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Volumn 45, Issue 2, 2017, Pages 205-221

Review article: mesenchymal stromal cell therapy for inflammatory bowel diseases

Author keywords

[No Author keywords available]

Indexed keywords

ALLOGENEIC STEM CELL TRANSPLANTATION; ANTIGEN PRESENTING CELL; AUTOLOGOUS STEM CELL TRANSPLANTATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL HOMING; CELL PROLIFERATION; CROHN DISEASE; EX VIVO STUDY; HUMAN; IMMUNOMODULATION; INFLAMMATORY BOWEL DISEASE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REMISSION; REVIEW; TH1 CELL; TH17 CELL; TISSUE REGENERATION; TISSUE REPAIR; TREATMENT RESPONSE; ULCERATIVE COLITIS; ANIMAL; COLON; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASES; PHYSIOLOGY; REGENERATION;

EID: 85002142098     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/apt.13864     Document Type: Review
Times cited : (83)

References (151)
  • 1
    • 79955554300 scopus 로고    scopus 로고
    • The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases
    • Chassaing B, Darfeuille-Michaud A. The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases. Gastroenterology 2011; 140: 1720–8.
    • (2011) Gastroenterology , vol.140 , pp. 1720-1728
    • Chassaing, B.1    Darfeuille-Michaud, A.2
  • 3
    • 0028843250 scopus 로고
    • Mesenchymal stem cells reside within the connective tissues of many organs
    • Young HE, Mancini ML, Wright RP, et al. Mesenchymal stem cells reside within the connective tissues of many organs. Dev Dyn 1995; 202: 137–44.
    • (1995) Dev Dyn , vol.202 , pp. 137-144
    • Young, H.E.1    Mancini, M.L.2    Wright, R.P.3
  • 4
    • 84901477349 scopus 로고    scopus 로고
    • Concise review: the surface markers and identity of human mesenchymal stem cells
    • Lv F-J, Tuan RS, Cheung KMC, Leung VYL. Concise review: the surface markers and identity of human mesenchymal stem cells. Stem Cells 2014; 32: 1408–19.
    • (2014) Stem Cells , vol.32 , pp. 1408-1419
    • Lv, F.-J.1    Tuan, R.S.2    Cheung, K.M.C.3    Leung, V.Y.L.4
  • 5
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315–7.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3
  • 6
    • 0141484485 scopus 로고    scopus 로고
    • HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells
    • Le Blanc K, Tammik C, Rosendahl K, Zetterberg E, Ringdén O. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 2003; 31: 890–6.
    • (2003) Exp Hematol , vol.31 , pp. 890-896
    • Le Blanc, K.1    Tammik, C.2    Rosendahl, K.3    Zetterberg, E.4    Ringdén, O.5
  • 7
    • 0037442264 scopus 로고    scopus 로고
    • Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation
    • Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 2003; 75: 389–97.
    • (2003) Transplantation , vol.75 , pp. 389-397
    • Tse, W.T.1    Pendleton, J.D.2    Beyer, W.M.3    Egalka, M.C.4    Guinan, E.C.5
  • 8
    • 69249119079 scopus 로고    scopus 로고
    • Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression
    • Ren G, Su J, Zhang L, et al. Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells 2009; 27: 1954–62.
    • (2009) Stem Cells , vol.27 , pp. 1954-1962
    • Ren, G.1    Su, J.2    Zhang, L.3
  • 9
    • 0042740515 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex
    • Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringdén O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 2003; 57: 11–20.
    • (2003) Scand J Immunol , vol.57 , pp. 11-20
    • Le Blanc, K.1    Tammik, L.2    Sundberg, B.3    Haynesworth, S.E.4    Ringdén, O.5
  • 10
    • 0036142769 scopus 로고    scopus 로고
    • Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    • Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002; 30: 42–8.
    • (2002) Exp Hematol , vol.30 , pp. 42-48
    • Bartholomew, A.1    Sturgeon, C.2    Siatskas, M.3
  • 11
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002; 99: 3838–43.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3
  • 12
    • 0038204193 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
    • Krampera M, Glennie S, Dyson J, et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003; 101: 3722–9.
    • (2003) Blood , vol.101 , pp. 3722-3729
    • Krampera, M.1    Glennie, S.2    Dyson, J.3
  • 13
    • 84925284704 scopus 로고    scopus 로고
    • Mesenchymal stromal cells inhibit proliferation of virus-specific CD8(+) T cells
    • Malcherek G, Jin N, Hückelhoven AG, et al. Mesenchymal stromal cells inhibit proliferation of virus-specific CD8(+) T cells. Leukemia 2014; 28: 2388–94.
    • (2014) Leukemia , vol.28 , pp. 2388-2394
    • Malcherek, G.1    Jin, N.2    Hückelhoven, A.G.3
  • 14
    • 69949166907 scopus 로고    scopus 로고
    • Reciprocal effect of mesenchymal stem cell on experimental autoimmune encephalomyelitis is mediated by transforming growth factor-beta and interleukin-6
    • Liu X-J, Zhang J-F, Sun B, et al. Reciprocal effect of mesenchymal stem cell on experimental autoimmune encephalomyelitis is mediated by transforming growth factor-beta and interleukin-6. Clin Exp Immunol 2009; 158: 37–44.
    • (2009) Clin Exp Immunol , vol.158 , pp. 37-44
    • Liu, X.-J.1    Zhang, J.-F.2    Sun, B.3
  • 15
    • 0033565302 scopus 로고    scopus 로고
    • Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance
    • Ina K, Itoh J, Fukushima K, et al. Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance. J Immunol 1999; 163: 1081–90.
    • (1999) J Immunol , vol.163 , pp. 1081-1090
    • Ina, K.1    Itoh, J.2    Fukushima, K.3
  • 16
    • 0034957289 scopus 로고    scopus 로고
    • Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease
    • Itoh J, de La Motte C, Strong SA, Levine AD, Fiocchi C. Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease. Gut 2001; 49: 35–41.
    • (2001) Gut , vol.49 , pp. 35-41
    • Itoh, J.1    de La Motte, C.2    Strong, S.A.3    Levine, A.D.4    Fiocchi, C.5
  • 17
    • 84902334386 scopus 로고    scopus 로고
    • Defective apoptosis in intestinal and mesenteric adipose tissue of Crohn's disease patients
    • Dias CB, Milanski M, Portovedo M, et al. Defective apoptosis in intestinal and mesenteric adipose tissue of Crohn's disease patients. PLoS ONE 2014; 9: e98547.
    • (2014) PLoS ONE , vol.9
    • Dias, C.B.1    Milanski, M.2    Portovedo, M.3
  • 18
    • 32044433980 scopus 로고    scopus 로고
    • A functional role of flip in conferring resistance of Crohn's disease lamina propria lymphocytes to FAS-mediated apoptosis
    • Monteleone I, Monteleone G, Fina D, et al. A functional role of flip in conferring resistance of Crohn's disease lamina propria lymphocytes to FAS-mediated apoptosis. Gastroenterology 2006; 130: 389–97.
    • (2006) Gastroenterology , vol.130 , pp. 389-397
    • Monteleone, I.1    Monteleone, G.2    Fina, D.3
  • 19
    • 84860636948 scopus 로고    scopus 로고
    • Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis
    • Akiyama K, Chen C, Wang D, et al. Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell 2012; 10: 544–55.
    • (2012) Cell Stem Cell , vol.10 , pp. 544-555
    • Akiyama, K.1    Chen, C.2    Wang, D.3
  • 20
    • 15944376184 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells
    • Glennie S, Soeiro I, Dyson PJ, Lam EW-F, Dazzi F. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood 2005; 105: 2821–7.
