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Volumn 69, Issue 1, 2017, Pages 9-16

Apocynin and enzymatically modified isoquercitrin suppress the expression of a NADPH oxidase subunit p22phox in steatosis-related preneoplastic liver foci of rats

Author keywords

Apocynin; Enzymatically modified isoquercetin; High fat diet; NADPH oxidase; Preneoplastic liver cell lesions; Two stage hepatocarcinogenesis model

Indexed keywords

ADIPOPHILIN; ALKALINE PHOSPHATASE; APOCYNIN; CASPASE 3; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; ISOQUERCITRIN; KI 67 ANTIGEN; LC3A PROTEIN; MALACHITE GREEN; MARKER; P22PHOX PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UNCLASSIFIED DRUG; ACETOPHENONE DERIVATIVE; ENZYME INHIBITOR; P22-PHOX PROTEIN, RAT; QUERCETIN;

EID: 85003520604     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2016.10.003     Document Type: Article
Times cited : (16)

References (37)
  • 1
    • 84866425239 scopus 로고    scopus 로고
    • Aiding and abetting roles of NOX oxidases in cellular transformation
    • Block, K., Gorin, Y., Aiding and abetting roles of NOX oxidases in cellular transformation. Nat. Rev. Cancer 12 (2012), 627–637.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 627-637
    • Block, K.1    Gorin, Y.2
  • 2
    • 55549098874 scopus 로고    scopus 로고
    • Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity
    • Carmona-Cuenca, I., Roncero, C., Sancho, P., Caja, L., Fausto, N., Fernandez, M., et al. Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. J. Hepatol. 49 (2008), 965–976.
    • (2008) J. Hepatol. , vol.49 , pp. 965-976
    • Carmona-Cuenca, I.1    Roncero, C.2    Sancho, P.3    Caja, L.4    Fausto, N.5    Fernandez, M.6
  • 3
    • 84880948171 scopus 로고    scopus 로고
    • Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis
    • Chatterjee, S., Ganini, D., Tokar, E.J., Kumar, A., Das, S., Corbett, J., et al. Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis. J. Hepatol. 58 (2013), 778–784.
    • (2013) J. Hepatol. , vol.58 , pp. 778-784
    • Chatterjee, S.1    Ganini, D.2    Tokar, E.J.3    Kumar, A.4    Das, S.5    Corbett, J.6
  • 5
    • 84901358645 scopus 로고    scopus 로고
    • Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma
    • Choi, J., Corder, N.L., Koduru, B., Wang, Y., Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma. Free Radic. Biol. Med. 72 (2014), 267–284.
    • (2014) Free Radic. Biol. Med. , vol.72 , pp. 267-284
    • Choi, J.1    Corder, N.L.2    Koduru, B.3    Wang, Y.4
  • 6
    • 0032853945 scopus 로고    scopus 로고
    • Toxicity and metabolism of malachite green and leucomalachite green during short-term feeding to Fischer 344 rats and B6C3F1 mice
    • Culp, S.J., Blankenship, L.R., Kusewitt, D.F., Doerge, D.R., Mulligan, L.T., Beland, F.A., Toxicity and metabolism of malachite green and leucomalachite green during short-term feeding to Fischer 344 rats and B6C3F1 mice. Chem. Biol. Interact. 122 (1999), 153–170.
    • (1999) Chem. Biol. Interact. , vol.122 , pp. 153-170
    • Culp, S.J.1    Blankenship, L.R.2    Kusewitt, D.F.3    Doerge, D.R.4    Mulligan, L.T.5    Beland, F.A.6
  • 8
    • 55749106570 scopus 로고    scopus 로고
    • A rodent model of NASH with cirrhosis, oval cell proliferation and hepatocellular carcinoma
    • de Lima, V.M., Oliveira, C.P., Alves, V.A., Chammas, M.C., Oliveira, E.P., Stefano, J.T., et al. A rodent model of NASH with cirrhosis, oval cell proliferation and hepatocellular carcinoma. J. Hepatol. 49 (2008), 1055–1061.
