Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats

Journal of Toxicological Sciences

Volumn 34, Issue 5, 2009, Pages 527-539

  Kojima, Sayuri ^a   Sasaki, Junya ^a   Tomita, Mariko ^a   Saka, Machiko ^a   Ishizuka, Katsumi ^a   Kawakatsu, Hisao ^a   Yoshida, Toshinori ^a   Kosaka, Tadashi ^a   Enomoto, Akiko ^a   Nakashima, Nobuaki ^a   Harada, Takanori ^a  

^a INSTITUTE OF ENVIRONMENTAL TOXICOLOGY   (Japan)

Author keywords

CHCMr; CHr; Hypochromic anemia; Transferrin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CALCIUM; CHLORIDE; CHOLESTEROL; CREATININE; CYANOCOBALAMIN; FOLIC ACID; GAMMA GLUTAMYLTRANSFERASE; GLOBULIN; GLUCOSE; HEMOGLOBIN; IRON; PENTOXYRESORUFIN DEALKYLASE; PHENOBARBITAL; PHOSPHATE; POTASSIUM; PROTEIN; SODIUM; TRANSFERRIN; TRIACYLGLYCEROL; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BASOPHIL; BILIRUBIN BLOOD LEVEL; CALCIUM BLOOD LEVEL; CELLULAR DISTRIBUTION; CHLORIDE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG BLOOD LEVEL; ELECTROLYTE METABOLISM; ENZYME INDUCTION; EOSINOPHIL; ERYTHROCYTE COUNT; FEMALE; FISCHER 344 RAT; FOOD INTAKE; GAIT DISORDER; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GOITER; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; KIDNEY MASS; LACRIMATION; LEUKOCYTE COUNT; LEUKOCYTE DIFFERENTIAL COUNT; LIPID METABOLISM; LIVER HYPERTROPHY; LIVER MICROSOME; LIVER TOXICITY; LIVER WEIGHT; LYMPHOCYTE; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; MONOCYTE; NEUTROPHIL; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PHOSPHATE BLOOD LEVEL; POTASSIUM BLOOD LEVEL; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; RAT; RETICULOCYTE; SEDATION; SODIUM BLOOD LEVEL; SPLEEN WEIGHT; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THYMUS; THYROID FOLLICLE CELL; THYROID GLAND; TOXICOKINETICS; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; URINALYSIS; WEIGHT GAIN;

ANIMALIA; RATTUS;

EID: 70349895553     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.527     Document Type: Article

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