Wnt signaling specifies and patterns intestinal endoderm

Mechanisms of Development

Volumn 128, Issue 7-10, 2011, Pages 387-400

  Sherwood, Richard I ^d   Maehr, Rene ^a   Mazzoni, Esteban O ^b   Melton, Douglas A ^c  

^a Harvard University   (United States)

^b Department of Medicine   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Embryonic stem cell differentiation; Endoderm; Intestinal development

Indexed keywords

TRANSCRIPTION FACTOR CDX2; WNT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; EMBRYO PATTERN FORMATION; EMBRYONIC STEM CELL; ENDODERM; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; INTESTINE; LARGE INTESTINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMALL INTESTINE;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; ENDODERM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; INTESTINE, LARGE; INTESTINE, SMALL; MICE; TRANS-ACTIVATORS; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 82855161367     PISSN: 09254773     EISSN: 18726356     Source Type: Journal    
DOI: 10.1016/j.mod.2011.07.005     Document Type: Article

References (55)

1. Ahlgren U., Jonsson J., Edlund H. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 1996, 122:1409-1416.
2. Atilla-Gokcumen G.E., Williams D.S., Bregman H., Pagano N., Meggers E. Organometallic compounds with biological activity: a very selective and highly potent cellular inhibitor for glycogen synthase kinase 3. Chembiochemistry 2006, 7:1443-1450.
3. Balciunaite G., Keller M.P., Balciunaite E., Piali L., Zuklys S., Mathieu Y.D., Gill J., Boyd R., Sussman D.J., Hollander G.A. Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nat. Immunol. 2002, 3:1102-1108.
4. Barker N., van de Wetering M., Clevers H. The intestinal stem cell. Genes Dev. 2008, 22:1856-1864.
5. Beck F., Erler T., Russell A., James R. Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev. Dyn. 1995, 204:219-227.
6. Borowiak M., Maehr R., Chen S., Chen A.E., Tang W., Fox J.L., Schreiber S.L., Melton D.A. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 2009, 4:348-358.
7. Bouillet P., Oulad-Abdelghani M., Ward S.J., Bronner S., Chambon P., Dolle P. A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid. Mech. Dev. 1996, 58:141-152.
8. Chawengsaksophak K., de Graaff W., Rossant J., Deschamps J., Beck F. Cdx2 is essential for axial elongation in mouse development. Proc. Natl. Acad. Sci. USA 2004, 101:7641-7645.
9. Chen S., Borowiak M., Fox J.L., Maehr R., Osafune K., Davidow L., Lam K., Peng L.F., Schreiber S.L., Rubin L.L., Melton D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat. Chem. Biol. 2009, 5:258-265.
10. Danielian P.S., Muccino D., Rowitch D.H., Michael S.K., McMahon A.P. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr. Biol. 1998, 8:1323-1326.
11. Gadue P., Huber T.L., Paddison P.J., Keller G.M. Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc. Natl. Acad. Sci. USA 2006, 103:16806-16811.
12. Gao N., Kaestner K.H. Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev. 2010, 24:1295-1305.
13. Gao N., White P., Kaestner K.H. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev. Cell 2009, 16:588-599.
14. Goss A.M., Tian Y., Tsukiyama T., Cohen E.D., Zhou D., Lu M.M., Yamaguchi T.P., Morrisey E.E. Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev. Cell 2009, 17:290-298.
15. Gregorieff A., Grosschedl R., Clevers H. Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. EMBO J. 2004, 23:1825-1833.
16. Guo R.J., Funakoshi S., Lee H.H., Kong J., Lynch J.P. The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex. Carcinogenesis 2010, 31:159-166.
17. Hansson M., Olesen D.R., Peterslund J.M., Engberg N., Kahn M., Winzi M., Klein T., Maddox-Hyttel P., Serup P. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev. Biol. 2009, 330:286-304.
18. Heller R.S., Dichmann D.S., Jensen J., Miller C., Wong G., Madsen O.D., Serup P. Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Dev. Dyn. 2002, 225:260-270.
19. Iacovino M., Hernandez C., Xu Z., Bajwa G., Prather M., Kyba M. A conserved role for Hox paralog group 4 in regulation of hematopoietic progenitors. Stem Cells Dev. 2009, 18:783-792.
20. Jacquemin P., Pierreux C.E., Fierens S., van Eyll J.M., Lemaigre F.P., Rousseau G.G. Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2. Gene Expr. Patterns 2003, 3:639-644.
21. Jho E.H., Zhang T., Domon C., Joo C.K., Freund J.N., Costantini F. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol. Cell Biol. 2002, 22:1172-1183.
22. Kim B.M., Buchner G., Miletich I., Sharpe P.T., Shivdasani R.A. The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev. Cell 2005, 8:611-622.
23. Kubo A., Shinozaki K., Shannon J.M., Kouskoff V., Kennedy M., Woo S., Fehling H.J., Keller G. Development of definitive endoderm from embryonic stem cells in culture. Development 2004, 131:1651-1662.