    • (2005) Blood , vol.105 , pp. 2821-2827
    • Glennie, S.1    Soeiro, I.2    Dyson, P.J.3    Lam, E.W.-F.4    Dazzi, F.5
  • 21
    • 34547212527 scopus 로고    scopus 로고
    • Human mesenchymal stem cells promote survival of T cells in a quiescent state
    • Benvenuto F, Ferrari S, Gerdoni E, et al. Human mesenchymal stem cells promote survival of T cells in a quiescent state. Stem Cells 2007; 25: 1753–60.
    • (2007) Stem Cells , vol.25 , pp. 1753-1760
    • Benvenuto, F.1    Ferrari, S.2    Gerdoni, E.3
  • 22
    • 79955563439 scopus 로고    scopus 로고
    • Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    • Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 2011; 140: 1756–67.
    • (2011) Gastroenterology , vol.140 , pp. 1756-1767
    • Strober, W.1    Fuss, I.J.2
  • 23
    • 84875935592 scopus 로고    scopus 로고
    • Role of the IL-23/IL-17 axis in Crohn's disease
    • Siakavellas SI, Bamias G. Role of the IL-23/IL-17 axis in Crohn's disease. Discov Med 2012; 14: 253–62.
    • (2012) Discov Med , vol.14 , pp. 253-262
    • Siakavellas, S.I.1    Bamias, G.2
  • 24
    • 84890096310 scopus 로고    scopus 로고
    • Crohn's disease: a review of treatment options and current research
    • Bandzar S, Gupta S, Platt MO. Crohn's disease: a review of treatment options and current research. Cell Immunol. 2013; 286: 45–52.
    • (2013) Cell Immunol , vol.286 , pp. 45-52
    • Bandzar, S.1    Gupta, S.2    Platt, M.O.3
  • 25
    • 84911962224 scopus 로고    scopus 로고
    • Imbalances of CD4(+) T-cell subgroups in Crohn's disease and their relationship with disease activity and prognosis
    • Chao K, Zhang S, Yao J, et al. Imbalances of CD4(+) T-cell subgroups in Crohn's disease and their relationship with disease activity and prognosis. J Gastroenterol Hepatol 2014; 29: 1808–14.
    • (2014) J Gastroenterol Hepatol , vol.29 , pp. 1808-1814
    • Chao, K.1    Zhang, S.2    Yao, J.3
  • 26
    • 84929872532 scopus 로고    scopus 로고
    • Harnessing regulatory T cells for the treatment of inflammatory bowel disease
    • Geem D, Harusato A, Flannigan K, Denning TL. Harnessing regulatory T cells for the treatment of inflammatory bowel disease. Inflamm Bowel Dis 2015; 21: 1409–18.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 1409-1418
    • Geem, D.1    Harusato, A.2    Flannigan, K.3    Denning, T.L.4
  • 27
    • 38949175025 scopus 로고    scopus 로고
    • Mesenchymal cells recruit and regulate T regulatory cells
    • Di Ianni M, Del Papa B, De Ioanni M, et al. Mesenchymal cells recruit and regulate T regulatory cells. Exp Hematol 2008; 36: 309–18.
    • (2008) Exp Hematol , vol.36 , pp. 309-318
    • Di Ianni, M.1    Del Papa, B.2    De Ioanni, M.3
  • 28
    • 34548739534 scopus 로고    scopus 로고
    • Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction
    • Prevosto C, Zancolli M, Canevali P, Zocchi MR, Poggi A. Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica 2007; 92: 881–8.
    • (2007) Haematologica , vol.92 , pp. 881-888
    • Prevosto, C.1    Zancolli, M.2    Canevali, P.3    Zocchi, M.R.4    Poggi, A.5
  • 29
    • 84975214996 scopus 로고    scopus 로고
    • Mesenchymal stem cells and immunomodulation: current status and future prospects
    • Gao F, Chiu SM, Motan DAL, et al. Mesenchymal stem cells and immunomodulation: current status and future prospects. Cell Death Dis 2016; 7: e2062.
    • (2016) Cell Death Dis , vol.7
    • Gao, F.1    Chiu, S.M.2    Motan, D.A.L.3
  • 30
    • 38349053355 scopus 로고    scopus 로고
    • Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells
    • Selmani Z, Naji A, Zidi I, et al. Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells. Stem Cells 2008; 26: 212–22.
    • (2008) Stem Cells , vol.26 , pp. 212-222
    • Selmani, Z.1    Naji, A.2    Zidi, I.3
  • 31
    • 33750933744 scopus 로고    scopus 로고
    • Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves
    • Batten P, Sarathchandra P, Antoniw JW, et al. Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves. Tissue Eng 2006; 12: 2263–73.
    • (2006) Tissue Eng , vol.12 , pp. 2263-2273
    • Batten, P.1    Sarathchandra, P.2    Antoniw, J.W.3
  • 32
    • 83655191263 scopus 로고    scopus 로고
    • Mesenchymal stem cell-mediated immature dendritic cells induce regulatory T cell-based immunosuppressive effect
    • Choi Y-S, Jeong J-A, Lim D-S. Mesenchymal stem cell-mediated immature dendritic cells induce regulatory T cell-based immunosuppressive effect. Immunol Invest 2012; 41: 214–29.
    • (2012) Immunol Invest , vol.41 , pp. 214-229
    • Choi, Y.-S.1    Jeong, J.-A.2    Lim, D.-S.3
  • 33
    • 23944519424 scopus 로고    scopus 로고
    • Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
    • Zappia E, Casazza S, Pedemonte E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 2005; 106: 1755–61.
    • (2005) Blood , vol.106 , pp. 1755-1761
    • Zappia, E.1    Casazza, S.2    Pedemonte, E.3
  • 34
    • 65249161683 scopus 로고    scopus 로고
    • Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells
    • González MA, Gonzalez-Rey E, Rico L, Büscher D, Delgado M. Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells. Arthritis Rheum 2009; 60: 1006–19.
    • (2009) Arthritis Rheum , vol.60 , pp. 1006-1019
    • González, M.A.1    Gonzalez-Rey, E.2    Rico, L.3    Büscher, D.4    Delgado, M.5
  • 35
    • 67349224622 scopus 로고    scopus 로고
    • Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells
    • Madec AM, Mallone R, Afonso G, et al. Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells. Diabetologia 2009; 52: 1391–9.
    • (2009) Diabetologia , vol.52 , pp. 1391-1399
    • Madec, A.M.1    Mallone, R.2    Afonso, G.3
  • 36
    • 60449093316 scopus 로고    scopus 로고
    • Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis
    • Gonzalez-Rey E, Anderson P, González MA, Rico L, Büscher D, Delgado M. Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis. Gut 2009; 58: 929–39.
    • (2009) Gut , vol.58 , pp. 929-939
    • Gonzalez-Rey, E.1    Anderson, P.2    González, M.A.3    Rico, L.4    Büscher, D.5    Delgado, M.6
  • 37
    • 60449100851 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses
    • González MA, Gonzalez-Rey E, Rico L, Büscher D, Delgado M. Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses. Gastroenterology 2009; 136: 978–89.
    • (2009) Gastroenterology , vol.136 , pp. 978-989
    • González, M.A.1    Gonzalez-Rey, E.2    Rico, L.3    Büscher, D.4    Delgado, M.5
  • 38
    • 80855129560 scopus 로고    scopus 로고
    • Human umbilical cord mesenchymal stem cells ameliorate mice trinitrobenzene sulfonic acid (TNBS)-induced colitis
    • Liang L, Dong C, Chen X, et al. Human umbilical cord mesenchymal stem cells ameliorate mice trinitrobenzene sulfonic acid (TNBS)-induced colitis. Cell Transplant 2011; 20: 1395–408.
