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Volumn 64, Issue 9, 2015, Pages 671-681

Gene delivery with IFN-γ-expression plasmids enhances the therapeutic effects of MSCs on DSS-induced mouse colitis

Author keywords

DSS induced colitis; IFN ; Immunosuppressive; MSC; Treg

Indexed keywords

GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; CYTOKINE; DEXTRAN SULFATE;

EID: 84939252160     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-015-0845-6     Document Type: Article
Times cited : (26)

References (37)
  • 1
    • 30344445931 scopus 로고    scopus 로고
    • Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities
    • PID: 16378007
    • Hanauer SB. Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflamm Bowel Dis. 2006;12(Suppl 1):S3–9.
    • (2006) Inflamm Bowel Dis. , vol.12 , pp. 3-9
    • Hanauer, S.B.1
  • 2
    • 84874652518 scopus 로고    scopus 로고
    • Geographical variability and environmental risk factors in inflammatory bowel disease
    • PID: 23335431
    • Ng SC, Bernstein CN, Vatn MH, Lakatos PL, Loftus EV Jr, Tysk C, et al. Geographical variability and environmental risk factors in inflammatory bowel disease. Gut. 2013;62:630–49.
    • (2013) Gut , vol.62 , pp. 630-649
    • Ng, S.C.1    Bernstein, C.N.2    Vatn, M.H.3    Lakatos, P.L.4    Loftus, E.V.5    Tysk, C.6
  • 3
    • 84886951561 scopus 로고    scopus 로고
    • Innate and adaptive immunity in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC3sXhtFWis7%2FJ, PID: 23774107
    • Geremia A, Biancheri P, Allan P, Corazza GR, Di Sabatino A. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev. 2014;13:3–10.
    • (2014) Autoimmun Rev , vol.13 , pp. 3-10
    • Geremia, A.1    Biancheri, P.2    Allan, P.3    Corazza, G.R.4    Di Sabatino, A.5
  • 4
    • 60449100851 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses
    • PID: 19135996
    • González MA, Gonzalez-Rey E, Rico L, Büscher D, Delgado M. Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses. Gastroenterology. 2009;136:978–89.
    • (2009) Gastroenterology , vol.136 , pp. 978-989
    • González, M.A.1    Gonzalez-Rey, E.2    Rico, L.3    Büscher, D.4    Delgado, M.5
  • 5
    • 60449093316 scopus 로고    scopus 로고
    • Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis
    • COI: 1:CAS:528:DC%2BD1MXovFSktb8%3D, PID: 19136511
    • Gonzalez-Rey E, Anderson P, González MA, Rico L, Büscher D, Delgado M. Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis. Gut. 2009;58:929–39.
    • (2009) Gut , vol.58 , pp. 929-939
    • Gonzalez-Rey, E.1    Anderson, P.2    González, M.A.3    Rico, L.4    Büscher, D.5    Delgado, M.6
  • 6
    • 84871638604 scopus 로고    scopus 로고
    • Systemic infusion of bone marrow-derived mesenchymal stem cells for treatment of experimental colitis in mice
    • PID: 22752635
    • He XW, He XS, Lian L, Wu XJ, Lan P. Systemic infusion of bone marrow-derived mesenchymal stem cells for treatment of experimental colitis in mice. Dig Dis Sci. 2012;57:3136–44.
    • (2012) Dig Dis Sci , vol.57 , pp. 3136-3144
    • He, X.W.1    He, X.S.2    Lian, L.3    Wu, X.J.4    Lan, P.5
  • 7
    • 77952094325 scopus 로고    scopus 로고
    • Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair
    • COI: 1:CAS:528:DC%2BC3cXlsFSqurY%3D, PID: 20368733
    • Shi Y, Hu G, Su J, Li W, Chen Q, Shou P, et al. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res. 2010;20:510–8.
    • (2010) Cell Res , vol.20 , pp. 510-518
    • Shi, Y.1    Hu, G.2    Su, J.3    Li, W.4    Chen, Q.5    Shou, P.6
  • 8
    • 77952944054 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha differentially affect cytokine expression and migration properties of mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BC3cXmsVSmurY%3D, PID: 20067407
    • Hemeda H, Jakob M, Ludwig AK, Giebel B, Lang S, Brandau S. Interferon-gamma and tumor necrosis factor-alpha differentially affect cytokine expression and migration properties of mesenchymal stem cells. Stem Cells Dev. 2010;19:693–706.
