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Volumn 59, Issue 5, 2015, Pages 879-893

Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease

Author keywords

Fatty acid uptake; Lipid metabolism; NAFLD; PI3K AKT pathway; Quercetin

Indexed keywords

MUS;

EID: 84928754745     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201400913     Document Type: Article
Times cited : (113)

References (67)
  • 2
    • 77649337140 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: pathology and pathogenesis
    • Tiniakos, D. G., Vos, M. B., Brunt, E. M., Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu. Rev. Pathol. 2010, 5, 145-171.
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 145-171
    • Tiniakos, D.G.1    Vos, M.B.2    Brunt, E.M.3
  • 3
    • 84898439031 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
    • Koo, S. H., Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis. Clin. Mol. Hepatol. 2013, 19, 210-215.
    • (2013) Clin. Mol. Hepatol. , vol.19 , pp. 210-215
    • Koo, S.H.1
  • 4
    • 77950863893 scopus 로고    scopus 로고
    • Nontriglyceride hepatic lipotoxicity: the new paradigm for the pathogenesis of NASH
    • Neuschwander-Tetri, B. A., Nontriglyceride hepatic lipotoxicity: the new paradigm for the pathogenesis of NASH. Curr. Gastroenterol. Rep. 2010, 12, 49-56.
    • (2010) Curr. Gastroenterol. Rep. , vol.12 , pp. 49-56
    • Neuschwander-Tetri, B.A.1
  • 5
    • 80052596785 scopus 로고    scopus 로고
    • Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C
    • Miquilena-Colina, M. E., Lima-Cabello, E., Sánchez-Campos, S., García-Mediavilla, M. V. et al., Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C. Gut 2011, 60, 1394-1402.
    • (2011) Gut , vol.60 , pp. 1394-1402
    • Miquilena-Colina, M.E.1    Lima-Cabello, E.2    Sánchez-Campos, S.3    García-Mediavilla, M.V.4
  • 6
    • 84873700660 scopus 로고    scopus 로고
    • The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARalpha, and repressed by C/EBPalpha: implications in FABP1 down-regulation in nonalcoholic fatty liver disease
    • Guzmán, C., Benet, M., Pisonero-Vaquero, S., Moya, M. et al., The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARalpha and repressed by C/EBPalpha: implications in FABP1 down-regulation in nonalcoholic fatty liver disease. Biochim. Biophys. Acta 2013, 1831, 803-818.
    • (2013) Biochim. Biophys. Acta , vol.1831 , pp. 803-818
    • Guzmán, C.1    Benet, M.2    Pisonero-Vaquero, S.3    Moya, M.4
  • 7
    • 42949154244 scopus 로고    scopus 로고
    • Diagnosis and therapy of nonalcoholic steatohepatitis
    • Torres, D. M., Harrison, S. A., Diagnosis and therapy of nonalcoholic steatohepatitis. Gastroenterology 2008, 134, 1682-1698.
    • (2008) Gastroenterology , vol.134 , pp. 1682-1698
    • Torres, D.M.1    Harrison, S.A.2
  • 8
    • 84877269694 scopus 로고    scopus 로고
    • The effects of curcumin derivative on experimental steatohepatitis
    • Zeng, C. H., Zeng, P., Deng, Y. H., Shen, N. et al., The effects of curcumin derivative on experimental steatohepatitis. Zhonghua Gan Zang Bing Za Zhi 2011, 19, 454-459.
    • (2011) Zhonghua Gan Zang Bing Za Zhi , vol.19 , pp. 454-459
    • Zeng, C.H.1    Zeng, P.2    Deng, Y.H.3    Shen, N.4
  • 9
    • 84861603829 scopus 로고    scopus 로고
    • Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis
    • Salamone, F., Galvano, F., Cappello, F., Mangiameli, A. et al., Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis. Transl. Res. 2012, 159, 477-486.
