-
1
-
-
0036721149
-
Flavonoid intake and risk of chronic diseases
-
Knekt, P., Kumpulainen, J., Jarvinen, R., Rissanen, H. et al., Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 2002, 76, 560-568.
-
(2002)
Am. J. Clin. Nutr.
, vol.76
, pp. 560-568
-
-
Knekt, P.1
Kumpulainen, J.2
Jarvinen, R.3
Rissanen, H.4
-
2
-
-
84865853940
-
Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations
-
Peterson, J. J., Dwyer, J. T., Jacques, P. F., McCullough, M. L., Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations. Nutr. Rev. 2012, 70, 491-508.
-
(2012)
Nutr. Rev.
, vol.70
, pp. 491-508
-
-
Peterson, J.J.1
Dwyer, J.T.2
Jacques, P.F.3
McCullough, M.L.4
-
3
-
-
84927950411
-
Estimated daily intake and seasonal food sources of quercetin in Japan
-
Nishimuro, H., Ohnishi, H., Sato, M., Ohnishi-Kameyama, M. et al., Estimated daily intake and seasonal food sources of quercetin in Japan. Nutrients 2015, 7, 2345-2358.
-
(2015)
Nutrients
, vol.7
, pp. 2345-2358
-
-
Nishimuro, H.1
Ohnishi, H.2
Sato, M.3
Ohnishi-Kameyama, M.4
-
4
-
-
67149116251
-
Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice
-
Kobori, M., Masumoto, S., Akimoto, Y., Takahashi, Y., Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice. Mol. Nutr. Food Res. 2009, 53, 859-868.
-
(2009)
Mol. Nutr. Food Res.
, vol.53
, pp. 859-868
-
-
Kobori, M.1
Masumoto, S.2
Akimoto, Y.3
Takahashi, Y.4
-
5
-
-
79953317030
-
Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice
-
Kobori, M., Masumoto, S., Akimoto, Y., Oike, H., Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice. Mol. Nutr. Food Res. 2011, 55, 530-540.
-
(2011)
Mol. Nutr. Food Res.
, vol.55
, pp. 530-540
-
-
Kobori, M.1
Masumoto, S.2
Akimoto, Y.3
Oike, H.4
-
6
-
-
84901424065
-
Cross-talk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity
-
Huh, J. Y., Park, Y. J., Ham, M., Kim, J. B., Cross-talk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. Mol. Cells 2014, 37, 365-371.
-
(2014)
Mol. Cells
, vol.37
, pp. 365-371
-
-
Huh, J.Y.1
Park, Y.J.2
Ham, M.3
Kim, J.B.4
-
7
-
-
68349150756
-
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K. et al., CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 2009, 15, 914-920.
-
(2009)
Nat. Med.
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
Manabe, I.2
Nagasaki, M.3
Eto, K.4
-
8
-
-
84925627014
-
NK cells link obesity-induced adipose stress to inflammation and insulin resistance
-
Wensveen, F. M., Jelencic, V., Valentic, S., Sestan, M. et al., NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat. Immunol. 2015, 16, 376-385.
-
(2015)
Nat. Immunol.
, vol.16
, pp. 376-385
-
-
Wensveen, F.M.1
Jelencic, V.2
Valentic, S.3
Sestan, M.4
-
9
-
-
0030061922
-
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
-
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R. et al., IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996, 271, 665-668.
-
(1996)
Science
, vol.271
, pp. 665-668
-
-
Hotamisligil, G.S.1
Peraldi, P.2
Budavari, A.3
Ellis, R.4
-
10
-
-
17944365228
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
-
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y. et al., The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 2001, 7, 941-946.
-
(2001)
Nat. Med.
, vol.7
, pp. 941-946
-
-
Yamauchi, T.1
Kamon, J.2
Waki, H.3
Terauchi, Y.4
-
11
-
-
0036081355
-
Gene expression omnibus: NCBI gene expression and hybridization array data repository
-
Edgar, R., Domrachev, M., Lash, A. E., Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 2002, 30, 207-210.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 207-210
-
-
Edgar, R.1
Domrachev, M.2
Lash, A.E.3
-
12
-
-
84929238019
-
Chronic high intake of quercetin reduces oxidative stress and induces expression of the antioxidant enzymes in the liver and visceral adipose tissues in mice
-
Kobori, M., Takahashi, Y., Akimoto, Y., Sakurai, M. et al., Chronic high intake of quercetin reduces oxidative stress and induces expression of the antioxidant enzymes in the liver and visceral adipose tissues in mice. J. Funct. Foods 2015, 15, 551-560.
