메뉴 건너뛰기




Volumn 55, Issue 4, 2011, Pages 530-540

Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice

Author keywords

Liver steatosis; Metabolic disorder; Oxidative stress; Quercetin; Western diet

Indexed keywords

GLUTATHIONE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; QUERCETIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL;

EID: 79953317030     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201000392     Document Type: Article
Times cited : (234)

References (50)
  • 3
    • 49149083331 scopus 로고    scopus 로고
    • Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women
    • Heidemann, C., Schulze, M. B., Franco, O. H., van Dam, R. M. et al., Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women. Circulation 2008, 118, 230-237.
    • (2008) Circulation , vol.118 , pp. 230-237
    • Heidemann, C.1    Schulze, M.B.2    Franco, O.H.3    van Dam, R.M.4
  • 4
    • 60749109535 scopus 로고    scopus 로고
    • Dietary total fat intake and ischemic stroke risk: the Northern Manhattan Study
    • Boden-Albala, B., Elkind, M. S., White, H., Szumski, A. et al., Dietary total fat intake and ischemic stroke risk: the Northern Manhattan Study. Neuroepidemiology 2009, 32, 296-301.
    • (2009) Neuroepidemiology , vol.32 , pp. 296-301
    • Boden-Albala, B.1    Elkind, M.S.2    White, H.3    Szumski, A.4
  • 5
    • 34248393099 scopus 로고    scopus 로고
    • High-fat diets: modeling the metabolic disorders of human obesity in rodents
    • Buettner, R., Scholmerich, J., Bollheimer, L. C., High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring) 2007, 15, 798-808.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 798-808
    • Buettner, R.1    Scholmerich, J.2    Bollheimer, L.C.3
  • 6
    • 60049092956 scopus 로고    scopus 로고
    • Consumption of sugars and body weight
    • van Baak, M. A., Astrup, A., Consumption of sugars and body weight. Obes. Rev. 2009, 10, 9-23.
    • (2009) Obes. Rev. , vol.10 , pp. 9-23
    • van Baak, M.A.1    Astrup, A.2
  • 7
    • 33847789892 scopus 로고    scopus 로고
    • Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women
    • Mink, P. J., Scrafford, C. G., Barraj, L. M., Harnack, L. et al., Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am. J. Clin. Nutr. 2007, 85, 895-909.
    • (2007) Am. J. Clin. Nutr. , vol.85 , pp. 895-909
    • Mink, P.J.1    Scrafford, C.G.2    Barraj, L.M.3    Harnack, L.4
  • 8
    • 12844272321 scopus 로고    scopus 로고
    • Polyphenols and disease risk in epidemiologic studies
    • Arts, I. C., Hollman, P. C., Polyphenols and disease risk in epidemiologic studies. Am. J. Clin. Nutr. 2005, 81, 317S-325S.
    • (2005) Am. J. Clin. Nutr. , vol.81
    • Arts, I.C.1    Hollman, P.C.2
  • 9
    • 49449116265 scopus 로고    scopus 로고
    • Tea, flavonoids, and nitric oxide-mediated vascular reactivity
    • Grassi, D., Aggio, A., Onori, L., Croce, G. et al., Tea, flavonoids, and nitric oxide-mediated vascular reactivity. J. Nutr. 2008, 138, 1554S-1560S.
    • (2008) J. Nutr. , vol.138
    • Grassi, D.1    Aggio, A.2    Onori, L.3    Croce, G.4
  • 10
    • 34247201439 scopus 로고    scopus 로고
    • Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation
    • Dufour, C., Loonis, M., Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. Biochim. Biophys. Acta 2007, 1770, 958-965.
