Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model

Oncotarget

Volumn 7, Issue 50, 2016, Pages 83071-83087

  Roel, María ^a   Rubiolo, Juan A ^a   Guerra Varela, Jorge ^a   Silva, Siguara B L ^b,c   Thomas, Olivier P ^b,d   Cabezas Sainz, Pablo ^a   Sánchez, Laura ^a   López, Rafael ^a   Botana, Luis M ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITÉ DE NICE SOPHIA ANTIPOLIS   (France)

^c UNIVERSITÉ PARIS SUD   (France)

^d NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Apoptosis; Cancer treatment; Cell cycle inhibition; Crambescidins; Zebrafish xenograft model

Indexed keywords

ALKALOID; ANTINEOPLASTIC AGENT; BETA TUBULIN; CASPASE 3; CLAUDIN 2; CRAMBESCIDINE 800; CRAMBESCIDINE 816; CRAMBESCIDINE 830; CRAMBESCIDINE DERIVATIVE; CYCLIN A; CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2D; FLUOROURACIL; MESSENGER RNA; OCCLUDIN; PROTEIN P53; UNCLASSIFIED DRUG; VINCULIN; CASP3 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CRAMBESCIDIN 800; CRAMBESCIDIN 816; GUANIDINE; SPIRO COMPOUND;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL ADHESION; CELL SURVIVAL; CELL VIABILITY; COLORECTAL CARCINOMA; CONTROLLED STUDY; CRAMBE CRAMBE; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; HEPG2 CELL LINE; IC50; IN VITRO STUDY; INTRACELLULAR SIGNALING; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; MTT ASSAY; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; TIGHT JUNCTION; TUMOR CELL; TUMOR XENOGRAFT; UPREGULATION; ZEBRA FISH; ANALOGS AND DERIVATIVES; ANIMAL; CELL PROLIFERATION; COLORECTAL TUMOR; CYTOSKELETON; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HEP-G2 CELL LINE; HT-29 CELL LINE; HUMAN; MCF-7 CELL LINE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR VOLUME;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL ADHESION; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL NEOPLASMS; CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; G1 PHASE CELL CYCLE CHECKPOINTS; GUANIDINE; HEP G2 CELLS; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; SIGNAL TRANSDUCTION; SPIRO COMPOUNDS; TIME FACTORS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS; ZEBRAFISH;

EID: 85003936095     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.13068     Document Type: Article

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