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Volumn 3, Issue 2, 2014, Pages 258-279

High-throughput sequencing, a versatileweapon to support genome-based diagnosis in infectious diseases: Applications to clinical bacteriology

Author keywords

Analysis pipeline; Bioinformatics; Genome based diagnosis; High throughput sequencing; P4 medicine; Pathogenomics; Whole genome sequencing

Indexed keywords

RNA 16S;

EID: 85006122803     PISSN: None     EISSN: 20760817     Source Type: Journal    
DOI: 10.3390/pathogens3020258     Document Type: Article
Times cited : (20)

References (107)
  • 2
    • 85041643459 scopus 로고    scopus 로고
    • Genomes OnLine Database. Available online, accessed on 27 March 2014
    • Genomes OnLine Database. Available online: http://genomesonline.org (accessed on 27 March 2014).
  • 4
    • 53449085370 scopus 로고    scopus 로고
    • Do DNA microarrays have their future behind them?
    • Coppee, J.Y. Do DNA microarrays have their future behind them? Microbes Infect. 2008, 10, 1067-1071.
    • (2008) Microbes Infect , vol.10 , pp. 1067-1071
    • Coppee, J.Y.1
  • 7
    • 84865231395 scopus 로고    scopus 로고
    • Transforming clinical microbiology with bacterial genome sequencing
    • Didelot, X.; Bowden, R.; Wilson, D.J.; Peto, T.E.; Crook, D.W. Transforming clinical microbiology with bacterial genome sequencing. Nat. Rev. Genet. 2012, 13, 601-612.
    • (2012) Nat. Rev. Genet , vol.13 , pp. 601-612
    • Didelot, X.1    Bowden, R.2    Wilson, D.J.3    Peto, T.E.4    Crook, D.W.5
  • 9
    • 85041690313 scopus 로고    scopus 로고
    • DNA Sequencing Costs. Available online, (accessed on 27 March 2014)
    • DNA Sequencing Costs. Available online: http://www.genome.gov/sequencingcosts/(accessed on 27 March 2014).
  • 13
    • 34249723655 scopus 로고    scopus 로고
    • Advanced sequencing technologies and their wider impact in microbiology
    • Hall, N. Advanced sequencing technologies and their wider impact in microbiology. J. Exp. Biol. 2007, 210, 1518-1525.
    • (2007) J. Exp. Biol , vol.210 , pp. 1518-1525
    • Hall, N.1
  • 14
    • 84866598795 scopus 로고    scopus 로고
    • Rapid whole-genome sequencing of bacterial pathogens in the clinical microbiology laboratory-Pipe dream or reality
    • Torok, M.E.; Peacock, S.J. Rapid whole-genome sequencing of bacterial pathogens in the clinical microbiology laboratory-Pipe dream or reality? J. Antimicrob. Chemother. 2012, 67, 2307-2308.
    • (2012) J. Antimicrob. Chemother , vol.67 , pp. 2307-2308
    • Torok, M.E.1    Peacock, S.J.2
  • 16
    • 52449087439 scopus 로고    scopus 로고
    • A technological update of molecular diagnostics for infectious diseases
    • Liu, Y.T. A technological update of molecular diagnostics for infectious diseases. Infect Disord. Drug Targets 2008, 8, 183-188.
    • (2008) Infect Disord. Drug Targets , vol.8 , pp. 183-188
    • Liu, Y.T.1
  • 17
    • 5444233459 scopus 로고    scopus 로고
    • Multiple-locus variable-number tandem repeat analysis, a novel typing scheme to study the genetic relatedness and epidemiology of Enterococcus faecium isolates
    • Top, J.; Schouls, L.M.; Bonten, M.J.; Willems, R.J. Multiple-locus variable-number tandem repeat analysis, a novel typing scheme to study the genetic relatedness and epidemiology of Enterococcus faecium isolates. J. Clin. Microbiol. 2004, 42, 4503-4511.
    • (2004) J. Clin. Microbiol , vol.42 , pp. 4503-4511
    • Top, J.1    Schouls, L.M.2    Bonten, M.J.3    Willems, R.J.4
  • 18
    • 0038772019 scopus 로고    scopus 로고
    • Nucleotide sequence-based typing of meningococci directly from clinical samples
    • Diggle, M.A.; Bell, C.M.; Clarke, S.C. Nucleotide sequence-based typing of meningococci directly from clinical samples. J. Med. Microbiol. 2003, 52, 505-508.