    • (2008) J. Hepatol. , vol.49 , pp. 1055-1061
    • de Lima, V.M.1    Oliveira, C.P.2    Alves, V.A.3    Chammas, M.C.4    Oliveira, E.P.5    Stefano, J.T.6
  • 9
    • 78650039966 scopus 로고    scopus 로고
    • Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice
    • Duval, C., Thissen, U., Keshtkar, S., Accart, B., Stienstra, R., Boekschoten, M.V., et al. Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice. Diabetes 59 (2010), 3181–3191.
    • (2010) Diabetes , vol.59 , pp. 3181-3191
    • Duval, C.1    Thissen, U.2    Keshtkar, S.3    Accart, B.4    Stienstra, R.5    Boekschoten, M.V.6
  • 10
    • 0025832018 scopus 로고
    • Enhanced expression of low molecular weight keratins during progressive diethylnitrosamine-induced hepatocarcinogenesis in rats is associated with the presence of high levels of gamma-glutamyl transpeptidase and glycogen-deficient islands
    • Fernandes, C., Rao, K.V., Enhanced expression of low molecular weight keratins during progressive diethylnitrosamine-induced hepatocarcinogenesis in rats is associated with the presence of high levels of gamma-glutamyl transpeptidase and glycogen-deficient islands. Cancer Lett. 59 (1991), 211–219.
    • (1991) Cancer Lett. , vol.59 , pp. 211-219
    • Fernandes, C.1    Rao, K.V.2
  • 11
    • 80052477222 scopus 로고    scopus 로고
    • DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH
    • Gabele, E., Dostert, K., Hofmann, C., Wiest, R., Scholmerich, J., Hellerbrand, C., et al. DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH. J. Hepatol. 55 (2011), 1391–1399.
    • (2011) J. Hepatol. , vol.55 , pp. 1391-1399
    • Gabele, E.1    Dostert, K.2    Hofmann, C.3    Wiest, R.4    Scholmerich, J.5    Hellerbrand, C.6
  • 12
    • 33644890756 scopus 로고    scopus 로고
    • Time course of the development of non-alcoholic hepatic steatosis in response to high-fat diet-induced obesity in rats
    • Gauthier, M.S., Favier, R., Lavoie, J.M., Time course of the development of non-alcoholic hepatic steatosis in response to high-fat diet-induced obesity in rats. Br. J. Nutr. 95 (2006), 273–281.
    • (2006) Br. J. Nutr. , vol.95 , pp. 273-281
    • Gauthier, M.S.1    Favier, R.2    Lavoie, J.M.3
  • 13
    • 77749289258 scopus 로고    scopus 로고
    • PAT protein mRNA expression in primary rat hepatocytes: effects of exposure to fatty acids
    • Grasselli, E., Voci, A., Pesce, C., Canesi, L., Fugassa, E., Gallo, G., et al. PAT protein mRNA expression in primary rat hepatocytes: effects of exposure to fatty acids. Int. J. Mol. Med. 25 (2010), 505–512.
    • (2010) Int. J. Mol. Med. , vol.25 , pp. 505-512
    • Grasselli, E.1    Voci, A.2    Pesce, C.3    Canesi, L.4    Fugassa, E.5    Gallo, G.6
  • 14
    • 0037289199 scopus 로고    scopus 로고
    • Tumor promotion by metanil yellow and malachite green during rat hepatocarcinogenesis is associated with dysregulated expression of cell cycle regulatory proteins
    • Gupta, S., Sundarrajan, M., Rao, K.V., Tumor promotion by metanil yellow and malachite green during rat hepatocarcinogenesis is associated with dysregulated expression of cell cycle regulatory proteins. Teratog. Carcinog. Mutagen., 2003, 301–312.
