Effects of prostratin on Cyclin TI/P-TEFb function and the gene expression profile in primary resting CD4+ T cells

Retrovirology

Volumn 3, Issue , 2006, Pages

  Sung, Tzu Ling ^a   Rice, Andrew P ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3B; CYCLIN DEPENDENT KINASE 9; CYCLIN T1; HYDROLASE; PHORBOL ESTER; PROSTRATIN; PROTEIN S 100; SMALL NUCLEAR RNA; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DNA MICROARRAY; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; PROTEIN FUNCTION; PROVIRUS; REPORTER GENE; UPREGULATION; VIRAL GENETICS; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS REPLICATION;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; CYCLIN T; CYCLIN-DEPENDENT KINASE 9; CYCLINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, VIRAL; GENES, REPORTER; HUMANS; MODELS, GENETIC; PHORBOL ESTERS; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; RNA-BINDING PROTEINS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33750051617     PISSN: 17424690     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-3-66     Document Type: Article

References (70)

1. Blankson JN, Persaud D, Siliciano RF: The challenge of viral reservoirs in HIV-1 infection. Annu Rev Med 2002, 53:557-593.
2. Lassen K, Han Y, Zhou Y, Siliciano J, Siliciano RF: The multifactorial nature of HIV-1 latency. Trends Mol Med 2004, 10(11):525-531.
3. Marcello A: Latency: the hidden HIV-1 challenge. Retrovirology 2006, 3(1):7.
4. Jordan A, Defechereux P, Verdin E: The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation. Embo J 2001, 20(7):1726-1738.
5. Karn J: Tackling Tat. J Mol Biol 1999, 293(2):235-254.
6. Peterlin BM, Trono D: Hide, shield and strike back: how HIV-infected cells avoid immune eradication. Nat Rev Immunol 2003, 3(2):97-107.
7. Rice AP, Herrmann CH: Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages. Curr HIV Res 2003, 1(4):395-404.
8. Ghose R, Liou LY, Herrmann CH, Rice AP: Induction of TAK (cyclin T1/ P-TEFb) in purified resting CD4(+) T lymphocytes by combination of cytokines. J Virol 2001, 75(23):11336-11343.
9. Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, Sedore SC, Price JP, Price DH, Lania L, Bensaude O: Binding of the 7SK snRNA turns the HEXIM I protein into a P-TEFb (CDK9/cyclin T) inhibitor. Embo J 2004, 23(13):2608-2619.
10. Yang Z, Zhu Q, Luo K, Zhou Q: The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription. Nature 2001, 414(6861):317-322.
11. Haaland RE, Herrmann CH, Rice AP: siRNA depletion of 7SK snRNA induces apoptosis but does not affect expression of the HIV-1 LTR or P-TEFb-dependent cellular genes. J Cell Physiol 2005, 205(3):463-470.
12. Fraldi A, Varrone F, Napolitano G, Michels AA, Majello B, Bensaude O, Lania L: Inhibition of Tat activity by the HEXIM I protein. Retrovirology 2005, 2(1):42.
13. Schulte A, Czudnochowski N, Barboric M, Schonichen A, Blazek D, Peterlin BM, Geyer M: Identification of a cyclin T-binding domain in Hexim I and biochemical analysis of its binding competition with HIV-1 Tat. J Biol Chem 2005, 280(26):24968-24977.
14. Haaland RE, Herrmann CH, Rice AP: Increased association of 7SK snRNA with Tat cofactor P-TEFb following activation of peripheral blood lymphocytes. Aids 2003, 17(17):2429-2436.
15. Kulkosky J, Culnan DM, Roman J, Dornadula G, Schnell M, Boyd MR, Pomerantz RJ: Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood 2001, 98(10):3006-3015.
16. Brooks DG, Hamer DH, Arlen PA, Gao L, Bristol G, Kitchen CM, Berger EA, Zack JA: Molecular characterization, reactivation, and depletion of latent HIV. Immunity 2003, 19(3):413-423.
17. Williams SA, Chen LF, Kwon H, Fenard D, Bisgrove D, Verdin E, Greene WC: Prostratin antagonizes HIV latency by activating NF-kappaB. J Biol Chem 2004, 279(40):42008-42017.
18. Korin YD, Brooks DG, Brown S, Korotzer A, Zack JA: Effects of prostratin on T-cell activation and human immunodeficiency virus latency. J Virol 2002, 76(16):8118-8123.
19. Biancotto A, Grivell JC, Gondois-Rey F, Bettendroffer L, Vigne R, Brown S, Margolis LB, Hirsch I: Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue. J Virol 2004, 78(19):10507-10515.
