메뉴 건너뛰기




Volumn 11, Issue 11, 2016, Pages

Fenugreek seed powder nullified aluminium chloride induced memory loss, biochemical changes, Aβ burden and apoptosis via regulating Akt/GSK3β signaling pathway

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ALUMINUM; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CASPASE 3; CASPASE 9; CYTOCHROME C; GAMMA SECRETASE; GLYCOGEN SYNTHASE KINASE 3BETA; HERBACEOUS AGENT; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; ALUMINUM CHLORIDE; ALUMINUM DERIVATIVE; CHLORIDE; FENUGREEK SEED MEAL; GSK3B PROTEIN, RAT; NEUROPROTECTIVE AGENT; PLANT EXTRACT;

EID: 84998693393     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0165955     Document Type: Article
Times cited : (55)

References (71)
  • 1
    • 70349102100 scopus 로고    scopus 로고
    • Memory enhancing activity of Coriandrum sativum in rats
    • Mani V, Parle M (2009) Memory enhancing activity of Coriandrum sativum in rats. Pharmacology online 2: 827-839.
    • (2009) Pharmacology Online , vol.2 , pp. 827-839
    • Mani, V.1    Parle, M.2
  • 2
    • 84866245593 scopus 로고    scopus 로고
    • Cognitive deterioration and associated pathology induced by chronic low level aluminum ingestion in a translational rat model provides an explanation of Alzheimer's disease, tests for susceptibility and avenues for treatment
    • Walton JR (2012) Cognitive deterioration and associated pathology induced by chronic low level aluminum ingestion in a translational rat model provides an explanation of Alzheimer's disease, tests for susceptibility and avenues for treatment. Int J Alzheimer's Dis 1-17. doi: 10.1155/2012/914947
    • (2012) Int J Alzheimer's Dis , pp. 1-17
    • Walton, J.R.1
  • 3
    • 79952701977 scopus 로고    scopus 로고
    • Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?
    • 21112383
    • Humpel C (2011) Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease? Exp Gerontol 46:225-232. doi: 10.1016/j.exger.2010.11.032 PMID: 21112383
    • (2011) Exp Gerontol , vol.46 , pp. 225-232
    • Humpel, C.1
  • 4
    • 85020652385 scopus 로고    scopus 로고
    • Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer's disease
    • in press
    • Justin Thenmozhi A, William Raja TR, Manivasagam T, Janakiraman U, EssaMM (2016) Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer's disease. Nutr Neurosci (in press).
    • (2016) Nutr Neurosci
    • Justin Thenmozhi, A.1    William Raja, T.R.2    Manivasagam, T.3    Janakiraman, U.4    Essa, M.M.5
  • 5
    • 33644503205 scopus 로고    scopus 로고
    • Aluminum-induced maternal and developmental toxicity and oxidative stress in rat brain: Response to combined administration of tiron and glutathione
    • 16040227
    • Sharma P, Mishra KP (2006) Aluminum-induced maternal and developmental toxicity and oxidative stress in rat brain: response to combined administration of tiron and glutathione. Reprod Toxicol 21:313-321. doi: 10.1016/j.reprotox.2005.06.004 PMID: 16040227
    • (2006) Reprod Toxicol , vol.21 , pp. 313-321
    • Sharma, P.1    Mishra, K.P.2
  • 6
    • 68049090834 scopus 로고    scopus 로고
    • Camel's milk protects against aluminum chloride-induced toxicity in the liver and kidney of white albino rats
    • Al-Hashem F (2009) Camel's milk protects against aluminum chloride-induced toxicity in the liver and kidney of white albino rats. Am J Biochem Biotechnol 5: 98-108.