    • (2003) J. Med. Microbiol , vol.52 , pp. 505-508
    • Diggle, M.A.1    Bell, C.M.2    Clarke, S.C.3
  • 19
    • 84879442753 scopus 로고    scopus 로고
    • Subtyping of Salmonella enterica serovar newport outbreak isolates by CRISPR-MVLST and determination of the relationship between CRISPR-MVLST and PFGE results
    • Shariat, N.; Kirchner, M.K.; Sandt, C.H.; Trees, E.; Barrangou, R.; Dudley, E.G. Subtyping of Salmonella enterica serovar newport outbreak isolates by CRISPR-MVLST and determination of the relationship between CRISPR-MVLST and PFGE results. J. Clin. Microbiol. 2013, 51, 2328-2336.
    • (2013) J. Clin. Microbiol , vol.51 , pp. 2328-2336
    • Shariat, N.1    Kirchner, M.K.2    Sandt, C.H.3    Trees, E.4    Barrangou, R.5    Dudley, E.G.6
  • 20
    • 22144489176 scopus 로고    scopus 로고
    • Comparison of multiple-locus variable-number tandem-repeat analysis with pulsed-field gel electrophoresis, spa typing, and multilocus sequence typing for clonal characterization of Staphylococcus aureus isolates
    • Malachowa, N.; Sabat, A.; Gniadkowski, M.; Krzyszton-Russjan, J.; Empel, J.; Miedzobrodzki, J.; Kosowska-Shick, K.; Appelbaum, P.C.; Hryniewicz, W. Comparison of multiple-locus variable-number tandem-repeat analysis with pulsed-field gel electrophoresis, spa typing, and multilocus sequence typing for clonal characterization of Staphylococcus aureus isolates. J. Clin. Microbiol. 2005, 43, 3095-3100.
    • (2005) J. Clin. Microbiol , vol.43 , pp. 3095-3100
    • Malachowa, N.1    Sabat, A.2    Gniadkowski, M.3    Krzyszton-Russjan, J.4    Empel, J.5    Miedzobrodzki, J.6    Kosowska-Shick, K.7    Appelbaum, P.C.8    Hryniewicz, W.9
  • 21
    • 84882287832 scopus 로고    scopus 로고
    • The time is now for gene- and genome-based bacterial diagnostics: 'You Say You Want a Revolution'
    • Ehrlich, G.D.; Post, J.C. The time is now for gene- and genome-based bacterial diagnostics: "You Say You Want a Revolution". JAMA Intern. Med. 2013, 173, 1405-1406.
    • (2013) JAMA Intern. Med , vol.173 , pp. 1405-1406
    • Ehrlich, G.D.1    Post, J.C.2
  • 22
    • 23244464600 scopus 로고    scopus 로고
    • Bacterial plurality as a general mechanism driving persistence in chronic infections
    • Ehrlich, G.D.; Hu, F.Z.; Shen, K.; Stoodley, P.; Post, J.C. Bacterial plurality as a general mechanism driving persistence in chronic infections. Clin. Orthop. Relat. Res. 2005, 437, 20-24.
    • (2005) Clin. Orthop. Relat. Res , vol.437 , pp. 20-24
    • Ehrlich, G.D.1    Hu, F.Z.2    Shen, K.3    Stoodley, P.4    Post, J.C.5
  • 23
    • 84874469388 scopus 로고    scopus 로고
    • Whole genome sequencing versus traditional genotyping for investigation of a Mycobacterium tuberculosis outbreak: A longitudinal molecular epidemiological study
    • Roetzer, A.; Diel, R.; Kohl, T.A.; Ruckert, C.; Nubel, U.; Blom, J.; Wirth, T.; Jaenicke, S.; Schuback, S.; Rusch-Gerdes, S. et al. Whole genome sequencing versus traditional genotyping for investigation of a Mycobacterium tuberculosis outbreak: A longitudinal molecular epidemiological study. PLoS Med. 2013, 10, e1001387.
    • (2013) PLoS Med , vol.10
    • Roetzer, A.1    Diel, R.2    Kohl, T.A.3    Ruckert, C.4    Nubel, U.5    Blom, J.6    Wirth, T.7    Jaenicke, S.8    Schuback, S.9    Rusch-Gerdes, S.10
  • 24
    • 78149306108 scopus 로고    scopus 로고
    • Generation of genic diversity among Streptococcus pneumoniae strains via horizontal gene transfer during a chronic polyclonal pediatric infection
    • Hiller, N.L.; Ahmed, A.; Powell, E.; Martin, D.P.; Eutsey, R.; Earl, J.; Janto, B.; Boissy, R.J.; Hogg, J.; Barbadora, K. et al. Generation of genic diversity among Streptococcus pneumoniae strains via horizontal gene transfer during a chronic polyclonal pediatric infection. PLoS Pathog. 2010, 6, e1001108.
