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Volumn 2, Issue 5, 2016, Pages 648-662.e8

LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation

Author keywords

Endoderm; Intestine; LGR5; Organoid; Pluripotent Stem Cells; WNT

Indexed keywords

BETA CATENIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; LGR4 PROTEIN; LGR5 PROTEIN; LYMPHOID ENHANCER FACTOR 1; MEMBRANE PROTEIN; MESSENGER RNA; NESTIN; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX17; UNCLASSIFIED DRUG; WNT3A PROTEIN;

EID: 84999648516     PISSN: None     EISSN: 2352345X     Source Type: Journal    
DOI: 10.1016/j.jcmgh.2016.06.002     Document Type: Article
Times cited : (21)

References (58)
  • 1
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in development and disease
    • 1 Clevers, H., Wnt/β-catenin signaling in development and disease. Cell 127 (2006), 469–480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 2
    • 84863756127 scopus 로고    scopus 로고
    • Wnt signaling, stem cells, and cancer of the gastrointestinal tract
    • 2 Schepers, A., Clevers, H., Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harb Perspect Biol, 4, 2012, a007989.
    • (2012) Cold Spring Harb Perspect Biol , vol.4 , pp. a007989
    • Schepers, A.1    Clevers, H.2
  • 3
    • 33747339465 scopus 로고    scopus 로고
    • Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors
    • 3 Gordon, M.D., Nusse, R., Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281 (2006), 22429–22433.
    • (2006) J Biol Chem , vol.281 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 4
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: a common theme in animal development
    • 4 Cadigan, K.M., Nusse, R., Wnt signaling: a common theme in animal development. Genes Dev 11 (1997), 3286–3305.
    • (1997) Genes Dev , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 5
    • 80053560465 scopus 로고    scopus 로고
    • LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling
    • 5 Glinka, A., Dolde, C., Kirsch, N., et al. LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Rep 12 (2011), 1055–1061.
    • (2011) EMBO Rep , vol.12 , pp. 1055-1061
    • Glinka, A.1    Dolde, C.2    Kirsch, N.3
  • 6
    • 84864012571 scopus 로고    scopus 로고
    • R-spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5
    • 6 Ruffner, H., Sprunger, J., Charlat, O., et al. R-spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5. PLoS One, 7, 2012, e40976.
    • (2012) PLoS One , vol.7 , pp. e40976
    • Ruffner, H.1    Sprunger, J.2    Charlat, O.3
  • 7
    • 80051926611 scopus 로고    scopus 로고
    • Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
    • 7 de Lau, W., Barker, N., Low, T.Y., et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 476 (2011), 293–297.
    • (2011) Nature , vol.476 , pp. 293-297
    • de Lau, W.1    Barker, N.2    Low, T.Y.3
  • 8
    • 79960990066 scopus 로고    scopus 로고
    • R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling
    • 8 Carmon, K.S., Gong, X., Lin, Q., et al. R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A 108 (2011), 11452–11457.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 11452-11457
    • Carmon, K.S.1    Gong, X.2    Lin, Q.3
  • 9
    • 84860765166 scopus 로고    scopus 로고
    • ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
    • 9 Hao, H.-X., Xie, Y., Zhang, Y., et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature 485 (2012), 195–200.
    • (2012) Nature , vol.485 , pp. 195-200
    • Hao, H.-X.1    Xie, Y.2    Zhang, Y.3
  • 10
    • 84865517676 scopus 로고    scopus 로고
    • Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
    • 10 Koo, B.-K., Spit, M., Jordens, I., et al. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature 488 (2012), 665–669.
    • (2012) Nature , vol.488 , pp. 665-669
    • Koo, B.-K.1    Spit, M.2    Jordens, I.3
  • 11
    • 84867353343 scopus 로고    scopus 로고
    • Cancer biology: a new RING to Wnt signaling
    • 11 Fearon, E.R., Spence, J.R., Cancer biology: a new RING to Wnt signaling. Curr Biol 22 (2012), R849–R851.
    • (2012) Curr Biol , vol.22 , pp. R849-R851
    • Fearon, E.R.1    Spence, J.R.2
  • 12
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • 12 Barker, N., van Es, J.H., Kuipers, J., et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449 (2007), 1003–1007.
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1    van Es, J.H.2    Kuipers, J.3
  • 13
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • 13 Sato, T., Vries, R.G., Snippert, H.J., et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459 (2009), 262–265.