    • (2010) Stem Cells Dev. , vol.19 , pp. 693-706
    • Hemeda, H.1    Jakob, M.2    Ludwig, A.K.3    Giebel, B.4    Lang, S.5    Brandau, S.6
  • 9
    • 55749112995 scopus 로고    scopus 로고
    • Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats
    • COI: 1:CAS:528:DC%2BD1cXhtlylu7vF, PID: 18950645
    • Tanaka F, Tominaga K, Ochi M, Tanigawa T, Watanabe T, Fujiwara Y, et al. Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats. Life Sci. 2008;83:771–9.
    • (2008) Life Sci , vol.83 , pp. 771-779
    • Tanaka, F.1    Tominaga, K.2    Ochi, M.3    Tanigawa, T.4    Watanabe, T.5    Fujiwara, Y.6
  • 10
    • 80053221596 scopus 로고    scopus 로고
    • Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis
    • COI: 1:CAS:528:DC%2BC3MXhsV2itb7F, PID: 21898680
    • Duijvestein M, Wildenberg ME, Welling MM, Hennink S, Molendijk I, van Zuylen VL, et al. Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis. Stem Cells. 2011;29:1549–58.
    • (2011) Stem Cells , vol.29 , pp. 1549-1558
    • Duijvestein, M.1    Wildenberg, M.E.2    Welling, M.M.3    Hennink, S.4    Molendijk, I.5    van Zuylen, V.L.6
  • 11
    • 38649105374 scopus 로고    scopus 로고
    • Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    • COI: 1:CAS:528:DC%2BD1cXitlygtb8%3D, PID: 18371435
    • Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI, et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell. 2008;2:141–50.
    • (2008) Cell Stem Cell , vol.2 , pp. 141-150
    • Ren, G.1    Zhang, L.2    Zhao, X.3    Xu, G.4    Zhang, Y.5    Roberts, A.I.6
  • 12
    • 33746889097 scopus 로고    scopus 로고
    • Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BD28XhtFGht7bJ, PID: 16123384
    • Krampera M, Cosmi L, Angeli R, Pasini A, Liotta F, Andreini A, et al. Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells. 2006;24:386–98.
    • (2006) Stem Cells , vol.24 , pp. 386-398
    • Krampera, M.1    Cosmi, L.2    Angeli, R.3    Pasini, A.4    Liotta, F.5    Andreini, A.6
  • 13
    • 84868566915 scopus 로고    scopus 로고
    • Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis
    • COI: 1:CAS:528:DC%2BC38Xhs1arsbzL, PID: 23085948
    • Fan H, Zhao G, Liu L, Liu F, Gong W, Liu X, et al. Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis. Cell Mol Immunol. 2012;9:473–81.
    • (2012) Cell Mol Immunol , vol.9 , pp. 473-481
    • Fan, H.1    Zhao, G.2    Liu, L.3    Liu, F.4    Gong, W.5    Liu, X.6
  • 14
    • 34447298069 scopus 로고    scopus 로고
    • Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BD2sXhtVShs73K, PID: 17521318
    • Ryan JM, Barry F, Murphy JM, Mahon BP. Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. Clin Exp Immunol. 2007;149:353–63.
    • (2007) Clin Exp Immunol , vol.149 , pp. 353-363
    • Ryan, J.M.1    Barry, F.2    Murphy, J.M.3    Mahon, B.P.4
  • 15
    • 77951889580 scopus 로고    scopus 로고
    • Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression
    • COI: 1:CAS:528:DC%2BC3cXitV2ks74%3D, PID: 20130212
    • Ren G, Zhao X, Zhang L, Zhang J, L’Huillier A, Ling W, et al. Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J Immunol. 2010;184:2321–8.
    • (2010) J Immunol. , vol.184 , pp. 2321-2328
    • Ren, G.1    Zhao, X.2    Zhang, L.3    Zhang, J.4    L’Huillier, A.5    Ling, W.6
  • 16
    • 79951934032 scopus 로고    scopus 로고
    • Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO)
    • COI: 1:CAS:528:DC%2BC3MXislCntrs%3D, PID: 21359206
    • Croitoru-Lamoury J, Lamoury FM, Caristo M, Suzuki K, Walker D, Takikawa O, et al. Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO). PLoS ONE. 2011;6:e14698.