    • (2012) Transl. Res. , vol.159 , pp. 477-486
    • Salamone, F.1    Galvano, F.2    Cappello, F.3    Mangiameli, A.4
  • 11
    • 84869869189 scopus 로고    scopus 로고
    • Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils
    • Ying, H. Z., Liu, Y. H., Yu, B., Wang, Z. Y. et al., Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils. Food Chem. Toxicol. 2013, 52, 53-60.
    • (2013) Food Chem. Toxicol. , vol.52 , pp. 53-60
    • Ying, H.Z.1    Liu, Y.H.2    Yu, B.3    Wang, Z.Y.4
  • 12
    • 84896896377 scopus 로고    scopus 로고
    • Modulation of PI3K-LXRalpha-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin
    • Pisonero-Vaquero, S., García-Mediavilla, M. V., Jorquera, F., Majano, P. L. et al., Modulation of PI3K-LXRalpha-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin. Lab. Invest. 2014, 94, 262-274.
    • (2014) Lab. Invest. , vol.94 , pp. 262-274
    • Pisonero-Vaquero, S.1    García-Mediavilla, M.V.2    Jorquera, F.3    Majano, P.L.4
  • 13
    • 84904618577 scopus 로고    scopus 로고
    • Quercetin improves insulin resistance and hepatic lipid accumulation in a NAFLD cell model
    • Li, X., Wang, R., Zhou, N., Wang, X. et al., Quercetin improves insulin resistance and hepatic lipid accumulation in a NAFLD cell model. Biomed. Rep. 2013, 1, 71-76.
    • (2013) Biomed. Rep. , vol.1 , pp. 71-76
    • Li, X.1    Wang, R.2    Zhou, N.3    Wang, X.4
  • 14
    • 84873696060 scopus 로고    scopus 로고
    • Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells
    • Vidyashankar, S., Sandeep Varma, R., Patki, P. S., Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells. Toxicol. In Vitro. 2013, 27, 945-953.
    • (2013) Toxicol. In Vitro. , vol.27 , pp. 945-953
    • Vidyashankar, S.1    Sandeep Varma, R.2    Patki, P.S.3
  • 15
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner, D. E., Brunt, E. M., VanNatta, M., Behling, C. et al., Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41, 1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4
  • 16
    • 77951436599 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    • Gupta, N. A., Mells, J., Dunham, R. M., Grakoui, A. et al., Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 2010, 51, 1584-1592.
    • (2010) Hepatology , vol.51 , pp. 1584-1592
    • Gupta, N.A.1    Mells, J.2    Dunham, R.M.3    Grakoui, A.4
  • 17
    • 33745802227 scopus 로고    scopus 로고
    • Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium
    • Sahai, A., Pan, X., Paul, R., Malladi, P. et al., Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 291, G55-G62.
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.291 , pp. G55-G62
    • Sahai, A.1    Pan, X.2    Paul, R.3    Malladi, P.4
  • 18
    • 53649084494 scopus 로고    scopus 로고
    • A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells
    • Crespo, I., García-Mediavilla, M. V., Gutiérrez, B., Sánchez-Campos, S. et al., A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells. Br. J. Nutr. 2008, 100, 968-976.
    • (2008) Br. J. Nutr. , vol.100 , pp. 968-976
    • Crespo, I.1    García-Mediavilla, M.V.2    Gutiérrez, B.3    Sánchez-Campos, S.4
  • 19
    • 64549142339 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A and core proteins induce oxidative stress-mediated calcium signalling alterations in hepatocytes
    • Dionisio, N., García-Mediavilla, M. V., Sánchez-Campos, S., Majano, P. L. et al., Hepatitis C virus NS5A and core proteins induce oxidative stress-mediated calcium signalling alterations in hepatocytes. J. Hepatol. 2009, 50, 872-882.
    • (2009) J. Hepatol. , vol.50 , pp. 872-882
    • Dionisio, N.1    García-Mediavilla, M.V.2    Sánchez-Campos, S.3    Majano, P.L.4
  • 20
    • 59249095410 scopus 로고    scopus 로고
    • Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis
    • Kretzmann, N. A., Fillmann, H., Mauriz, J. L., Marroni, C. A. et al., Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis. Inflamm. Bowel Dis. 2008, 14, 1504-1513.
