HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells

Cell Reports

Volumn 17, Issue 2, 2016, Pages 413-424

  Vermeire, Jolien ^a,d   Roesch, Ferdinand ^b   Sauter, Daniel ^c   Rua, Réjane ^b,e   Hotter, Dominik ^c   Van Nuffel, Anouk ^a   Vanderstraeten, Hanne ^a   Naessens, Evelien ^a   Iannucci, Veronica ^a   Landi, Alessia ^a   Witkowski, Wojciech ^a   Baeyens, Ann ^a   Kirchhoff, Frank ^c   Verhasselt, Bruno ^a  

^a GHENT UNIVERSITY   (Belgium)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITY HOSPITAL ULM   (Germany)

^d USA   (United States)

^e NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

CD4; cGAS; dendritic cells; HIV; innate sensing; interferon; NF B; T cells; Vpr; Vpu

Indexed keywords

BINDING PROTEIN; CGAS PROTEIN; INTERFERON; UNCLASSIFIED DRUG; VIRAL PROTEIN; VPR PROTEIN; VPU PROTEIN; VPX PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; MB21D1 PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE; VPR PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; VPU PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSOL; DENDRITIC CELL; DNA INTEGRATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SENSOR; GENETICS; HEK293 CELL LINE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; INNATE IMMUNITY; LENTIVIRINAE; METABOLISM; PATHOGENICITY; VIROLOGY;

CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; HEK293 CELLS; HIV INFECTIONS; HIV-1; HUMAN IMMUNODEFICIENCY VIRUS PROTEINS; HUMANS; IMMUNITY, INNATE; INTERFERON TYPE I; LENTIVIRUS; NUCLEOTIDYLTRANSFERASES; VIRAL REGULATORY AND ACCESSORY PROTEINS; VPR GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 85003972577     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.09.023     Document Type: Article

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