    • (2011) PLoS ONE , vol.6 , pp. 14698
    • Croitoru-Lamoury, J.1    Lamoury, F.M.2    Caristo, M.3    Suzuki, K.4    Walker, D.5    Takikawa, O.6
  • 17
    • 84856960632 scopus 로고    scopus 로고
    • Human MSC suppression correlates with cytokine induction of indoleamine 2, 3-dioxygenase and bystander M2 macrophage differentiation
    • François M, Romieu-Mourez R, Li M, Galipeau J. Human MSC suppression correlates with cytokine induction of indoleamine 2, 3-dioxygenase and bystander M2 macrophage differentiation. Mol Ther. 2012;2012(20):187–95.
    • (2012) Mol Ther , vol.2012 , Issue.20 , pp. 187-195
    • François, M.1    Romieu-Mourez, R.2    Li, M.3    Galipeau, J.4
  • 18
    • 84888072366 scopus 로고    scopus 로고
    • IFN-γ stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro
    • COI: 1:CAS:528:DC%2BC3sXhslykt7fN, PID: 23795941
    • Noone C, Kihm A, English K, O’Dea S, Mahon BP. IFN-γ stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro. Stem Cells Dev. 2013;22:3003–14.
    • (2013) Stem Cells Dev. , vol.22 , pp. 3003-3014
    • Noone, C.1    Kihm, A.2    English, K.3    O’Dea, S.4    Mahon, B.P.5
  • 19
    • 84899935769 scopus 로고    scopus 로고
    • Interferon-gamma modification of mesenchymal stem cells: implications of autologous and allogeneic mesenchymal stem cell therapy in allotransplantation
    • COI: 1:CAS:528:DC%2BC2cXns1Wnsb8%3D, PID: 24510581
    • Sivanathan KN, Gronthos S, Rojas-Canales D, Thierry B, Coates PT. Interferon-gamma modification of mesenchymal stem cells: implications of autologous and allogeneic mesenchymal stem cell therapy in allotransplantation. Stem Cell Rev. 2014;10:351–75.
    • (2014) Stem Cell Rev. , vol.10 , pp. 351-375
    • Sivanathan, K.N.1    Gronthos, S.2    Rojas-Canales, D.3    Thierry, B.4    Coates, P.T.5
  • 20
    • 84864142890 scopus 로고    scopus 로고
    • Delivery of IL-12p40 ameliorates DSS-induced colitis by suppressing IL-17A expression and inflammation in the intestinal mucosa
    • COI: 1:CAS:528:DC%2BC38Xht1aktLzN, PID: 22836084
    • Kim DJ, Kim KS, Song MY, Seo SH, Kim SJ, Yang BG, et al. Delivery of IL-12p40 ameliorates DSS-induced colitis by suppressing IL-17A expression and inflammation in the intestinal mucosa. Clin Immunol. 2012;144:190–9.
    • (2012) Clin Immunol. , vol.144 , pp. 190-199
    • Kim, D.J.1    Kim, K.S.2    Song, M.Y.3    Seo, S.H.4    Kim, S.J.5    Yang, B.G.6
  • 21
    • 84898482138 scopus 로고    scopus 로고
    • Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids
    • PID: 24717973
    • Ankrum JA, Dastidar RG, Ong JF, Levy O, Karp JM. Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids. Sci Rep. 2014;4:4645.
    • (2014) Sci Rep. , vol.4 , pp. 4645
    • Ankrum, J.A.1    Dastidar, R.G.2    Ong, J.F.3    Levy, O.4    Karp, J.M.5
  • 22
    • 84864753787 scopus 로고    scopus 로고
    • A novel way to isolate MSCs from umbilical cords
    • COI: 1:CAS:528:DC%2BC38XhtFakur7K, PID: 22585466
    • Liu L, Zhao X, Li P, Zhao G, Wang Y, Hu Y, et al. A novel way to isolate MSCs from umbilical cords. Eur J Immunol. 2012;42:2190–3.
    • (2012) Eur J Immunol. , vol.42 , pp. 2190-2193
    • Liu, L.1    Zhao, X.2    Li, P.3    Zhao, G.4    Wang, Y.5    Hu, Y.6
  • 23
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • COI: 1:CAS:528:DyaK2MXovFWru7s%3D, PID: 7595199
    • Neurath MF, Fuss I, Kelsall BL, Stüber E, Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med. 1995;182:1281–90.
    • (1995) J Exp Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stüber, E.4    Strober, W.5
  • 24
    • 77950792860 scopus 로고    scopus 로고
    • Targeting delivery of anti-TNF alpha oligonucleotide into activated colonic macrophages protects against experimental colitis
    • COI: 1:CAS:528:DC%2BC3cXlsFSju7o%3D, PID: 19951904
    • Zuo L, Huang Z, Dong L, Xu L, Zhu Y, Zeng K, et al. Targeting delivery of anti-TNF alpha oligonucleotide into activated colonic macrophages protects against experimental colitis. Gut. 2010;59:470–9.