    • (2010) PLoS Pathog , vol.6
    • Hiller, N.L.1    Ahmed, A.2    Powell, E.3    Martin, D.P.4    Eutsey, R.5    Earl, J.6    Janto, B.7    Boissy, R.J.8    Hogg, J.9    Barbadora, K.10
  • 25
    • 77951297611 scopus 로고    scopus 로고
    • High-throughput whole-genome sequencing to dissect the epidemiology of Acinetobacter baumannii isolates from a hospital outbreak
    • Lewis, T.; Loman, N.J.; Bingle, L.; Jumaa, P.; Weinstock, G.M.; Mortiboy, D.; Pallen, M.J. High-throughput whole-genome sequencing to dissect the epidemiology of Acinetobacter baumannii isolates from a hospital outbreak. J. Hosp. Infect. 2010, 75, 37-41.
    • (2010) J. Hosp. Infect , vol.75 , pp. 37-41
    • Lewis, T.1    Loman, N.J.2    Bingle, L.3    Jumaa, P.4    Weinstock, G.M.5    Mortiboy, D.6    Pallen, M.J.7
  • 27
    • 84864013926 scopus 로고    scopus 로고
    • High-throughput multilocus sequence typing: Bringing molecular typing to the next level
    • Boers, S.A.; van der Reijden, W.A.; Jansen, R. High-throughput multilocus sequence typing: Bringing molecular typing to the next level. PLoS One 2012, 7, e39630.
    • (2012) PLoS One , vol.7
    • Boers, S.A.1    van der Reijden, W.A.2    Jansen, R.3
  • 28
    • 84862318037 scopus 로고    scopus 로고
    • A pilot study of rapid benchtop sequencing of Staphylococcus aureus and Clostridium difficile for outbreak detection and surveillance
    • Eyre, D.W.; Golubchik, T.; Gordon, N.C.; Bowden, R.; Piazza, P.; Batty, E.M.; Ip, C.L.; Wilson, D.J.; Didelot, X.; O'Connor, L. et al. A pilot study of rapid benchtop sequencing of Staphylococcus aureus and Clostridium difficile for outbreak detection and surveillance. BMJ Open 2012, 12. e001124
    • (2012) BMJ Open , vol.12
    • Eyre, D.W.1    Golubchik, T.2    Gordon, N.C.3    Bowden, R.4    Piazza, P.5    Batty, E.M.6    Ip, C.L.7    Wilson, D.J.8    Didelot, X.9    O'Connor, L.10
  • 29
    • 84876764053 scopus 로고    scopus 로고
    • Outbreak investigation using high-throughput genome sequencing within a diagnostic microbiology laboratory
    • Sherry, N.L.; Porter, J.L.; Seemann, T.; Watkins, A.; Stinear, T.P.; Howden, B.P. Outbreak investigation using high-throughput genome sequencing within a diagnostic microbiology laboratory. J. Clin. Microbiol. 2013, 51, 1396-1401.
    • (2013) J. Clin. Microbiol , vol.51 , pp. 1396-1401
    • Sherry, N.L.1    Porter, J.L.2    Seemann, T.3    Watkins, A.4    Stinear, T.P.5    Howden, B.P.6
  • 31
    • 84872045758 scopus 로고    scopus 로고
    • Real-time sequencing to decipher the molecular mechanism of resistance of a clinical pan-drug-resistant Acinetobacter baumannii isolate from Marseille, France
    • Rolain, J.M.; Diene, S.M.; Kempf, M.; Gimenez, G.; Robert, C.; Raoult, D. Real-time sequencing to decipher the molecular mechanism of resistance of a clinical pan-drug-resistant Acinetobacter baumannii isolate from Marseille, France. Antimicrob. Agents Chemother. 2013, 57, 592-596.
    • (2013) Antimicrob. Agents Chemother , vol.57 , pp. 592-596
    • Rolain, J.M.1    Diene, S.M.2    Kempf, M.3    Gimenez, G.4    Robert, C.5    Raoult, D.6
  • 33
    • 84890547166 scopus 로고    scopus 로고
    • Recent recombination events in the core genome are associated with adaptive evolution in Enterococcus faecium
    • de Been, M.; van Schaik, W.; Cheng, L.; Corander, J.; Willems, R.J. Recent recombination events in the core genome are associated with adaptive evolution in Enterococcus faecium. Genome Biol. Evol. 2013, 5, 1524-1535.
