Modulation of adult mesenchymal stem cells activity by toll-like receptors: Implications on therapeutic potential

Mediators of Inflammation

Volumn 2010, Issue , 2010, Pages

  Lombardo, Eleuterio ^a   Delarosa, Olga ^a  

^a Cellerix SA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 10; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NOTCH RECEPTOR; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; SCATTER FACTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR BETA1;

ADIPOSE TISSUE CELL; ANUS FISTULA; CELL ACTIVITY; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; CELL SURVIVAL; CLINICAL TRIAL; ENTERITIS; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOGENICITY; IMMUNOMODULATION; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOSURVEILLANCE; IN VIVO STUDY; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MIXED LYMPHOCYTE REACTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; UMBILICAL CORD BLOOD; BIOLOGICAL THERAPY; CELL CULTURE; CELL MOTION; METABOLISM; METHODOLOGY; PHYSIOLOGY;

CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; HUMANS; LIGANDS; MESENCHYMAL STEM CELLS; SIGNAL TRANSDUCTION; TISSUE THERAPY; TOLL-LIKE RECEPTORS;

EID: 77954551154     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2010/865601     Document Type: Review

References (72)

1. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F. C., Krause D. S., Deans R. J., Keating A., Prockop D. J., Horwitz E. M., Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy Position Cytotherapy 2006 8 4 315 317
2. Friedenstein A. J., Gorskaja U. F., Kulagina N. N., Fibroblast precursors in normal and irradiated mouse hematopoietic organs Experimental Hematology 1976 4 5 267 274
3. Pittenger M. F., Mackay A. M., Beck S. C., Jaiswal R. K., Douglas R., Mosca J. D., Moorman M. A., Simonetti D. W., Craig S., Marshak D. R., Multilineage potential of adult human mesenchymal stem cells Science 1999 284 5411 143 147
4. Jiang Y., Jahagirdar B. N., Reinhardt R. L., Pluripotency of mesenchymal stem cells derived from adult marrow Nature 2002 418 6893 41 49
5. Zuk P. A., Zhu M., Ashjian P., De Ugarte D. A., Huang J. I., Mizuno H., Alfonso Z. C., Fraser J. K., Benhaim P., Hedrick M. H., Human adipose tissue is a source of multipotent stem cells Molecular Biology of the Cell 2002 13 12 4279 4295
6. Stagg J., Immune regulation by mesenchymal stem cells: two sides to the coin Tissue Antigens 2007 69 1 1 9
7. Le Blanc K., Tammik C., Rosendahl K., Zetterberg E., Ringdn O., HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells Experimental Hematology 2003 31 10 890 896
8. Le Blanc K., Tammik L., Sundberg B., Haynesworth S. E., Ringdn O., Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex Scandinavian Journal of Immunology 2003 57 1 11 20
9. Majumdar M. K., Keane-Moore M., Buyaner D., Hardy W. B., Moorman M. A., McIntosh K. R., Mosca J. D., Characterization and functionality of cell surface molecules on human mesenchymal stem cells Journal of Biomedical Science 2003 10 2 228 241
10. McIntosh K., Zvonic S., Garrett S., Mitchell J. B., Floyd Z. E., Hammill L., Kloster A., Di Halvorsen Y., Ting J. P., Storms R. W., Goh B., Kilroy G., Wu X., Gimble J. M., The immunogenicity of human adipose-derived cells: temporal changes in vitro Stem Cells 2006 24 5 1246 1253
11. Chamberlain G., Fox J., Ashton B., Middleton J., Concise review: Mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing Stem Cells 2007 25 11 2739 2749
12. Rasmusson I., Ringdn O., Sundberg B., Le Blanc K., Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells Transplantation 2003 76 8 1208 1213
13. Bartholomew A., Sturgeon C., Siatskas M., Ferrer K., McIntosh K., Patil S., Hardy W., Devine S., Ucker D., Deans R., Moseley A., Hoffman R., Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo Experimental Hematology 2002 30 1 42 48
14. Krampera M., Glennie S., Dyson J., Scott D., Laylor R., Simpson E., Dazzi F., Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide Blood 2003 101 9 3722 3729