    • (2011) Cell Transplant , vol.20 , pp. 1395-1408
    • Liang, L.1    Dong, C.2    Chen, X.3
  • 39
    • 84871638604 scopus 로고    scopus 로고
    • Systemic infusion of bone marrow-derived mesenchymal stem cells for treatment of experimental colitis in mice
    • He X-W, He X-S, Lian L, Wu X-J, Lan P. Systemic infusion of bone marrow-derived mesenchymal stem cells for treatment of experimental colitis in mice. Dig Dis Sci 2012; 57: 3136–44.
    • (2012) Dig Dis Sci , vol.57 , pp. 3136-3144
    • He, X.-W.1    He, X.-S.2    Lian, L.3    Wu, X.-J.4    Lan, P.5
  • 40
    • 79952313924 scopus 로고    scopus 로고
    • Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes
    • Parekkadan B, Upadhyay R, Dunham J, et al. Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes. Gastroenterology 2011; 140: 966–75.
    • (2011) Gastroenterology , vol.140 , pp. 966-975
    • Parekkadan, B.1    Upadhyay, R.2    Dunham, J.3
  • 41
    • 84905860693 scopus 로고    scopus 로고
    • Intestinal antigen-presenting cells in mucosal immune homeostasis: Crosstalk between dendritic cells, macrophages and B-cells
    • Mann ER, Li X. Intestinal antigen-presenting cells in mucosal immune homeostasis: Crosstalk between dendritic cells, macrophages and B-cells. World J Gastroenterol 2014; 20: 9653–64.
    • (2014) World J Gastroenterol , vol.20 , pp. 9653-9664
    • Mann, E.R.1    Li, X.2
  • 42
    • 33746898242 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells
    • Nauta AJ, Kruisselbrink AB, Lurvink E, Willemze R, Fibbe WE. Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J Immunol 2006; 177: 2080–7.
    • (2006) J Immunol , vol.177 , pp. 2080-2087
    • Nauta, A.J.1    Kruisselbrink, A.B.2    Lurvink, E.3    Willemze, R.4    Fibbe, W.E.5
  • 43
    • 33846220680 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle
    • Ramasamy R, Fazekasova H, Lam EW-F, Soeiro I, Lombardi G, Dazzi F. Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle. Transplantation 2007; 83: 71–6.
    • (2007) Transplantation , vol.83 , pp. 71-76
    • Ramasamy, R.1    Fazekasova, H.2    Lam, E.W.-F.3    Soeiro, I.4    Lombardi, G.5    Dazzi, F.6
  • 44
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105: 1815–22.
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 45
    • 40749110247 scopus 로고    scopus 로고
    • Human mesenchymal stem cells license adult CD34+ hemopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the Notch pathway
    • Li Y-P, Paczesny S, Lauret E, et al. Human mesenchymal stem cells license adult CD34+ hemopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the Notch pathway. J Immunol 2008; 180: 1598–608.
    • (2008) J Immunol , vol.180 , pp. 1598-1608
    • Li, Y.-P.1    Paczesny, S.2    Lauret, E.3
  • 46
    • 59449096601 scopus 로고    scopus 로고
    • Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2 dependent regulatory dendritic cell population
    • Zhang B, Liu R, Shi D, et al. Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2 dependent regulatory dendritic cell population. Blood 2009; 113: 46–57.
    • (2009) Blood , vol.113 , pp. 46-57
    • Zhang, B.1    Liu, R.2    Shi, D.3
  • 47
    • 80054809361 scopus 로고    scopus 로고
    • Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells
    • Chiesa S, Morbelli S, Morando S, et al. Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells. Proc Natl Acad Sci USA 2011; 108: 17384–9.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 17384-17389
    • Chiesa, S.1    Morbelli, S.2    Morando, S.3
  • 48
    • 77949537626 scopus 로고    scopus 로고
    • Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profile
    • Maggini J, Mirkin G, Bognanni I, et al. Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profile. PLoS ONE 2010; 5: e9252.
    • (2010) PLoS ONE , vol.5
    • Maggini, J.1    Mirkin, G.2    Bognanni, I.3
  • 49
    • 58149326737 scopus 로고    scopus 로고
    • Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
    • Németh K, Leelahavanichkul A, Yuen PST, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 2009; 15: 42–9.
    • (2009) Nat Med , vol.15 , pp. 42-49
    • Németh, K.1    Leelahavanichkul, A.2    Yuen, P.S.T.3
  • 50
    • 84880305357 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stromal cells induce immunomodulatory macrophages which protect from experimental colitis and sepsis
    • Anderson P, Souza-Moreira L, Morell M, et al. Adipose-derived mesenchymal stromal cells induce immunomodulatory macrophages which protect from experimental colitis and sepsis. Gut 2013; 62: 1131–41.
    • (2013) Gut , vol.62 , pp. 1131-1141
    • Anderson, P.1    Souza-Moreira, L.2    Morell, M.3
  • 51
    • 18844404360 scopus 로고    scopus 로고
    • Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway
    • Augello A, Tasso R, Negrini SM, et al. Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur J Immunol 2005; 35: 1482–90.
    • (2005) Eur J Immunol , vol.35 , pp. 1482-1490
    • Augello, A.1    Tasso, R.2    Negrini, S.M.3
  • 52
    • 30144440925 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate B-cell functions
    • Corcione A, Benvenuto F, Ferretti E, et al. Human mesenchymal stem cells modulate B-cell functions. Blood 2006; 107: 367–72.
    • (2006) Blood , vol.107 , pp. 367-372
    • Corcione, A.1    Benvenuto, F.2    Ferretti, E.3
  • 53
    • 84919782445 scopus 로고    scopus 로고
    • Inhibition of B-cell proliferation and antibody production by mesenchymal stromal cells is mediated by T cells
    • Rosado MM, Bernardo ME, Scarsella M, et al. Inhibition of B-cell proliferation and antibody production by mesenchymal stromal cells is mediated by T cells. Stem Cells Dev 2015; 24: 93–103.
    • (2015) Stem Cells Dev , vol.24 , pp. 93-103
    • Rosado, M.M.1    Bernardo, M.E.2    Scarsella, M.3
  • 54
    • 84924614444 scopus 로고    scopus 로고
    • Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin 10
    • Peng Y, Chen X, Liu Q, et al. Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin 10. Leukemia 2015; 29: 636–46.
    • (2015) Leukemia , vol.29 , pp. 636-646
    • Peng, Y.1    Chen, X.2    Liu, Q.3
  • 55
    • 40949119840 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus erythematosus patients
    • Traggiai E, Volpi S, Schena F, et al. Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus erythematosus patients. Stem Cells 2008; 26: 562–9.
    • (2008) Stem Cells , vol.26 , pp. 562-569
    • Traggiai, E.1    Volpi, S.2    Schena, F.3
  • 57
    • 38949183675 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2
    • Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L. Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2. Blood 2008; 111: 1327–33.
    • (2008) Blood , vol.111 , pp. 1327-1333
    • Spaggiari, G.M.1    Capobianco, A.2    Abdelrazik, H.3    Becchetti, F.4    Mingari, M.C.5    Moretta, L.6
  • 58
    • 0242300602 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells
    • Rasmusson I, Ringdén O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 2003; 76: 1208–13.
