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Volumn 7, Issue 1, 2017, Pages 132-143

Chromatin remodeling factor LSH is upregulated by the LRP6-GSK3β-E2F1 axis linking reversely with survival in gliomas

Author keywords

Astrocytomas; E2F1; Gioblastoma; GSK3 ; LRP6; LSH

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; HELICASE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LYMPHOID SPECIFIC HELICASE; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; DNA HELICASE; E2F1 PROTEIN, HUMAN; GSK3B PROTEIN, HUMAN; HELLS PROTEIN, HUMAN; LRP6 PROTEIN, HUMAN;

EID: 84999750706     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.17032     Document Type: Article
Times cited : (57)

References (55)
  • 1
    • 77952555038 scopus 로고    scopus 로고
    • Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma
    • Van Meir EG, Hadjipanayis CG, Norden AD, et al. Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma. CA Cancer J Clin 2010; 60: 166-193.
    • (2010) CA Cancer J Clin , vol.60 , pp. 166-193
    • Van Meir, E.G.1    Hadjipanayis, C.G.2    Norden, A.D.3
  • 2
    • 84897019565 scopus 로고    scopus 로고
    • Glioblastoma: from molecular pathology to targeted treatment
    • Cloughesy TF, Cavenee WK, Mischel PS. Glioblastoma: from molecular pathology to targeted treatment. Annu Rev Pathol 2014; 9: 1-25.
    • (2014) Annu Rev Pathol , vol.9 , pp. 1-25
    • Cloughesy, T.F.1    Cavenee, W.K.2    Mischel, P.S.3
  • 3
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 2009; 10: 459-466.
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3
  • 4
    • 84936845832 scopus 로고    scopus 로고
    • Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide
    • Messaoudi K, Clavreul A, Lagarce F. Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide. Drug Discov Today 2015; 20: 899-905.
    • (2015) Drug Discov Today , vol.20 , pp. 899-905
    • Messaoudi, K.1    Clavreul, A.2    Lagarce, F.3
  • 5
    • 84939935260 scopus 로고    scopus 로고
    • Nanomedicine to overcome radioresistance in glioblastoma stem-like cells and surviving clones
    • Sehedic D, Cikankowitz A, Hindre F, et al. Nanomedicine to overcome radioresistance in glioblastoma stem-like cells and surviving clones. Trends Pharmacol Sci 2015; 36: 236-252.
    • (2015) Trends Pharmacol Sci , vol.36 , pp. 236-252
    • Sehedic, D.1    Cikankowitz, A.2    Hindre, F.3
  • 6
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987-996.
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 7
    • 84942307003 scopus 로고    scopus 로고
    • DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors
    • Mazor T, Pankov A, Johnson BE, et al. DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors. Cancer Cell 2015; 28: 307-317.
    • (2015) Cancer Cell , vol.28 , pp. 307-317
    • Mazor, T.1    Pankov, A.2    Johnson, B.E.3
  • 8
    • 84955561447 scopus 로고    scopus 로고
    • Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
    • Ceccarelli M, Barthel FP, Malta TM, et al. Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. Cell 2016; 164: 550-563.
    • (2016) Cell , vol.164 , pp. 550-563
    • Ceccarelli, M.1    Barthel, F.P.2    Malta, T.M.3
  • 9
    • 84873362485 scopus 로고    scopus 로고
    • Intrinsic molecular subtypes of glioma are prognostic and predict benefit from adjuvant procarbazine, lomustine, and vincristine chemotherapy in combination with other prognostic factors in anaplastic oligodendroglial brain tumors: a report from EORTC study 26951
    • Erdem-Eraslan L, Gravendeel LA, de Rooi J, et al. Intrinsic molecular subtypes of glioma are prognostic and predict benefit from adjuvant procarbazine, lomustine, and vincristine chemotherapy in combination with other prognostic factors in anaplastic oligodendroglial brain tumors: a report from EORTC study 26951. J Clin Oncol 2013; 31: 328-336.