    • (2009) Am J Biochem Biotechnol , vol.5 , pp. 98-108
    • Al-Hashem, F.1
  • 7
    • 84937572354 scopus 로고    scopus 로고
    • Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer's disease in wistar rats
    • 25630717
    • Justin Thenmozhi A, William Raja TR, Janakiraman U, Manivasagam T (2015a) Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer's disease in wistar rats. Neurochem Res 40: 767-776. doi: 10.1007/s11064-015-1525-1 PMID: 25630717
    • (2015) Neurochem Res , vol.40 , pp. 767-776
    • Justin Thenmozhi, A.1    William Raja, T.R.2    Janakiraman, U.3    Manivasagam, T.4
  • 8
    • 84959900703 scopus 로고    scopus 로고
    • Tannoid principles of Emblica officinalis renovate cognitive deficits and attenuate amyloid pathologies against aluminum chloride induced rat model of Alzheimer's disease
    • in press
    • Justin Thenmozhi A, Dhivyabharathi M, William Raja TR, Manivasagam T, Essa MM (2015b) Tannoid principles of Emblica officinalis renovate cognitive deficits and attenuate amyloid pathologies against aluminum chloride induced rat model of Alzheimer's disease, Nutr Neurosci (in press).
    • (2015) Nutr Neurosci
    • Justin Thenmozhi, A.1    Dhivyabharathi, M.2    William Raja, T.R.3    Manivasagam, T.4    Essa, M.M.5
  • 9
    • 77951931900 scopus 로고    scopus 로고
    • The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease
    • 20175748
    • Muirhead KE, Borger E, Aitken L, Conway SJ, Gunn-Moore FJ (2010) The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease. Biochem J 426: 255-270. doi: 10.1042/BJ20091941 PMID: 20175748
    • (2010) Biochem J , vol.426 , pp. 255-270
    • Muirhead, K.E.1    Borger, E.2    Aitken, L.3    Conway, S.J.4    Gunn-Moore, F.J.5
  • 10
    • 84885333380 scopus 로고    scopus 로고
    • U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease
    • 24023061
    • Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, et al. (2013) U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Proc Natl Acad Sci USA. 110: 16562-16567. doi: 10.1073/pnas.1310249110 PMID: 24023061
    • (2013) Proc Natl Acad Sci USA. , vol.110 , pp. 16562-16567
    • Bai, B.1    Hales, C.M.2    Chen, P.C.3    Gozal, Y.4    Dammer, E.B.5    Fritz, J.J.6
  • 11
    • 84866385935 scopus 로고    scopus 로고
    • Interplay between MEK-ERK signalling, cyclin D1 and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons
    • 22833568
    • Modi PK, Komaravelli N, Singh N, Sharma P (2012) Interplay between MEK-ERK signalling, cyclin D1 and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons. Mol Biol Cell 23: 3722-3730. doi: 10.1091/mbc.E12-02-0125 PMID: 22833568
    • (2012) Mol Biol Cell , vol.23 , pp. 3722-3730
    • Modi, P.K.1    Komaravelli, N.2    Singh, N.3    Sharma, P.4
  • 12
    • 84865729526 scopus 로고    scopus 로고
    • Photobiomodulation by low-power laser irradiation attenuates Abetainduced cell apoptosis through the Akt/GSK3beta/beta-catenin pathway
    • 22917976
    • Liang J, Liu L, Xing D (2012) Photobiomodulation by low-power laser irradiation attenuates Abetainduced cell apoptosis through the Akt/GSK3beta/beta-catenin pathway. Free Radic Biol Med 53:1459-1467. doi: 10.1016/j.freeradbiomed.2012.08.003 PMID: 22917976
    • (2012) Free Radic Biol Med , vol.53 , pp. 1459-1467
    • Liang, J.1    Liu, L.2    Xing, D.3
  • 13
    • 0036884291 scopus 로고    scopus 로고
    • Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway
    • 12397090
    • Garrido JL, Godoy JA, Alvarez A, Bronfman M, Inestrosa NC (2002) Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway. FASEB. J. 16: 1982-1984. doi: 10.1096/fj.02-0327fje PMID: 12397090
    • (2002) FASEB. J. , vol.16 , pp. 1982-1984
    • Garrido, J.L.1    Godoy, J.A.2    Alvarez, A.3    Bronfman, M.4    Inestrosa, N.C.5
  • 14
    • 84954497911 scopus 로고    scopus 로고
    • Caspase-3 is involved in aluminum-induced impairment of longterm potentiation in rats through the Akt/GSK-3β pathway
    • 26787483
    • Zhang H, Yang X, Qin X, Niu Q (2016) Caspase-3 is involved in aluminum-induced impairment of longterm potentiation in rats through the Akt/GSK-3β pathway. Neurotox Res 29: 484-494. doi: 10.1007/s12640-016-9597-5 PMID: 26787483
    • (2016) Neurotox Res , vol.29 , pp. 484-494
    • Zhang, H.1    Yang, X.2    Qin, X.3    Niu, Q.4
  • 15
    • 85019521435 scopus 로고    scopus 로고
    • Fenugreek: An 'old world' crop for the 'new world'
    • Acharya SN, Thomas JE, Basu SK (2006) Fenugreek: an 'old world' crop for the 'new world'. Biodiversity. 7: 27-30.