    • (2013) Genome Biol. Evol , vol.5 , pp. 1524-1535
    • de Been, M.1    van Schaik, W.2    Cheng, L.3    Corander, J.4    Willems, R.J.5
  • 35
    • 84880831180 scopus 로고    scopus 로고
    • Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota
    • Hu, Y.; Yang, X.; Qin, J.; Lu, N.; Cheng, G.; Wu, N.; Pan, Y.; Li, J.; Zhu, L.; Wang, X. et al. Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota. Nat Commun. 2013, 4, 2151.
    • (2013) Nat Commun , vol.4 , pp. 2151
    • Hu, Y.1    Yang, X.2    Qin, J.3    Lu, N.4    Cheng, G.5    Wu, N.6    Pan, Y.7    Li, J.8    Zhu, L.9    Wang, X.10
  • 36
    • 84875921666 scopus 로고    scopus 로고
    • A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4
    • Loman, N.J.; Constantinidou, C.; Christner, M.; Rohde, H.; Chan, J.Z.; Quick, J.; Weir, J.C.; Quince, C.; Smith, G.P.; Betley, J.R. et al. A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4. JAMA 2013, 309, 1502-1510.
    • (2013) JAMA , vol.309 , pp. 1502-1510
    • Loman, N.J.1    Constantinidou, C.2    Christner, M.3    Rohde, H.4    Chan, J.Z.5    Quick, J.6    Weir, J.C.7    Quince, C.8    Smith, G.P.9    Betley, J.R.10
  • 37
    • 80053550915 scopus 로고    scopus 로고
    • Unbiased parallel detection of viral pathogens in clinical samples by use of a metagenomic approach
    • Yang, J.; Yang, F.; Ren, L.; Xiong, Z.; Wu, Z.; Dong, J.; Sun, L.; Zhang, T.; Hu, Y.; Du, J. et al. Unbiased parallel detection of viral pathogens in clinical samples by use of a metagenomic approach. J. Clin. Microbiol. 2011, 49, 3463-3469.
    • (2011) J. Clin. Microbiol , vol.49 , pp. 3463-3469
    • Yang, J.1    Yang, F.2    Ren, L.3    Xiong, Z.4    Wu, Z.5    Dong, J.6    Sun, L.7    Zhang, T.8    Hu, Y.9    Du, J.10
  • 38
    • 84877126520 scopus 로고    scopus 로고
    • Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform
    • McLean, J.S.; Lombardo, M.J.; Ziegler, M.G.; Novotny, M.; Yee-Greenbaum, J.; Badger, J.H.; Tesler, G.; Nurk, S.; Lesin, V.; Brami, D. et al. Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform. Genome Res. 2013, 23, 867-877.
    • (2013) Genome Res , vol.23 , pp. 867-877
    • McLean, J.S.1    Lombardo, M.J.2    Ziegler, M.G.3    Novotny, M.4    Yee-Greenbaum, J.5    Badger, J.H.6    Tesler, G.7    Nurk, S.8    Lesin, V.9    Brami, D.10
  • 41
    • 84870977260 scopus 로고    scopus 로고
    • Whole genome sequencing in the prevention and control of Staphylococcus aureus infection
    • Price, J.R.; Didelot, X.; Crook, D.W.; Llewelyn, M.J.; Paul, J. Whole genome sequencing in the prevention and control of Staphylococcus aureus infection. J. Hosp. Infect. 2013, 83, 14-21.
    • (2013) J. Hosp. Infect , vol.83 , pp. 14-21
    • Price, J.R.1    Didelot, X.2    Crook, D.W.3    Llewelyn, M.J.4    Paul, J.5
  • 45
    • 84876670668 scopus 로고    scopus 로고
    • Pathogen sequencing: Picking and choosing
    • Stower, H. Pathogen sequencing: Picking and choosing. Nat. Rev. Genet. 2013, 14, 304.
    • (2013) Nat. Rev. Genet , vol.14 , pp. 304
    • Stower, H.1
  • 46
    • 77957769655 scopus 로고    scopus 로고
    • High-throughput sequencing and clinical microbiology: Progress, opportunities and challenges
    • Pallen, M.J.; Loman, N.J.; Penn, C.W. High-throughput sequencing and clinical microbiology: Progress, opportunities and challenges. Curr. Opin. Microbiol. 2010, 13, 625-631.