    • (2003) Transplantation , vol.76 , pp. 1208-1213
    • Rasmusson, I.1    Ringdén, O.2    Sundberg, B.3    Le Blanc, K.4
  • 59
    • 84860238652 scopus 로고    scopus 로고
    • Multipotent mesenchymal stromal cells and the innate immune system
    • Le Blanc K, Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol 2012; 12: 383–96.
    • (2012) Nat Rev Immunol , vol.12 , pp. 383-396
    • Le Blanc, K.1    Mougiakakos, D.2
  • 60
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation
    • Meisel R, Zibert A, Laryea M, Göbel U, Däubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004; 103: 4619–21.
    • (2004) Blood , vol.103 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3    Göbel, U.4    Däubener, W.5    Dilloo, D.6
  • 61
    • 33846006154 scopus 로고    scopus 로고
    • Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells
    • Sato K, Ozaki K, Oh I, et al. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 2007; 109: 228–34.
    • (2007) Blood , vol.109 , pp. 228-234
    • Sato, K.1    Ozaki, K.2    Oh, I.3
  • 62
    • 34547647603 scopus 로고    scopus 로고
    • Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G
    • Nasef A, Mathieu N, Chapel A, et al. Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G. Transplantation 2007; 84: 231–7.
    • (2007) Transplantation , vol.84 , pp. 231-237
    • Nasef, A.1    Mathieu, N.2    Chapel, A.3
  • 63
    • 84888258395 scopus 로고    scopus 로고
    • Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2
    • Kim HS, Shin TH, Lee BC, et al. Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2. Gastroenterology 2013; 145: 1392–403.
    • (2013) Gastroenterology , vol.145 , pp. 1392-1403
    • Kim, H.S.1    Shin, T.H.2    Lee, B.C.3
  • 64
    • 84856958929 scopus 로고    scopus 로고
    • Aire controls mesenchymal stem cell-mediated suppression in chronic colitis
    • Parekkadan B, Fletcher AL, Li M, et al. Aire controls mesenchymal stem cell-mediated suppression in chronic colitis. Mol Ther 2012; 20: 178–86.
    • (2012) Mol Ther , vol.20 , pp. 178-186
    • Parekkadan, B.1    Fletcher, A.L.2    Li, M.3
  • 65
    • 77954551154 scopus 로고    scopus 로고
    • Modulation of adult mesenchymal stem cells activity by toll-like receptors: implications on therapeutic potential
    • Lombardo E, Delarosa O. Modulation of adult mesenchymal stem cells activity by toll-like receptors: implications on therapeutic potential. Mediators Inflamm 2010; 2010: 865601.
    • (2010) Mediators Inflamm , vol.2010 , pp. 865601
    • Lombardo, E.1    Delarosa, O.2
  • 66
    • 77956420421 scopus 로고    scopus 로고
    • A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype
    • Waterman RS, Tomchuck SL, Henkle SL, Betancourt AM. A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype. PLoS ONE 2010; 5: e10088.
    • (2010) PLoS ONE , vol.5
    • Waterman, R.S.1    Tomchuck, S.L.2    Henkle, S.L.3    Betancourt, A.M.4
  • 67
    • 33846914143 scopus 로고    scopus 로고
    • Toll-like receptors and their ligands control mesenchymal stem cell functions
    • Pevsner-Fischer M, Morad V, Cohen-Sfady M, et al. Toll-like receptors and their ligands control mesenchymal stem cell functions. Blood 2007; 109: 1422–32.
    • (2007) Blood , vol.109 , pp. 1422-1432
    • Pevsner-Fischer, M.1    Morad, V.2    Cohen-Sfady, M.3
  • 68
    • 38649105374 scopus 로고    scopus 로고
    • Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    • Ren G, Zhang L, Zhao X, et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008; 2: 141–50.
    • (2008) Cell Stem Cell , vol.2 , pp. 141-150
    • Ren, G.1    Zhang, L.2    Zhao, X.3
  • 69
    • 80053221596 scopus 로고    scopus 로고
    • Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis
    • Duijvestein M, Wildenberg ME, Welling MM, et al. Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis. Stem Cells 2011; 29: 1549–58.
    • (2011) Stem Cells , vol.29 , pp. 1549-1558
    • Duijvestein, M.1    Wildenberg, M.E.2    Welling, M.M.3
  • 70
    • 84939252160 scopus 로고    scopus 로고
    • Gene delivery with IFN-γ-expression plasmids enhances the therapeutic effects of MSCs on DSS-induced mouse colitis
    • Chen Y, Song Y, Miao H, et al. Gene delivery with IFN-γ-expression plasmids enhances the therapeutic effects of MSCs on DSS-induced mouse colitis. Inflamm Res 2015; 64: 671–81.
    • (2015) Inflamm Res , vol.64 , pp. 671-681
    • Chen, Y.1    Song, Y.2    Miao, H.3
  • 71
    • 84868566915 scopus 로고    scopus 로고
    • Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis
    • Fan H, Zhao G, Liu L, et al. Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis. Cell Mol Immunol 2012; 9: 473–81.
    • (2012) Cell Mol Immunol , vol.9 , pp. 473-481
    • Fan, H.1    Zhao, G.2    Liu, L.3
  • 72
    • 0038281370 scopus 로고    scopus 로고
    • Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates
    • Devine SM, Cobbs C, Jennings M, Bartholomew A, Hoffman R. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood 2003; 101: 2999–3001.
    • (2003) Blood , vol.101 , pp. 2999-3001
    • Devine, S.M.1    Cobbs, C.2    Jennings, M.3    Bartholomew, A.4    Hoffman, R.5
  • 73
    • 84875426087 scopus 로고    scopus 로고
    • Impact of bone marrow-derived mesenchymal stromal cells on experimental xenogeneic gr-aft-versus-host disease
    • Bruck F, Belle L, Lechanteur C, et al. Impact of bone marrow-derived mesenchymal stromal cells on experimental xenogeneic gr-aft-versus-host disease. Cytotherapy 2013; 15: 267–79.
    • (2013) Cytotherapy , vol.15 , pp. 267-279
    • Bruck, F.1    Belle, L.2    Lechanteur, C.3
  • 74
    • 55749112995 scopus 로고    scopus 로고
    • Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats
    • Tanaka F, Tominaga K, Ochi M, et al. Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats. Life Sci 2008; 83: 771–9.
    • (2008) Life Sci , vol.83 , pp. 771-779
    • Tanaka, F.1    Tominaga, K.2    Ochi, M.3
  • 75
    • 84881042027 scopus 로고    scopus 로고
    • Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses
    • Chen QQ, Yan L, Wang CZ, et al. Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses. World J Gastroenterol 2013; 19: 4702–17.
    • (2013) World J Gastroenterol , vol.19 , pp. 4702-4717
    • Chen, Q.Q.1    Yan, L.2    Wang, C.Z.3
  • 76
    • 84858166198 scopus 로고    scopus 로고
    • Intraperitoneal but not intravenous cryopreserved mesenchymal stromal cells home to the inflamed colon and ameliorate experimental colitis
    • Castelo-Branco MTL, Soares IDP, Lopes DV, et al. Intraperitoneal but not intravenous cryopreserved mesenchymal stromal cells home to the inflamed colon and ameliorate experimental colitis. PLoS ONE 2012; 7: e33360.
    • (2012) PLoS ONE , vol.7
    • Castelo-Branco, M.T.L.1    Soares, I.D.P.2    Lopes, D.V.3
  • 77
    • 43049139914 scopus 로고    scopus 로고
    • Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells
    • Spaeth E, Klopp A, Dembinski J, Andreeff M, Marini F. Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther 2008; 15: 730–8.