15. Zhang W., Ge W., Li C., You S., Liao L., Han Q., Deng W., Zhao R. C. H., Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells Stem Cells and Development 2004 13 3 263 271
16. Beyth S., Borovsky Z., Mevorach D., Liebergall M., Gazit Z., Aslan H., Galun E., Rachmilewitz J., Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness Blood 2005 105 5 2214 2219
17. Glennie S., Soeiro I., Dyson P. J., Lam E. W.-F., Dazzi F., Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells Blood 2005 105 7 2821 2827
18. Puissant B., Barreau C., Bourin P., Clavel C., Corre J., Bousquet C., Taureau C., Cousin B., Abbal M., Laharrague P., Penicaud L., Casteilla L., Blancher A., Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells British Journal of Haematology 2005 129 1 118 129
19. Nauta A. J., Kruisselbrink A. B., Lurvink E., Willemze R., Fibbe W. E., Mesenchymal stem cells inhibit generation and function of both CD34 +-derived and monocyte-derived dendritic cells Journal of Immunology 2006 177 4 2080 2087
20. Rasmusson I., Immune modulation by mesenchymal stem cells Experimental Cell Research 2006 312 12 2169 2179
21. Yaez R., Lamana M. L., Garca-Castro J., Colmenero I., Ramrez M., Bueren J. A., Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease Stem Cells 2006 24 11 2582 2591
22. Cui L., Yin S., Liu W., Li N., Zhang W., Cao Y., Expanded adipose-derived stem cells suppress mixed lymphocyte reaction by secretion of prostaglandin E 2 Tissue Engineering Part A 2007 13 6 1185 1195
23. Lombardo E., Delarosa O., Mancheo-Corvo P., Menta R., Ramrez C., Bscher D., Toll-like receptor-mediated signaling in human adipose-derived stem cells: implications for immunogenicity and immunosuppressive potential Tissue Engineering Part A 2009 15 7 1579 1589
24. DelaRosa O., Lombardo E., Beraza A., Requirement of IFN-gamma-mediated indoleamine 2,3-dioxygenase expression in the modulation of lymphocyte proliferation by human adipose-derived stem cells Tissue Engineering Part A 2009 15 10 2795 2806
25. Djouad F., Plence P., Bony C., Tropel P., Apparailly F., Sany J., Nol D., Jorgensen C., Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals Blood 2003 102 10 3837 3844
26. Tse W. T., Pendleton J. D., Beyer W. M., Egalka M. C., Guinan E. C., Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation Transplantation 2003 75 3 389 397
27. Aggarwal S., Pittenger M. F., Human mesenchymal stem cells modulate allogeneic immune cell responses Blood 2005 105 4 1815 1822
28. Augello A., Tasso R., Negrini S. M., Amateis A., Indiveri F., Cancedda R., Pennesi G., Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway European Journal of Immunology 2005 35 5 1482 1490
29. Sato K., Ozaki K., Oh I., Meguro A., Hatanaka K., Nagai T., Muroi K., Ozawa K., Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells Blood 2007 109 1 228 234
30. Maccario R., Podest M., Moretta A., Cometa A., Comoli P., Montagna D., Daudt L., Ibatici A., Piaggio G., Pozzi S., Frassoni F., Locatelli F., Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4 + T-cell subsets expressing a regulatory/suppressive phenotype Haematologica 2005 90 4 516 525
31. Gonzlez M. A., Gonzlez-Rey E., Rico L., Bscher D., Delgado M., Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells Arthritis and Rheumatism 2009 60 4 1006 1019
32. Gonzalez-Rey E., Anderson P., Gonzlez M. A., Rico L., Bscher D., Delgado M., Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis Gut 2009 58 7 929 939
33. Gonzlez M. A., Gonzalez-Rey E., Rico L., Bscher D., Delgado M., Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses Gastroenterology 2009 136 3 978 989
34. Gonzalez-Rey E., Gonzalez M. A., Varela N., Human adipose-derived mesenchymal stem cells reduce inflammatory and T cell responses and induce regulatory T cells in vitro in rheumatoid arthritis Annals of the Rheumatic Diseases 2010 69 1 241 248