    • (2003) Teratog. Carcinog. Mutagen. , pp. 301-312
    • Gupta, S.1    Sundarrajan, M.2    Rao, K.V.3
  • 15
    • 67349123432 scopus 로고    scopus 로고
    • Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver
    • Gupte, R.S., Floyd, B.C., Kozicky, M., George, S., Ungvari, Z.I., Neito, V., et al. Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver. Free Radic. Biol. Med. 47 (2009), 219–228.
    • (2009) Free Radic. Biol. Med. , vol.47 , pp. 219-228
    • Gupte, R.S.1    Floyd, B.C.2    Kozicky, M.3    George, S.4    Ungvari, Z.I.5    Neito, V.6
  • 16
    • 84901060709 scopus 로고    scopus 로고
    • Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model
    • Hara, S., Morita, R., Ogawa, T., Segawa, R., Takimoto, N., Suzuki, K., et al. Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. Exp. Toxicol. Pathol. 66 (2014), 225–234.
    • (2014) Exp. Toxicol. Pathol. , vol.66 , pp. 225-234
    • Hara, S.1    Morita, R.2    Ogawa, T.3    Segawa, R.4    Takimoto, N.5    Suzuki, K.6
  • 17
    • 84872345173 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: current and potential therapies
    • Ibrahim, M.A., Kelleni, M., Geddawy, A., Nonalcoholic fatty liver disease: current and potential therapies. Life Sci. 92 (2013), 114–118.
    • (2013) Life Sci. , vol.92 , pp. 114-118
    • Ibrahim, M.A.1    Kelleni, M.2    Geddawy, A.3
  • 18
    • 0037648908 scopus 로고    scopus 로고
    • A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals
    • Ito, N., Tamano, S., Shirai, T., A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals. Cancer Sci. 94 (2003), 3–8.
    • (2003) Cancer Sci. , vol.94 , pp. 3-8
    • Ito, N.1    Tamano, S.2    Shirai, T.3
  • 19
    • 84878776025 scopus 로고    scopus 로고
    • Teaching the basics of redox biology to medical and graduate students: oxidants, antioxidants and disease mechanisms
    • Kalyanaraman, B., Teaching the basics of redox biology to medical and graduate students: oxidants, antioxidants and disease mechanisms. Redox Biol. 1 (2013), 244–257.
    • (2013) Redox Biol. , vol.1 , pp. 244-257
    • Kalyanaraman, B.1
  • 20
    • 20044374023 scopus 로고    scopus 로고
    • Nonalcoholic Steatohepatitis Clinical Research Network: design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner, D.E., Brunt, E.M., Van Natta, M., Behling, C., Contos, M.J., Cummings, O.W., et al. Nonalcoholic Steatohepatitis Clinical Research Network: design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41 (2005), 1313–1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 21
    • 70349895553 scopus 로고    scopus 로고
    • Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats
    • Kojima, S., Sasaki, J., Tomita, M., Saka, M., Ishizuka, K., Kawakatsu, H., et al. Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats. J. Toxicol. Sci. 34 (2009), 527–539.
    • (2009) J. Toxicol. Sci. , vol.34 , pp. 527-539
    • Kojima, S.1    Sasaki, J.2    Tomita, M.3    Saka, M.4    Ishizuka, K.5    Kawakatsu, H.6
  • 22
    • 79953120050 scopus 로고    scopus 로고
    • Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by beta-naphthoflavone involving TNFalpha-signaling due to oxidative cellular stress in rats
    • Kuwata, K., Shibutani, M., Hayashi, H., Shimamoto, K., Hayashi, S.M., Suzuki, K., et al. Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by beta-naphthoflavone involving TNFalpha-signaling due to oxidative cellular stress in rats. Toxicology 283 (2011), 8–17.
