Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells

British Journal of Pharmacology

Volumn 171, Issue 7, 2014, Pages 1655-1667

  Rubiolo, J A ^a   Lopez Alonso H ^a   Roel, M ^a   Vieytes, M R ^a   Thomas, O ^b   Ternon, E ^b   Vega, F V ^a   Botana, L M ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITÉ DE NICE SOPHIA ANTIPOLIS   (France)

Author keywords

crambescidin 816; transcriptomic analysis; tumour cell adhesion; tumour cell migration; tumour cell viability

Indexed keywords

ANTINEOPLASTIC AGENT; CRAMBESCIDIN 816; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOGENICITY; CELL ADHESION; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL MIGRATION; CELL VIABILITY; COLON CARCINOMA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRAMBE; CYTOSKELETON; CYTOTOXICITY; DRUG MECHANISM; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN PURIFICATION; TIGHT JUNCTION; TRANSCRIPTOMICS; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL; WESTERN BLOTTING;

CRAMBESCIDIN-816; TRANSCRIPTOMIC ANALYSIS; TUMOUR CELL ADHESION; TUMOUR CELL MIGRATION; TUMOUR CELL VIABILITY;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CELL ADHESION; CELL COMMUNICATION; CELL CYCLE CHECKPOINTS; CELL MOVEMENT; CELL SURVIVAL; CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; NEOPLASM INVASIVENESS; SPIRO COMPOUNDS; TIGHT JUNCTIONS; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 84908876040     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12552     Document Type: Article

References (41)