    • (2008) Gene Ther , vol.15 , pp. 730-738
    • Spaeth, E.1    Klopp, A.2    Dembinski, J.3    Andreeff, M.4    Marini, F.5
  • 78
    • 77958572322 scopus 로고    scopus 로고
    • Mesenchymal stem cells: mechanisms of immunomodulation and homing
    • Yagi H, Soto-Gutierrez A, Parekkadan B, et al. Mesenchymal stem cells: mechanisms of immunomodulation and homing. Cell Transplant. 2010. p. 667–79.
    • (2010) Cell Transplant , pp. 667-679
    • Yagi, H.1    Soto-Gutierrez, A.2    Parekkadan, B.3
  • 79
    • 77954242073 scopus 로고    scopus 로고
    • Targeting improves MSC treatment of inflammatory bowel disease
    • Ko IK, Kim B-G, Awadallah A, et al. Targeting improves MSC treatment of inflammatory bowel disease. Mol Ther 2010; 18: 1365–72.
    • (2010) Mol Ther , vol.18 , pp. 1365-1372
    • Ko, I.K.1    Kim, B.-G.2    Awadallah, A.3
  • 80
    • 0028788268 scopus 로고
    • Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine
    • Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 1995; 18: 1417–26.
    • (1995) Muscle Nerve , vol.18 , pp. 1417-1426
    • Wakitani, S.1    Saito, T.2    Caplan, A.I.3
  • 81
    • 55449132839 scopus 로고    scopus 로고
    • Do mesenchymal stromal cells transdifferentiate into functional cardiomyocytes?
    • Rose RA, Keating A, Backx PH. Do mesenchymal stromal cells transdifferentiate into functional cardiomyocytes?. Circ Res 2008;103: e120.
    • (2008) Circ Res , vol.103
    • Rose, R.A.1    Keating, A.2    Backx, P.H.3
  • 82
    • 67649871060 scopus 로고    scopus 로고
    • Mesenchymal stem cell homing capacity
    • Sordi V. Mesenchymal stem cell homing capacity. Transplantation 2009; 87(9 Suppl): S42–5.
    • (2009) Transplantation , vol.87 , Issue.9 , pp. S42-S45
    • Sordi, V.1
  • 83
    • 84878962431 scopus 로고    scopus 로고
    • Mesenchymal stem cells for cardiac therapy: practical challenges and potential mechanisms
    • Cashman TJ, Gouon-Evans V, Costa KD. Mesenchymal stem cells for cardiac therapy: practical challenges and potential mechanisms. Stem Cell Rev 2013; 9: 254–65.
    • (2013) Stem Cell Rev , vol.9 , pp. 254-265
    • Cashman, T.J.1    Gouon-Evans, V.2    Costa, K.D.3
  • 84
    • 33746547311 scopus 로고    scopus 로고
    • Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis
    • Kunter U, Rong S, Djuric Z, et al. Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis. J Am Soc Nephrol 2006; 17: 2202–12.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2202-2212
    • Kunter, U.1    Rong, S.2    Djuric, Z.3
  • 86
    • 84884969589 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells for the treatment of liver diseases, is there enough evidence?
    • Meier RPH, Müller YD, Morel P, Gonelle-Gispert C, Bühler LH. Transplantation of mesenchymal stem cells for the treatment of liver diseases, is there enough evidence?. Stem Cell Res 2013; 11: 1348–64.
    • (2013) Stem Cell Res , vol.11 , pp. 1348-1364
    • Meier, R.P.H.1    Müller, Y.D.2    Morel, P.3    Gonelle-Gispert, C.4    Bühler, L.H.5
  • 87
    • 84885087642 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy in lung disorders: pathogenesis of lung diseases and mechanism of action of mesenchymal stem cell
    • Inamdar AC, Inamdar AA. Mesenchymal stem cell therapy in lung disorders: pathogenesis of lung diseases and mechanism of action of mesenchymal stem cell. Exp Lung Res 2013; 39: 315–27.
    • (2013) Exp Lung Res , vol.39 , pp. 315-327
    • Inamdar, A.C.1    Inamdar, A.A.2
  • 88
    • 84888199128 scopus 로고    scopus 로고
    • Mesenchymal stem cells in acute lung injury: are they ready for translational medicine?
    • Xu F, Hu Y, Zhou J, Wang X. Mesenchymal stem cells in acute lung injury: are they ready for translational medicine? J Cell Mol Med 2013; 17: 927–35.
    • (2013) J Cell Mol Med , vol.17 , pp. 927-935
    • Xu, F.1    Hu, Y.2    Zhou, J.3    Wang, X.4
  • 89
    • 84887818574 scopus 로고    scopus 로고
    • The secretome of mesenchymal stem cells: potential implications for neuroregeneration
    • Paul G, Anisimov SV. The secretome of mesenchymal stem cells: potential implications for neuroregeneration. Biochimie, 2013; 95: 2246–56.
    • (2013) Biochimie , vol.95 , pp. 2246-2256
    • Paul, G.1    Anisimov, S.V.2
  • 90
    • 34547907770 scopus 로고    scopus 로고
    • Stemness” does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs)
    • Prockop DJ. “Stemness” does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs). Clin Pharmacol Ther 2007; 82: 241–3.
    • (2007) Clin Pharmacol Ther , vol.82 , pp. 241-243
    • Prockop, D.J.1
  • 91
    • 79952281645 scopus 로고    scopus 로고
    • Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms
    • Kachgal S, Putnam AJ. Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms. Angiogenesis 2011; 14: 47–59.
    • (2011) Angiogenesis , vol.14 , pp. 47-59
    • Kachgal, S.1    Putnam, A.J.2
  • 92
    • 58449135981 scopus 로고    scopus 로고
    • Why are MSCs therapeutic? New data: new insight
    • Caplan AI. Why are MSCs therapeutic? New data: new insight. J Pathol 2009; 217: 318–24.
    • (2009) J Pathol , vol.217 , pp. 318-324
    • Caplan, A.I.1
  • 93
    • 47949120741 scopus 로고    scopus 로고
    • Topical implantation of mesenchymal stem cells has beneficial effects on healing of experimental colitis in rats
    • Hayashi Y, Tsuji S, Tsujii M, et al. Topical implantation of mesenchymal stem cells has beneficial effects on healing of experimental colitis in rats. J Pharmacol Exp Ther 2008; 326: 523–31.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 523-531
    • Hayashi, Y.1    Tsuji, S.2    Tsujii, M.3
  • 94
    • 67650093720 scopus 로고    scopus 로고
    • Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity
    • Yabana T, Arimura Y, Tanaka H, et al. Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity. J Pathol 2009; 218: 350–9.
    • (2009) J Pathol , vol.218 , pp. 350-359
    • Yabana, T.1    Arimura, Y.2    Tanaka, H.3
  • 96
    • 64049104052 scopus 로고    scopus 로고
    • Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase ii clinical trial
    • Garcia-Olmo D, Herreros D, Pascual I, et al. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase ii clinical trial. Dis Colon Rectum 2009; 52: 79–86.
    • (2009) Dis Colon Rectum , vol.52 , pp. 79-86
    • Garcia-Olmo, D.1    Herreros, D.2    Pascual, I.3
  • 97
  • 98
    • 84874356143 scopus 로고    scopus 로고
    • Autologous adipose tissue-derived stem cells for the treatment of Crohn's fistula: a phase I clinical study
    • Cho YB, Lee WY, Park KJ, Kim M, Yoo HW, Yu CS. Autologous adipose tissue-derived stem cells for the treatment of Crohn's fistula: a phase I clinical study. Cell Transplant 2013; 22: 279–85.
