Human umbilical cord mesenchymal stem cells ameliorate mice trinitrobenzene sulfonic acid (TNBS)-induced colitis

Cell Transplantation

Volumn 20, Issue 9, 2011, Pages 1395-1408

  Liang, Lu ^a   Dong, Chunlan ^a   Chen, Xiaojun ^a   Fang, Zhihong ^a   Xu, Jie ^a   Liu, Meng ^a   Zhang, Xiaoguang ^a   Gu, Dong Sheng ^a   Wang, Ding ^a   Du, Weiting ^a   Zhu, Delin ^b   Han, Zhong Chao ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^b AmCellGene Co Ltd   (China)

Author keywords

Colitis; Il 17; Immunosuppression; Mesenchymal stem cells (mscs)

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; TRINITROBENZENESULFONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; COLITIS; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOLOGY; IMMUNE RESPONSE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOMODULATION; IMMUNOREGULATION; IN VIVO STUDY; INFLAMMATION; LAMINA PROPRIA; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; TH1 CELL; TREATMENT OUTCOME;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; CELL SEPARATION; CELL SURVIVAL; COCULTURE TECHNIQUES; COLITIS; COLON; CYTOKINES; HUMANS; IMMUNOPHENOTYPING; INFLAMMATION MEDIATORS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED BALB C; MICROSCOPY, FLUORESCENCE; MUCOUS MEMBRANE; SPLEEN; TRINITROBENZENESULFONIC ACID; UMBILICAL CORD;

ANIMALIA; MUS;

EID: 80855129560     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368910X557245     Document Type: Article

References (44)