    • (2007) Biochim. Biophys. Acta , vol.1770 , pp. 958-965
    • Dufour, C.1    Loonis, M.2
  • 11
    • 80051828975 scopus 로고    scopus 로고
    • Influence of dietary quercetin on glutathione redox status in mice
    • Meyers, K. J., Rudolf, J. L., Mitchell, A. E., Influence of dietary quercetin on glutathione redox status in mice. J. Agric. Food Chem. 2008, 56, 830-836.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 830-836
    • Meyers, K.J.1    Rudolf, J.L.2    Mitchell, A.E.3
  • 12
    • 67149116251 scopus 로고    scopus 로고
    • Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice
    • Kobori, M., Masumoto, S., Akimoto, Y., Takahashi, Y., Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice. Mol. Nutr. Food Res. 2009, 53, 859-868.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 859-868
    • Kobori, M.1    Masumoto, S.2    Akimoto, Y.3    Takahashi, Y.4
  • 13
    • 0032544087 scopus 로고    scopus 로고
    • Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein
    • Conseil, G., Baubichon-Cortay, H., Dayan, G., Jault, J. M. et al., Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein. Proc. Natl. Acad. Sci. USA 1998, 95, 9831-9836.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9831-9836
    • Conseil, G.1    Baubichon-Cortay, H.2    Dayan, G.3    Jault, J.M.4
  • 14
    • 0026755773 scopus 로고
    • Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids
    • Hosokawa, N., Hirayoshi, K., Kudo, H., Takechi, H. et al., Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. Mol. Cell. Biol. 1992, 12, 3490-3498.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 3490-3498
    • Hosokawa, N.1    Hirayoshi, K.2    Kudo, H.3    Takechi, H.4
  • 15
    • 34249804783 scopus 로고    scopus 로고
    • Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture
    • van Meeuwen, J. A., Korthagen, N., de Jong, P. C., Piersma, A. H., van den Berg, M., (Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture. Toxicol. Appl. Pharmacol. 2007, 221, 372-383.
    • (2007) Toxicol. Appl. Pharmacol. , vol.221 , pp. 372-383
    • van Meeuwen, J.A.1    Korthagen, N.2    de Jong, P.C.3    Piersma, A.H.4    van den Berg, M.5
  • 16
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W. et al., Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003, 425, 191-196.
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3    Lamming, D.W.4
  • 17
    • 50649107938 scopus 로고    scopus 로고
    • Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
    • Rivera, L., Moron, R., Sanchez, M., Zarzuelo, A., Galisteo, M., Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring) 2008, 16, 2081-2087.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 2081-2087
    • Rivera, L.1    Moron, R.2    Sanchez, M.3    Zarzuelo, A.4    Galisteo, M.5
  • 18
    • 59449098776 scopus 로고    scopus 로고
    • Failure of dietary quercetin to alter the temporal progression of insulin resistance among tissues of C57BL/6J mice during the development of diet-induced obesity
    • Stewart, L. K., Wang, Z., Ribnicky, D., Soileau, J. L. et al., Failure of dietary quercetin to alter the temporal progression of insulin resistance among tissues of C57BL/6J mice during the development of diet-induced obesity. Diabetologia 2009, 52, 514-523.
    • (2009) Diabetologia , vol.52 , pp. 514-523
    • Stewart, L.K.1    Wang, Z.2    Ribnicky, D.3    Soileau, J.L.4
  • 19
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • Harwood, M., Danielewska-Nikiel, B., Borzelleca, J. F., Flamm, G. W. et al., A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem. Toxicol. 2007, 45, 2179-2205.
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4
  • 20
    • 22144495044 scopus 로고    scopus 로고
    • Tissue distribution of quercetin in rats and pigs
    • de Boer, V. C., Dihal, A. A., van der Woude, H., Arts, I. C. et al., Tissue distribution of quercetin in rats and pigs. J. Nutr. 2005, 135, 1718-1725.
    • (2005) J. Nutr. , vol.135 , pp. 1718-1725
    • de Boer, V.C.1    Dihal, A.A.2    van der Woude, H.3    Arts, I.C.4
  • 21
    • 69949089784 scopus 로고    scopus 로고
    • Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program
    • Radonjic, M., de Haan, J. R., van Erk, M. J., van Dijk, K. W. et al., Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program. PLoS One 2009, 4, e6646.