    • (2008) Inflamm. Bowel Dis. , vol.14 , pp. 1504-1513
    • Kretzmann, N.A.1    Fillmann, H.2    Mauriz, J.L.3    Marroni, C.A.4
  • 21
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    • Leclercq, I. A., Farrell, G. C., Field, J., Bell, D. R. et al., CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J. Clin. Invest. 2000, 105, 1067-1075.
    • (2000) J. Clin. Invest. , vol.105 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4
  • 22
    • 0038643427 scopus 로고    scopus 로고
    • Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice
    • Ip, E., Farrell, G. C., Robertson, G., Hall, P. et al., Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Hepatology 2003, 38, 123-132.
    • (2003) Hepatology , vol.38 , pp. 123-132
    • Ip, E.1    Farrell, G.C.2    Robertson, G.3    Hall, P.4
  • 23
    • 84928209634 scopus 로고    scopus 로고
    • Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up
    • Ekstedt, M., Hagstrom, H., Nasr, P., Fredrikson, M. et al., Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology 2014, doi:10.1002/hep.27368.
    • (2014) Hepatology
    • Ekstedt, M.1    Hagstrom, H.2    Nasr, P.3    Fredrikson, M.4
  • 24
    • 77954239704 scopus 로고    scopus 로고
    • A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease
    • Musso, G., Gambino, R., Cassader, M., Pagano, G., A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology 2010, 52, 79-104.
    • (2010) Hepatology , vol.52 , pp. 79-104
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 26
    • 84861738395 scopus 로고    scopus 로고
    • Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • Takahashi, Y., Soejima, Y., Fukusato, T., Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J. Gastroenterol. 2012, 18, 2300-2308.
    • (2012) World J. Gastroenterol. , vol.18 , pp. 2300-2308
    • Takahashi, Y.1    Soejima, Y.2    Fukusato, T.3
  • 27
    • 84873257485 scopus 로고    scopus 로고
    • Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition
    • Ronis, M. J., Baumgardner, J. N., Marecki, J. C., Hennings, L. et al., Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition. Physiol. Genomics 2012, 44, 1073-1089.
    • (2012) Physiol. Genomics , vol.44 , pp. 1073-1089
    • Ronis, M.J.1    Baumgardner, J.N.2    Marecki, J.C.3    Hennings, L.4
  • 28
    • 84872089657 scopus 로고    scopus 로고
    • Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes
    • Jung, C. H., Cho, I., Ahn, J., Jeon, T. I. et al., Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes. Phytother. Res. 2013, 27, 139-143.
    • (2013) Phytother. Res. , vol.27 , pp. 139-143
    • Jung, C.H.1    Cho, I.2    Ahn, J.3    Jeon, T.I.4
  • 29
    • 84910095428 scopus 로고    scopus 로고
    • Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity
    • Zhang, L., Xu, J., Song, H., Yao, Z. et al., Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity. J. Transl. Med. 2014, 12, 236-014-0236-8.
    • (2014) J. Transl. Med. , vol.12 , pp. 236
    • Zhang, L.1    Xu, J.2    Song, H.3    Yao, Z.4
  • 30
    • 79251639639 scopus 로고    scopus 로고
    • Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C
    • Lima-Cabello, E., García-Mediavilla, M. V., Miquilena-Colina, M. E., Vargas-Castrillón, J. et al., Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C. Clin. Sci. 2011, 120, 239-250.
    • (2011) Clin. Sci. , vol.120 , pp. 239-250
    • Lima-Cabello, E.1    García-Mediavilla, M.V.2    Miquilena-Colina, M.E.3    Vargas-Castrillón, J.4
  • 31
    • 84869121923 scopus 로고    scopus 로고
    • Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis
    • Marcolin, E., San-Miguel, B., Vallejo, D., Tieppo, J. et al., Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. J. Nutr. 2012, 142, 1821-1828.