    • (2013) J Clin Oncol , vol.31 , pp. 328-336
    • Erdem-Eraslan, L.1    Gravendeel, L.A.2    de Rooi, J.3
  • 10
    • 84932628860 scopus 로고    scopus 로고
    • Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
    • Cancer Genome Atlas Research N, Brat DJ, Verhaak RG, et al. Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med 2015; 372: 2481-2498.
    • (2015) N Engl J Med , vol.372 , pp. 2481-2498
    • Cancer Genome Atlas Research, N.1    Brat, D.J.2    Verhaak, R.G.3
  • 11
    • 84932649039 scopus 로고    scopus 로고
    • Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors
    • Eckel-Passow JE, Lachance DH, Molinaro AM, et al. Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. N Engl J Med 2015; 372: 2499-2508.
    • (2015) N Engl J Med , vol.372 , pp. 2499-2508
    • Eckel-Passow, J.E.1    Lachance, D.H.2    Molinaro, A.M.3
  • 12
    • 79959653996 scopus 로고    scopus 로고
    • SWI/SNF nucleosome remodellers and cancer
    • Wilson BG, Roberts CW. SWI/SNF nucleosome remodellers and cancer. Nat Rev Cancer 2011; 11: 481-492.
    • (2011) Nat Rev Cancer , vol.11 , pp. 481-492
    • Wilson, B.G.1    Roberts, C.W.2
  • 13
    • 84875741680 scopus 로고    scopus 로고
    • The Arabidopsis nucleosome remodeler DDM1 allows DNA methyltransferases to access H1-containing heterochromatin
    • Zemach A, Kim MY, Hsieh PH, et al. The Arabidopsis nucleosome remodeler DDM1 allows DNA methyltransferases to access H1-containing heterochromatin. Cell 2013; 153: 193-205.
    • (2013) Cell , vol.153 , pp. 193-205
    • Zemach, A.1    Kim, M.Y.2    Hsieh, P.H.3
  • 14
    • 84907550669 scopus 로고    scopus 로고
    • Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways
    • Yu W, McIntosh C, Lister R, et al. Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways. Genome Res 2014; 24: 1613-1623.
    • (2014) Genome Res , vol.24 , pp. 1613-1623
    • Yu, W.1    McIntosh, C.2    Lister, R.3
  • 15
    • 79954993753 scopus 로고    scopus 로고
    • Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences
    • Tao Y, Xi S, Shan J, et al. Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences. Proc Natl Acad Sci U S A 2011; 108: 5626-5631.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5626-5631
    • Tao, Y.1    Xi, S.2    Shan, J.3
  • 16
    • 78651521292 scopus 로고    scopus 로고
    • LSH and G9a/GLP complex are required for developmentally programmed DNA methylation
    • Myant K, Termanis A, Sundaram AY, et al. LSH and G9a/GLP complex are required for developmentally programmed DNA methylation. Genome Res 2011; 21: 83-94.
    • (2011) Genome Res , vol.21 , pp. 83-94
    • Myant, K.1    Termanis, A.2    Sundaram, A.Y.3
  • 17
    • 0043136702 scopus 로고    scopus 로고
    • Lsh-deficient murine embryonal fibroblasts show reduced proliferation with signs of abnormal mitosis
    • Fan T, Yan Q, Huang J, et al. Lsh-deficient murine embryonal fibroblasts show reduced proliferation with signs of abnormal mitosis. Cancer Res 2003; 63: 4677-4683.
    • (2003) Cancer Res , vol.63 , pp. 4677-4683
    • Fan, T.1    Yan, Q.2    Huang, J.3
  • 18
    • 84873560971 scopus 로고    scopus 로고
    • The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells
    • Burrage J, Termanis A, Geissner A, et al. The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells. J Cell Sci 2012; 125: 5524-5534.
    • (2012) J Cell Sci , vol.125 , pp. 5524-5534
    • Burrage, J.1    Termanis, A.2    Geissner, A.3
  • 19
    • 79551607574 scopus 로고    scopus 로고
    • DeltaNp63alpha is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis
    • Keyes WM, Pecoraro M, Aranda V, et al. DeltaNp63alpha is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell 2011; 8: 164-176.