20. Bocklandt S, Blumberg PM, Hamer DH: Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate. Antiviral Res 2003, 59(2):89-98.
21. Kulkosky J, Sullivan J, Xu Y, Souder E, Hamer DH, Pomerantz RJ: Expression of latent HAART-persistent HIV type 1 induced by novel cellular activating agents. AIDS Res Hum Retroviruses 2004, 20(5):497-505.
22. Witvrouw M, Pannecouque C, Fikkert V, Hantson A, Van Remoortel B, Hezareh M, De Clercq E, Brown SJ: Potent and selective inhibition of HIV and SIV by prostratin interacting with viral entry. Antivir Chem Chemother 2003, 14(6):321-328.
23. Hezareh M, Moukil MA, Szanto I, Pondarzewski M, Mouche S, Cherix N, Brown SJ, Carpentier JL, Foti M: Mechanisms of HIV receptor and co-receptor down-regulation by prostratin: role of conventional and novel PKC isoforms. Antivir Chem Chemother 2004, 15(4):207-222.
24. Herrmann CH, Carroll RG, Wei P, Jones KA, Rice AP: Tat-associated kinase, TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell lines. J Virol 1998, 72(12):9881-9888.
25. Yang X, Gold MO, Tang DN, Lewis DE, Aguilar-Cordova E, Rice AP, Herrmann CH: TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines. Proc Natl Acad Sci U S A 1997, 94(23):12331-12336.
26. Marshall RM, Salerno D, Garriga J, Grana X: Cyclin T 1 expression is regulated by multiple signaling pathways and mechanisms during activation of human peripheral blood lymphocytes. J Immunol 2005, 175(10):6402-6411.
27. Garriga J, Peng J, Parreno M, Price DH, Henderson EE, Grana X: Upregulation of cyclin T1/CDK9 complexes during T cell activation. Oncogene 1998, 17(24):3093-3102.
28. Egloff S, Van Herreweghe E, Kiss T: Regulation of polymerase II transcription by 7SK snRNA: two distinct RNA elements direct P-TEFb and HEXIM I binding. Mol Cell Biol 2006, 26(2):630-642.
29. Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K: The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell 2005, 19(4):523-534.
30. Yang Z, Yik JH, Chen R, He N, Jang MK, Ozato K, Zhou Q: Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell 2005, 19(4):535-545.
31. Chao SH, Fujinaga K, Marion JE, Taube R, Sausville EA, Senderowicz AM, Peterlin BM, Price DH: Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. J Biol Chem 2000, 275(37):28345-28348.
32. Parker BW, Kaur G, Nieves-Neira W, Taimi M, Kohlhagen G, Shimizu T, Losiewicz MD, Pommier Y, Sausville EA, Senderowicz AM: Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood 1998, 91(2):458-465.
33. Herrmann-Rice Laboratory website [http://www-dev.bcm.edu/molvir/labs/ herrmann-rice-lab/1-5_gene_list_zip]
34. Reiner A, Yekutieli D, Benjamini Y: Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 2003, 19(3):368-375.
35. Buckley AF, Kuo CT, Leiden JM: Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-- dependent pathway. Nat Immunol 2001, 2(8):698-704.
36. Haaland RE, Yu W, Rice AP, Identification of LKLF-regulated genes in quiescent CD4+ T lymphocytes. Mol Immunol 2005, 42(5):627-641.
37. Rethi B, Fluur C, Atlas A, Krzyzowska M, Mowafi F, Grutzmeier S, De Milito A, Bellocco R, Falk KI, Rajnavolgyi E, Chiodi F: Loss of IL-7Ralpha is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients. Aids 2005, 19(18):2077-2086.
38. Koesters SA, Alimonti JB, Wachihi C, Matu L, Anzala O, Kimani J, Embree JE, Plummer FA, Fowke KR: IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation. Eur J Immunol 2006, 36(2):336-344.
39. Doehle BP, Schafer A, Cullen BR: Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif. Virology 2005, 339(2):281-288.
40. Takahashi Y, Tanaka Y, Yamashita A, Koyanagi Y, Nakamura M, Yamamoto N: OX40 stimulation by gp34/OX40 ligand enhances productive human immunodeficiency virus type 1 infection. J Virol 2001, 75(15):6748-6757.
41. Chang TL, Vargas JJ, DelPortillo A, Klotman ME: Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. J Clin Invest 2005, 115(3):765-773.
42. Ryckman C, Robichaud GA, Roy J, Cantin R, Tremblay MJ, Tessier PA: HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes. J Immunol 2002, 169(6):3307-3313.
43. Barboric M, Nissen RM, Kanazawa S, Jabrane-Ferrat N, Peterlin BM: NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. Mol Cell 2001, 8(2):327-337.