    • (2012) J. Nutr. , vol.142 , pp. 1821-1828
    • Marcolin, E.1    San-Miguel, B.2    Vallejo, D.3    Tieppo, J.4
  • 32
    • 84863550183 scopus 로고    scopus 로고
    • Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats
    • Panchal, S. K., Poudyal, H., Brown, L., Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. J. Nutr. 2012, 142, 1026-1032.
    • (2012) J. Nutr. , vol.142 , pp. 1026-1032
    • Panchal, S.K.1    Poudyal, H.2    Brown, L.3
  • 33
    • 40849085134 scopus 로고    scopus 로고
    • Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells
    • Crespo, I., García-Mediavilla, M. V., Almar, M., González, P. et al., Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells. Food Chem. Toxicol. 2008, 46, 1555-1569.
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 1555-1569
    • Crespo, I.1    García-Mediavilla, M.V.2    Almar, M.3    González, P.4
  • 35
    • 70349260288 scopus 로고    scopus 로고
    • Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner
    • Chanda, D., Lee, C. H., Kim, Y. H., Noh, J. R. et al., Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner. Hepatology 2009, 50, 880-892.
    • (2009) Hepatology , vol.50 , pp. 880-892
    • Chanda, D.1    Lee, C.H.2    Kim, Y.H.3    Noh, J.R.4
  • 36
    • 84859935042 scopus 로고    scopus 로고
    • Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease
    • Park, H. S., Jeon, B. H., Woo, S. H., Leem, J. et al., Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease. Mol. Cells 2011, 32, 571-577.
    • (2011) Mol. Cells , vol.32 , pp. 571-577
    • Park, H.S.1    Jeon, B.H.2    Woo, S.H.3    Leem, J.4
  • 37
    • 84922696660 scopus 로고    scopus 로고
    • CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis
    • Zhang, X., Shen, J., Man, K., Chu, E. S. et al., CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis. J. Hepatol. 2014, 61, 1365-1375.
    • (2014) J. Hepatol. , vol.61 , pp. 1365-1375
    • Zhang, X.1    Shen, J.2    Man, K.3    Chu, E.S.4
  • 38
    • 84879357128 scopus 로고    scopus 로고
    • Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats
    • Wang, W., Wang, C., Ding, X. Q., Pan, Y. et al., Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats. Br. J. Pharmacol. 2013, 169, 1352-1371.
    • (2013) Br. J. Pharmacol. , vol.169 , pp. 1352-1371
    • Wang, W.1    Wang, C.2    Ding, X.Q.3    Pan, Y.4
  • 39
    • 63749108094 scopus 로고    scopus 로고
    • Cellular fatty acid uptake: a pathway under construction
    • Su, X., Abumrad, N. A., Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol. Metab. 2009, 20, 72-77.
    • (2009) Trends Endocrinol. Metab. , vol.20 , pp. 72-77
    • Su, X.1    Abumrad, N.A.2
  • 40
    • 33947140482 scopus 로고    scopus 로고
    • Importance of the carboxyl terminus of FAT/CD36 for plasma membrane localization and function in long-chain fatty acid uptake
    • Eyre, N. S., Cleland, L. G., Tandon, N. N., Mayrhofer, G., Importance of the carboxyl terminus of FAT/CD36 for plasma membrane localization and function in long-chain fatty acid uptake. J. Lipid Res. 2007, 48, 528-542.
    • (2007) J. Lipid Res. , vol.48 , pp. 528-542
    • Eyre, N.S.1    Cleland, L.G.2    Tandon, N.N.3    Mayrhofer, G.4
  • 41
    • 84904678224 scopus 로고    scopus 로고
    • Inflammatory stress increases hepatic CD36 translational efficiency via activation of the mTOR signalling pathway
    • Wang, C., Hu, L., Zhao, L., Yang, P. et al., Inflammatory stress increases hepatic CD36 translational efficiency via activation of the mTOR signalling pathway. PLoS One 2014, 9, e103071.