35. Le Blanc K., Rasmusson I., Sundberg B., Gtherstrm C., Hassan M., Uzunel M., Ringdn O., Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells The Lancet 2004 363 9419 1439 1441
36. Zappia E., Casazza S., Pedemonte E., Benvenuto F., Bonanni I., Gerdoni E., Giunti D., Ceravolo A., Cazzanti F., Frassoni F., Mancardi G., Uccelli A., Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy Blood 2005 106 5 1755 1761
37. Ohnishi S., Yanagawa B., Tanaka K., Miyahara Y., Obata H., Kataoka M., Kodama M., Ishibashi-Ueda H., Kangawa K., Kitamura S., Nagaya N., Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis Journal of Molecular and Cellular Cardiology 2007 42 1 88 97
38. Nmeth K., Leelahavanichkul A., Yuen P. S. T., Mayer B., Parmelee A., Doi K., Robey P. G., Leelahavanichkul K., Koller B. H., Brown J. M., Hu X., Jelinek I., Star R. A., Mezey., Bone marrow stromal cells attenuate sepsis via prostaglandin E2 -dependent reprogramming of host macrophages to increase their interleukin-10 production Nature Medicine 2009 15 1 42 49
39. Garca-Olmo D., Garca-Arranz M., Herreros D., Pascual I., Peiro C., Rodrguez-Montes J. A., A phase I clinical trial of the treatment of crohn's fistula by adipose mesenchymal stem cell transplantation Diseases of the Colon and Rectum 2005 48 7 1416 1423
40. Garcia-Olmo D., Herreros D., Pascual I., Pascual J. A., Del-Valle E., Zorrilla J., De-La-Quintana P., Garcia-Arranz M., Pascual M., Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial Diseases of the Colon and Rectum 2009 52 1 79 86
41. Yamamoto-Furusho J. K., Podolsky D. K., Innate immunity in inflammatory bowel disease World Journal of Gastroenterology 2007 13 42 5577 5580
42. Ishihara S., Rumi M. A. K., Ortega-Cava C.-F., Kazumori H., Kadowaki Y., Ishimura N., Kinoshita Y., Therapeutic targeting of toll-like receptors in gastrointestinal inflammation Current Pharmaceutical Design 2006 12 32 4215 4228
43. Opitz C. A., Litzenburger U. M., Lutz C., Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via Interferon- and protein kinase R Stem Cells 2009 27 4 909 919
44. Hwa Cho H., Bae Y. C., Jung J. S., Role of toll-like receptors on human adipose-derived stromal cells Stem Cells 2006 24 12 2744 2752
45. Mo I. F. Y., Yip K. H. K., Chan W. K., Law H. K. W., Lau Y. L., Chan G. C. F., Prolonged exposure to bacterial toxins downregulated expression of toll-like receptors in mesenchymal stromal cell-derived osteoprogenitors BMC Cell Biology 2008 9, article 52
46. Chen G.-Y., Shiah H.-C., Su H.-J., Baculovirus transduction of mesenchymal stem cells triggers the toll-like receptor 3 pathway Journal of Virology 2009 83 20 10548 10556
47. Akira S., Uematsu S., Takeuchi O., Pathogen recognition and innate immunity Cell 2006 124 4 783 801
48. Ozinsky A., Underhill D. M., Fontenot J. D., Hajjar A. M., Smith K. D., Wilson C. B., Schroeder L., Aderem A., The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors Proceedings of the National Academy of Sciences of the United States of America 2000 97 25 13766 13771
49. Pasare C., Medzhitov R., Toll-like receptors: linking innate and adaptive immunity Advances in Experimental Medicine and Biology 2005 560 11 18
50. Hoebe K., Jiang Z., Georgel P., Tabeta K., Janssen E., Du X., Beutler B., TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy Current Pharmaceutical Design 2006 12 32 4123 4134
51. Kawai T., Akira S., TLR signaling Seminars in Immunology 2007 19 1 24 32
52. O'Neill L. A. J., Bowie A. G., The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling Nature Reviews Immunology 2007 7 5 353 364
53. Tomchuck S. L., Zwezdaryk K. J., Coffelt S. B., Waterman R. S., Danka E. S., Scandurro A. B., Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses Stem Cells 2008 26 1 99 107
54. Tsan M.-F., Clark R. N., Goyert S. M., White J. E., Induction of TNF- and MnSOD by endotoxin: role of membrane CD14 and Toll-like receptor-4 American Journal of Physiology 2001 280 6 C1422 C1430