    • (2006) Biodiversity. , vol.7 , pp. 27-30
    • Acharya, S.N.1    Thomas, J.E.2    Basu, S.K.3
  • 16
    • 0000657236 scopus 로고    scopus 로고
    • Biotechnology to harness the benefits of dietary phenolics; Focus on Lamiaceae
    • Shetty K (1997) Biotechnology to harness the benefits of dietary phenolics; focus on Lamiaceae. Asia Pac J Clin Nutr 21: 79-102.
    • (1997) Asia Pac J Clin Nutr , vol.21 , pp. 79-102
    • Shetty, K.1
  • 18
    • 75249098801 scopus 로고    scopus 로고
    • Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L and its constituents
    • 19576740
    • Satheeshkumar N, Mukherjee PK, Bhadra S, Saha BP (2010) Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L and its constituents. Phytomedicine 17: 292-295. doi: 10.1016/j.phymed.2009.06.006 PMID: 19576740
    • (2010) Phytomedicine , vol.17 , pp. 292-295
    • Satheeshkumar, N.1    Mukherjee, P.K.2    Bhadra, S.3    Saha, B.P.4
  • 20
    • 84908514078 scopus 로고    scopus 로고
    • Antidepressant effect and categorization of inhibitory activity of monoamine oxidase type A and B of ethanolic extract of seeds of Trigonella foenum graecum Linn
    • 25176235
    • Khursheed R, Rizwani GH, Sultana V, Ahmed M, Kamil A (2014) Antidepressant effect and categorization of inhibitory activity of monoamine oxidase type A and B of ethanolic extract of seeds of Trigonella foenum graecum Linn. Pak J Pharm Sci 27: 1419-1425. PMID: 25176235
    • (2014) Pak J Pharm Sci , vol.27 , pp. 1419-1425
    • Khursheed, R.1    Rizwani, G.H.2    Sultana, V.3    Ahmed, M.4    Kamil, A.5
  • 21
    • 84935014211 scopus 로고    scopus 로고
    • Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: Decisive role of Bax, Nrf2, NF-κB, Muc5ac, TNF-α and IL-1β
    • Kandhare AD, Bodhankar SL, Mohan V, Thakurdesai PA (2015) Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: decisive role of Bax, Nrf2, NF-κB, Muc5ac, TNF-α and IL-1β. Chem Biol Interact 25: 151-165. doi: 10.1016/j.cbi.2015.06.019
    • (2015) Chem Biol Interact , vol.25 , pp. 151-165
    • Kandhare, A.D.1    Bodhankar, S.L.2    Mohan, V.3    Thakurdesai, P.A.4
  • 22
    • 84943238922 scopus 로고    scopus 로고
    • Diosgenin, 4-hydroxyisoleucine and fiber from fenugreek: Mechanisms of actions and potential effects on metabolic syndrome
    • 25770257
    • Fuller S, Stephens JM (2015) Diosgenin, 4-hydroxyisoleucine and fiber from fenugreek: Mechanisms of actions and potential effects on metabolic syndrome. Adv Nutr 6: 189-197. doi: 10.3945/an.114. 007807 PMID: 25770257
    • (2015) Adv Nutr , vol.6 , pp. 189-197
    • Fuller, S.1    Stephens, J.M.2
  • 23
    • 84883170629 scopus 로고    scopus 로고
    • Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: Possible relevance to its anti-oxidant and anti-apoptosis mechanism
    • 23224641
    • Prakash A, Kumar A (2013) Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanism. Neurol Sci 34: 1403-1409. doi: 10.1007/s10072-012-1252-1 PMID: 23224641
    • (2013) Neurol Sci , vol.34 , pp. 1403-1409
    • Prakash, A.1    Kumar, A.2
  • 25
    • 70349774240 scopus 로고    scopus 로고
    • Protective effect of curcumin (Curcuma longa), against aluminum toxicity: Possible behavioral and biochemical alterations in rats
    • Kumar A, Dogra S, Prakash A (2009a) Protective effect of curcumin (Curcuma longa), against aluminum toxicity: possible behavioral and biochemical alterations in rats. Behav Brain Res 205:384-390.