    • (2014) PLoS One , vol.9 , pp. e103071
    • Wang, C.1    Hu, L.2    Zhao, L.3    Yang, P.4
  • 42
    • 84897589965 scopus 로고    scopus 로고
    • Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats
    • Luo, Z. L., Tang, L. J., Wang, T., Dai, R. W. et al., Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats. J. Gastroenterol. Hepatol. 2014, 29, 215-222.
    • (2014) J. Gastroenterol. Hepatol. , vol.29 , pp. 215-222
    • Luo, Z.L.1    Tang, L.J.2    Wang, T.3    Dai, R.W.4
  • 43
    • 63649104470 scopus 로고    scopus 로고
    • Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease
    • Mitsuyoshi, H., Yasui, K., Harano, Y., Endo, M. et al., Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease. Hepatol. Res. 2009, 39, 366-373.
    • (2009) Hepatol. Res. , vol.39 , pp. 366-373
    • Mitsuyoshi, H.1    Yasui, K.2    Harano, Y.3    Endo, M.4
  • 44
    • 52049117445 scopus 로고    scopus 로고
    • Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia
    • Doege, H., Grimm, D., Falcon, A., Tsang, B. et al., Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia. J. Biol. Chem. 2008, 283, 22186-22192.
    • (2008) J. Biol. Chem. , vol.283 , pp. 22186-22192
    • Doege, H.1    Grimm, D.2    Falcon, A.3    Tsang, B.4
  • 45
    • 84899999241 scopus 로고    scopus 로고
    • Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes
    • Ding, L., Liu, J. L., Hassan, W., Wang, L. L. et al., Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes. Sci. Rep. 2014, 4, 4715.
    • (2014) Sci. Rep. , vol.4 , pp. 4715
    • Ding, L.1    Liu, J.L.2    Hassan, W.3    Wang, L.L.4
  • 46
    • 39549108872 scopus 로고    scopus 로고
    • Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo
    • Shen, B., Yu, J., Wang, S., Chu, E. S. et al., Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo. Hepatology 2008, 47, 473-483.
    • (2008) Hepatology , vol.47 , pp. 473-483
    • Shen, B.1    Yu, J.2    Wang, S.3    Chu, E.S.4
  • 47
    • 44049084267 scopus 로고    scopus 로고
    • Transcriptional regulation of fatty acid translocase/CD36 expression by CCAAT/enhancer-binding protein alpha
    • Qiao, L., Zou, C., Shao, P., Schaack, J. et al., Transcriptional regulation of fatty acid translocase/CD36 expression by CCAAT/enhancer-binding protein alpha. J. Biol. Chem. 2008, 283, 8788-8795.
    • (2008) J. Biol. Chem. , vol.283 , pp. 8788-8795
    • Qiao, L.1    Zou, C.2    Shao, P.3    Schaack, J.4
  • 48
    • 0037155907 scopus 로고    scopus 로고
    • Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells
    • Cabrero, A., Alegret, M., Sanchez, R. M., Adzet, T. et al., Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells. J. Biol. Chem. 2002, 277, 10100-10107.
    • (2002) J. Biol. Chem. , vol.277 , pp. 10100-10107
    • Cabrero, A.1    Alegret, M.2    Sanchez, R.M.3    Adzet, T.4
  • 49
    • 0032479423 scopus 로고    scopus 로고
    • Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner
    • Motojima, K., Passilly, P., Peters, J. M., Gonzalez, F. J. et al., Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J. Biol. Chem. 1998, 273, 16710-16714.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16710-16714
    • Motojima, K.1    Passilly, P.2    Peters, J.M.3    Gonzalez, F.J.4
  • 50
    • 34547411540 scopus 로고    scopus 로고
    • Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver
    • Huang, J., Iqbal, J., Saha, P. K., Liu, J. et al., Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology 2007, 46, 147-157.
