Autologous adipose tissue-derived stem cells for the treatment of crohn's fistula: A phase I clinical study

Cell Transplantation

Volumn 22, Issue 2, 2013, Pages 279-285

  Cho, Yong Beom ^a   Lee, Woo Yong ^a   Park, Kyu Joo ^b   Kim, Mihyung ^c   Yoo, Hee Won ^d   Yu, Chang Sik ^e  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Anterogen Co Ltd   (South Korea)

^d Bukwang Pharmaceutical Company   (South Korea)

^e University of Ulsan College of Medicine   (South Korea)

Author keywords

Adipose tissue derived stem cells (ASCs); Autologous stem cells; Complete healing; Crohn's fistula

Indexed keywords

ADULT; ANUS FISTULA; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CLINICAL ARTICLE; DIARRHEA; ENTEROCOLITIS; FEMALE; FISTULA; HEALING; HUMAN; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PAIN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; SAFETY;

ADIPOSE TISSUE; ADULT; CROHN DISEASE; FEMALE; HUMANS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; RECTAL FISTULA; TREATMENT OUTCOME;

EID: 84874356143     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368912X656045     Document Type: Article

References (38)

1. American Gastroenterological Association 1. Clinical Practice Committee. American Gastroenterological Association medical position statement: Perianal Crohn's disease. Gastroenterology 125:1503-1507; 2003
2. Bernardo, M.; Avanzini, M.; Ciccocioppo, R.; Perotti, C.; Cometa, A.; Moretta, A.; Marconi, M.; Valli, M.; Novara, F.; Bonetti, F.; Zuffardi, O.; Maccario, R.; Corazza, G.; Locatelli, F. Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease. Cytotherapy 7:825-836; 2009
3. Cassinotti, A.; Annaloro, C.; Ardizzone, S.; Onida, F.; Della Volpe, A.; Clerici, M.; Usardi, P.; Greco, S.; Maconi, G.; Porro, G. B.; Deliliers, G. L. Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn's disease. Gut 57:211-217; 2008
4. Ciccocioppo, R.; Bernardo, M. E.; Sgarella, A.; Maccario, R.; Avanzini, M. A.; Ubezio, C.; Minelli, A.; Alvisi, C.; Vanoli, A.; Calliada, F.; Dionigi, P.; Perotti, C.; Locatelli, F.; Corazza, G. R. Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease. Gut 60:788-798; 2011
5. Ding, D. C.; Shyu, W. C.; Lin, S. Z. Mesenchymal stem cells. Cell Transplant. 20:5-14; 2011
6. Farmer, R. G.; Hawk, W. A.; Turnbull, Jr., R. B. Clinical patterns in Crohn's disease: A statistical study of 615 cases. Gastroenterology 68:627-635; 1975
7. García-Olmo, D.; García-Arranz, M.; Gomez-García, L.; Cuellar, E. S.; Blanco, I. F.; Prianes, L. A.; Montes, J. A. R.; Pinto, F. L.; Marcos, D. H.; Garcia-Sancho, L. Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease: A new cell-based therapy. Int. J. Colorectal Dis. 18:451-454; 2003
8. García-Olmo, D.; García-Arranz, M.; Herreros, D.; Pascual, I.; Peiro, C.; Rodriguez-Montes, J. A. A Phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis. Colon Rectum 48:1416-1423; 2005
9. Garcia-Olmo, D.; Herreros, D.; De-La-Quintana, P.; Guadalajara, H.; Trebol, J.; Georgiev-Hristov, T.; Garcia- Arranz, M. Adipose-derived stem cells in Crohn's rectovaginal fistula. Case Report Med. 2010:961758; 2010
10. Garcia-Olmo, D.; Herreros, D.; Pascual, I.; Pascual, J. A.; Del-Valle, E.; Zorrilla, J.; De-La-Quintana, P.; Garcia- Arranz, M.; Pascual, M. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: A Phase II clinical trial. Dis. Colon Rectum 52:79-86; 2009
11. Garcia-Olmo, D.; Herreros, D.; Pascual, M.; Pascual, I.; De-La-Quintana, P.; Trebol, J.; Garcia-Arranz, M. Treatment of enterocutaneous fistula in Crohn's disease with adipose-derived stem cells: A comparison of protocols with and without cell expansion. Int. J. Colorectal Dis. 24:27-30; 2009
12. Gimble, J. M.; Guilak, F. Adipose-derived adult stem cells: Isolation, characterization, and differentiation potential. Cytotherapy 5:362-369; 2003
13. Gimble, J. M.; Katz, A. J.; Bunnell, B. A. Adipose-derived stem cells for regenerative medicine. Circ. Res. 100:1249-1260; 2007
14. Greenstein, A. J.; Kark, A. E.; Dreiling, D. A. Crohn's disease of the colon. I. Fistula in Crohn's disease of the colon, classification presenting features and management in 63 patients. Am. J. Gastroenterol. 62:419-429; 1974
15. Kim, M.; Kim, I.; Lee, S. K.; Bang, S. I.; Lim, S. Y. Clinical trial of autologous differentiated adipocytes from stem cells derived from human adipose tissue, Dermatol. Surg. 37(6):750-759; 2011