    • (2013) Cell Transplant , vol.22 , pp. 279-285
    • Cho, Y.B.1    Lee, W.Y.2    Park, K.J.3    Kim, M.4    Yoo, H.W.5    Yu, C.S.6
  • 99
    • 84887040879 scopus 로고    scopus 로고
    • Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn's fistula
    • Lee WY, Park KJ, Cho YB, et al. Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn's fistula. Stem Cells 2013; 31: 2575–81.
    • (2013) Stem Cells , vol.31 , pp. 2575-2581
    • Lee, W.Y.1    Park, K.J.2    Cho, Y.B.3
  • 100
    • 79955853222 scopus 로고    scopus 로고
    • Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease
    • Ciccocioppo R, Bernardo ME, Sgarella A, et al. Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease. Gut 2011; 60: 788–98.
    • (2011) Gut , vol.60 , pp. 788-798
    • Ciccocioppo, R.1    Bernardo, M.E.2    Sgarella, A.3
  • 101
    • 84879459518 scopus 로고    scopus 로고
    • Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial
    • De La Portilla F, Alba F, García-Olmo D, Herrerías JM, González FX, Galindo A. Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial. Int J Colorectal Dis 2013; 28: 313–23.
    • (2013) Int J Colorectal Dis , vol.28 , pp. 313-323
    • De La Portilla, F.1    Alba, F.2    García-Olmo, D.3    Herrerías, J.M.4    González, F.X.5    Galindo, A.6
  • 102
    • 84979752747 scopus 로고    scopus 로고
    • Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial
    • Panès J, Garcia-Olmo D, Van Assche G, et al. Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial. Lancet 2016; 388: 1281–90.
    • (2016) Lancet , vol.388 , pp. 1281-1290
    • Panès, J.1    Garcia-Olmo, D.2    Van Assche, G.3
  • 103
    • 84942328578 scopus 로고    scopus 로고
    • Allogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn's disease
    • e
    • Molendijk I, Bonsing BA, Roelofs H, et al. Allogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn's disease. Gastroenterology. 2015; 149:918–27; e6.
    • (2015) Gastroenterology , vol.149 , pp. 918-927
    • Molendijk, I.1    Bonsing, B.A.2    Roelofs, H.3
  • 104
    • 78649895490 scopus 로고    scopus 로고
    • Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study
    • Duijvestein M, Vos ACW, Roelofs H, et al. Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study. Gut 2010; 59: 1662–9.
    • (2010) Gut , vol.59 , pp. 1662-1669
    • Duijvestein, M.1    Vos, A.C.W.2    Roelofs, H.3
  • 105
    • 84982860584 scopus 로고    scopus 로고
    • The safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn's disease – a phase 1 trial with three doses
    • Dhere T, Copland I, Garcia M, et al. The safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn's disease – a phase 1 trial with three doses. Aliment Pharmacol Ther 2016; 44: 471–81.
    • (2016) Aliment Pharmacol Ther , vol.44 , pp. 471-481
    • Dhere, T.1    Copland, I.2    Garcia, M.3
  • 107
    • 84857047378 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cell transplantation in seven patients with refractory inflammatory bowel disease
    • Liang J, Zhang H, Wang D, et al. Allogeneic mesenchymal stem cell transplantation in seven patients with refractory inflammatory bowel disease. Gut 2012; 61: 468–9.
    • (2012) Gut , vol.61 , pp. 468-469
    • Liang, J.1    Zhang, H.2    Wang, D.3
  • 108
    • 84890190232 scopus 로고    scopus 로고
    • A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy
    • Forbes GM, Sturm MJ, Leong RW, et al. A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy. Clin Gastroenterol Hepatol 2014; 12: 64–71.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 64-71
    • Forbes, G.M.1    Sturm, M.J.2    Leong, R.W.3
  • 109
    • 42749084909 scopus 로고    scopus 로고
    • Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen-stimulated B-cell immunoglobulin production in vitro
    • Bochev I, Elmadjian G, Kyurkchiev D, et al. Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen-stimulated B-cell immunoglobulin production in vitro. Cell Biol Int 2008; 32: 384–93.
    • (2008) Cell Biol Int , vol.32 , pp. 384-393
    • Bochev, I.1    Elmadjian, G.2    Kyurkchiev, D.3
  • 110
    • 70249108406 scopus 로고    scopus 로고
    • Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow-derived mesenchymal stem cells
    • Ivanova-Todorova E, Bochev I, Mourdjeva M, et al. Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow-derived mesenchymal stem cells. Immunol Lett 2009; 126: 37–42.
    • (2009) Immunol Lett , vol.126 , pp. 37-42
    • Ivanova-Todorova, E.1    Bochev, I.2    Mourdjeva, M.3
  • 111
    • 84904959350 scopus 로고    scopus 로고
    • Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation
    • Li X, Bai J, Ji X, Li R, Xuan Y, Wang Y. Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation. Int J Mol Med 2014; 34: 695–704.
    • (2014) Int J Mol Med , vol.34 , pp. 695-704
    • Li, X.1    Bai, J.2    Ji, X.3    Li, R.4    Xuan, Y.5    Wang, Y.6
  • 112
    • 20244381685 scopus 로고    scopus 로고
    • Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells
    • Puissant B, Barreau C, Bourin P, et al. Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells. Br J Haematol 2005; 129: 118–29.
    • (2005) Br J Haematol , vol.129 , pp. 118-129
    • Puissant, B.1    Barreau, C.2    Bourin, P.3
  • 113
    • 84885350762 scopus 로고    scopus 로고
    • Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells
    • Ribeiro A, Laranjeira P, Mendes S, et al. Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells. Stem Cell Res Ther 2013; 4: 125–41.
    • (2013) Stem Cell Res Ther , vol.4 , pp. 125-141
    • Ribeiro, A.1    Laranjeira, P.2    Mendes, S.3
  • 114
    • 33847374613 scopus 로고    scopus 로고
    • Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus
    • Sun LY, Zhang HY, Feng XB, Hou YY, Lu LW, Fan LM. Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 2007; 16: 121–8.
    • (2007) Lupus , vol.16 , pp. 121-128
    • Sun, L.Y.1    Zhang, H.Y.2    Feng, X.B.3    Hou, Y.Y.4    Lu, L.W.5    Fan, L.M.6
  • 115
    • 33847386693 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous- and allogeneic-stimulated lymphocytes in vitro
    • Bocelli-Tyndall C, Bracci L, Spagnoli G, et al. Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous- and allogeneic-stimulated lymphocytes in vitro. Rheumatology 2007; 46: 403–8.
    • (2007) Rheumatology , vol.46 , pp. 403-408
    • Bocelli-Tyndall, C.1    Bracci, L.2    Spagnoli, G.3
  • 116
    • 85002141744 scopus 로고    scopus 로고
    • Mesenchymal stem cells administered via novel selective mesenteric artery cannulation for the treatment of severe refractory Crohn's disease
    • February 5-7; Hamburg, German
    • Dinesen L, Wang A, Vianello F, et al. Mesenchymal stem cells administered via novel selective mesenteric artery cannulation for the treatment of severe refractory Crohn's disease. Proceedings of the 4th congress of European Crohn's and Colitis Organisation; 2009 February 5-7; Hamburg, Germany.
    • (2009) Proceedings of the 4th congress of European Crohn's and Colitis Organisation
    • Dinesen, L.1    Wang, A.2    Vianello, F.3
  • 117
    • 49649106257 scopus 로고    scopus 로고
    • IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease
    • Polchert D, Sobinsky J, Douglas GW, et al. IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease. Eur J Immunol 2008; 38: 1745–55.