    • (2007) Hepatology , vol.46 , pp. 147-157
    • Huang, J.1    Iqbal, J.2    Saha, P.K.3    Liu, J.4
  • 51
    • 84876146580 scopus 로고    scopus 로고
    • Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis
    • Bechmann, L. P., Kocabayoglu, P., Sowa, J. P., Sydor, S. et al., Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis. Hepatology 2013, 57, 1394-1406.
    • (2013) Hepatology , vol.57 , pp. 1394-1406
    • Bechmann, L.P.1    Kocabayoglu, P.2    Sowa, J.P.3    Sydor, S.4
  • 52
    • 84877956229 scopus 로고    scopus 로고
    • Small heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2
    • Yang, C. S., Yuk, J. M., Kim, J. J., Hwang, J. H. et al., Small heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2. PLoS One 2013, 8, e63435.
    • (2013) PLoS One , vol.8 , pp. e63435
    • Yang, C.S.1    Yuk, J.M.2    Kim, J.J.3    Hwang, J.H.4
  • 53
    • 34547476712 scopus 로고    scopus 로고
    • A little orphan runs to fat: the orphan receptor small heterodimer partner as a key player in the regulation of hepatic lipid metabolism
    • Trauner, M., A little orphan runs to fat: the orphan receptor small heterodimer partner as a key player in the regulation of hepatic lipid metabolism. Hepatology 2007, 46, 1-5.
    • (2007) Hepatology , vol.46 , pp. 1-5
    • Trauner, M.1
  • 54
    • 55449133428 scopus 로고    scopus 로고
    • Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner
    • Del Bas, J. M., Ricketts, M. L., Baiges, I., Quesada, H. et al., Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner. Mol. Nutr. Food Res. 2008, 52, 1172-1181.
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 1172-1181
    • Del Bas, J.M.1    Ricketts, M.L.2    Baiges, I.3    Quesada, H.4
  • 55
    • 84864475305 scopus 로고    scopus 로고
    • Liver X receptor alpha-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication
    • García-Mediavilla, M. V., Pisonero-Vaquero, S., Lima-Cabello, E., Benedicto, I. et al., Liver X receptor alpha-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication. Lab. Invest. 2012, 92, 1191-1202.
    • (2012) Lab. Invest. , vol.92 , pp. 1191-1202
    • García-Mediavilla, M.V.1    Pisonero-Vaquero, S.2    Lima-Cabello, E.3    Benedicto, I.4
  • 56
    • 83355174170 scopus 로고    scopus 로고
    • Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in NAFLD
    • Xu, D., Huang, X. D., Yuan, J. P., Wu, J. et al., Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in NAFLD. Hepatogastroenterology 2011, 58, 1703-1707.
    • (2011) Hepatogastroenterology , vol.58 , pp. 1703-1707
    • Xu, D.1    Huang, X.D.2    Yuan, J.P.3    Wu, J.4
  • 57
    • 84872296508 scopus 로고    scopus 로고
    • 27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages
    • Kim, S. M., Jang, H., Son, Y., Lee, S. A. et al., 27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages. Biochem. Biophys. Res. Commun. 2013, 430, 454-459.
    • (2013) Biochem. Biophys. Res. Commun. , vol.430 , pp. 454-459
    • Kim, S.M.1    Jang, H.2    Son, Y.3    Lee, S.A.4
  • 58
    • 84860530517 scopus 로고    scopus 로고
    • Co-stimulation of PAFR and CD36 is required for oxLDL-induced human macrophages activation
    • Rios, F. J., Koga, M. M., Ferracini, M., Jancar, S., Co-stimulation of PAFR and CD36 is required for oxLDL-induced human macrophages activation. PLoS One 2012, 7, e36632.
    • (2012) PLoS One , vol.7 , pp. e36632
    • Rios, F.J.1    Koga, M.M.2    Ferracini, M.3    Jancar, S.4
  • 59
    • 34047263219 scopus 로고    scopus 로고
    • Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade
    • Datta, J., Majumder, S., Kutay, H., Motiwala, T. et al., Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade. Cancer Res. 2007, 67, 2736-2746.