    • (2010) Curr. Opin. Microbiol , vol.13 , pp. 625-631
    • Pallen, M.J.1    Loman, N.J.2    Penn, C.W.3
  • 49
    • 85041688338 scopus 로고    scopus 로고
    • Software list, (accessed on 27 March 2014)
    • Software list, http://seqanswers.com/wiki/Software/list (accessed on 27 March 2014).
  • 50
    • 84882860961 scopus 로고    scopus 로고
    • Viral pathogen discovery
    • Chiu, C.Y. Viral pathogen discovery. Curr. Opin. Microbiol. 2013, 16, 468-478.
    • (2013) Curr. Opin. Microbiol , vol.16 , pp. 468-478
    • Chiu, C.Y.1
  • 51
    • 84870822864 scopus 로고    scopus 로고
    • Tools for mapping high-throughput sequencing data
    • Fonseca, N.A.; Rung, J.; Brazma, A.; Marioni, J.C. Tools for mapping high-throughput sequencing data. Bioinformatics 2012, 28, 3169-3177.
    • (2012) Bioinformatics , vol.28 , pp. 3169-3177
    • Fonseca, N.A.1    Rung, J.2    Brazma, A.3    Marioni, J.C.4
  • 54
    • 84873296417 scopus 로고    scopus 로고
    • READSCAN: A fast and scalable pathogen discovery program with accurate genome relative abundance estimation
    • Naeem, R.; Rashid, M.; Pain, A. READSCAN: a fast and scalable pathogen discovery program with accurate genome relative abundance estimation. Bioinformatics 2013, 29, 391-392.
    • (2013) Bioinformatics , vol.29 , pp. 391-392
    • Naeem, R.1    Rashid, M.2    Pain, A.3
  • 55
    • 84859770226 scopus 로고    scopus 로고
    • Rapid identification of non-human sequences in high-throughput sequencing datasets
    • Bhaduri, A.; Qu, K.; Lee, C.S.; Ungewickell, A.; Khavari, P.A. Rapid identification of non-human sequences in high-throughput sequencing datasets. Bioinformatics 2012, 28, 1174-1175.
    • (2012) Bioinformatics , vol.28 , pp. 1174-1175
    • Bhaduri, A.1    Qu, K.2    Lee, C.S.3    Ungewickell, A.4    Khavari, P.A.5
  • 56
    • 84878151016 scopus 로고    scopus 로고
    • VirusFinder: Software for efficient and accurate detection of viruses and their integration sites in host genomes through next generation sequencing data
    • Wang, Q.; Jia, P.; Zhao, Z. VirusFinder: Software for efficient and accurate detection of viruses and their integration sites in host genomes through next generation sequencing data. PLoS One 2013, 8, e64465.
    • (2013) PLoS One , vol.8
    • Wang, Q.1    Jia, P.2    Zhao, Z.3
  • 57
    • 70450177746 scopus 로고    scopus 로고
    • BFAST: An alignment tool for large scale genome resequencing
    • Homer, N.; Merriman, B.; Nelson, S.F. BFAST: An alignment tool for large scale genome resequencing. PLoS One 2009, 4, e7767.
    • (2009) PLoS One , vol.4
    • Homer, N.1    Merriman, B.2    Nelson, S.F.3
  • 58
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with Bowtie 2
    • Langmead, B.; Salzberg, S.L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 2012, 9, 357-359.
    • (2012) Nat. Methods , vol.9 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 59
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows-Wheeler transform
    • Li, H.; Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 2009, 25, 1754-1760.
    • (2009) Bioinformatics , vol.25 , pp. 1754-1760
    • Li, H.1    Durbin, R.2
  • 60
    • 77949587649 scopus 로고    scopus 로고
    • Fast and accurate long-read alignment with Burrows-Wheeler transform
    • Li, H.; Durbin, R. Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 2010, 26, 589-595.
    • (2010) Bioinformatics , vol.26 , pp. 589-595
    • Li, H.1    Durbin, R.2
  • 61
    • 55549097836 scopus 로고    scopus 로고
    • Mapping short DNA sequencing reads and calling variants using mapping quality scores
    • Li, H.; Ruan, J.; Durbin, R. Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res. 2008, 18, 1851-1858.
    • (2008) Genome Res , vol.18 , pp. 1851-1858
    • Li, H.1    Ruan, J.2    Durbin, R.3
  • 62
    • 79953310937 scopus 로고    scopus 로고
    • SHRiMP2: Sensitive yet practical short read mapping
    • David, M.; Dzamba, M.; Lister, D.; Ilie, L.; Brudno, M. SHRiMP2: Sensitive yet practical short read mapping. Bioinformatics 2011, 27, 1011-1012.