    • (2010) Gut. , vol.59 , pp. 470-479
    • Zuo, L.1    Huang, Z.2    Dong, L.3    Xu, L.4    Zhu, Y.5    Zeng, K.6
  • 25
    • 25444432287 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from CD133-positive cells in mobilized peripheral blood and cord blood: proliferation, Oct4 expression, and plasticity
    • COI: 1:CAS:528:DC%2BD2MXhtFCks7vO, PID: 15955825
    • Tondreau T, Meuleman N, Delforge A, Dejeneffe M, Leroy R, Massy M, et al. Mesenchymal stem cells derived from CD133-positive cells in mobilized peripheral blood and cord blood: proliferation, Oct4 expression, and plasticity. Stem Cells. 2005;23:1105–12.
    • (2005) Stem Cells , vol.23 , pp. 1105-1112
    • Tondreau, T.1    Meuleman, N.2    Delforge, A.3    Dejeneffe, M.4    Leroy, R.5    Massy, M.6
  • 26
    • 66149137296 scopus 로고    scopus 로고
    • Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis
    • PID: 18942757
    • Alex P, Zachos NC, Nguyen T, Gonzales L, Chen TE, Conklin LS, et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis. 2009;15:341–52.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 341-352
    • Alex, P.1    Zachos, N.C.2    Nguyen, T.3    Gonzales, L.4    Chen, T.E.5    Conklin, L.S.6
  • 27
    • 50249158511 scopus 로고    scopus 로고
    • Mesenchymal stem cells in health and disease
    • COI: 1:CAS:528:DC%2BD1cXhtVamu7vF, PID: 19172693
    • Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol. 2008;8:726–36.
    • (2008) Nat Rev Immunol , vol.8 , pp. 726-736
    • Uccelli, A.1    Moretta, L.2    Pistoia, V.3
  • 28
    • 84904501880 scopus 로고    scopus 로고
    • A125: immunomodulatory factors produced by mesenchymal stem cells after in vitro priming with danger signals
    • Bukulmez H, Bilgin A, Bebek G, Caplan AI, Jones O. A125: immunomodulatory factors produced by mesenchymal stem cells after in vitro priming with danger signals. Arthritis Rheumatol. 2014;66(Suppl 11):S163.
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 163
    • Bukulmez, H.1    Bilgin, A.2    Bebek, G.3    Caplan, A.I.4    Jones, O.5
  • 29
    • 34249662219 scopus 로고    scopus 로고
    • IFN-gamma and TNF-alpha differentially regulateimmunomodulation by murine mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BD2sXmtVantb4%3D, PID: 17507101
    • English K, Barry FP, Field-Corbett CP, Mahon BP. IFN-gamma and TNF-alpha differentially regulateimmunomodulation by murine mesenchymal stem cells. Immunol Lett. 2007;110:91–100.
    • (2007) Immunol Lett , vol.110 , pp. 91-100
    • English, K.1    Barry, F.P.2    Field-Corbett, C.P.3    Mahon, B.P.4
  • 30
    • 84894521405 scopus 로고    scopus 로고
    • The toll-like receptor 3 ligand, poly (I:C), improves immunosuppressive function and therapeutic effect of mesenchymal stem cells on sepsis via inhibiting miR-143
    • COI: 1:CAS:528:DC%2BC2cXlsFOrurs%3D, PID: 24105952
    • Zhao X, Liu D, Gong W, Zhao G, Liu L, Yang L, et al. The toll-like receptor 3 ligand, poly (I:C), improves immunosuppressive function and therapeutic effect of mesenchymal stem cells on sepsis via inhibiting miR-143. Stem Cells. 2014;32:521–33.
    • (2014) Stem Cells , vol.32 , pp. 521-533
    • Zhao, X.1    Liu, D.2    Gong, W.3    Zhao, G.4    Liu, L.5    Yang, L.6
  • 31
    • 84907212871 scopus 로고    scopus 로고
    • Stimulation of mesenchymal stromal cells (MSCs) via TLR3 reveals a novel mechanism of autocrine priming
    • COI: 1:CAS:528:DC%2BC2cXhsFanur7M, PID: 24830384
    • Dumitru CA, Hemeda H, Jakob M, Lang S, Brandau S. Stimulation of mesenchymal stromal cells (MSCs) via TLR3 reveals a novel mechanism of autocrine priming. FASEB J. 2014;28:3856–66.