    • (2009) PLoS One , vol.4
    • Radonjic, M.1    de Haan, J.R.2    van Erk, M.J.3    van Dijk, K.W.4
  • 22
    • 59249098656 scopus 로고    scopus 로고
    • Oxidative stress in rats fed a high-fat high-sucrose diet and preventive effect of polyphenols: Involvement of mitochondrial and NAD(P)H oxidase systems
    • Feillet-Coudray, C., Sutra, T., Fouret, G., Ramos, J. et al., Oxidative stress in rats fed a high-fat high-sucrose diet and preventive effect of polyphenols: Involvement of mitochondrial and NAD(P)H oxidase systems. Free Radic. Biol. Med. 2009, 46, 624-632.
    • (2009) Free Radic. Biol. Med. , vol.46 , pp. 624-632
    • Feillet-Coudray, C.1    Sutra, T.2    Fouret, G.3    Ramos, J.4
  • 23
    • 40949141493 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases
    • Mantena, S. K., King, A. L., Andringa, K. K., Eccleston, H. B., Bailey, S. M., Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases. Free Radic. Biol. Med. 2008, 44, 1259-1272.
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 1259-1272
    • Mantena, S.K.1    King, A.L.2    Andringa, K.K.3    Eccleston, H.B.4    Bailey, S.M.5
  • 24
    • 18144444592 scopus 로고    scopus 로고
    • Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis
    • Perez-Carreras, M., Del Hoyo, P., Martin, M. A., Rubio, J. C. et al., Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 2003, 38, 999-1007.
    • (2003) Hepatology , vol.38 , pp. 999-1007
    • Perez-Carreras, M.1    Del Hoyo, P.2    Martin, M.A.3    Rubio, J.C.4
  • 25
    • 33845542363 scopus 로고    scopus 로고
    • Weight gain induced by high-fat feeding involves increased liver oxidative stress
    • Milagro, F. I., Campion, J., Martinez, J. A., Weight gain induced by high-fat feeding involves increased liver oxidative stress. Obesity (Silver Spring) 2006, 14, 1118-1123.
    • (2006) Obesity (Silver Spring) , vol.14 , pp. 1118-1123
    • Milagro, F.I.1    Campion, J.2    Martinez, J.A.3
  • 26
    • 33750562169 scopus 로고    scopus 로고
    • Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome
    • Fujita, K., Nishizawa, H., Funahashi, T., Shimomura, I., Shimabukuro, M., Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome. Circ. J. 2006, 70, 1437-1442.
    • (2006) Circ. J. , vol.70 , pp. 1437-1442
    • Fujita, K.1    Nishizawa, H.2    Funahashi, T.3    Shimomura, I.4    Shimabukuro, M.5
  • 27
    • 15444366991 scopus 로고    scopus 로고
    • Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation
    • Dandona, P., Aljada, A., Chaudhuri, A., Mohanty, P., Garg, R., Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005, 111, 1448-1454.
    • (2005) Circulation , vol.111 , pp. 1448-1454
    • Dandona, P.1    Aljada, A.2    Chaudhuri, A.3    Mohanty, P.4    Garg, R.5
  • 28
    • 50949102655 scopus 로고    scopus 로고
    • Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance
    • Kumashiro, N., Tamura, Y., Uchida, T., Ogihara, T. et al., Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance. Diabetes 2008, 57, 2083-2091.
    • (2008) Diabetes , vol.57 , pp. 2083-2091
    • Kumashiro, N.1    Tamura, Y.2    Uchida, T.3    Ogihara, T.4
  • 29
    • 62749172933 scopus 로고    scopus 로고
    • Insulin resistance and steatosis in humans
    • Capeau, J., Insulin resistance and steatosis in humans. Diabetes Metab. 2008, 34, 649-657.