    • (2009) Behav Brain Res , vol.205 , pp. 384-390
    • Kumar, A.1    Dogra, S.2    Prakash, A.3
  • 27
    • 84937543905 scopus 로고    scopus 로고
    • Protective effect of black tea extract against aluminium chloride-induced Alzheimer's disease in rats: A behavioural, biochemical and molecular approach
    • Dhivya Bharathi M, Justin Thenmozhi A, Manivasagam T (2015) Protective effect of black tea extract against aluminium chloride-induced Alzheimer's disease in rats: A behavioural, biochemical and molecular approach. J Funct Foods 16: 423-435. doi: 10.1016/j.jff.2015.05.001
    • (2015) J Funct Foods , vol.16 , pp. 423-435
    • Dhivya Bharathi, M.1    Justin Thenmozhi, A.2    Manivasagam, T.3
  • 28
    • 84955317992 scopus 로고    scopus 로고
    • Influences of chronic mild stress exposure on motor, non-motor impairments and neurochemical variables in specific brain areas of MPTP/probenecid induced neurotoxicity in mice
    • 26765842
    • Janakiraman U, Manivasagam T, Justin Thenmozhi A, Essa MM, Barathidasan R, Saravana Babu C, et al. (2016) Influences of chronic mild stress exposure on motor, non-motor impairments and neurochemical variables in specific brain areas of MPTP/probenecid induced neurotoxicity in mice. PLoS One. 11: e0146671. doi: 10.1371/journal.pone.0146671 PMID: 26765842
    • (2016) PLoS One. , vol.11
    • Janakiraman, U.1    Manivasagam, T.2    Justin Thenmozhi, A.3    Essa, M.M.4    Barathidasan, R.5    Saravana Babu, C.6
  • 29
    • 71849104860 scopus 로고
    • Protein measurement with the Folin phenol reagent
    • 14907713
    • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275. PMID: 14907713
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, A.L.3    Randall, R.J.4
  • 30
    • 84962163532 scopus 로고    scopus 로고
    • Vanillin attenuated behavioural impairments, neurochemical deficts, oxidative stress and apoptosis against rotenone induced rat model of Parkinson's disease
    • in press
    • Dhanalakshmi C, Janakiraman U, Manivasagam T, Justin Thenmozhi A, Essa MM, Kalandar A, et al. (2016) Vanillin attenuated behavioural impairments, neurochemical deficts, oxidative stress and apoptosis against rotenone induced rat model of Parkinson's disease. Neurochem Res (in press).
    • (2016) Neurochem Res
    • Dhanalakshmi, C.1    Janakiraman, U.2    Manivasagam, T.3    Justin Thenmozhi, A.4    Essa, M.M.5    Kalandar, A.6
  • 31
    • 0021144848 scopus 로고
    • Behavioral methods for measuring effects of drugs on learning and memory in animals
    • 6387332
    • Heise GA (1984) Behavioral methods for measuring effects of drugs on learning and memory in animals. Med Res Rev 4:535-558. PMID: 6387332
    • (1984) Med Res Rev , vol.4 , pp. 535-558
    • Heise, G.A.1
  • 32
    • 0037757999 scopus 로고    scopus 로고
    • Accumulation of aluminum in rat brain: Does it lead to behavioral and electrophysiological changes?
    • Baydar T, Papp A, Aydin A, Nagymajtenyi L, Schulz H, Isimer A et al. (2003) Accumulation of aluminum in rat brain: Does it lead to behavioral and electrophysiological changes? Biol Trace Ele Res 92: 231-244.