    • (2011) Bioinformatics , vol.27 , pp. 1011-1012
    • David, M.1    Dzamba, M.2    Lister, D.3    Ilie, L.4    Brudno, M.5
  • 64
    • 84861760530 scopus 로고    scopus 로고
    • IDBA-UD: A de novo assembler for single-cell and metagenomic sequencing data with highly uneven depth
    • Peng, Y.; Leung, H.C.; Yiu, S.M.; Chin, F.Y. IDBA-UD: A de novo assembler for single-cell and metagenomic sequencing data with highly uneven depth. Bioinformatics 2012, 28, 1420-1428.
    • (2012) Bioinformatics , vol.28 , pp. 1420-1428
    • Peng, Y.1    Leung, H.C.2    Yiu, S.M.3    Chin, F.Y.4
  • 65
    • 84867397631 scopus 로고    scopus 로고
    • MetaVelvet: An extension of Velvet assembler to de novo metagenome assembly from short sequence reads
    • Namiki, T.; Hachiya, T.; Tanaka, H.; Sakakibara, Y. MetaVelvet: An extension of Velvet assembler to de novo metagenome assembly from short sequence reads. Nucleic Acids Res. 2012, 40, e155.
    • (2012) Nucleic Acids Res , vol.40
    • Namiki, T.1    Hachiya, T.2    Tanaka, H.3    Sakakibara, Y.4
  • 67
    • 84942887758 scopus 로고    scopus 로고
    • SOAPdenovo2: An empirically improved memory-efficient short-read de novo assembler
    • Luo, R.; Liu, B.; Xie, Y.; Li, Z.; Huang, W.; Yuan, J.; He, G.; Chen, Y.; Pan, Q.; Liu, Y. et al. SOAPdenovo2: An empirically improved memory-efficient short-read de novo assembler. Gigascience 2012, 1, 18.
    • (2012) Gigascience , vol.1 , pp. 18
    • Luo, R.1    Liu, B.2    Xie, Y.3    Li, Z.4    Huang, W.5    Yuan, J.6    He, G.7    Chen, Y.8    Pan, Q.9    Liu, Y.10
  • 69
    • 43149115851 scopus 로고    scopus 로고
    • Velvet: Algorithms for de novo short read assembly using de Bruijn graphs
    • Zerbino, D.R.; Birney, E. Velvet: Algorithms for de novo short read assembly using de Bruijn graphs. Genome Res. 2008, 18, 821-829.
    • (2008) Genome Res , vol.18 , pp. 821-829
    • Zerbino, D.R.1    Birney, E.2
  • 70
    • 84869750558 scopus 로고    scopus 로고
    • BG7: A new approach for bacterial genome annotation designed for next generation sequencing data
    • Pareja-Tobes, P.; Manrique, M.; Pareja-Tobes, E.; Pareja, E.; Tobes, R. BG7: A new approach for bacterial genome annotation designed for next generation sequencing data. PLoS One 2012, 7, e49239.
    • (2012) PLoS One , vol.7
    • Pareja-Tobes, P.1    Manrique, M.2    Pareja-Tobes, E.3    Pareja, E.4    Tobes, R.5
  • 71
    • 63549147824 scopus 로고    scopus 로고
    • DIYA: A bacterial annotation pipeline for any genomics lab
    • Stewart, A.C.; Osborne, B.; Read, T.D. DIYA: A bacterial annotation pipeline for any genomics lab. Bioinformatics 2009, 25, 962-963.
    • (2009) Bioinformatics , vol.25 , pp. 962-963
    • Stewart, A.C.1    Osborne, B.2    Read, T.D.3
  • 77
    • 58149183697 scopus 로고    scopus 로고
    • ARDB-Antibiotic resistance genes database
    • Liu, B.; Pop, M. ARDB-Antibiotic resistance genes database. Nucleic Acids Res. 2009, 37, D443-D447.
    • (2009) Nucleic Acids Res , vol.37
    • Liu, B.1    Pop, M.2
  • 82
    • 77957244650 scopus 로고    scopus 로고
    • Search and clustering orders of magnitude faster than BLAST
    • Edgar, R.C. Search and clustering orders of magnitude faster than BLAST. Bioinformatics 2010, 26, 2460-2461.