55. Wang Z.-J., Zhang F.-M., Wang L.-S., Yao Y.-W., Zhao Q., Gao X., Lipopolysaccharides can protect mesenchymal stem cells (MSCs) from oxidative stress-induced apoptosis and enhance proliferation of MSCs via Toll-like receptor(TLR)-4 and PI3K/Akt Cell Biology International 2009 33 6 665 674
56. Yao Y., Zhang F., Wang L., Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction Journal of Biomedical Science 2009 16 1, article 74
57. Liotta F., Angeli R., Cosmi L., Fil L., Manuelli C., Frosali F., Mazzinghi B., Maggi L., Pasini A., Lisi V., Santarlasci V., Consoloni L., Angelotti M. L., Romagnani P., Parronchi P., Krampera M., Maggi E., Romagnani S., Annunziato F., Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing notch signaling Stem Cells 2008 26 1 279 289
58. Pevsner-Fischer M., Morad V., Cohen-Sfady M., Rousso-Noori L., Zanin-Zhorov A., Cohen S., Cohen I. R., Zipori D., Toll-like receptors and their ligands control mesenchymal stem cell functions Blood 2007 109 4 1422 1432
59. Djouad F., Charbonnier L.-M., Bouffi C., Louis-Plence P., Bony C., Apparailly F., Cantos C., Jorgensen C., Nol D., Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-dependent mechanism Stem Cells 2007 25 8 2025 2032
60. Nemeth K., Mayer B., Mezey E., Modulation of bone marrow stromal cell functions in infectious diseases by toll-like receptor ligands Journal of Molecular Medicine 2010 88 1 5 10
61. Ohashi K., Burkart V., Floh S., Kolb H., Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex Journal of Immunology 2000 164 2 558 561
62. Asea A., Kraeft S.-K., Kurt-Jones E. A., Stevenson M. A., Chen L. B., Finberg R. W., Koo G. C., Calderwood S. K., HSP70 stimulates cytokine production through a CD 14-dependant pathway, demonstrating its dual role as a chaperone and cytokine Nature Medicine 2000 6 4 435 442
63. Johnson G. B., Brunn G. J., Kodaira Y., Platt J. L., Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4 Journal of Immunology 2002 168 10 5233 5239
64. Termeer C., Benedix F., Sleeman J., Fieber C., Voith U., Ahrens T., Miyake K., Freudenberg M., Galanos C., Simon J. C., Oligosaccharides of hyaluronan activate dendritic cells via Toll-like receptor 4 Journal of Experimental Medicine 2002 195 1 99 111
65. Okamura Y., Watari M., Jerud E. S., Young D. W., Ishizaka S. T., Rose J., Chow J. C., Strauss J. F. III, The Extra Domain A of Fibronectin Activates Toll-like Receptor 4 The Journal of Biological Chemistry 2001 276 13 10229 10233
66. Liu-Bryan R., Scott P., Sydlaske A., Rose D. M., Terkeltaub R., Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation Arthritis and Rheumatism 2005 52 9 2936 2946
67. Miller Y. I., Viriyakosol S., Binder C. J., Feramisco J. R., Kirkland T. N., Witztum J. L., Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells The Journal of Biological Chemistry 2003 278 3 1561 1568
68. Barrat F. J., Meeker T., Gregorio J., Chan J. H., Uematsu S., Akira S., Chang B., Duramad O., Coffman R. L., Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus Journal of Experimental Medicine 2005 202 8 1131 1139
69. Boul M. W., Broughton C., Mackay F., Akira S., Marshak-Rothstein A., Rifkin I. R., Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes Journal of Experimental Medicine 2004 199 12 1631 1640
70. Vogl T., Tenbrock K., Ludwig S., Leukert N., Ehrhardt C., Van Zoelen M. A. D., Nacken W., Foell D., Van Der Poll T., Sorg C., Roth J., Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock Nature Medicine 2007 13 9 1042 1049
71. Yang D., Chen Q., Shao B. S., Zhang P., Kurosaka K., Caspi R. R., Michalek S. M., Rosenberg H. F., Zhang N., Oppenheim J. J., Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses Journal of Experimental Medicine 2008 205 1 79 90
72. Funderburg N., Lederman M. M., Feng Z., Drage M. G., Jadlowsky J., Harding C. V., Weinberg A., Sieg S. F., Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2 Proceedings of the National Academy of Sciences of the United States of America 2007 104 47 18631 18635