44. Williams SA, Chen LF, Kwon H, Ruiz-Jarabo CM, Verdin E, Greene WC: NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. Embo J 2006, 25(1):139-149.
45. Chen R, Yang Z, Zhou Q: Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA. J Biol Chem 2004, 279(6):4153-4160.
46. Barboric M, Kohoutek J, Price JP, Blazek D, Price DH, Peterlin BM: Interplay between 7SK snRNA and oppositely charged regions in HEXIM I direct the inhibition of P-TEFb. Embo J 2005, 24(24):4291-4303.
47. Alimonti JB, Ball TB, Fowke KR: Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS. J Gen Virol 2003, 84(Pt 7):1649-1661.
48. Lenardo M, Chan KM, Hornung F, McFarland H, Siegel R, Wang J, Zheng L: Mature T lymphocyte apoptosis - immune regulation in a dynamic and unpredictable antigenic environment. Annu Rev Immunol 1999, 17:221-253.
49. Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR: MAPP Finder: using Gene Ontology and Gen-MAPP to create a global gene-expression profile from microarray data. Genome Biol 2003, 4(1):R7.
50. Huang Y, Wange RL: T cell receptor signaling: beyond complex complexes. J Biol Chem 2004, 279(28):28827-28830.
51. Rincon M, Pedraza-Alva G: JNK and p38 MAP kinases in CD4+ and CD8+ T cells. Immunol Rev 2003, 192:131-142.
52. Gold MO, Yang X, Herrmann CH, Rice AP: PITALRE, the catalytic subunit of TAK, is required for human immunodeficiency virus Tat transactivation in vivo. J Virol 1998, 72(5):4448-4453.
53. Herrmann CH, Rice AP: Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. J Virol 1995, 69(3):1612-1620.
54. Rice AP, Carlotti F: Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein. J Virol 1990, 64(4):1864-1868.
55. Wang Y, Rice AP: Interleukin-10 inhibits HIV-1 LTR-directed gene expression in human macrophages through the induction of cyclin T1 proteolysis. Virology 2006.
56. Baylor Microarray Core Facility [http://www.bcm.edu/mcfweb].
57. Maere S, Heymans K, Kuiper M: BINGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics 2005, 21(16):3448-3449.
58. Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T: Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 2003, 13(11):2498-2504.
59. Cocchi F, DeVico, AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 1995, 270(5243):1811-1815.
60. Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD: HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter. J Biol Chem 2002, 277(22):19482-19487.
61. Hicar MD, Liu Y, Allen CE, Wu LC: Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exonintron structure, and comparison with paralogous genes HIVEP1 and HIVEP2. Genomics 2001, 71(1):89- 100.
62. Guan KL, Butch E: Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase. J Biol Chem 1995, 270(13):7197-7203.
63. Ishibashi T, Bottaro DP, Michieli P, Kelley CA, Aaronson SA: A novel dual specificity phosphatase induced by serum stimulation and heat shock. J Biol Chem 1994, 269(47):29897-29902.
64. Groom LA, Sneddon AA, Alessi DR, Dowd S, Keyse SM: Differential regulation of the MAP, SAP and RK/p3B kinases by Pyst 1, a novel cytosolic dual-specificity phosphatase. Embo J 1996, 15(14):3621-3632.
65. Tanoue T, Moriguchi T, Nishida E: Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J Biol Chem 1999, 274(28):19949-19956.
66. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N: Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000, 288(5468):1053-1058.
67. Schwarz H, Blanco FJ, von Kempis J, Valbracht J, Lotz M: ILA. a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival. Blood 1996, 87(7):2839-2845.
68. Brdickova N, Brdicka T, Angelisova P, Horvath O, Spicka J, Hilgert I, Paces J, Simeoni L, Kliche S, Merten C, Schraven B, Horejsi V: LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. J Exp Med 2003, 198(10):1453-1462.
69. Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C: Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB. Blood 2001, 98(3):743-753.
70. Berrebi D, Bruscoli S, Cohen N, Foussat A, Migliorati G, Bouchet-Delbos L, Maillot MC, Portier A, Couderc J, Galanaud P, Peuchmaur M, Riccardi C, Emilie D: Synthesis of glucocorticold-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10. Blood 2003, 101(2):729-738.