    • (2010) Bioinformatics , vol.26 , pp. 2460-2461
    • Edgar, R.C.1
  • 83
    • 77949601825 scopus 로고    scopus 로고
    • CD-HIT Suite: A web server for clustering and comparing biological sequences
    • Huang, Y.; Niu, B.; Gao, Y.; Fu, L.; Li, W. CD-HIT Suite: A web server for clustering and comparing biological sequences. Bioinformatics 2010, 26, 680-682.
    • (2010) Bioinformatics , vol.26 , pp. 680-682
    • Huang, Y.1    Niu, B.2    Gao, Y.3    Fu, L.4    Li, W.5
  • 90
    • 79952199044 scopus 로고    scopus 로고
    • The missing graphical user interface for genomics
    • Schatz, M.C. The missing graphical user interface for genomics. Genome Biol. 2010, 11, 128.
    • (2010) Genome Biol , vol.11 , pp. 128
    • Schatz, M.C.1
  • 92
    • 84858330364 scopus 로고    scopus 로고
    • Cloud BioLinux: Pre-configured and on-demand bioinformatics computing for the genomics community
    • Krampis, K.; Booth, T.; Chapman, B.; Tiwari, B.; Bicak, M.; Field, D.; Nelson, K.E. Cloud BioLinux: Pre-configured and on-demand bioinformatics computing for the genomics community. BMC Bioinformatics 2012, 13, 42.
    • (2012) BMC Bioinformatics , vol.13 , pp. 42
    • Krampis, K.1    Booth, T.2    Chapman, B.3    Tiwari, B.4    Bicak, M.5    Field, D.6    Nelson, K.E.7
  • 93
    • 84892915273 scopus 로고    scopus 로고
    • How bioinformatics influences health informatics: Usage of biomolecular sequences, expression profiles and automated microscopic image analyses for clinical needs and public health
    • Kuznetsov, V.; Lee, H.; Maurer-Stroh, S.; Molnar, M.; Pongor, S.; Eisenhaber, B.; Eisenhaber, F. How bioinformatics influences health informatics: Usage of biomolecular sequences, expression profiles and automated microscopic image analyses for clinical needs and public health. Health Inf. Sci. Syst. 2013, 1, 2.
    • (2013) Health Inf. Sci. Syst , vol.1 , pp. 2
    • Kuznetsov, V.1    Lee, H.2    Maurer-Stroh, S.3    Molnar, M.4    Pongor, S.5    Eisenhaber, B.6    Eisenhaber, F.7
  • 95
    • 84876783779 scopus 로고    scopus 로고
    • Next generation sequencing in clinical medicine: Challenges and lessons for pathology and biomedical informatics
    • Gullapalli, R.R.; Desai, K.V.; Santana-Santos, L.; Kant, J.A.; Becich, M.J. Next generation sequencing in clinical medicine: Challenges and lessons for pathology and biomedical informatics. J. Pathol. Inform. 2012, 3, 40.
    • (2012) J. Pathol. Inform , vol.3 , pp. 40
    • Gullapalli, R.R.1    Desai, K.V.2    Santana-Santos, L.3    Kant, J.A.4    Becich, M.J.5
  • 96
    • 84861918294 scopus 로고    scopus 로고
    • Barriers to integrating personalized medicine into clinical practice: A best-worst scaling choice experiment
    • Najafzadeh, M.; Lynd, L.D.; Davis, J.C.; Bryan, S.; Anis, A.; Marra, M.; Marra, C.A. Barriers to integrating personalized medicine into clinical practice: a best-worst scaling choice experiment. Genet. Med. 2012, 14, 520-526.
    • (2012) Genet. Med , vol.14 , pp. 520-526
    • Najafzadeh, M.1    Lynd, L.D.2    Davis, J.C.3    Bryan, S.4    Anis, A.5    Marra, M.6    Marra, C.A.7
  • 97
    • 85006201950 scopus 로고    scopus 로고
    • Lessons learned from implementing a national infrastructure in Sweden for storage and analysis of next-generation sequencing data
    • Lampa, S.; Dahlo, M.; Olason, P.I.; Hagberg, J.; Spjuth, O. Lessons learned from implementing a national infrastructure in Sweden for storage and analysis of next-generation sequencing data. Gigascience 2013, 2, 9.
    • (2013) Gigascience , vol.2 , pp. 9
    • Lampa, S.1    Dahlo, M.2    Olason, P.I.3    Hagberg, J.4    Spjuth, O.5
  • 98
    • 84873826425 scopus 로고    scopus 로고
    • Bioinformatics in bacterial molecular epidemiology and public health: Databases, tools and the next-generation sequencing revolution
    • Carrico, J.A.; Sabat, A.J.; Friedrich, A.W.; Ramirez, M. Bioinformatics in bacterial molecular epidemiology and public health: Databases, tools and the next-generation sequencing revolution. Euro Surveill. 2013, 18, 20382.