    • (2011) Cell Stem Cell , vol.8 , pp. 164-176
    • Keyes, W.M.1    Pecoraro, M.2    Aranda, V.3
  • 20
    • 84857048728 scopus 로고    scopus 로고
    • The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation
    • von Eyss B, Maaskola J, Memczak S, et al. The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation. EMBO J 2012; 31: 972-985.
    • (2012) EMBO J , vol.31 , pp. 972-985
    • von Eyss, B.1    Maaskola, J.2    Memczak, S.3
  • 21
    • 84899081951 scopus 로고    scopus 로고
    • CG hypomethylation in Lsh-/-mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity
    • Yu W, Briones V, Lister R, et al. CG hypomethylation in Lsh-/-mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity. Proc Natl Acad Sci U S A 2014; 111: 5890-5895.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 5890-5895
    • Yu, W.1    Briones, V.2    Lister, R.3
  • 22
    • 35248864084 scopus 로고    scopus 로고
    • Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression
    • Ryu B, Kim DS, Deluca AM, et al. Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PLoS One 2007; 2: e594.
    • (2007) PLoS One , vol.2
    • Ryu, B.1    Kim, D.S.2    Deluca, A.M.3
  • 23
    • 84989928165 scopus 로고    scopus 로고
    • Chromatin remodeling factor LSH drives cancer progression by suppressing the activity of fumarate hydratase
    • He X, Yan B, Liu S, et al. Chromatin remodeling factor LSH drives cancer progression by suppressing the activity of fumarate hydratase. Cancer Res 2016.
    • (2016) Cancer Res
    • He, X.1    Yan, B.2    Liu, S.3
  • 25
    • 84883110364 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta (GSK-3beta) and its dysregulation in glioblastoma multiforme
    • Atkins RJ, Stylli SS, Luwor RB, et al. Glycogen synthase kinase-3beta (GSK-3beta) and its dysregulation in glioblastoma multiforme. J Clin Neurosci 2013; 20: 1185-1192.
    • (2013) J Clin Neurosci , vol.20 , pp. 1185-1192
    • Atkins, R.J.1    Stylli, S.S.2    Luwor, R.B.3
  • 26
    • 84861307078 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta, NF-kappaB signaling, and tumorigenesis of human osteosarcoma
    • Tang QL, Xie XB, Wang J, et al. Glycogen synthase kinase-3beta, NF-kappaB signaling, and tumorigenesis of human osteosarcoma. J Natl Cancer Inst 2012; 104: 749-763.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 749-763
    • Tang, Q.L.1    Xie, X.B.2    Wang, J.3
  • 27
    • 0035875098 scopus 로고    scopus 로고
    • Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition
    • Dajani R, Fraser E, Roe SM, et al. Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. Cell 2001; 105: 721-732.
    • (2001) Cell , vol.105 , pp. 721-732
    • Dajani, R.1    Fraser, E.2    Roe, S.M.3
  • 28
    • 33847287210 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity
    • Garcia-Alvarez G, Ventura V, Ros O, et al. Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity. Biochim Biophys Acta 2007; 1773: 375-382.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 375-382
    • Garcia-Alvarez, G.1    Ventura, V.2    Ros, O.3
  • 29
    • 52949093102 scopus 로고    scopus 로고
    • E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8
    • Morris EJ, Ji JY, Yang F, et al. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature 2008; 455: 552-556.
    • (2008) Nature , vol.455 , pp. 552-556
    • Morris, E.J.1    Ji, J.Y.2    Yang, F.3
  • 30
    • 0742324404 scopus 로고    scopus 로고
    • Life and death decisions by E2F-1
    • Bell LA, Ryan KM. Life and death decisions by E2F-1. Cell Death Differ 2004; 11: 137-142.
    • (2004) Cell Death Differ , vol.11 , pp. 137-142
    • Bell, L.A.1    Ryan, K.M.2
  • 31
    • 70349437076 scopus 로고    scopus 로고
    • p53 and E2f: partners in life and death
    • Polager S, Ginsberg D. p53 and E2f: partners in life and death. Nat Rev Cancer 2009; 9: 738-748.
