Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy

Haematologica

Volumn 96, Issue 4, 2011, Pages 612-616

  Pruvot, Benoist ^a,b   Jacquel, Arnaud ^a,b   Droin, Nathalie ^a,b,f   Auberger, Patrick ^c   Bouscary, Didier ^d   Tamburini, Jérome ^d   Muller, Marc ^e   Fontenay, Michaela ^d   Chluba, Johanna ^a,b   Solary, Eric ^a,b,f  

^a boulevard Jeanne d'Arc   (France)

^b UNIVERSITÉ DE BOURGOGNE   (France)

^c INSERM   (France)

^d INSTITUT COCHIN   (France)

^e UNIVERSITY OF LIÈGE   (Belgium)

^f INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Acute leukemia; Antileukemic drugs; Pharmacology; Teratogenicity; Zebrafish model

Indexed keywords

4EGI 1; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; IMATINIB; MAFOSFAMIDE; RETINOIC ACID; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ARTICLE; BLAST CELL; CELL STRAIN K 562; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; ENGRAFTMENT; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL LINE; NONHUMAN; TUMOR XENOGRAFT; ZEBRA FISH;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; JURKAT CELLS; K562 CELLS; PIPERAZINES; PYRIMIDINES; TRETINOIN; XENOGRAFT MODEL ANTITUMOR ASSAYS; ZEBRAFISH;

EID: 79953907200     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.031401     Document Type: Article

References (25)

1. Zon LI, Peterson RT. In vivo drug discovery in the zebrafish. Nat Rev Drug Discov. 2005;4(1):35-44.
2. Smith AC, Raimondi AR, Salthouse CD, Ignatius MS, Blackburn JS, Mizgirev IV, et al. High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lym-phoblastic leukemia. Blood. 2010;115(16): 3296-3303.
3. Mizgirev IV, Revskoy S. A new zebrafish model for experimental leukemia therapy. Cancer Biol Ther. 2010;9(11):895-902.
4. Kalev-Zylinska ML, Horsfield JA, Flores MV, Postlethwait JH, Vitas MR, Baas AM, et al. Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemoge-nesis. Development. 2002;129(8):2015-2030.
5. Onnebo SM, Condron MM, McPhee DO, Lieschke GJ, Ward AC. Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion. Exp Hematol. 2005;33(2):182-188.
6. Zhuravleva J, Paggetti J, Martin L, Hammann A, Solary E, Bastie JN, et al. MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish. Br J Haematol. 2008;143(3):378-382.
7. Nicoli S, Ribatti D, Cotelli F, Presta M. Mammalian tumor xenografts induce neo-vascularization in zebrafish embryos. Cancer Res. 2007;67(7):2927-2931.
8. Lally BE, Geiger GA, Kridel S, Arcury-Quandt AE, Robbins ME, Kock ND, et al. Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. Cancer Res. 2007;67(18): 8791-8799.
9. White RM, Sessa A, Burke C, Bowman T, LeBlanc J, Ceol C, et, al. Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell. 2008(2);2:183-189
10. Stoletov K, Kato H, Zardouzian E, Kelber J, Yang J, Shattil S, et al. Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci 2010;123(13);1332-2341.
11. Weiss FU, Marques IJ, Woltering JM, Vlecken DH, Aghdassi A, Partecke LI, et al. Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer. Gastroenterology. 2009;137(6):2136-2145.
12. Fishman MC, Stainier DY, Breitbart RE, Westerfield M. Zebrafish: genetic and embryological methods in a transparent vertebrate embryo. Methods Cell Biol. 1997;52:67-82.
13. Jacquel A, Colosetti P, Grosso S, Belhacene N, Puissant A, Marchetti S, et al. Apoptosis and erythroid differentiation triggered by Bcr-Abl inhibitors in CML cell lines are fully distinguishable processes that exhibit different sensitivity to caspase inhibition. Oncogene 2007;26(17):2445-2458.
14. Haldi M, Ton C, Seng WL, McGrath P. Human melanoma cells transplanted into zebrafish proliferate, migrate, produce melanin, form masses and stimulate angio-genesis in zebrafish. Angiogenesis. 2006;9 (3):139-151.
15. Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, Wheaton WW, et al. Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med. 2006;12(8):925-932.
16. Lee LM, Seftor EA, Bonde G, Cornell RA, Hendrix MJ. The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formation. Dev Dyn. 2005;233(4):1560-1570.
17. Zhang X, Ren R. Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulo-cyte-macrophage colony-stimulating factor in mice: a novel model for chronic myel-ogenous leukemia. Blood. 1998;92(10): 3829-3840.
18. Kantarjian H, Sawyers C, Hochhaus A, Guilhot F, Schiffer C, Gambacorti-Passerini C, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med. 2002;346(9):645-652.
19. Roussel MJ, Lanotte M. Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes. Oncogene. 2001;20(49):7287-7291.
20. Collins MD, Mao GE. Teratology of retinoids. Annu Rev Pharmacol Toxicol. 1999;39:399-430.
21. Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, et al. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 2007;128(2):257-267.
22. Park S, Chapuis N, Tamburini J, Bardet V, Cornillet-Lefebvre P, Willems L, et al. Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia. Haematologica. 2010;95(3):819-828.
23. Tamburini J, Green AS, Bardet V, Chapuis N, Park S, Willems L, et al. Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia. Blood. 2009;114(8): 1618-1627.
24. Selderslaghs IW, Van Rompay AR, De Coen W, Witters HE. Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo. Reprod Toxicol. 2009;28(3):308-320.
25. Eimon PM, Rubinstein AL. The use of in vivo zebrafish assays in drug toxicity screening. Expert Opin Drug Metab Toxicol. 2009;5(4):393-401.