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3
  • 14
    • 67349157318 scopus 로고    scopus 로고
    • Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
    • 14 Ootani, A., Li, X., Sangiorgi, E., et al. Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med 15 (2009), 701–706.
    • (2009) Nat Med , vol.15 , pp. 701-706
    • Ootani, A.1    Li, X.2    Sangiorgi, E.3
  • 15
    • 0346458662 scopus 로고    scopus 로고
    • Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
    • 15 Kuhnert, F., Davis, C.R., Wang, H.-T., et al. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci U S A 101 (2003), 266–271.
    • (2003) Proc Natl Acad Sci U S A , vol.101 , pp. 266-271
    • Kuhnert, F.1    Davis, C.R.2    Wang, H.-T.3
  • 16
    • 0037829660 scopus 로고    scopus 로고
    • Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
    • 16 Pinto, D., Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev 17 (2003), 1709–1713.
    • (2003) Genes Dev , vol.17 , pp. 1709-1713
    • Pinto, D.1
  • 17
    • 67349197237 scopus 로고    scopus 로고
    • LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine
    • 17 Garcia, M.I., Ghiani, M., Lefort, A., et al. LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine. Dev Biol 331 (2009), 58–67.
    • (2009) Dev Biol , vol.331 , pp. 58-67
    • Garcia, M.I.1    Ghiani, M.2    Lefort, A.3
  • 18
    • 84899480869 scopus 로고    scopus 로고
    • Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice
    • 18 Kinzel, B., Pikiolek, M., Orsini, V., et al. Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice. Dev Biol 390 (2014), 181–190.
    • (2014) Dev Biol , vol.390 , pp. 181-190
    • Kinzel, B.1    Pikiolek, M.2    Orsini, V.3
  • 19
    • 84887026104 scopus 로고    scopus 로고
    • Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium
    • 19 Mustata, R.C., Vasile, G., Fernandez-Vallone, V., et al. Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium. Cell Rep 5 (2013), 421–432.
    • (2013) Cell Rep , vol.5 , pp. 421-432
    • Mustata, R.C.1    Vasile, G.2    Fernandez-Vallone, V.3
  • 20
    • 73949140059 scopus 로고    scopus 로고
    • A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
    • 20 Madisen, L., Zwingman, T.A., Sunkin, S.M., et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13 (2009), 133–140.
    • (2009) Nat Neurosci , vol.13 , pp. 133-140
    • Madisen, L.1    Zwingman, T.A.2    Sunkin, S.M.3
  • 21
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • 21 Soriano, P., Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21 (1999), 70–71.
    • (1999) Nat Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 22
    • 67650246360 scopus 로고    scopus 로고
    • Sox17 regulates organ lineage segregation of ventral foregut progenitor cells
    • 22 Spence, J.R., Lange, A.W., Lin, S.-C.J., et al. Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 17 (2009), 62–74.
    • (2009) Dev Cell , vol.17 , pp. 62-74
    • Spence, J.R.1    Lange, A.W.2    Lin, S.-C.J.3
  • 23
    • 84930926224 scopus 로고    scopus 로고
    • Transcriptome-wide analysis reveals hallmarks of human intestine development and maturation in vitro and in vivo
    • 23 Finkbeiner, S.R., Hill, D.R., Altheim, C.H., et al. Transcriptome-wide analysis reveals hallmarks of human intestine development and maturation in vitro and in vivo. Stem Cell Rep 4 (2015), 1140–1155.
    • (2015) Stem Cell Rep , vol.4 , pp. 1140-1155
    • Finkbeiner, S.R.1    Hill, D.R.2    Altheim, C.H.3
  • 24
    • 84918561297 scopus 로고    scopus 로고
    • Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
    • 24 McCracken, K.W., Catá, E.M., Crawford, C.M., et al. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature 516 (2014), 400–404.
    • (2014) Nature , vol.516 , pp. 400-404
    • McCracken, K.W.1    Catá, E.M.2    Crawford, C.M.3
  • 25
    • 79551686425 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
    • 25 Spence, J.R., Mayhew, C.N., Rankin, S.A., et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470 (2011), 105–109.
    • (2011) Nature , vol.470 , pp. 105-109
    • Spence, J.R.1    Mayhew, C.N.2    Rankin, S.A.3
  • 26
    • 28644448149 scopus 로고    scopus 로고
    • Efficient differentiation of human embryonic stem cells to definitive endoderm
    • 26 D'Amour, K.A., Agulnick, A.D., Eliazer, S., et al. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 23 (2005), 1534–1541.