    • (2007) Cancer Res , vol.67 , pp. 2736-2746
    • Datta, J.1    Majumder, S.2    Kutay, H.3    Motiwala, T.4
  • 60
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco, I., Sawyers, C. L., The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2002, 2, 489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 61
    • 1942466512 scopus 로고    scopus 로고
    • Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity
    • Wang, G. L., Iakova, P., Wilde, M., Awad, S. et al., Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev. 2004, 18, 912-925.
    • (2004) Genes Dev , vol.18 , pp. 912-925
    • Wang, G.L.1    Iakova, P.2    Wilde, M.3    Awad, S.4
  • 62
    • 84884252657 scopus 로고    scopus 로고
    • A tetrahydroisoquinoline alkaloid THI-28 reduces LPS-induced HMGB1 and diminishes organ injury in septic mice through p38 and PI3K/Nrf2/HO-1 signals
    • Kim, H. S., Park, E. J., Park, S. W., Kim, H. J. et al., A tetrahydroisoquinoline alkaloid THI-28 reduces LPS-induced HMGB1 and diminishes organ injury in septic mice through p38 and PI3K/Nrf2/HO-1 signals. Int. Immunopharmacol. 2013, 17, 684-692.
    • (2013) Int. Immunopharmacol. , vol.17 , pp. 684-692
    • Kim, H.S.1    Park, E.J.2    Park, S.W.3    Kim, H.J.4
  • 63
    • 84890508650 scopus 로고    scopus 로고
    • Inhibitory effects of baicalin in the early stage of 3T3-L1 preadipocytes differentiation by down-regulation of PDK1/Akt phosphorylation
    • Kwak, D. H., Lee, J. H., Song, K. H., Ma, J. Y., Inhibitory effects of baicalin in the early stage of 3T3-L1 preadipocytes differentiation by down-regulation of PDK1/Akt phosphorylation. Mol. Cell. Biochem. 2014, 385, 257-264.
    • (2014) Mol. Cell. Biochem. , vol.385 , pp. 257-264
    • Kwak, D.H.1    Lee, J.H.2    Song, K.H.3    Ma, J.Y.4
  • 64
    • 84924634426 scopus 로고    scopus 로고
    • The flavones apigenin and luteolin induce FOXO1 translocation but inhibit gluconeogenic and lipogenic gene expression in human cells
    • Bumke-Vogt, C., Osterhoff, M. A., Borchert, A., Guzman-Perez, V. et al., The flavones apigenin and luteolin induce FOXO1 translocation but inhibit gluconeogenic and lipogenic gene expression in human cells. PLoS One 2014, 9, e104321.
    • (2014) PLoS One , vol.9 , pp. e104321
    • Bumke-Vogt, C.1    Osterhoff, M.A.2    Borchert, A.3    Guzman-Perez, V.4
  • 65
    • 0036787393 scopus 로고    scopus 로고
    • Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36
    • Luiken, J. J., Koonen, D. P., Willems, J., Zorzano, A. et al., Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36. Diabetes 2002, 51, 3113-3119.
    • (2002) Diabetes , vol.51 , pp. 3113-3119
    • Luiken, J.J.1    Koonen, D.P.2    Willems, J.3    Zorzano, A.4
  • 66
    • 78649746191 scopus 로고    scopus 로고
    • Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism
    • Huang, J., Tabbi-Anneni, I., Gunda, V., Wang, L., Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism. Am. J. Physiol. Gastrointest. Liver Physiol. 2010, 299, G1211-G1221.
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.299 , pp. G1211-G1221
    • Huang, J.1    Tabbi-Anneni, I.2    Gunda, V.3    Wang, L.4
  • 67
    • 34547097746 scopus 로고    scopus 로고
    • Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress
    • Waris, G., Felmlee, D. J., Negro, F., Siddiqui, A., Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J. Virol. 2007, 81, 8122-8130.
    • (2007) J. Virol. , vol.81 , pp. 8122-8130
    • Waris, G.1    Felmlee, D.J.2    Negro, F.3    Siddiqui, A.4


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