1. Aggarwal S.; Pittenger M. F. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815-1822; 2005.
2. Allers C.; Sierralta W. D.; Neubauer S.; Rivera F.; Minguell J. J.; Conget P. A. Dynamic of distribution of human bone marrow-derived mesenchymal stem cells after transplantation into adult unconditioned mice. Transplantation 78:503-508; 2004.
3. Caplan A. I. Mesenchymal stem cells. J. Orthop. Res. 9:641-650; 1991.
4. da Silva Meirelles L.; Caplan A. I.; Nardi N. B. In search of the in vivo identity of mesenchymal stem cells. Stem Cells 26(9):2287-2299; 2008.
5. Devine S. M.; Cobbs C.; Jennings M.; Bartholomew A.; Hoffman R. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood 101:2999-3001; 2003.
6. Di Nicola M.; Carlo-Stella C.; Magni M.; Milanesi M.; Longoni P. D.; Matteucci P.; Grisanti S.; Gianni A. M. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838-3843; 2002.
7. Dryden G. W. Overview of stem cell therapy for Crohn's disease. Expert Opin. Biol. Ther. 9(7):841-847; 2009.
8. Duerr R. H.; Taylor K. D.; Brant S. R.; Rioux J. D.; Silverberg M. S.; Daly M. J.; Steinhart A. H.; Abraham C.; Regueiro M.; Griffiths A.; Dassopoulos T.; Bitton A.; Yang H.; Targan S.; Datta L. W.; Kistner E. O.; Schumm L. P.; Lee A. T.; Gregersen P. K.; Barmada M. M.; Rotter J. I.; Nicolae D. L.; Cho J. H. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314:1461-1463; 2006.
9. Edinger M.; Cao Y. A.; Verneris M. R.; Bachmann M. H.; Contag C. H.; Negrin R. S. Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging. Blood 101:640-648; 2003.
10. Elson C. O.; Cong Y.; Weaver C. T.; Schoeb T. R.; McClanahan T. K.; Fick R. B.; Kastelein R. A. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132:2359-2370; 2007.
11. François S.; Bensidhoum M.; Mouiseddine M.; Mazurier C.; Allenet B.; Semont A.; Frick J.; Saché A.; Bouchet S.; Thierry D.; Gourmelon P.; Gorin N. C.; Chapel A. Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: A study of their quantitative distribution after irradiation damage. Stem Cells 24(4):1020-1029; 2006.
12. Fujino S.; Andoh A.; Bamba S.; Ogawa A.; Hata K.; Araki Y.; Bamba T.; Fujiyama Y. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52:65-70; 2003.
13. Fuss I. J.; Becker C.; Yang Z.; Groden C.; Hornung R. L.; Heller F.; Neurath M. F.; Strober W.; Mannon P. J. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm. Bowel Dis. 12:9-15; 2006.
14. Gonzalez M. A.; Gonzalez-Rey E.; Rico L.; Buscher D.; Delgado M. Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses. Gastroenterology 136:978-989; 2009.
15. Gonzalez-Rey E.; Anderson P.; Gonzélez M. A.; Rico L.; Büscher D.; Delgado M. Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis. Gut 58(7):929-939; 2009.
16. Hue S.; Ahern P.; Buonocore S.; Kullberg M. C.; Cua D. J.; McKenzie B. S.; Powrie F.; Maloy K. J. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J. Exp. Med. 203:2473-2483; 2006.
17. Ivanov I. I.; McKenzie B. S.; Zhou L.; Tadokoro C. E.; Lepelley A.; Lafaille J. J.; Cua D. J.; Littman D. R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126:1121-1133; 2006.
18. Jiang X. X.; Zhang Y.; Liu B.; Zhang S. X.; Wu Y.; Yu X. D.; Mao N. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 105:4120-4126; 2005.
19. Jung M.; Kaszap B.; Redhl A.; Steck E.; Breusch S.; Richter W.; Gotterbarm T. Enhanced early tissue regeneration after matrix assisted autologous mesenchymal stem cell transplantation in full thickness chondral defects in a minipig model. Cell Transplant. 18(8):923-932; 2009.
20. Keyser K. A.; Beagles K. E.; Kiem H. P. Comparison of mesenchymal stem cells from different tissues to suppress T-cell activation. Cell Transplant. 16(5):555-562; 2007.
21. Khalil P. N.; Weiler V.; Nelson P. J.; Khalil M. N.; Moosmann S.; Mutschler W. E.; Siebeck M.; Huss R. Nonmyeloablative stem cell therapy enhances microcirculation and tissue regeneration in murine inflammatory bowel disease. Gastroenterology 132:944-954; 2007.
22. Kleinschek M. A.; Boniface K.; Sadekova S.; Grein J.; Murphy E. E.; Turner S. P.; Raskin L.; Desai B.; Faubion W. A.; de Waal Malefyt R.; Pierce R. H.; McClanahan T.; Kastelein R. A. Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J. Exp. Med. 206:525-534; 2009.