    • (2003) Biol Trace Ele Res , vol.92 , pp. 231-244
    • Baydar, T.1    Papp, A.2    Aydin, A.3    Nagymajtenyi, L.4    Schulz, H.5    Isimer, A.6
  • 33
    • 0027164617 scopus 로고
    • Regionally specific loss of neurons in the aging human hippocampus
    • 8367010
    • West MJ (1993) Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 14:287-293. PMID: 8367010
    • (1993) Neurobiol Aging , vol.14 , pp. 287-293
    • West, M.J.1
  • 35
    • 0037012468 scopus 로고    scopus 로고
    • Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyse acetylcholine
    • 11934471
    • Mesulam MM, Guillozet A, Shaw P, Levey A, Duysen EG, Lockridge O (2002) Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyse acetylcholine. Neuroscience 110:627-639. PMID: 11934471
    • (2002) Neuroscience , vol.110 , pp. 627-639
    • Mesulam, M.M.1    Guillozet, A.2    Shaw, P.3    Levey, A.4    Duysen, E.G.5    Lockridge, O.6
  • 36
    • 78650153306 scopus 로고    scopus 로고
    • Cholinergic system under aluminium toxicity in rat brain
    • 21170257
    • Yellamma K, Saraswathamma S, Kumar BN (2010) Cholinergic system under aluminium toxicity in rat brain. Toxicol Int 17: 106-112. doi: 10.4103/0971-6580.72682 PMID: 21170257
    • (2010) Toxicol Int , vol.17 , pp. 106-112
    • Yellamma, K.1    Saraswathamma, S.2    Kumar, B.N.3
  • 37
    • 0027509140 scopus 로고
    • Regulation of serine protease activity by Al: Implications for Alzheimer disease
    • 7679214
    • Clauberg M, Joshi JG (1993) Regulation of serine protease activity by Al: Implications for Alzheimer disease. Proc Natl Acad Sci USA 90: 1009-1012. PMID: 7679214
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1009-1012
    • Clauberg, M.1    Joshi, J.G.2
  • 38
    • 0035929569 scopus 로고    scopus 로고
    • Neuroscience. New leads on the 'how' of Alzheimer's
    • 11567120
    • Marx J (2001) Neuroscience. New leads on the 'how' of Alzheimer's. Science 293: 2192-2194. doi: 10. 1126/science.293.5538.2192 PMID: 11567120
    • (2001) Science , vol.293 , pp. 2192-2194
    • Marx, J.1
  • 39
    • 0037013602 scopus 로고    scopus 로고
    • Aluminum chelation principles and recent advances
    • Yokel RA (2002a) Aluminum chelation principles and recent advances. Coord Chem Rev 228: 97-113.
    • (2002) Coord Chem Rev , vol.228 , pp. 97-113
    • Yokel, R.A.1
  • 40
    • 0036801988 scopus 로고    scopus 로고
    • Brain uptake, retention, and efflux of aluminum and manganese
    • Yokel RA (2002b) Brain uptake, retention, and efflux of aluminum and manganese. Environ Health Perspect 110: 699-704.
    • (2002) Environ Health Perspect , vol.110 , pp. 699-704
    • Yokel, R.A.1
  • 41
    • 77951661903 scopus 로고    scopus 로고
    • Antioxidative activity of extracts from Fenugreek Seeds (Trigonella foenum-graecum)
    • Bukhari SB, Bhanger MI, Memon S (2008) Antioxidative activity of extracts from Fenugreek Seeds (Trigonella foenum-graecum). Pak J Anal Environ Chem 9: 78-83.
    • (2008) Pak J Anal Environ Chem , vol.9 , pp. 78-83
    • Bukhari, S.B.1    Bhanger, M.I.2    Memon, S.3
  • 42
    • 84890543148 scopus 로고    scopus 로고
    • A review on the functional properties, nutritional content, medicinal utilization and potential application of Fenugreek
    • Meghwal M, Goswami TK (2012) A review on the functional properties, nutritional content, medicinal utilization and potential application of Fenugreek. J Food Process Technol 9: 1-10.
    • (2012) J Food Process Technol , vol.9 , pp. 1-10
    • Meghwal, M.1    Goswami, T.K.2
  • 43
    • 84859974568 scopus 로고    scopus 로고
    • Psychopharmacological investigation of the nootropic potential of Trigonella foenum linn. In mice
    • Saini D, Dhingra AK, Chopra B, Parle M (2011) Psychopharmacological investigation of the nootropic potential of Trigonella foenum linn. in mice. Asian J Pharm Clin Res 4: 76-84.