-
(2015)
J. Funct. Foods
, vol.15
, pp. 551-560
-
-
Kobori, M.1
Takahashi, Y.2
Akimoto, Y.3
Sakurai, M.4
-
13
-
-
0036313033
-
Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory
-
Ruan, H., Hacohen, N., Golub, T. R., Van Parijs, L. et al., Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. Diabetes 2002, 51, 1319-1336.
-
(2002)
Diabetes
, vol.51
, pp. 1319-1336
-
-
Ruan, H.1
Hacohen, N.2
Golub, T.R.3
Van Parijs, L.4
-
14
-
-
84874428240
-
Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin
-
Piya, M. K., McTernan, P. G., Kumar, S., Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin. J. Endocrinol. 2013, 216, T1-T15.
-
(2013)
J. Endocrinol.
, vol.216
, pp. T1-T15
-
-
Piya, M.K.1
McTernan, P.G.2
Kumar, S.3
-
15
-
-
0030615201
-
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases
-
Barnes, P. J., Karin, M., Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. New Engl. J. Med. 1997, 336, 1066-1071.
-
(1997)
New Engl. J. Med.
, vol.336
, pp. 1066-1071
-
-
Barnes, P.J.1
Karin, M.2
-
16
-
-
84862150859
-
A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation
-
Zhuang, G., Meng, C., Guo, X., Cheruku, P. S. et al., A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation 2012, 125, 2892-2903.
-
(2012)
Circulation
, vol.125
, pp. 2892-2903
-
-
Zhuang, G.1
Meng, C.2
Guo, X.3
Cheruku, P.S.4
-
17
-
-
0030036803
-
The Ets protein Spi-B is expressed exclusively in B cells and T cells during development
-
Su, G. H., Ip, H. S., Cobb, B. S., Lu, M. M. et al., The Ets protein Spi-B is expressed exclusively in B cells and T cells during development. J. Exp. Med. 1996, 184, 203-214.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 203-214
-
-
Su, G.H.1
Ip, H.S.2
Cobb, B.S.3
Lu, M.M.4
-
18
-
-
84875280888
-
Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
-
Deng, T., Lyon, C. J., Minze, L. J., Lin, J. et al., Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab. 2013, 17, 411-422.
-
(2013)
Cell Metab.
, vol.17
, pp. 411-422
-
-
Deng, T.1
Lyon, C.J.2
Minze, L.J.3
Lin, J.4
-
19
-
-
84864286000
-
Systemic inflammation and insulin sensitivity in obese IFN-gamma knockout mice
-
O'Rourke, R. W., White, A. E., Metcalf, M. D., Winters, B. R. et al., Systemic inflammation and insulin sensitivity in obese IFN-gamma knockout mice. Metab. Clin. Exp. 2012, 61, 1152-1161.
-
(2012)
Metab. Clin. Exp.
, vol.61
, pp. 1152-1161
-
-
O'Rourke, R.W.1
White, A.E.2
Metcalf, M.D.3
Winters, B.R.4
-
20
-
-
0030864185
-
Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice
-
Ventre, J., Doebber, T., Wu, M., MacNaul, K. et al., Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice. Diabetes 1997, 46, 1526-1531.
-
(1997)
Diabetes
, vol.46
, pp. 1526-1531
-
-
Ventre, J.1
Doebber, T.2
Wu, M.3
MacNaul, K.4
-
21
-
-
54049086276
-
Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity
-
Rocha, V. Z., Folco, E. J., Sukhova, G., Shimizu, K. et al., Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ. Res. 2008, 103, 467-476.
-
(2008)
Circ. Res.
, vol.103
, pp. 467-476
-
-
Rocha, V.Z.1
Folco, E.J.2
Sukhova, G.3
Shimizu, K.4
-
22
-
-
85027938385
-
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
-
Winer, D. A., Winer, S., Shen, L., Wadia, P. P. et al., B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat. Med. 2011, 17, 610-617.
-
(2011)
Nat. Med.
, vol.17
, pp. 610-617
-
-
Winer, D.A.1
Winer, S.2
Shen, L.3
Wadia, P.P.4
-
23
-
-
68349160704
-
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
-
Liu, J., Divoux, A., Sun, J., Zhang, J. et al., Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat. Med. 2009, 15, 940-945.
-
(2009)
Nat. Med.
, vol.15
, pp. 940-945
-
-
Liu, J.1
Divoux, A.2
Sun, J.3
Zhang, J.4
-
24
-
-
84865460082
-
Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver
-
Stefanovic-Racic, M., Yang, X., Turner, M. S., Mantell, B. S. et al., Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver. Diabetes 2012, 61, 2330-2339.
-
(2012)
Diabetes
, vol.61
, pp. 2330-2339
-
-
Stefanovic-Racic, M.1
Yang, X.2
Turner, M.S.3
Mantell, B.S.4
-
25
-
-
84868671526
-
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
-
Talukdar, S., Oh da, Y., Bandyopadhyay, G., Li, D. et al., Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat. Med. 2012, 18, 1407-1412.