23. Kolls J. K.; Linden A. Interleukin-17 family members and inflammation. Immunity 21:467-476; 2004.
24. Krawisz J. E.; Sharon P.; Stenson W. F. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 87:1344-1350; 1984.
25. Kullberg M. C.; Jankovic D.; Feng C. G.; Hue S.; Gorelick P. L.; McKenzie B. S.; Cua D. J.; Powrie F.; Cheever A. W.; Maloy K. J.; Sher A. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J. Exp. Med. 203:2485-2494; 2006.
26. Langrish C. L.; Chen Y.; Blumenschein W. M.; Mattson J.; Basham B.; Sedgwick J. D.; McClanahan T.; Kastelein R. A.; Cua D. J. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201:233-240; 2005.
27. Lanzoni G.; Roda G.; Belluzzi A.; Roda E.; Bagnara G. P. Inflammatory bowel disease: Moving toward a stem cell-based therapy. World J. Gastroenterol. 14(29):4616-4626; 2008.
28. Le Blanc K.; Frassoni F.; Ball L.; Locatelli F.; Roelofs H.; Lewis I.; Lanino E.; Sundberg B.; Bernardo M. E.; Remberger M.; Dini G.; Egeler R. M.; Bacigalupo A.; Fibbe W.; Ringden O. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study. Lancet 371:1579-1586; 2008.
29. Liao W.; Zhong J.; Yu J.; Xie J.; Liu Y.; Du L.; Yang S.; Liu P.; Xu J.; Wang J.; Han Z.; Han Z. C. Therapeutic benefit of human umbilical cord derived mesenchymal stromal cells in intracerebral hemorrhage rat: Implications of anti-inflammation and angiogenesis. Cell. Physiol. Biochem. 24(3-4):307-316; 2009.
30. Lu L. L.; Liu Y. J.; Yang S. G.; Zhao Q. J.; Wang X.; Gong W.; Han Z. B.; Xu Z. S.; Lu Y. X.; Liu D.; Chen Z. Z.; Han Z. C. Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica 91:1017-1026; 2006.
31. Ma X. T.; Zhang X. J.; Zhang B.; Geng Y. Q.; Lin Y. M.; Li G.; Wu K. F. Expression and regulation of interleukin-23 subunits in human peripheral blood mononuclear cells and hematopoietic cell lines in response to various inducers. Cell Biol. Int. 28:689-697; 2004.
32. MacPherson B. R.; Pfeiffer C. J. Experimental production of diffuse colitis in rats. Digestion 17:135-150; 1978.
33. McGovern D.; Powrie F. The IL23 axis plays a key role in the pathogenesis of IBD. Gut 56:1333-1336; 2007.
34. Morris G. P.; Beck P. L.; Herridge M. S.; Depew W. T.; Szewczuk M. R.; Wallace J. L. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 96:795-803; 1989.
35. Neurath M. F.; Fuss I.; Kelsall B. L.; Stuber E.; Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1281-1290; 1995.
36. Okamoto S.; Watanabe M.; Yamazaki M.; Yajima T.; Hayashi T.; Ishii H.; Mukai M.; Yamada T.; Watanabe N.; Jameson B. A.; Hibi T. A synthetic mimetic of CD4 is able to suppress disease in a rodent model of immune colitis. Eur. J. Immunol. 29:355-366; 1999.
37. Pereira R. F.; Halford K. W.; O'Hara M. D.; Leeper D. B.; Sokolov B. P.; Pollard M. D.; Bagasra O.; Prockop D. J. Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc. Natl. Acad. Sci. USA 92:4857-4861; 1995.
38. Rivera E.; Flores I.; Rivera E.; Appleyard C. B. Molecular profiling of a rat model of colitis: Validation of known inflammatory genes and identification of novel disease-associated targets. Inflamm. Bowel Dis. 12:950-966; 2006.
39. Sato Y.; Araki H.; Kato J.; Nakamura K.; Kawano Y.; Kobune M.; Sato T.; Miyanishi K.; Takayama T.; Takahashi M.; Takimoto R.; Iyama S.; Matsunaga T.; Ohtani S.; Matsuura A.; Hamada H.; Niitsu Y. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood 106:756-763; 2005.
40. Strober W.; Fuss I. J.; Blumberg R. S. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20:495-549; 2002.
41. Tse W. T.; Pendleton J. D.; Beyer W. M.; Egalka M. C.; Guinan E. C. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation. Transplantation 75:389-397; 2003.
42. Viney J. L.; MacDonald T. T.; Kilshaw P. J. T-cell receptor expression in intestinal intra-epithelial lymphocyte subpopulations of normal and athymic mice. Immunology 66:583-587; 1989.
43. Zappia E.; Casazza S.; Pedemonte E.; Benvenuto F.; Bonanni I.; Gerdoni E.; Giunti D.; Ceravolo A.; Cazzanti F.; Frassoni F.; Mancardi G.; Uccelli A. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 106:1755-1761; 2005.
44. Zhang Z.; Zheng M.; Bindas J.; Schwarzenberger P.; Kolls J. K. Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm. Bowel Dis. 12:382-388; 2006.