    • (2008) Eur J Immunol , vol.38 , pp. 1745-1755
    • Polchert, D.1    Sobinsky, J.2    Douglas, G.W.3
  • 118
    • 84927636027 scopus 로고    scopus 로고
    • Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with Crohn's disease
    • Taddio A, Tommasini A, Valencic E, et al. Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with Crohn's disease. World J Gastroenterol 2015; 21: 4379–84.
    • (2015) World J Gastroenterol , vol.21 , pp. 4379-4384
    • Taddio, A.1    Tommasini, A.2    Valencic, E.3
  • 119
    • 36348946918 scopus 로고    scopus 로고
    • No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients
    • Sundin M, Ringdén O, Sundberg B, Nava S, Götherström C, Le Blanc K. No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients. Haematologica 2007; 92: 1208–15.
    • (2007) Haematologica , vol.92 , pp. 1208-1215
    • Sundin, M.1    Ringdén, O.2    Sundberg, B.3    Nava, S.4    Götherström, C.5    Le Blanc, K.6
  • 120
    • 84940982075 scopus 로고    scopus 로고
    • Human cord blood-derived platelet lysate enhances the therapeutic activity of adipose-derived mesenchymal stromal cells isolated from Crohn's disease patients in a mouse model of colitis
    • Forte D, Ciciarello M, Valerii MC, et al. Human cord blood-derived platelet lysate enhances the therapeutic activity of adipose-derived mesenchymal stromal cells isolated from Crohn's disease patients in a mouse model of colitis. Stem Cell Res Ther 2015; 6: 170.
    • (2015) Stem Cell Res Ther , vol.6 , pp. 170
    • Forte, D.1    Ciciarello, M.2    Valerii, M.C.3
  • 121
    • 84881102185 scopus 로고    scopus 로고
    • Pooled human platelet lysate versus fetal bovine serum-investigating the proliferation rate, chromosome stability and angiogenic potential of human adipose tissue-derived stem cells intended for clinical use
    • Trojahn Kølle SF, Oliveri RS, Glovinski PV, et al. Pooled human platelet lysate versus fetal bovine serum-investigating the proliferation rate, chromosome stability and angiogenic potential of human adipose tissue-derived stem cells intended for clinical use. Cytotherapy 2013; 15: 1086–97.
    • (2013) Cytotherapy , vol.15 , pp. 1086-1097
    • Trojahn Kølle, S.F.1    Oliveri, R.S.2    Glovinski, P.V.3
  • 122
    • 84959382669 scopus 로고    scopus 로고
    • Human platelet lysate: replacing fetal bovine serum as a gold standard for human cell propagation?
    • Burnouf T, Strunk D, Koh MBC, Schallmoser K. Human platelet lysate: replacing fetal bovine serum as a gold standard for human cell propagation? Biomaterials 2016; 76: 371–87.
    • (2016) Biomaterials , vol.76 , pp. 371-387
    • Burnouf, T.1    Strunk, D.2    Koh, M.B.C.3    Schallmoser, K.4
  • 123
    • 84961164161 scopus 로고    scopus 로고
    • Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: systematic review and meta-analysis
    • Hashmi S, Ahmed M, Murad MH, et al. Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: systematic review and meta-analysis. Lancet Haematol 2016; 3: e45–52.
    • (2016) Lancet Haematol , vol.3 , pp. e45-52
    • Hashmi, S.1    Ahmed, M.2    Murad, M.H.3
  • 124
    • 84943235710 scopus 로고    scopus 로고
    • Efficacy of mesenchymal stem cell therapy for steroid-refractory acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis
    • Chen X, Wang C, Yin J, et al. Efficacy of mesenchymal stem cell therapy for steroid-refractory acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis. PLoS ONE 2015; 10: e0136991.
    • (2015) PLoS ONE , vol.10
    • Chen, X.1    Wang, C.2    Yin, J.3
  • 125
    • 0035144015 scopus 로고    scopus 로고
    • Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion
    • Devine SM, Bartholomew AM, Mahmud N, et al. Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion. Exp Hematol 2001; 29: 244–55.
    • (2001) Exp Hematol , vol.29 , pp. 244-255
    • Devine, S.M.1    Bartholomew, A.M.2    Mahmud, N.3
  • 126
    • 84862835586 scopus 로고    scopus 로고
    • Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation
    • Von Bahr L, Batsis I, Moll G, et al. Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation. Stem Cells 2012; 30: 1575–8.
    • (2012) Stem Cells , vol.30 , pp. 1575-1578
    • Von Bahr, L.1    Batsis, I.2    Moll, G.3
  • 127
    • 85002500202 scopus 로고    scopus 로고
    • Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: increasing transplanted cell resistance and increasing tissue receptivity
    • Ezquer FE, Ezquer ME, Vicencio JM, Calligaris SD. Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: increasing transplanted cell resistance and increasing tissue receptivity. Cell Adh Migr 2016; 13: 1–10.
    • (2016) Cell Adh Migr , vol.13 , pp. 1-10
    • Ezquer, F.E.1    Ezquer, M.E.2    Vicencio, J.M.3    Calligaris, S.D.4
  • 128
    • 80052875315 scopus 로고    scopus 로고
    • Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease
    • Duijvestein M, Molendijk I, Roelofs H, et al. Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease. Cytotherapy 2011; 13: 1066–73.
    • (2011) Cytotherapy , vol.13 , pp. 1066-1073
    • Duijvestein, M.1    Molendijk, I.2    Roelofs, H.3
  • 129
    • 84893859041 scopus 로고    scopus 로고
    • Effects of azathioprine and infliximab on mesenchymal stem cells derived from the bone marrow of rats in vitro
    • Huang HR, Zan H, Lin Y, Zhong YQ. Effects of azathioprine and infliximab on mesenchymal stem cells derived from the bone marrow of rats in vitro. Mol Med Rep 2014; 9: 1005–12.
    • (2014) Mol Med Rep , vol.9 , pp. 1005-1012
    • Huang, H.R.1    Zan, H.2    Lin, Y.3    Zhong, Y.Q.4
  • 130
    • 79951512356 scopus 로고    scopus 로고
    • Mesenchymal stem cells together with mycophenolate mofetil inhibit antigen presenting cell and T cell infiltration into allogeneic heart grafts
    • Eggenhofer E, Steinmann JF, Renner P, et al. Mesenchymal stem cells together with mycophenolate mofetil inhibit antigen presenting cell and T cell infiltration into allogeneic heart grafts. Transpl Immunol 2011; 24: 157–63.
    • (2011) Transpl Immunol , vol.24 , pp. 157-163
    • Eggenhofer, E.1    Steinmann, J.F.2    Renner, P.3
  • 131
    • 80052316642 scopus 로고    scopus 로고
    • Features of synergism between mesenchymal stem cells and immunosuppressive drugs in a murine heart transplantation model
    • Eggenhofer E, Renner P, Soeder Y, et al. Features of synergism between mesenchymal stem cells and immunosuppressive drugs in a murine heart transplantation model. Transpl Immunol 2011; 25: 141–7.
    • (2011) Transpl Immunol , vol.25 , pp. 141-147
    • Eggenhofer, E.1    Renner, P.2    Soeder, Y.3
  • 132
    • 84860835823 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: a new tool against graft-versus-host disease?
    • Baron F, Storb R. Mesenchymal stromal cells: a new tool against graft-versus-host disease?. Biol Blood Marrow Transplant 2012; 18: 822–40.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 822-840
    • Baron, F.1    Storb, R.2
  • 133
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study
    • Le Blanc K, Frassoni F, Ball L, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008; 371: 1579–86.
