Inhibition of innate immune cytosolic surveillance by an M.Tuberculosis phosphodiesterase

Nature Chemical Biology

Volumn 13, Issue 2, 2017, Pages 210-217

  Dey, Ruchi Jain ^a,b   Dey, Bappaditya ^a,b,e,f   Zheng, Yue ^c,d,e,f   Cheung, Laurene S ^a   Zhou, Jie ^c,d   Sayre, David ^c   Kumar, Pankaj ^a   Guo, Haidan ^a   Lamichhane, Gyanu ^a   Sintim, Herman O ^c,d   Bishai, William R ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d PURDUE UNIVERSITY   (United States)

^e BOSTON UNIVERSITY   (United States)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BETA INTERFERON; CYCLIC AMP; CYCLIC DIADENOSINE MONOPHOSPHATE; CYCLIC DIGUANOSINE MONOPHOSPHATE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; PHOSPHODIESTERASE; STIMULATOR OF INTERFERON GENE PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; 2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIAL LOAD; BACTERIAL VIRULENCE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOKINE RESPONSE; CYTOSOL; CYTOSOLIC SURVEILLANCE PATHWAY; ENZYME DEGRADATION; EXPERIMENTAL TUBERCULOSIS; FEMALE; GENE MUTATION; HOMEOSTASIS; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNOSURVEILLANCE; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LUNG TUBERCULOSIS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; MICROBIOLOGY;

2',3'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; CYTOSOL; IMMUNITY, INNATE; MYCOBACTERIUM TUBERCULOSIS;

EID: 85004064485     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2254     Document Type: Article

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