeted therapy for malignant glioma Cancer 110 2007 13 24
13. A.L. Russo, H.C. Kwon, and W.E. Burgan In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016 Clin Cancer Res 15 2009 607 612
14. R. Blum, J. Jacob-Hirsch, and N. Amariglio Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death Cancer Res 65 2005 999 1006 (Pubitemid 40216462)
15. M.W. Dewhirst, Y. Cao, and B. Moeller Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response Nat Rev Cancer 8 2008 425 437 (Pubitemid 351744964)
16. A. King, and E. Gottlieb Glucose metabolism and programmed cell death: an evolutionary and mechanistic perspective Curr Opin Cell Biol 21 2009 885 893
17. E. Gottlieb, and K.H. Vousden p53 regulation of metabolic pathways Cold Spring Harb Perspect Biol 2 2010 a001040
18. E.I. Chen, J. Hewel, and J.S. Krueger Adaptation of energy metabolism in breast cancer brain metastases Cancer Res 67 2007 1472 1486 (Pubitemid 46383371)
19. V.W. Lui, C.P. Lau, and C.S. Cheung An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation Biochem Pharmacol 79 2010 1772 1780
20. S.M. Elbashir, J. Harborth, K. Weber, and T. Tuschl Analysis of gene function in somatic mammalian cells using small interfering RNAs Methods 26 2002 199 213 (Pubitemid 34969582)
21. M.N. Calvo, R. Bartrons, and E. Castano PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells FEBS Lett 580 2006 3308 3314 (Pubitemid 44251000)
22. W.N. Burnette "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A Anal Biochem 112 1981 195 203
23. E. Van Schaftingen, B. Lederer, R. Bartrons, and H.G. Hers A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate Eur J Biochem 129 1982 191 195
24. H.U. Bergmeyer Methods of enzymatic analysis 1974 1464 1468
25. A.P. Senft, T.P. Dalton, and H.G. Shertzer Determining glutathione and glutathione disulfide using the fluorescence probe o-phthalaldehyde Anal Biochem 280 2000 80 86 (Pubitemid 30210815)
26. N.A. Franken, H.M. Rodermond, J. Stap, J. Haveman, and C. van Bree Clonogenic assay of cells in vitro Nat Protoc 1 2006 2315 2319
27. M. Van Engeland LN, F.C. Ramaekers, B. Schutte, and C.P. Reutelingsperger Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure Cytometry 31 1998 1 9 (Pubitemid 28050057)
28. G.P. Dimri, X. Lee, and G. Basile A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proc Natl Acad Sci USA 92 1995 9363 9367
29. K. Rothkamm, I. Kruger, L.H. Thompson, and M. Lobrich Pathways of DNA double-strand break repair during the mammalian cell cycle Mol Cell Biol 23 2003 5706 5715 (Pubitemid 36951334)
30. C. Krakstad, and M. Chekenya Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics Mol Cancer 9 2010 135
31. M. Niyazi, A. Siefert, and S.B. Schwarz Therapeutic options for recurrent malignant glioma Radiother Oncol 98 2011 1 14
32. Y. Sun, D.K. St. Clair, Y. Xu, P.A. Crooks, and W.H. St. Clair A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells Cancer Res 70 2010 2880 2890
33. M. Iida, S. Sunaga, and N. Hirota Effect of glutathione-modulating compounds on hydrogen-peroxide-induced cytotoxicity in human glioblastoma and glioma cell lines J Cancer Res Clin Oncol 123 1997 619 622 (Pubitemid 28035501)
34. W. Zhuang, Z. Qin, and Z. Liang The role of autophagy in sensitizing malignant glioma cells to radiation therapy Acta Biochim Biophys Sin (Shanghai) 41 2009 341 351
35. R. Singh, J. George, and Y. Shukla Role of senescence and mitotic catastrophe in cancer therapy Cell Div 5 2010 4
36. Y. Hirose, M. Katayama, and O.K. Mirzoeva Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence Cancer Res 65 2005 4861 4869 (Pubitemid 40740825)
37. E. Morandi, C. Severini, and D. Quercioli Gene expression time-series analysis of camptothecin effects in U87-MG, DBTRG-05 glioblastoma cell lines Mol Cancer 7 2008 66
38. Y. Sato, A. Kurose, and A. Ogawa Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide Cancer Biol Ther 8 2009 452 457
39. T. Lu, and T. Finkel Free radicals and senescence Exp Cell Res 314 2008 1918 1922
40. C. Zhou, Z. Li, and H. Diao DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors Mutat Res 604 2006 8 18
41. D. Amelio, S. Lorentini, M. Schwarz, and M. Amichetti Intensity-modulated radiation therapy in newly diagnosed glioblastoma: a systematic review on clinical and technical issues Radiother Oncol 97 2010 361 369
42. J. Grotius, C. Dittfeld, and M. Huether Impact of exogenous lactate on survival and radioresponse of carcinoma cells in vitro Int J Radiat Biol 85 2009 989 1001
43. U.G. Sattler, S.S. Meyer, and V. Quennet Glycolytic metabolism and tumour response to fractionated irradiation Radiother Oncol 94 2010 102 109
44. O. Feron Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells Radiother Oncol 92 2009 329 333
45. C.B. Colen, N. Seraji-Bozorgzad, and B. Marples Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study Neurosurgery 59 2006 1313 1323 [discussion 1323-1314] (Pubitemid 44949778)
46. F. Dal-Pizzol, C. Ritter, and F. Klamt Modulation of oxidative stress in response to gamma-radiation in human glioma cell lines J Neurooncol 61 2003 89 94 (Pubitemid 36253653)
47. A. Anandharaj, S. Cinghu, and W.Y. Park Rapamycin-mediated mTOR inhibition attenuates survivin and sensitizes glioblastoma cells to radiation therapy Acta Biochim Biophys Sin (Shanghai) 43 2011 292 300
48. Q.A. Quick, and D.A. Gewirtz An accelerated senescence response to radiation in wild-type p53 glioblastoma multiforme cells J Neurosurg 105 2006 111 118 (Pubitemid 43979105)
49. I.B. Roninson, E.V. Broude, and B.D. Chang If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells Drug Resist Updat 4 2001 303 313 (Pubitemid 34456384)
50. E.P. Rogakou, D.R. Pilch, A.H. Orr, V.S. Ivanova, and W.M. Bonner DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 J Biol Chem 273 1998 5858 5868 (Pubitemid 28124064)
51. O.A. Sedelnikova, E.P. Rogakou, I.G. Panyutin, and W.M. Bonner Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody Radiat Res 158 2002 486 492
52. Short SC, Giampieri S, Worku M, et al. Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cells. Neuro Oncol; 13:487-9.
53. S. Burdak-Rothkamm, S.C. Short, and M. Folkard ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells Oncogene 26 2007 993 1002