    • (2008) Lancet , vol.371 , pp. 1579-1586
    • Le Blanc, K.1    Frassoni, F.2    Ball, L.3
  • 134
    • 77952584405 scopus 로고    scopus 로고
    • Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning
    • Baron F, Lechanteur C, Willems E, et al. Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLA-mismatched allogeneic transplantation following nonmyeloablative conditioning. Biol Blood Marrow Transplant 2010; 16: 838–47.
    • (2010) Biol Blood Marrow Transplant , vol.16 , pp. 838-847
    • Baron, F.1    Lechanteur, C.2    Willems, E.3
  • 135
    • 84863338204 scopus 로고    scopus 로고
    • Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial
    • Tan J, Wu W, Xu X, et al. Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA 2012; 307: 1169–77.
    • (2012) JAMA , vol.307 , pp. 1169-1177
    • Tan, J.1    Wu, W.2    Xu, X.3
  • 136
    • 79251549505 scopus 로고    scopus 로고
    • Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months
    • Wakitani S, Okabe T, Horibe S, et al. Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months. J Tissue Eng Regen Med 2011; 5: 146–50.
    • (2011) J Tissue Eng Regen Med , vol.5 , pp. 146-150
    • Wakitani, S.1    Okabe, T.2    Horibe, S.3
  • 137
    • 80053222316 scopus 로고    scopus 로고
    • Mesenchymal stem cells: from experiment to clinic
    • Otto WR, Wright NA. Mesenchymal stem cells: from experiment to clinic. Fibrogenesis Tissue Repair 2011; 4: 20–34.
    • (2011) Fibrogenesis Tissue Repair , vol.4 , pp. 20-34
    • Otto, W.R.1    Wright, N.A.2
  • 138
    • 84868091993 scopus 로고    scopus 로고
    • Safety of cell therapy with mesenchymal stromal cells (safecell): a systematic review and meta-analysis of clinical trials
    • Lalu MM, McIntyre L, Pugliese C, et al. Safety of cell therapy with mesenchymal stromal cells (safecell): a systematic review and meta-analysis of clinical trials. PLoS ONE 2012; 7: e47559.
    • (2012) PLoS ONE , vol.7
    • Lalu, M.M.1    McIntyre, L.2    Pugliese, C.3
  • 139
    • 84870933589 scopus 로고    scopus 로고
    • CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα
    • Ren G, Zhao X, Wang Y, et al. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα Cell Stem Cell 2012; 11: 812–24.
    • (2012) Cell Stem Cell , vol.11 , pp. 812-824
    • Ren, G.1    Zhao, X.2    Wang, Y.3
  • 140
    • 84903763003 scopus 로고    scopus 로고
    • Mesenchymal stromal cells promote tumor progression in fibrosarcoma and gastric cancer cells
    • Song B, Kim B, Choi S-H, et al. Mesenchymal stromal cells promote tumor progression in fibrosarcoma and gastric cancer cells. Korean J Pathol 2014; 48: 217–24.
    • (2014) Korean J Pathol , vol.48 , pp. 217-224
    • Song, B.1    Kim, B.2    Choi, S.-H.3
  • 141
    • 84870929405 scopus 로고    scopus 로고
    • Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity
    • Lee RH, Yoon N, Reneau JC, Prockop DJ. Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity. Cell Stem Cell 2012; 11: 825–35.
    • (2012) Cell Stem Cell , vol.11 , pp. 825-835
    • Lee, R.H.1    Yoon, N.2    Reneau, J.C.3    Prockop, D.J.4
  • 142
    • 84905561289 scopus 로고    scopus 로고
    • Effect of bone marrow-derived mesenchymal stromal cells on hepatoma
    • Abd-Allah SH, Shalaby SM, El-Shal AS, et al. Effect of bone marrow-derived mesenchymal stromal cells on hepatoma. Cytotherapy 2014; 16: 1197–206.
    • (2014) Cytotherapy , vol.16 , pp. 1197-1206
    • Abd-Allah, S.H.1    Shalaby, S.M.2    El-Shal, A.S.3
  • 143
    • 84902126135 scopus 로고    scopus 로고
    • Conditioned media from human adipose tissue-derived mesenchymal stem cells and umbilical cord-derived mesenchymal stem cells efficiently induced the apoptosis and differentiation in human glioma cell lines in vitro
    • Yang C, Lei D, Ouyang W, et al. Conditioned media from human adipose tissue-derived mesenchymal stem cells and umbilical cord-derived mesenchymal stem cells efficiently induced the apoptosis and differentiation in human glioma cell lines in vitro. Biomed Res Int 2014; 2014: 109389.
    • (2014) Biomed Res Int , vol.2014 , pp. 109389
    • Yang, C.1    Lei, D.2    Ouyang, W.3
  • 144
    • 84870946957 scopus 로고    scopus 로고
    • MSCs, macrophages, and cancer: a dangerous ménage-à-trois
    • Mantovani A. MSCs, macrophages, and cancer: a dangerous ménage-à-trois. Cell Stem Cell 2012; 11: 730–2.
    • (2012) Cell Stem Cell , vol.11 , pp. 730-732
    • Mantovani, A.1
  • 145
    • 48649088234 scopus 로고    scopus 로고
    • Concise review: adult multipotent stromal cells and cancer: risk or benefit?
    • Lazennec G, Jorgensen C. Concise review: adult multipotent stromal cells and cancer: risk or benefit? Stem Cells 2008; 26: 1387–94.
    • (2008) Stem Cells , vol.26 , pp. 1387-1394
    • Lazennec, G.1    Jorgensen, C.2
  • 146
    • 40749112327 scopus 로고    scopus 로고
    • The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study
    • Ning H, Yang F, Jiang M, et al. The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia 2008; 22: 593–9.
    • (2008) Leukemia , vol.22 , pp. 593-599
    • Ning, H.1    Yang, F.2    Jiang, M.3
  • 147
    • 84906098372 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells ameliorate colitis-Associated tumorigenesis in mice
    • Chen Z, He X, He X, et al. Bone marrow mesenchymal stem cells ameliorate colitis-Associated tumorigenesis in mice. Biochem Biophys Res Commun 2014; 450: 1402–8.
    • (2014) Biochem Biophys Res Commun , vol.450 , pp. 1402-1408
    • Chen, Z.1    He, X.2    He, X.3
  • 148
    • 84928567303 scopus 로고    scopus 로고
    • Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer
    • Tang R, Shen S, Zhao X, et al. Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer. Stem Cell Res Ther 2015; 6: 1–11.
    • (2015) Stem Cell Res Ther , vol.6 , pp. 1-11
    • Tang, R.1    Shen, S.2    Zhao, X.3
  • 149
    • 77956215701 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype
    • Ghannam S, Pène J, Moquet-Torcy G, Jorgensen C, Yssel H. Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype. J Immunol 2010; 185: 302–12.
    • (2010) J Immunol , vol.185 , pp. 302-312
    • Ghannam, S.1    Pène, J.2    Moquet-Torcy, G.3    Jorgensen, C.4    Yssel, H.5
  • 151
    • 78751704606 scopus 로고    scopus 로고
    • Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4+ T cell activation
    • Carrión F, Nova E, Luz P, Apablaza F, Figueroa F. Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4+ T cell activation. Immunol Lett 2011; 135: 10–6.
    • (2011) Immunol Lett , vol.135 , pp. 10-16
    • Carrión, F.1    Nova, E.2    Luz, P.3    Apablaza, F.4    Figueroa, F.5


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