    • (2014) FASEB J. , vol.28 , pp. 3856-3866
    • Dumitru, C.A.1    Hemeda, H.2    Jakob, M.3    Lang, S.4    Brandau, S.5
  • 32
    • 84878401681 scopus 로고    scopus 로고
    • Mesenchymal stem cells generate a CD4+ CD25+ Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells
    • COI: 1:CAS:528:DC%2BC3sXhtV2jsL7J, PID: 23734780
    • Luz-Crawford P, Kurte M, Bravo-Alegría J, Contreras R, Nova-Lamperti E, Tejedor G, et al. Mesenchymal stem cells generate a CD4+ CD25+ Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells. Stem Cell Res Ther. 2013;4:65.
    • (2013) Stem Cell Res Ther. , vol.4 , pp. 65
    • Luz-Crawford, P.1    Kurte, M.2    Bravo-Alegría, J.3    Contreras, R.4    Nova-Lamperti, E.5    Tejedor, G.6
  • 33
    • 79959644782 scopus 로고    scopus 로고
    • Immunosuppressive mechanisms of embryonic stem cells and mesenchymal stem cells in alloimmune response
    • COI: 1:CAS:528:DC%2BC3MXosFags74%3D, PID: 21635949
    • Han KH, Ro H, Hong JH, Lee EM, Cho B, Yeom HJ, et al. Immunosuppressive mechanisms of embryonic stem cells and mesenchymal stem cells in alloimmune response. Transpl Immunol. 2011;25:7–15.
    • (2011) Transpl Immunol , vol.25 , pp. 7-15
    • Han, K.H.1    Ro, H.2    Hong, J.H.3    Lee, E.M.4    Cho, B.5    Yeom, H.J.6
  • 34
    • 84878794983 scopus 로고    scopus 로고
    • The effect of mesenchymal stem cells on dynamic changes of T cell subsets in experimental autoimmune uveoretinitis
    • COI: 1:CAS:528:DC%2BC3sXptFehsL0%3D, PID: 23607419
    • Li G, Yuan L, Ren X, Nian H, Zhang L, Han ZC, et al. The effect of mesenchymal stem cells on dynamic changes of T cell subsets in experimental autoimmune uveoretinitis. Clin Exp Immunol. 2013;173:28–37.
    • (2013) Clin Exp Immunol , vol.173 , pp. 28-37
    • Li, G.1    Yuan, L.2    Ren, X.3    Nian, H.4    Zhang, L.5    Han, Z.C.6
  • 35
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3-dioxygenase-mediated tryptophan degradation
    • COI: 1:CAS:528:DC%2BD2cXlt1Krt7k%3D, PID: 15001472
    • Meisel R, Zibert A, Laryea M, Göbel U, Däubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3-dioxygenase-mediated tryptophan degradation. Blood. 2004;103:4619–21.
    • (2004) Blood , vol.103 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3    Göbel, U.4    Däubener, W.5    Dilloo, D.6
  • 36
    • 84904993611 scopus 로고    scopus 로고
    • A CD8 T cell-IDO axis is required for mesenchymal stem cell suppression of human SLE
    • COI: 1:CAS:528:DC%2BC2cXhs1Chs7vK, PID: 24756936
    • Wang D, Feng X, Lu L, Konkel JE, Zhang H, Chen Z, et al. A CD8 T cell-IDO axis is required for mesenchymal stem cell suppression of human SLE. Arthritis Rheumatol. 2014;66:2234–45.
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 2234-2245
    • Wang, D.1    Feng, X.2    Lu, L.3    Konkel, J.E.4    Zhang, H.5    Chen, Z.6
  • 37
    • 84896727247 scopus 로고    scopus 로고
    • IDO-independent suppression of T cell effector function by IFN-γ-licensed human mesenchymal stromal cells
    • COI: 1:CAS:528:DC%2BC2cXitFWnu74%3D, PID: 24403533
    • Chinnadurai R, Copland IB, Patel SR, Galipeau J. IDO-independent suppression of T cell effector function by IFN-γ-licensed human mesenchymal stromal cells. J Immunol. 2014;192:1491–501.
    • (2014) J Immunol. , vol.192 , pp. 1491-1501
    • Chinnadurai, R.1    Copland, I.B.2    Patel, S.R.3    Galipeau, J.4


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