16. Koperen, P. J.; Safiruddin, F.; Bemelman, W. A.; Slors, J. F. Outcome of surgical treatment for fistula in ano in Crohn's disease. Br. J. Surg. 96:675-679; 2009
17. Le Blanc, K. Mesenchymal stromal cells: Tissue repair and immune modulation. Cytotherapy 8:559-561; 2006
18. Levy, C.; Tremaine, W. J. Management of internal fistulas in Crohn's disease. Inflamm. Bowel Dis. 8:106-111; 2002
19. Maeda, Y.; Heyckendorff-Diebold, T.; Tei, T. M.; Lundby, L.; Buntzen, S. Gracilis muscle transposition for complex fistula and persistent nonhealing sinus in perianal Crohn's disease. Inflamm. Bowel Dis. 17:583-589; 2011
20. Mizuno, H.; Hyakusoku, H. Mesengenic Potential and future clinical perspective of human processed lipoaspirate cells. J. Nippon Med. Sch. 70:300-306; 2003
21. Mizuno, H.; Zuk, P. A.; Zhu, M.; Lorenz, H. P.; Benhaim, P.; Hedrick, M. H. Myogenic differentiation by human processed lipoaspirated cells. Plast. Reconstr. Surg. 109:199-209; 2002
22. Ritchie, R. D.; Sackier, J. M.; Hodde, J. P. Incontinence rates after cutting seton treatment for anal fistula. Colorectal Dis. 11:564-571; 2009
23. Rodriguez, A. M.; Elabd, C.; Amri, E.-Z.; Ailhaud, G.; Dani, C. The human adipose tissue is a source of multipotent stem cells. Biochimie 87:125-128; 2005
24. Schouten, W. R.; Zimmerman, D. D.; Briel, J. W. Transanal advancement flap repair of transsphincteric fistulas. Dis. Colon Rectum 42:1419-1422; 1999
25. Sciaudone, G.; Di Stazio, C.; Limongelli, P.; Guadagni, I.; Pellino, G.; Riegler, G.; Coscione, P.; Selvaggi, F. Treatment of complex perianal fistulas in Crohn disease: Infliximab, surgery or combined approach. Can. J. Surg. 53:299-304; 2010
26. Singh, U. P.; Singh, N. P.; Singh, B.; Mishra, M. K.; Nagarkatti, M.; Nagarkatti, P. S.; Singh, S. R. Stem cells as potential therapeutic targets for inflammatory bowel Disease. Front. Biosci. 2:993-1008; 2010
27. Sonoda, T.; Hull, T.; Piedmonte, M. R.; Fazio, V. W. Outcomes of primary repair of anorectal and rectovaginal fistulas using the endorectal advancement flap. Dis. Colon Rectum 45:1622-1628; 2002
28. Strem, B. M.; Hicok, K. C.; Zhu, M.; Wulur, I.; Alfonso, Z.; Schreiber, R. E.; Fraser, J. K.; Hedrick, M. H. Multipotential differentiation of adipose tissue-derived stem cells. Keio J. Med. 54:132-141; 2005
29. Taxonera, C.; Schwartz, D. A.; García-Olmo, D. Emerging treatments for complex perianal fistula in Crohn's disease. World J. Gastroenterol. 15:4263-4272; 2009
30. Tozer, P. J.; Burling, D.; Gupta, A.; Phillips, R. K.; Hart, A. L. Review article: Medical, surgical and radiological management of perianal Crohn's fistulas. Aliment. Pharmacol. Ther. 33:5-22; 2011
31. Van Assche, G.; Vanbeckevoort, D.; Bielen, D.; Coremans, G.; Aerden, I.; Noman, M.; D'Hoore, A.; Penninckx, F.; Marchal, G.; Cornillie, F.; Rutgeerts, P. Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn's disease. Am. J. Gastroenterol. 98:332-339; 2003
32. Von Heimburg, D.; Hemmrich, K.; Haydarlioglu, S.; Staiger, H.; Pallua, N. Comparison of viable cell yield from excised versus aspirate adipose tissue. Cells Tissues Organs 178:87-92; 2004
33. Whiteford, M. H.; Kilkenny III, J.; Hyman, N.; Buie, W. D.; Cohen, J.; Orsay, C.; Dunn, G.; Perry, W. B.; Ellis, C. N.; Rakinic, J.; Gregorcyk, S.; Shellito, P.; Nelson, R.; Tjandra, J. J.; Newstead, G. Practice parameters for the treatment of perianal abscess and fistula-in-ano (revised). Dis. Colon Rectum 48:1337-1342; 2005
34. Williams, J. G.; MacLeod, C. A.; Rothenberger, D. A.; Goldberg, S. M. Seton treatment of high anal fistulae. Br. J. Surg. 78:1159-1161; 1991
35. Yagi, H.; Soto-Gutierrez, A.; Parekkadan, B.; Kitagawa, Y.; Tompkins, R. G.; Kobayashi, N.; Yarmush, M. L. Mesenchymal stem cells: Mechanisms of immunomodulation and homing. Cell Transplant. 19:667-679; 2010
36. Yoo, K. H.; Jang, I. K.; Lee, M. W.; Kim, H. E.; Yang, M. S.; Eom, Y.; Lee, J. E.; Kim, Y. J.; Yang, S. K.; Jung, H. L.; Sung, K. W.; Kim, C. W.; Koo, H. H. Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues. Cell. Immunol. 259:150-156; 2009
37. Zuk, P. A.; Zhu, M.; Ashjian, P.; De Ugarte, D. A.; Huang, J. I.; Mizuno, H.; Alfonso, Z. C.; Fraser, J. K.; Benhaim, P.; Hedrick, M. H. Human adipose tissue is a source of multipotent stem cells. Mol. Biol. Cell 3:4279-4295; 2002
38. Zuk, P. A.; Zhu, M.; Mizuno, H.; Huang, J.; Futrell, J. W.; Katz, A. J.; Benhaim, P.; Lorenz, H. P.; Hedrick, M. H. Mulitlineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng. 7:211-228; 2001.