    • (2013) Euro Surveill , vol.18 , pp. 20382
    • Carrico, J.A.1    Sabat, A.J.2    Friedrich, A.W.3    Ramirez, M.4
  • 99
    • 84873705940 scopus 로고    scopus 로고
    • Critical role of bioinformatics in translating huge amounts of next-generation sequencing data into personalized medicine
    • Hong, H.; Zhang, W.; Shen, J.; Su, Z.; Ning, B.; Han, T.; Perkins, R.; Shi, L.; Tong, W. Critical role of bioinformatics in translating huge amounts of next-generation sequencing data into personalized medicine. Sci. China Life Sci. 2013, 56, 110-118.
    • (2013) Sci. China Life Sci , vol.56 , pp. 110-118
    • Hong, H.1    Zhang, W.2    Shen, J.3    Su, Z.4    Ning, B.5    Han, T.6    Perkins, R.7    Shi, L.8    Tong, W.9
  • 100
    • 84866419093 scopus 로고    scopus 로고
    • Next-generation and whole-genome sequencing in the diagnostic clinical microbiology laboratory
    • Dunne, W.M.; Westblade, L.F.; Ford, B. Next-generation and whole-genome sequencing in the diagnostic clinical microbiology laboratory. Eur. J. Clin. Microbiol. Infect. Dis. 2012, 31, 1719-1726.
    • (2012) Eur. J. Clin. Microbiol. Infect. Dis , vol.31 , pp. 1719-1726
    • Dunne, W.M.1    Westblade, L.F.2    Ford, B.3
  • 101
    • 84882729023 scopus 로고    scopus 로고
    • Harnessing virtual machines to simplify next-generation DNA sequencing analysis
    • Nocq, J.; Celton, M.; Gendron, P.; Lemieux, S.; Wilhelm, B.T. Harnessing virtual machines to simplify next-generation DNA sequencing analysis. Bioinformatics 2013, 29, 2075-2083.
    • (2013) Bioinformatics , vol.29 , pp. 2075-2083
    • Nocq, J.1    Celton, M.2    Gendron, P.3    Lemieux, S.4    Wilhelm, B.T.5
  • 102
    • 84865226981 scopus 로고    scopus 로고
    • Next-generation sequencing data interpretation: Enhancing reproducibility and accessibility
    • Nekrutenko, A.; Taylor, J. Next-generation sequencing data interpretation: Enhancing reproducibility and accessibility. Nat. Rev. Genet. 2012, 13, 667-672.
    • (2012) Nat. Rev. Genet , vol.13 , pp. 667-672
    • Nekrutenko, A.1    Taylor, J.2
  • 104
    • 84863870157 scopus 로고    scopus 로고
    • Bioinformatics as a driver, not a passenger, of translational biomedical research: Perspectives from the 6th Benelux bioinformatics conference
    • Azuaje, F.J.; Heymann, M.; Ternes, A.M.; Wienecke-Baldacchino, A.; Struck, D.; Moes, D.; Schneider, R. Bioinformatics as a driver, not a passenger, of translational biomedical research: Perspectives from the 6th Benelux bioinformatics conference. J. Clin. Bioinforma 2012, 2, 7.
    • (2012) J. Clin. Bioinforma , vol.2 , pp. 7
    • Azuaje, F.J.1    Heymann, M.2    Ternes, A.M.3    Wienecke-Baldacchino, A.4    Struck, D.5    Moes, D.6    Schneider, R.7
  • 106
    • 84864767911 scopus 로고    scopus 로고
    • Infection systems biology: From reactive to proactive (P4) medicine
    • Bengoechea, J.A. Infection systems biology: From reactive to proactive (P4) medicine. Int. Microbiol. 2012, 15, 55-60.
    • (2012) Int. Microbiol , vol.15 , pp. 55-60
    • Bengoechea, J.A.1
  • 107
    • 84890417231 scopus 로고    scopus 로고
    • First FDA authorization for next-generation sequencer
    • Collins, F.S.; Hamburg, M.A. First FDA authorization for next-generation sequencer. N. Engl. J. Med. 2013, 369, 2369-2371.
    • (2013) N. Engl. J. Med , vol.369 , pp. 2369-2371
    • Collins, F.S.1    Hamburg, M.A.2


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