-
(2012)
Nat. Med.
, vol.18
, pp. 1407-1412
-
-
Talukdar, S.1
Oh da, Y.2
Bandyopadhyay, G.3
Li, D.4
-
26
-
-
0032740439
-
Cholesterol accumulation in tissues of the Niemann-pick type C mouse is determined by the rate of lipoprotein-cholesterol uptake through the coated-pit pathway in each organ
-
Xie, C., Turley, S. D., Dietschy, J. M., Cholesterol accumulation in tissues of the Niemann-pick type C mouse is determined by the rate of lipoprotein-cholesterol uptake through the coated-pit pathway in each organ. Proc. Natl. Acad. Sci. USA 1999, 96, 11992-11997.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11992-11997
-
-
Xie, C.1
Turley, S.D.2
Dietschy, J.M.3
-
27
-
-
29144510014
-
Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity
-
Wang, M. Y., Orci, L., Ravazzola, M., Unger, R. H., Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity. Proc. Natl. Acad. Sci. USA 2005, 102, 18011-18016.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 18011-18016
-
-
Wang, M.Y.1
Orci, L.2
Ravazzola, M.3
Unger, R.H.4
-
28
-
-
77951630780
-
5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity
-
Horrillo, R., Gonzalez-Periz, A., Martinez-Clemente, M., Lopez-Parra, M. et al., 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity. J. Immunol. 2010, 184, 3978-3987.
-
(2010)
J. Immunol.
, vol.184
, pp. 3978-3987
-
-
Horrillo, R.1
Gonzalez-Periz, A.2
Martinez-Clemente, M.3
Lopez-Parra, M.4
-
29
-
-
84870754011
-
Up-regulation of the complement system in subcutaneous adipocytes from nonobese, hypertriglyceridemic subjects is associated with adipocyte insulin resistance
-
van Greevenbroek, M. M., Ghosh, S., van der Kallen, C. J., Brouwers, M. C. et al., Up-regulation of the complement system in subcutaneous adipocytes from nonobese, hypertriglyceridemic subjects is associated with adipocyte insulin resistance. J. Clin. Endocrinol. Metab. 2012, 97, 4742-4752.
-
(2012)
J. Clin. Endocrinol. Metab.
, vol.97
, pp. 4742-4752
-
-
van Greevenbroek, M.M.1
Ghosh, S.2
van der Kallen, C.J.3
Brouwers, M.C.4
-
30
-
-
70350560546
-
Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice
-
Fujisaka, S., Usui, I., Bukhari, A., Ikutani, M. et al., Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 2009, 58, 2574-2582.
-
(2009)
Diabetes
, vol.58
, pp. 2574-2582
-
-
Fujisaka, S.1
Usui, I.2
Bukhari, A.3
Ikutani, M.4
-
31
-
-
65349188107
-
Different profiles of quercetin metabolites in rat plasma: comparison of two administration methods
-
Kawai, Y., Saito, S., Nishikawa, T., Ishisaka, A. et al., Different profiles of quercetin metabolites in rat plasma: comparison of two administration methods. Biosci. Biotechnol. Biochem. 2009, 73, 517-523.
-
(2009)
Biosci. Biotechnol. Biochem.
, vol.73
, pp. 517-523
-
-
Kawai, Y.1
Saito, S.2
Nishikawa, T.3
Ishisaka, A.4
-
32
-
-
42149109611
-
Influence of the metabolic profile on the in vivo antioxidant activity of quercetin under a low dosage oral regimen in rats
-
Santos, M. R., Rodriguez-Gomez, M. J., Justino, G. C., Charro, N. et al., Influence of the metabolic profile on the in vivo antioxidant activity of quercetin under a low dosage oral regimen in rats. Brit. J. Pharmacol. 2008, 153, 1750-1761.
-
(2008)
Brit. J. Pharmacol.
, vol.153
, pp. 1750-1761
-
-
Santos, M.R.1
Rodriguez-Gomez, M.J.2
Justino, G.C.3
Charro, N.4
-
33
-
-
85030434746
-
Increased oxidative stress in obesity and its impact on metabolic syndrome
-
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M. et al., Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 2004, 114, 1752-1761.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1752-1761
-
-
Furukawa, S.1
Fujita, T.2
Shimabukuro, M.3
Iwaki, M.4
-
34
-
-
33645860825
-
Reactive oxygen species have a causal role in multiple forms of insulin resistance
-
Houstis, N., Rosen, E. D., Lander, E. S., Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440, 944-948.