    • (2009) Nat Rev Cancer , vol.9 , pp. 738-748
    • Polager, S.1    Ginsberg, D.2
  • 32
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127: 469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 33
    • 84898749421 scopus 로고    scopus 로고
    • Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6
    • Stamos JL, Chu ML, Enos MD, et al. Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife 2014; 3: e01998.
    • (2014) Elife , vol.3
    • Stamos, J.L.1    Chu, M.L.2    Enos, M.D.3
  • 34
    • 85047290468 scopus 로고    scopus 로고
    • Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3beta-Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System
    • Cheng PW, Chen YY, Cheng WH, et al. Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3beta-Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System. Diabetes 2015; 64: 3413-3424.
    • (2015) Diabetes , vol.64 , pp. 3413-3424
    • Cheng, P.W.1    Chen, Y.Y.2    Cheng, W.H.3
  • 35
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: components, mechanisms, and diseases
    • MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009; 17: 9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 36
    • 80755186530 scopus 로고    scopus 로고
    • Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling
    • Chen S, Bubeck D, MacDonald BT, et al. Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling. Dev Cell 2011; 21: 848-861.
    • (2011) Dev Cell , vol.21 , pp. 848-861
    • Chen, S.1    Bubeck, D.2    MacDonald, B.T.3
  • 37
    • 84871846692 scopus 로고    scopus 로고
    • WNT signalling pathways as therapeutic targets in cancer
    • Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 2013; 13: 11-26.
    • (2013) Nat Rev Cancer , vol.13 , pp. 11-26
    • Anastas, J.N.1    Moon, R.T.2
  • 38
    • 84949624399 scopus 로고    scopus 로고
    • Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8
    • Jiang Y, Yan B, Lai W, et al. Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8. Oncogene 2015; 34: 6079-6091.
    • (2015) Oncogene , vol.34 , pp. 6079-6091
    • Jiang, Y.1    Yan, B.2    Lai, W.3
  • 39
    • 84865346500 scopus 로고    scopus 로고
    • Nuclear epidermal growth factor receptor interacts with transcriptional intermediary factor 2 to activate cyclin D1 gene expression triggered by the oncoprotein latent membrane protein 1
    • Shi Y, Tao Y, Jiang Y, et al. Nuclear epidermal growth factor receptor interacts with transcriptional intermediary factor 2 to activate cyclin D1 gene expression triggered by the oncoprotein latent membrane protein 1. Carcinogenesis 2012; 33: 1468-1478.
    • (2012) Carcinogenesis , vol.33 , pp. 1468-1478
    • Shi, Y.1    Tao, Y.2    Jiang, Y.3
  • 40
    • 78650656329 scopus 로고    scopus 로고
    • Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling?
    • Voskas D, Ling LS, Woodgett JR. Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling? F1000 Biol Rep 2010; 2: 82.
    • (2010) F1000 Biol Rep , vol.2 , pp. 82
    • Voskas, D.1    Ling, L.S.2    Woodgett, J.R.3
  • 41
    • 84936774638 scopus 로고    scopus 로고
    • The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences
    • Ren J, Briones V, Barbour S, et al. The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences. Nucleic Acids Res 2015; 43: 1444-1455.
    • (2015) Nucleic Acids Res , vol.43 , pp. 1444-1455
    • Ren, J.1    Briones, V.2    Barbour, S.3
  • 42
    • 4644250896 scopus 로고    scopus 로고
    • Lsh, an epigenetic guardian of repetitive elements
    • Huang J, Fan T, Yan Q, et al. Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Res 2004; 32: 5019-5028.
    • (2004) Nucleic Acids Res , vol.32 , pp. 5019-5028
    • Huang, J.1    Fan, T.2    Yan, Q.3
  • 43
    • 0141628697 scopus 로고    scopus 로고
    • Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin
    • Yan Q, Cho E, Lockett S, et al. Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin. Mol Cell Biol 2003; 23: 8416-8428.