1. Aoki S, Kong D, Matsui K, Kobayashi M, (2004). Erythroid differentiation in K562 chronic myelogenous cells induced by crambescidin 800, a pentacyclic guanidine alkaloid. Anticancer Res 24: 2325-2330.
2. Aron ZD, Pietraszkiewicz H, Overman LE, Valeriote F, Cuevas C, (2004). Synthesis and anticancer activity of side chain analogs of the crambescidin alkaloids. Bioorg Med Chem Lett 14: 3445-3449.
3. Bates S, Bonetta L, MacAllan D, Parry D, Holder A, Dickson C, et al. (1994). CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. Oncogene 9: 71-79.
4. Belarbi el H, Contreras Gomez A, Chisti Y, Garcia Camacho F, Molina Grima E, (2003). Producing drugs from marine sponges. Biotechnol Adv 21: 585-598.
5. Berlinck RG, Braekman JC, Daloze D, Bruno I, Riccio R, Ferri S, et al. (1993). Polycyclic guanidine alkaloids from the marine sponge Crambe crambe and Ca++ channel blocker activity of crambescidin 816. J Nat Prod 56: 1007-1015.
6. Blunt JW, Copp BR, Hu WP, Munro MH, Northcote PT, Prinsep MR, (2009). Marine natural products. Nat Prod Rep 26: 170-244.
7. Bojarski C, Weiske J, Schoneberg T, Schroder W, Mankertz J, Schulzke JD, et al. (2004). The specific fates of tight junction proteins in apoptotic epithelial cells. J Cell Sci 117 (Pt 10): 2097-2107.
8. Bondu S, Genta-Jouve G, Leirõs M, Vale C, Guigonis J-M, Botana LM, et al. (2012). Additional bioactive guanidine alkaloids from the Mediterranean sponge Crambe crambe. RSC Adv 2: 2828-2835.
9. Buchert M, Papin M, Bonnans C, Darido C, Raye WS, Garambois V, et al. (2010). Symplekin promotes tumorigenicity by up-regulating claudin-2 expression. Proc Natl Acad Sci U S A 107: 2628-2633.
10. Burkholder PR, Ruetzler K, (1969). Antimicrobial activity of some marine sponges. Nature 222: 983-984.
11. Buscema M, Van de Vyver G, (1985). Cytotoxic rejection of xenografts between marine sponges. J Exp Zoolog 235: 297-308.
12. Cramer LP, Siebert M, Mitchison TJ, (1997). Identification of novel graded polarity actin filament bundles in locomoting heart fibroblasts: implications for the generation of motile force. J Cell Biol 136: 1287-1305.
13. Dulic V, Lees E, Reed SI, (1992). Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257: 1958-1961.
14. Hirata Y, Uemura D, (1986). Halichondrins-antitumor polyether macrolides from a marine sponge. Pure Appl Chem 58: 701-710.
15. Hotulainen P, Lappalainen P, (2006). Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. J Cell Biol 173: 383-394.
16. Huang da W, Sherman BT, Lempicki RA, (2009a). Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37: 1-13.
17. Huang da W, Sherman BT, Lempicki RA, (2009b). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
18. Jockusch BM, Bubeck P, Giehl K, Kroemker M, Moschner J, Rothkegel M, et al. (1995). The molecular architecture of focal adhesions. Annu Rev Cell Dev Biol 11: 379-416.
19. Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, et al. (1992). Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257: 1689-1694.
20. Lopez-Alonso H, Rubiolo JA, Vega F, Vieytes MR, Botana LM, (2013). Protein synthesis inhibition and oxidative stress induced by cylindrospermopsin elicit apoptosis in primary rat hepatocytes. Chem Res Toxicol 26: 203-212.
21. Martin V, Vale C, Bondu S, Thomas OP, Vieytes MR, Botana LM, (2013). Differential effects of crambescins and crambescidin 816 in voltage-gated sodium, potassium and calcium channels in neurons. Chem Res Toxicol. [Epub ahead of print].
22. Matsushime H, Ewen ME, Strom DK, Kato JY, Hanks SK, Roussel MF, et al. (1992). Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell 71: 323-334.
23. Mayer AM, Glaser KB, Cuevas C, Jacobs RS, Kem W, Little RD, et al. (2010). The odyssey of marine pharmaceuticals: a current pipeline perspective. Trends Pharmacol Sci 31: 255-265.
24. Meyerson M, Harlow E, (1994). Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol 14: 2077-2086.
25. Mima S, Takehara M, Takada H, Nishimura T, Hoshino T, Mizushima T, (2008). NSAIDs suppress the expression of claudin-2 to promote invasion activity of cancer cells. Carcinogenesis 29: 1994-2000.
26. Molinski TF, Dalisay DS, Lievens SL, Saludes JP, (2009). Drug development from marine natural products. Nat Rev Drug Discov 8: 69-85.
27. Ottinger S, Kloppel A, Rausch V, Liu L, Kallifatidis G, Gross W, et al. (2012). Targeting of pancreatic and prostate cancer stem cell characteristics by Crambe crambe marine sponge extract. Int J Cancer 130: 1671-1681.
28. Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G, (1992). Cyclin A is required at two points in the human cell cycle. EMBO J 11: 961-971.
29. Peng X, Nelson ES, Maiers JL, DeMali KA, (2011). Chapter five-new insights into vinculin function and regulation. In:, Kwang WJ, (ed.). International Review of Cell and Molecular Biology, Vol. 287. Academic Press: San Diego, pp. 191-231.
30. Proksch P, Ebel R, Edrada RA, Wray V, Steube K, (2003). Bioactive natural products from marine invertebrates and associated fungi. Prog Mol Subcell Biol 37: 117-142.
31. Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N, et al. (2003). TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34: 374-378.
32. Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, Howe EA, et al. (2006). TM4 microarray software suite. Methods Enzymol 411: 134-193.
33. Schneeberger EE, Lynch RD, (2004). The tight junction: a multifunctional complex. Am J Physiol Cell Physiol 286: C1213-C1228.
34. Schneider CA, Rasband WS, Eliceiri KW, (2012). NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9: 671-675.
35. Schwartsmann G, Brondani da Rocha A, Berlinck RG, Jimeno J, (2001). Marine organisms as a source of new anticancer agents. Lancet Oncol 2: 221-225.
36. Sipkema D, Franssen MC, Osinga R, Tramper J, Wijffels RH, (2005). Marine sponges as pharmacy. Mar Biotechnol (NY) 7: 142-162.
37. Talpir R, Benayahu Y, Kashman Y, Pannell L, Schleyer M, (1994). Hemiasterlin and geodiamolide TA: two new cytotoxic peptides from the marine sponge Hemiasterella minor (Kirkpatrick). Tetrahedron Lett 44: 53-56.
38. Tojkander S, Gateva G, Lappalainen P, (2012). Actin stress fibers-assembly, dynamics and biological roles. J Cell Sci 125 (Pt 8): 1855-1864.
39. Uriz MJ, Beccero MA, Tur JM, Turon X, (1996). Location of toxicity within the Mediterranean sponge Crambe crambe. Mar Biol 124: 583-590.
40. Xiong Y, Zhang H, Beach D, (1992). D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71: 505-514.
41. Zhu X, Ohtsubo M, Bohmer RM, Roberts JM, Assoian RK, (1996). Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J Cell Biol 133: 391-403.