-
(2006)
Nature
, vol.440
, pp. 944-948
-
-
Houstis, N.1
Rosen, E.D.2
Lander, E.S.3
-
35
-
-
84871309275
-
Oxidative stress and inflammation interactions in human obesity
-
Bondia-Pons, I., Ryan, L., Martinez, J. A., Oxidative stress and inflammation interactions in human obesity. J. Physiol. Biochem. 2012, 68, 701-711.
-
(2012)
J. Physiol. Biochem.
, vol.68
, pp. 701-711
-
-
Bondia-Pons, I.1
Ryan, L.2
Martinez, J.A.3
-
36
-
-
77954859197
-
The role of mitochondria in the pathogenesis of type 2 diabetes
-
Patti, M. E., Corvera, S., The role of mitochondria in the pathogenesis of type 2 diabetes. Endocrine Rev. 2010, 31, 364-395.
-
(2010)
Endocrine Rev.
, vol.31
, pp. 364-395
-
-
Patti, M.E.1
Corvera, S.2
-
37
-
-
84865440201
-
Mitochondrial dysfunction in white adipose tissue
-
Kusminski, C. M., Scherer, P. E., Mitochondrial dysfunction in white adipose tissue. Trends Endocrinol. Metab. 2012, 23, 435-443.
-
(2012)
Trends Endocrinol. Metab.
, vol.23
, pp. 435-443
-
-
Kusminski, C.M.1
Scherer, P.E.2
-
38
-
-
33644821858
-
Mitochondria are impaired in the adipocytes of type 2 diabetic mice
-
Choo, H. J., Kim, J. H., Kwon, O. B., Lee, C. S. et al., Mitochondria are impaired in the adipocytes of type 2 diabetic mice. Diabetologia 2006, 49, 784-791.
-
(2006)
Diabetologia
, vol.49
, pp. 784-791
-
-
Choo, H.J.1
Kim, J.H.2
Kwon, O.B.3
Lee, C.S.4
-
39
-
-
84876012684
-
Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice
-
Ryu, M. J., Kim, S. J., Kim, Y. K., Choi, M. J. et al., Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice. PLoS Genet. 2013, 9, e1003356.
-
(2013)
PLoS Genet.
, vol.9
, pp. e1003356
-
-
Ryu, M.J.1
Kim, S.J.2
Kim, Y.K.3
Choi, M.J.4
-
40
-
-
77950353854
-
SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol
-
Fullerton, M. D., Steinberg, G. R., SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol. Diabetes 2010, 59, 551-553.
-
(2010)
Diabetes
, vol.59
, pp. 551-553
-
-
Fullerton, M.D.1
Steinberg, G.R.2
-
41
-
-
84894815681
-
Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKalpha1/SIRT1
-
Dong, J., Zhang, X., Zhang, L., Bian, H. X. et al., Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKalpha1/SIRT1. J. Lipid Res. 2014, 55, 363-374.
-
(2014)
J. Lipid Res.
, vol.55
, pp. 363-374
-
-
Dong, J.1
Zhang, X.2
Zhang, L.3
Bian, H.X.4
-
42
-
-
84862162100
-
Development of insulin resistance in mice lacking PGC-1alpha in adipose tissues
-
Kleiner, S., Mepani, R. J., Laznik, D., Ye, L. et al., Development of insulin resistance in mice lacking PGC-1alpha in adipose tissues. Proc. Natl. Acad. Sci. USA 2012, 109, 9635-9640.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 9635-9640
-
-
Kleiner, S.1
Mepani, R.J.2
Laznik, D.3
Ye, L.4
-
43
-
-
84899007613
-
Quercetin differently regulates insulin-mediated glucose transporter 4 translocation under basal and inflammatory conditions in adipocytes
-
Xu, M., Hu, J., Zhao, W., Gao, X. et al., Quercetin differently regulates insulin-mediated glucose transporter 4 translocation under basal and inflammatory conditions in adipocytes. Mol. Nutr. Food Res. 2014, 58, 931-941.
-
(2014)
Mol. Nutr. Food Res.
, vol.58
, pp. 931-941
-
-
Xu, M.1
Hu, J.2
Zhao, W.3
Gao, X.4
-
44
-
-
84866104856
-
Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK
-
Shen, Y., Croft, K. D., Hodgson, J. M., Kyle, R. et al., Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK. Biochem. Pharmacol. 2012, 84, 1036-1044.
-
(2012)
Biochem. Pharmacol.
, vol.84
, pp. 1036-1044
-
-
Shen, Y.1
Croft, K.D.2
Hodgson, J.M.3
Kyle, R.4
-
45
-
-
0015423808
-
Effect of age, sex, and sites on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet
-
Lemonnier, D., Effect of age, sex, and sites on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet. J. Clin. Invest. 1972, 51, 2907-2915.
-
(1972)
J. Clin. Invest.
, vol.51
, pp. 2907-2915
-
-
Lemonnier, D.1
|