    • (2011) Toxicology , vol.283 , pp. 8-17
    • Kuwata, K.1    Shibutani, M.2    Hayashi, H.3    Shimamoto, K.4    Hayashi, S.M.5    Suzuki, K.6
  • 23
    • 84867725631 scopus 로고    scopus 로고
    • Perinatal undernutrition alters intestinal alkaline phosphatase and its main transcription factors KLF4 and Cdx1 in adult offspring fed a high-fat diet
    • Lalles, J.P., Orozco-Solis, R., Bolanos-Jimenez, F., de Coppet, P., Le Drean, G., Segain, J.P., Perinatal undernutrition alters intestinal alkaline phosphatase and its main transcription factors KLF4 and Cdx1 in adult offspring fed a high-fat diet. J. Nutr. Biochem. 23 (2012), 1490–1497.
    • (2012) J. Nutr. Biochem. , vol.23 , pp. 1490-1497
    • Lalles, J.P.1    Orozco-Solis, R.2    Bolanos-Jimenez, F.3    de Coppet, P.4    Le Drean, G.5    Segain, J.P.6
  • 24
    • 84864572232 scopus 로고    scopus 로고
    • The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis
    • Levin, I., Petrasek, J., Szabo, G., The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis. Alcohol. Clin. Exp. Res. 36 (2012), 1397–1406.
    • (2012) Alcohol. Clin. Exp. Res. , vol.36 , pp. 1397-1406
    • Levin, I.1    Petrasek, J.2    Szabo, G.3
  • 25
    • 73449106123 scopus 로고    scopus 로고
    • Enzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than other quercetin glycosides or aglycone after oral administration in rats
    • Makino, T., Shimizu, R., Kanemaru, M., Suzuki, Y., Moriwaki, M., Mizukami, H., Enzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than other quercetin glycosides or aglycone after oral administration in rats. Biol. Pharm. Bull. 32 (2009), 2034–2040.
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 2034-2040
    • Makino, T.1    Shimizu, R.2    Kanemaru, M.3    Suzuki, Y.4    Moriwaki, M.5    Mizukami, H.6
  • 26
    • 84869121923 scopus 로고    scopus 로고
    • Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis
    • Marcolin, E., San-Miguel, B., Vallejo, D., Tieppo, J., Marroni, N., Gonzalez-Gallego, J., et al. Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. J. Nutr. 142 (2012), 1821–1828.
    • (2012) J. Nutr. , vol.142 , pp. 1821-1828
    • Marcolin, E.1    San-Miguel, B.2    Vallejo, D.3    Tieppo, J.4    Marroni, N.5    Gonzalez-Gallego, J.6
  • 27
    • 84880030138 scopus 로고    scopus 로고
    • Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research
    • Montezano, A.C., Touyz, R.M., Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research. Antioxid. Redox Signal. 20 (2014), 164–182.
    • (2014) Antioxid. Redox Signal. , vol.20 , pp. 164-182
    • Montezano, A.C.1    Touyz, R.M.2
  • 28
    • 80755135480 scopus 로고    scopus 로고
    • Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats
    • Morita, R., Shimamoto, K., Ishii, Y., Kuwata, K., Ogawa, B., Imaoka, M., et al. Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats. Arch. Toxicol. 85 (2011), 1475–1484.
    • (2011) Arch. Toxicol. , vol.85 , pp. 1475-1484
    • Morita, R.1    Shimamoto, K.2    Ishii, Y.3    Kuwata, K.4    Ogawa, B.5    Imaoka, M.6
  • 29
    • 77956106562 scopus 로고    scopus 로고
    • alpha-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans
    • Murota, K., Matsuda, N., Kashino, Y., Fujikura, Y., Nakamura, T., Kato, Y., et al. alpha-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans. Arch. Biochem. Biophys. 501 (2010), 91–97.
    • (2010) Arch. Biochem. Biophys. , vol.501 , pp. 91-97
    • Murota, K.1    Matsuda, N.2    Kashino, Y.3    Fujikura, Y.4    Nakamura, T.5    Kato, Y.6
  • 30
    • 76949099850 scopus 로고    scopus 로고
    • Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats
    • Nishimura, J., Saegusa, Y., Dewa, Y., Jin, M., Kawai, M., Kemmochi, S., et al. Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats. Arch. Toxicol. 84 (2010), 143–153.