24. Lickert H., Domon C., Huls G., Wehrle C., Duluc I., Clevers H., Meyer B.I., Freund J.N., Kemler R. Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine. Development 2000, 127:3805-3813.
25. Maretto S., Cordenonsi M., Dupont S., Braghetta P., Broccoli V., Hassan A.B., Volpin D., Bressan G.M., Piccolo S. Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc. Natl. Acad. Sci. USA 2003, 100:3299-3304.
26. McLin V.A., Rankin S.A., Zorn A.M. Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development 2007, 134:2207-2217.
27. Mlodzik M., Fjose A., Gehring W.J. Isolation of caudal, a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage. EMBO J. 1985, 4:2961-2969.
28. Offield M.F., Jetton T.L., Labosky P.A., Ray M., Stein R.W., Magnuson M.A., Hogan B.L., Wright C.V. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 1996, 122:983-995.
29. Okubo T., Hogan B.L. Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. J. Biol. 2004, 3:11.
30. Pierreux C.E., Poll A.V., Jacquemin P., Lemaigre F.P., Rousseau G.G. Gene transfer into mouse prepancreatic endoderm by whole embryo electroporation. JOP 2005, 6:128-135.
31. Pilon N., Oh K., Sylvestre J.R., Bouchard N., Savory J., Lohnes D. Cdx4 is a direct target of the canonical Wnt pathway. Dev. Biol. 2006, 289:55-63.
32. Prinos P., Joseph S., Oh K., Meyer B.I., Gruss P., Lohnes D. Multiple pathways governing Cdx1 expression during murine development. Dev. Biol. 2001, 239:257-269.
33. Ratineau C., Duluc I., Pourreyron C., Kedinger M., Freund J.N., Roche C. Endoderm- and mesenchyme-dependent commitment of the differentiated epithelial cell types in the developing intestine of rat. Differentiation 2003, 71:163-169.
34. Roberts D.J., Smith D.M., Goff D.J., Tabin C.J. Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development 1998, 125:2791-2801.
35. Schohl A., Fagotto F. Beta-catenin, MAPK and Smad signaling during early Xenopus development. Development 2002, 129:37-52.
36. Sherwood R.I., Chen T.Y., Melton D.A. Transcriptional dynamics of endodermal organ formation. Dev. Dyn. 2009, 238:29-42.
37. Sherwood R.I., Jitianu C., Cleaver O., Shaywitz D.A., Lamenzo J.O., Chen A.E., Golub T.R., Melton D.A. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev. Biol. 2007, 304:541-555.
38. Siegfried E., Wilder E.L., Perrimon N. Components of wingless signalling in Drosophila. Nature 1994, 367:76-80.
39. Spence J.R., Mayhew C.N., Rankin S.A., Kuhar M.F., Vallance J.E., Tolle K., Hoskins E.E., Kalinichenko V.V., Wells S.I., Zorn A.M., Shroyer N.F., Wells J.M. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 2011, 470:105-109.
40. Stanger B.Z., Datar R., Murtaugh L.C., Melton D.A. Direct regulation of intestinal fate by Notch. Proc. Natl. Acad. Sci. USA 2005, 102:12443-12448.
41. Subramanian V., Meyer B.I., Gruss P. Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell 1995, 83:641-653.
42. Tada S., Era T., Furusawa C., Sakurai H., Nishikawa S., Kinoshita M., Nakao K., Chiba T., Nishikawa S. Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development 2005, 132:4363-4374.
43. Takada S., Stark K.L., Shea M.J., Vassileva G., McMahon J.A., McMahon A.P. Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 1994, 8:174-189.
44. Theodosiou N.A., Tabin C.J. Wnt signaling during development of the gastrointestinal tract. Dev. Biol. 2003, 259:258-271.
45. Toyofuku T., Hong Z., Kuzuya T., Tada M., Hori M. Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex. J. Cell Biol. 2000, 150:225-241.
46. van den Akker E., Forlani S., Chawengsaksophak K., de Graaff W., Beck F., Meyer B.I., Deschamps J. Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. Development 2002, 129:2181-2193.
47. van der Flier L.G., Clevers H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol. 2009, 71:241-260.
48. Verzi M.P., Hatzis P., Sulahian R., Philips J., Schuijers J., Shin H., Freed E., Lynch J.P., Dang D.T., Brown M., Clevers H., Liu X.S., Shivdasani R.A. TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proc. Natl. Acad. Sci. USA 2010, 107:15157-15162.
49. Verzi M.P., Shivdasani R.A. Wnt signaling in gut organogenesis. Organogenesis 2008, 4:87-91.
50. Warot X., Fromental-Ramain C., Fraulob V., Chambon P., Dolle P. Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts. Development 1997, 124:4781-4791.
51. Whitcomb D.C., Lowe M.E. Human pancreatic digestive enzymes. Dig. Dis. Sci. 2007, 52:1-17.
52. Wilkinson D.G., Nieto M.A. Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol. 1993, 225:361-373.
53. Wu D., Pan W. GSK3: a multifaceted kinase in Wnt signaling. Trends. Biochem. Sci. 2010, 35:161-168.
54. Yamaguchi T.P., Bradley A., McMahon A.P., Jones S. A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 1999, 126:1211-1223.
55. Young T., Rowland J.E., van de Ven C., Bialecka M., Novoa A., Carapuco M., van Nes J., de Graaff W., Duluc I., Freund J.N., Beck F., Mallo M., Deschamps J. Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Dev. Cell 2009, 17:516-526.