HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Huang, Chih Yang ^a   Chiang, Shu Fen ^a   Lin, Tze Yi ^b   Chiou, Shiow Her ^a   Chow, Kuan Chih ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIN RELATED PROTEIN 1; MEMBRANE PROTEIN; MITOFUSIN 2; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; VPR PROTEIN; DNM1L PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATASE; MFN2 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MITOCHONDRIAL PROTEIN; VPR PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL DESTRUCTION; CELL INTERACTION; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS INFECTION; MITOCHONDRIAL DESTRUCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; T LYMPHOBLAST; CELL LINE; CONFOCAL MICROSCOPY; DRUG ANTAGONISM; GENE SILENCING; GENETICS; HOST PATHOGEN INTERACTION; MEMBRANE FUSION; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PATHOGENICITY; PATHOLOGY; PERMEABILITY; PHYSIOLOGY; PROTEIN TRANSPORT; TIME LAPSE IMAGING; TRANSMISSION ELECTRON MICROSCOPY; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS;

CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; ENDOPLASMIC RETICULUM; GENE KNOCKDOWN TECHNIQUES; GTP PHOSPHOHYDROLASES; HEK293 CELLS; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; MEMBRANE FUSION; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTEINS; PERMEABILITY; PROTEIN TRANSPORT; TIME-LAPSE IMAGING; VPR GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84863346611     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033657     Document Type: Article

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