    • (2005) Nat Biotechnol , vol.23 , pp. 1534-1541
    • D'Amour, K.A.1    Agulnick, A.D.2    Eliazer, S.3
  • 27
    • 84982803613 scopus 로고    scopus 로고
    • Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids
    • 27 Finkbeiner, S.R., Freeman, J.J., Wieck, M.M., et al. Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids. Biol Open 4 (2015), 1462–1472.
    • (2015) Biol Open , vol.4 , pp. 1462-1472
    • Finkbeiner, S.R.1    Freeman, J.J.2    Wieck, M.M.3
  • 28
    • 84919478713 scopus 로고    scopus 로고
    • Persistence and toxin production by Clostridium difficile within human intestinal organoids results in disruption of epithelial paracellular barrier function
    • 28 Leslie, J.L., Huang, S., Opp, J.S., et al. Persistence and toxin production by Clostridium difficile within human intestinal organoids results in disruption of epithelial paracellular barrier function. Infect Immun 83 (2015), 138–145.
    • (2015) Infect Immun , vol.83 , pp. 138-145
    • Leslie, J.L.1    Huang, S.2    Opp, J.S.3
  • 29
    • 84876998128 scopus 로고    scopus 로고
    • ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response
    • 29 Heijmans, J., de Jeude, J., Koo, B.K., et al. ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep 3 (2013), 1128–1139.
    • (2013) Cell Rep , vol.3 , pp. 1128-1139
    • Heijmans, J.1    de Jeude, J.2    Koo, B.K.3
  • 30
    • 42549128765 scopus 로고    scopus 로고
    • R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
    • 30 Bell, S.M., Schreiner, C.M., Wert, S.E., et al. R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development 135 (2008), 1049–1058.
    • (2008) Development , vol.135 , pp. 1049-1058
    • Bell, S.M.1    Schreiner, C.M.2    Wert, S.E.3
  • 31
    • 84888112949 scopus 로고    scopus 로고
    • Sox9 plays multiple roles in the lung epithelium during branching morphogenesis
    • 31 Rockich, B.E., Hrycaj, S.M., Shih, H.-P., et al. Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A 110 (2013), E4456–E4464.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. E4456-E4464
    • Rockich, B.E.1    Hrycaj, S.M.2    Shih, H.-P.3
  • 32
    • 80955137949 scopus 로고    scopus 로고
    • Generating human intestinal tissue from pluripotent stem cells in vitro
    • 32 McCracken, K.W., Howell, J.C., Spence, J.R., et al. Generating human intestinal tissue from pluripotent stem cells in vitro. Nat Protoc 6 (2011), 1920–1928.
    • (2011) Nat Protoc , vol.6 , pp. 1920-1928
    • McCracken, K.W.1    Howell, J.C.2    Spence, J.R.3
  • 33
    • 84884390272 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice
    • 33 Xue, X., Ramakrishnan, S., Anderson, E., et al. Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice. Gastroenterology 145 (2013), 831–841.
    • (2013) Gastroenterology , vol.145 , pp. 831-841
    • Xue, X.1    Ramakrishnan, S.2    Anderson, E.3
  • 34
    • 84925459906 scopus 로고    scopus 로고
    • In vitro generation of human pluripotent stem cell derived lung organoids
    • 34 Dye, B.R., Hill, D.R., Ferguson, M.A., et al. In vitro generation of human pluripotent stem cell derived lung organoids. Elife, 4, 2015, e05098.
    • (2015) Elife , vol.4 , pp. e05098
    • Dye, B.R.1    Hill, D.R.2    Ferguson, M.A.3
  • 35
    • 84946490100 scopus 로고    scopus 로고
    • SMADs and YAP compete to control elongation of β-catenin:LEF-1-recruited RNAPII during hESC differentiation
    • 35 Estarás, C., Benner, C., Jones, K.A., SMADs and YAP compete to control elongation of β-catenin:LEF-1-recruited RNAPII during hESC differentiation. Mol Cell 58 (2015), 780–793.
    • (2015) Mol Cell , vol.58 , pp. 780-793
    • Estarás, C.1    Benner, C.2    Jones, K.A.3
  • 36
    • 84926180401 scopus 로고    scopus 로고
    • Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates
    • 36 Wang, A., Yue, F., Li, Y., et al. Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates. Cell Stem Cell 16 (2015), 386–399.