    • (2003) Mol Cell Biol , vol.23 , pp. 8416-8428
    • Yan, Q.1    Cho, E.2    Lockett, S.3
  • 44
    • 84872012864 scopus 로고    scopus 로고
    • Genome-wide distribution of DNA methylation and DNA demethylation and related chromatin regulators in cancer
    • Jiang Y, Liu S, Chen X, et al. Genome-wide distribution of DNA methylation and DNA demethylation and related chromatin regulators in cancer. Biochim Biophys Acta 2013; 1835: 155-163.
    • (2013) Biochim Biophys Acta , vol.1835 , pp. 155-163
    • Jiang, Y.1    Liu, S.2    Chen, X.3
  • 45
    • 84871756779 scopus 로고    scopus 로고
    • Interplay between chromatin modifications and paused RNA polymerase II in dynamic transition between stalled and activated genes
    • Liu S, Tao Y. Interplay between chromatin modifications and paused RNA polymerase II in dynamic transition between stalled and activated genes. Biol Rev Camb Philos Soc 2013; 88: 40-48.
    • (2013) Biol Rev Camb Philos Soc , vol.88 , pp. 40-48
    • Liu, S.1    Tao, Y.2
  • 46
    • 84901811688 scopus 로고    scopus 로고
    • Playing TETris with DNA modifications
    • Delatte B, Deplus R, Fuks F. Playing TETris with DNA modifications. EMBO J 2014; 33: 1198-1211.
    • (2014) EMBO J , vol.33 , pp. 1198-1211
    • Delatte, B.1    Deplus, R.2    Fuks, F.3
  • 47
    • 84879235514 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine: generation, fate, and genomic distribution
    • Shen L, Zhang Y. 5-Hydroxymethylcytosine: generation, fate, and genomic distribution. Curr Opin Cell Biol 2013; 25: 289-296.
    • (2013) Curr Opin Cell Biol , vol.25 , pp. 289-296
    • Shen, L.1    Zhang, Y.2
  • 48
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • Turcan S, Rohle D, Goenka A, et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 2012; 483: 479-483.
    • (2012) Nature , vol.483 , pp. 479-483
    • Turcan, S.1    Rohle, D.2    Goenka, A.3
  • 49
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
    • Xu W, Yang H, Liu Y, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 2011; 19: 17-30.
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3
  • 50
    • 84927698415 scopus 로고    scopus 로고
    • Loss of 5-hydroxymethylcytosine in cancer: cause or consequence?
    • Ficz G, Gribben JG. Loss of 5-hydroxymethylcytosine in cancer: cause or consequence? Genomics 2014; 104: 352-357.
    • (2014) Genomics , vol.104 , pp. 352-357
    • Ficz, G.1    Gribben, J.G.2
  • 51
    • 84864120277 scopus 로고    scopus 로고
    • Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas
    • Muller T, Gessi M, Waha A, et al. Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas. Am J Pathol 2012; 181: 675-683.
    • (2012) Am J Pathol , vol.181 , pp. 675-683
    • Muller, T.1    Gessi, M.2    Waha, A.3
  • 52
    • 84943404222 scopus 로고    scopus 로고
    • TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma
    • Murata A, Baba Y, Ishimoto T, et al. TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma. Oncotarget 2015.
    • (2015) Oncotarget
    • Murata, A.1    Baba, Y.2    Ishimoto, T.3
  • 53
    • 84919491383 scopus 로고    scopus 로고
    • Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma
    • Hara K, Kageji T, Mizobuchi Y, et al. Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma. Cancer Lett 2015; 356: 496-505.
    • (2015) Cancer Lett , vol.356 , pp. 496-505
    • Hara, K.1    Kageji, T.2    Mizobuchi, Y.3
  • 54
    • 84973528361 scopus 로고    scopus 로고
    • miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathway
    • Zhang W, Shen C, Li C, et al. miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathway. Mol Carcinog 2015.
    • (2015) Mol Carcinog
    • Zhang, W.1    Shen, C.2    Li, C.3
  • 55
    • 84885139912 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling
    • Pyko IV, Nakada M, Sabit H, et al. Glycogen synthase kinase 3beta inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling. Carcinogenesis 2013; 34: 2206-2217.
    • (2013) Carcinogenesis , vol.34 , pp. 2206-2217
    • Pyko, I.V.1    Nakada, M.2    Sabit, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.