    • (2008) Diabetes Metab. , vol.34 , pp. 649-657
    • Capeau, J.1
  • 30
    • 51449123847 scopus 로고    scopus 로고
    • Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells
    • Sekiya, M., Hiraishi, A., Touyama, M., Sakamoto, K., Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells. Biochem. Biophys. Res. Commun. 2008, 375, 602-607.
    • (2008) Biochem. Biophys. Res. Commun. , vol.375 , pp. 602-607
    • Sekiya, M.1    Hiraishi, A.2    Touyama, M.3    Sakamoto, K.4
  • 31
    • 37349073710 scopus 로고    scopus 로고
    • Effects of cysteine-containing compounds on biosynthesis of triacylglycerol and cholesterol and anti-oxidative protection in liver from mice consuming a high-fat diet
    • Lin, C. C., Yin, M. C., Effects of cysteine-containing compounds on biosynthesis of triacylglycerol and cholesterol and anti-oxidative protection in liver from mice consuming a high-fat diet. Br. J. Nutr. 2008, 99, 37-43.
    • (2008) Br. J. Nutr. , vol.99 , pp. 37-43
    • Lin, C.C.1    Yin, M.C.2
  • 32
    • 69249239041 scopus 로고    scopus 로고
    • SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats
    • Aragno, M., Tomasinelli, C. E., Vercellinatto, I., Catalano, M. G. et al., SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats. Free Radic. Biol. Med. 2009, 47, 1067-1074.
    • (2009) Free Radic. Biol. Med. , vol.47 , pp. 1067-1074
    • Aragno, M.1    Tomasinelli, C.E.2    Vercellinatto, I.3    Catalano, M.G.4
  • 33
    • 33749349202 scopus 로고    scopus 로고
    • Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
    • Zang, M., Xu, S., Maitland-Toolan, K. A., Zuccollo, A. et al., Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 2006, 55, 2180-2191.
    • (2006) Diabetes , vol.55 , pp. 2180-2191
    • Zang, M.1    Xu, S.2    Maitland-Toolan, K.A.3    Zuccollo, A.4
  • 34
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning, J. D., Horton, J. D., Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest. 2004, 114, 147-152.
    • (2004) J. Clin. Invest. , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 35
    • 77954652820 scopus 로고    scopus 로고
    • Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea
    • Eid, H. M., Martineau, L. C., Saleem, A., Muhammad, A. et al., Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea. Mol. Nutr. Food Res. 2010, 54, 991-1003.
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 991-1003
    • Eid, H.M.1    Martineau, L.C.2    Saleem, A.3    Muhammad, A.4
  • 36
    • 48949115243 scopus 로고    scopus 로고
    • The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
    • Ahn, J., Lee, H., Kim, S., Park, J., Ha, T., The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem. Biophys. Res. Commun. 2008, 373, 545-549.
    • (2008) Biochem. Biophys. Res. Commun. , vol.373 , pp. 545-549
    • Ahn, J.1    Lee, H.2    Kim, S.3    Park, J.4    Ha, T.5
  • 37
    • 0033549840 scopus 로고    scopus 로고
    • Drug treatment of lipid disorders
    • Knopp, R. H., Drug treatment of lipid disorders. N. Engl. J. Med. 1999, 341, 498-511.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 498-511
    • Knopp, R.H.1
  • 38
    • 0034713444 scopus 로고    scopus 로고
    • Roles of PPARs in health and disease
    • Kersten, S., Desvergne, B., Wahli, W., Roles of PPARs in health and disease. Nature 2000, 405, 421-424.
    • (2000) Nature , vol.405 , pp. 421-424
    • Kersten, S.1    Desvergne, B.2    Wahli, W.3
  • 39
    • 0348049842 scopus 로고    scopus 로고
    • Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling
    • Le Marchand-Brustel, Y., Gual, P., Gremeaux, T., Gonzalez, T. et al., Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling. Biochem. Soc. Trans. 2003, 31, 1152-1156.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 1152-1156
    • Le Marchand-Brustel, Y.1    Gual, P.2    Gremeaux, T.3    Gonzalez, T.4
  • 40
    • 0346003777 scopus 로고    scopus 로고
    • Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression
    • Yu, S., Matsusue, K., Kashireddy, P., Cao, W. Q. et al., Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. J. Biol. Chem. 2003, 278, 498-505.