    • (2015) Cell Stem Cell , vol.16 , pp. 386-399
    • Wang, A.1    Yue, F.2    Li, Y.3
  • 37
    • 80054790130 scopus 로고    scopus 로고
    • Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea
    • 37 Chai, R., Xia, A., Wang, T., et al. Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea. J Assoc Res Otolaryngol 12 (2011), 455–469.
    • (2011) J Assoc Res Otolaryngol , vol.12 , pp. 455-469
    • Chai, R.1    Xia, A.2    Wang, T.3
  • 38
    • 84964313624 scopus 로고    scopus 로고
    • An in vivo model of human small intestine using pluripotent stem cells
    • 38 Watson, C.L., Mahe, M.M., Múnera, J., et al. An in vivo model of human small intestine using pluripotent stem cells. Nat Med 20 (2014), 1310–1314.
    • (2014) Nat Med , vol.20 , pp. 1310-1314
    • Watson, C.L.1    Mahe, M.M.2    Múnera, J.3
  • 39
    • 84893283877 scopus 로고    scopus 로고
    • How to make an intestine
    • 39 Wells, J.M., Spence, J.R., How to make an intestine. Development 141 (2014), 752–760.
    • (2014) Development , vol.141 , pp. 752-760
    • Wells, J.M.1    Spence, J.R.2
  • 40
    • 73049116186 scopus 로고    scopus 로고
    • Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
    • 40 Barker, N., Huch, M., Kujala, P., et al. Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Stem Cell 6 (2010), 25–36.
    • (2010) Stem Cell , vol.6 , pp. 25-36
    • Barker, N.1    Huch, M.2    Kujala, P.3
  • 41
    • 84866926354 scopus 로고    scopus 로고
    • Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development
    • 41 Barker, N., Rookmaaker, M.B., Kujala, P., et al. Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell Rep 2 (2012), 540–552.
    • (2012) Cell Rep , vol.2 , pp. 540-552
    • Barker, N.1    Rookmaaker, M.B.2    Kujala, P.3
  • 42
    • 84928393314 scopus 로고    scopus 로고
    • Bending gradients: how the intestinal stem cell gets its home
    • 42 Shyer, A.E., Huycke, T.R., Lee, C., et al. Bending gradients: how the intestinal stem cell gets its home. Cell 161 (2015), 569–580.
    • (2015) Cell , vol.161 , pp. 569-580
    • Shyer, A.E.1    Huycke, T.R.2    Lee, C.3
  • 43
    • 0033562351 scopus 로고    scopus 로고
    • Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways
    • 43 Zorn, A.M., Butler, K., Gurdon, J.B., Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways. Dev Biol 209 (1999), 282–297.
    • (1999) Dev Biol , vol.209 , pp. 282-297
    • Zorn, A.M.1    Butler, K.2    Gurdon, J.B.3
  • 44
    • 79951680385 scopus 로고    scopus 로고
    • A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer
    • 44 Rankin, S.A., Kormish, J., Kofron, M., et al. A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer. Dev Biol 351 (2011), 297–310.
    • (2011) Dev Biol , vol.351 , pp. 297-310
    • Rankin, S.A.1    Kormish, J.2    Kofron, M.3
  • 45
    • 0036696415 scopus 로고    scopus 로고
    • Formation of multiple hearts in mice following deletion of β-catenin in the embryonic endoderm
    • 45 Lickert, H., Kutsch, S., Kanzler, B., et al. Formation of multiple hearts in mice following deletion of β-catenin in the embryonic endoderm. Dev Cell 3 (2002), 171–181.
    • (2002) Dev Cell , vol.3 , pp. 171-181
    • Lickert, H.1    Kutsch, S.2    Kanzler, B.3
  • 46
    • 33750936779 scopus 로고    scopus 로고
    • Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells
    • 46 Gadue, P., Huber, T.L., Paddison, P.J., et al. Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc Natl Acad Sci U S A 103 (2006), 16806–16811.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16806-16811
    • Gadue, P.1    Huber, T.L.2    Paddison, P.J.3
  • 47
    • 79551580013 scopus 로고    scopus 로고
    • Stage-specific signaling through TGF family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells
    • 47 Nostro, M.C., Sarangi, F., Ogawa, S., et al. Stage-specific signaling through TGF family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development 138 (2011), 861–871.