    • (2010) Arch. Toxicol. , vol.84 , pp. 143-153
    • Nishimura, J.1    Saegusa, Y.2    Dewa, Y.3    Jin, M.4    Kawai, M.5    Kemmochi, S.6
  • 31
    • 84891402274 scopus 로고    scopus 로고
    • Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds
    • Pan, M.H., Lai, C.S., Tsai, M.L., Ho, C.T., Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds. Mol. Nutr. Food Res. 58 (2014), 147–171.
    • (2014) Mol. Nutr. Food Res. , vol.58 , pp. 147-171
    • Pan, M.H.1    Lai, C.S.2    Tsai, M.L.3    Ho, C.T.4
  • 32
    • 84928754745 scopus 로고    scopus 로고
    • Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease
    • Pisonero-Vaquero, S., Martinez-Ferreras, A., Garcia-Mediavilla, M.V., Martinez-Florez, S., Fernandez, A., Benet, M., et al. Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease. Mol. Nutr. Food Res. 59 (2015), 879–893.
    • (2015) Mol. Nutr. Food Res. , vol.59 , pp. 879-893
    • Pisonero-Vaquero, S.1    Martinez-Ferreras, A.2    Garcia-Mediavilla, M.V.3    Martinez-Florez, S.4    Fernandez, A.5    Benet, M.6
  • 34
    • 76749146400 scopus 로고    scopus 로고
    • Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by beta-naphthoflavone
    • Shimada, Y., Dewa, Y., Ichimura, R., Suzuki, T., Mizukami, S., Hayashi, S.M., et al. Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by beta-naphthoflavone. Toxicology 268 (2010), 213–218.
    • (2010) Toxicology , vol.268 , pp. 213-218
    • Shimada, Y.1    Dewa, Y.2    Ichimura, R.3    Suzuki, T.4    Mizukami, S.5    Hayashi, S.M.6
  • 35
    • 0033949046 scopus 로고    scopus 로고
    • Overexpression of G1/S cyclins and PCNA and their relationship to tyrosine phosphorylation and dephosphorylation during tumor promotion by metanil yellow and malachite green
    • Sundarrajan, M., Fernandis, A.Z., Subrahmanyam, G., Prabhudesai, S., Krishnamurthy, S.C., Rao, K.V., Overexpression of G1/S cyclins and PCNA and their relationship to tyrosine phosphorylation and dephosphorylation during tumor promotion by metanil yellow and malachite green. Toxicol. Lett. 116 (2000), 119–130.
    • (2000) Toxicol. Lett. , vol.116 , pp. 119-130
    • Sundarrajan, M.1    Fernandis, A.Z.2    Subrahmanyam, G.3    Prabhudesai, S.4    Krishnamurthy, S.C.5    Rao, K.V.6
  • 36
    • 0034823864 scopus 로고    scopus 로고
    • Effect of metanil yellow and malachite green on DNA synthesis in N-nitrosodiethylamine induced preneoplastic rat livers
    • Sundarrajan, M., Prabhudesai, S., Krishnamurthy, S.C., Rao, K.V., Effect of metanil yellow and malachite green on DNA synthesis in N-nitrosodiethylamine induced preneoplastic rat livers. Indian J. Exp. Biol. 39 (2001), 845–852.
    • (2001) Indian J. Exp. Biol. , vol.39 , pp. 845-852
    • Sundarrajan, M.1    Prabhudesai, S.2    Krishnamurthy, S.C.3    Rao, K.V.4
  • 37
    • 44649095633 scopus 로고    scopus 로고
    • Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    • Younossi, Z.M., Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment. Pharmacol. Ther. 28 (2008), 2–12.
    • (2008) Aliment. Pharmacol. Ther. , vol.28 , pp. 2-12
    • Younossi, Z.M.1


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