    • (2003) J. Biol. Chem. , vol.278 , pp. 498-505
    • Yu, S.1    Matsusue, K.2    Kashireddy, P.3    Cao, W.Q.4
  • 41
    • 24344468717 scopus 로고    scopus 로고
    • Increased expression of PPAR gamma in high fat diet-induced liver steatosis in mice
    • Inoue, M., Ohtake, T., Motomura, W., Takahashi, N. et al., Increased expression of PPAR gamma in high fat diet-induced liver steatosis in mice. Biochem. Biophys. Res. Commun. 2005, 336, 215-222.
    • (2005) Biochem. Biophys. Res. Commun. , vol.336 , pp. 215-222
    • Inoue, M.1    Ohtake, T.2    Motomura, W.3    Takahashi, N.4
  • 42
    • 50949085716 scopus 로고    scopus 로고
    • Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice
    • Gomez-Valades, A. G., Mendez-Lucas, A., Vidal-Alabro, A., Blasco, F. X. et al., Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice. Diabetes 2008, 57, 2199-2210.
    • (2008) Diabetes , vol.57 , pp. 2199-2210
    • Gomez-Valades, A.G.1    Mendez-Lucas, A.2    Vidal-Alabro, A.3    Blasco, F.X.4
  • 43
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • Kadowaki, T., Yamauchi, T., Adiponectin and adiponectin receptors. Endocr. Rev. 2005, 26, 439-451.
    • (2005) Endocr. Rev. , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 44
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki, T., Yamauchi, T., Kubota, N., Hara, K. et al., Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest. 2006, 116, 1784-1792.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4
  • 45
    • 85030434746 scopus 로고    scopus 로고
    • Increased oxidative stress in obesity and its impact on metabolic syndrome
    • Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M. et al., Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 2004, 114, 1752-1761.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1752-1761
    • Furukawa, S.1    Fujita, T.2    Shimabukuro, M.3    Iwaki, M.4
  • 46
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis, N., Rosen, E. D., Lander, E. S., Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440, 944-948.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 47
    • 77952049390 scopus 로고    scopus 로고
    • The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease
    • Polyzos, S. A., Kountouras, J., Zavos, C., Tsiaousi, E., The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease. Diabetes Obes. Metab. 12, 365-383.
    • Diabetes Obes. Metab. , vol.12 , pp. 365-383
    • Polyzos, S.A.1    Kountouras, J.2    Zavos, C.3    Tsiaousi, E.4
  • 48
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil, G. S., Shargill, N. S., Spiegelman, B. M., Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259, 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 49
    • 0035988185 scopus 로고    scopus 로고
    • Alterations of insulin sensitivity by the implantation of 3T3-L1 cells in nude mice. A role for TNF-alpha?
    • Shibasaki, M., Takahashi, K., Itou, T., Miyazawa, S. et al., Alterations of insulin sensitivity by the implantation of 3T3-L1 cells in nude mice. A role for TNF-alpha? Diabetologia 2002, 45, 518-526.
    • (2002) Diabetologia , vol.45 , pp. 518-526
    • Shibasaki, M.1    Takahashi, K.2    Itou, T.3    Miyazawa, S.4
  • 50
    • 33645509490 scopus 로고    scopus 로고
    • Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol
    • Osada, K., Suzuki, T., Kawakami, Y., Senda, M. et al., Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol. Lipids 2006, 41, 133-139.
    • (2006) Lipids , vol.41 , pp. 133-139
    • Osada, K.1    Suzuki, T.2    Kawakami, Y.3    Senda, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.