    • (2011) Development , vol.138 , pp. 861-871
    • Nostro, M.C.1    Sarangi, F.2    Ogawa, S.3
  • 48
    • 58149262961 scopus 로고    scopus 로고
    • Transcriptional dynamics of endodermal organ formation
    • 48 Sherwood, R.I., Chen, T.Y., Melton, D.A., Transcriptional dynamics of endodermal organ formation. Dev Dyn 238 (2009), 29–42.
    • (2009) Dev Dyn , vol.238 , pp. 29-42
    • Sherwood, R.I.1    Chen, T.Y.2    Melton, D.A.3
  • 49
    • 79959281790 scopus 로고    scopus 로고
    • Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
    • 49 Biechele, S., Cox, B.J., Rossant, J., Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos. Dev Biol 355 (2011), 275–285.
    • (2011) Dev Biol , vol.355 , pp. 275-285
    • Biechele, S.1    Cox, B.J.2    Rossant, J.3
  • 50
    • 58249122326 scopus 로고    scopus 로고
    • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
    • 50 Chen, B., Dodge, M.E., Tang, W., et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5 (2009), 100–107.
    • (2009) Nat Chem Biol , vol.5 , pp. 100-107
    • Chen, B.1    Dodge, M.E.2    Tang, W.3
  • 51
    • 0037163113 scopus 로고    scopus 로고
    • Regulation of Wnt signaling during adipogenesis
    • 51 Bennett, C.N., Ross, S.E., Longo, K.A., et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem 277 (2002), 30998–31004.
    • (2002) J Biol Chem , vol.277 , pp. 30998-31004
    • Bennett, C.N.1    Ross, S.E.2    Longo, K.A.3
  • 52
    • 0037339766 scopus 로고    scopus 로고
    • Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo
    • 52 Ring, D.B., Johnson, K.W., Henriksen, E.J., et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 52 (2003), 588–595.
    • (2003) Diabetes , vol.52 , pp. 588-595
    • Ring, D.B.1    Johnson, K.W.2    Henriksen, E.J.3
  • 53
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
    • 53 Sato, N., Meijer, L., Skaltsounis, L., et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 10 (2004), 55–63.
    • (2004) Nat Med , vol.10 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3
  • 54
    • 34248393912 scopus 로고    scopus 로고
    • Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency
    • 54 Miyabayashi, T., Teo, J.-L., Yamamoto, M., et al. Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A 104 (2007), 5668–5673.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5668-5673
    • Miyabayashi, T.1    Teo, J.-L.2    Yamamoto, M.3
  • 55
    • 84952638414 scopus 로고    scopus 로고
    • Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells
    • 55 Muñoz-Descalzo, S., Hadjantonakis, A.-K., Arias, A.M., Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells. Semin Cell Dev Biol 47 (2015), 101–109.
    • (2015) Semin Cell Dev Biol , vol.47 , pp. 101-109
    • Muñoz-Descalzo, S.1    Hadjantonakis, A.-K.2    Arias, A.M.3
  • 56
    • 84908225334 scopus 로고    scopus 로고
    • From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo
    • 56 Zernicka-Goetz, M., Hadjantonakis, A.-K., From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo. Philos Trans R Soc Lond B Biol Sci, 369, 2014, 20130535.
    • (2014) Philos Trans R Soc Lond B Biol Sci , vol.369 , pp. 20130535
    • Zernicka-Goetz, M.1    Hadjantonakis, A.-K.2
  • 57
    • 82855161367 scopus 로고    scopus 로고
    • Wnt signaling specifies and patterns intestinal endoderm
    • 57 Sherwood, R.I., Maehr, R., Mazzoni, E.O., et al. Wnt signaling specifies and patterns intestinal endoderm. Mech Dev, 128, 2011, 14.
    • (2011) Mech Dev , vol.128 , pp. 14
    • Sherwood, R.I.1    Maehr, R.2    Mazzoni, E.O.3
  • 58
    • 84924910660 scopus 로고    scopus 로고
    • Ascl2 Acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts
    • 58 Schuijers, J., Junker, J.P., Mokry, M., et al. Ascl2 Acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. Cell Stem Cell 16 (2015), 158–170.
    • (2015) Cell Stem Cell , vol.16 , pp. 158-170
    • Schuijers, J.1    Junker, J.P.2    Mokry, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.