    • (2011) Asian J Pharm Clin Res , vol.4 , pp. 76-84
    • Saini, D.1    Dhingra, A.K.2    Chopra, B.3    Parle, M.4
  • 44
    • 0028174977 scopus 로고
    • The cholinesterases: From genes to proteins
    • 8042853
    • Taylor P, Radic Z (1994) The cholinesterases: from genes to proteins. Annu Rev Pharmacol Toxicol 34: 281-320. doi: 10.1146/annurev.pa.34.040194.001433 PMID: 8042853
    • (1994) Annu Rev Pharmacol Toxicol , vol.34 , pp. 281-320
    • Taylor, P.1    Radic, Z.2
  • 46
    • 70350272866 scopus 로고    scopus 로고
    • Effect of carvedilol on behavioral, mitochondrial dysfunction and oxidative damage against D-galactose induced senescence in mice
    • Kumar A, Dogra S, Prakash A (2009b) Effect of carvedilol on behavioral, mitochondrial dysfunction and oxidative damage against D-galactose induced senescence in mice. Naunyn Schmiedebergs Arch Pharmacol 380: 431-441. doi: 10.1007/s00210-009-0442-8
    • (2009) Naunyn Schmiedebergs Arch Pharmacol , vol.380 , pp. 431-441
    • Kumar, A.1    Dogra, S.2    Prakash, A.3
  • 47
    • 0028071281 scopus 로고
    • Activation of acetylcholinesterase by aluminium(III): The relevance of the metal species
    • 7827330
    • Zatta P, Zambenedetti P, Bruna V, Filippi B (1994) Activation of acetylcholinesterase by aluminium(III): the relevance of the metal species. Neuroreport 5: 1777-1780. PMID: 7827330
    • (1994) Neuroreport , vol.5 , pp. 1777-1780
    • Zatta, P.1    Zambenedetti, P.2    Bruna, V.3    Filippi, B.4
  • 48
    • 0036315026 scopus 로고    scopus 로고
    • Inhibition of acetyl-and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: Correlation with cognitive benefit
    • 12111443
    • Giacobini E, Spiegel R, Enz A, Verff AE, Cutler NR (2002) Inhibition of acetyl-and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: correlation with cognitive benefit. J Neural Transm 109: 1053-1065. doi: 10.1007/s007020200089 PMID: 12111443
    • (2002) J Neural Transm , vol.109 , pp. 1053-1065
    • Giacobini, E.1    Spiegel, R.2    Enz, A.3    Verff, A.E.4    Cutler, N.R.5
  • 49
    • 84887972850 scopus 로고    scopus 로고
    • The multifactorial nature of Alzheimer's disease for developing potential therapeutics
    • 23931435
    • Carreiras MC, Mendes E, Perry MJ, Francisco AP, Marco-Contelles J (2013) The multifactorial nature of Alzheimer's disease for developing potential therapeutics. Curr Top Med Chem 13: 1745-1770. PMID: 23931435
    • (2013) Curr Top Med Chem , vol.13 , pp. 1745-1770
    • Carreiras, M.C.1    Mendes, E.2    Perry, M.J.3    Francisco, A.P.4    Marco-Contelles, J.5
  • 50
    • 19944433845 scopus 로고    scopus 로고
    • Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways
    • 15659232
    • Tamagno E, Parola M, Bardini P, Piccini A, Borgh R, Guglielmotto M, et al. (2005) Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways. J Neurochem 92: 628-636. doi: 10.1111/j.1471-4159.2004.02895.x PMID: 15659232
    • (2005) J Neurochem , vol.92 , pp. 628-636
    • Tamagno, E.1    Parola, M.2    Bardini, P.3    Piccini, A.4    Borgh, R.5    Guglielmotto, M.6
  • 51
    • 0027425060 scopus 로고
    • The C-terminus of the beta protein is critical in amyloidogenesis
    • 8239273
    • Jarrett JT, Berger EP, Lansbury PT (1993) The C-terminus of the beta protein is critical in amyloidogenesis. Ann N Y Acad Sci. 695: 144-148. PMID: 8239273
    • (1993) Ann N y Acad Sci. , vol.695 , pp. 144-148
    • Jarrett, J.T.1    Berger, E.P.2    Lansbury, P.T.3
  • 52
    • 84904576773 scopus 로고    scopus 로고
    • Effects of aluminium on β-Amyloid1-42 and secretases (APP-Cleaving Enzymes) in rat brain
    • 24792732
    • Wang L, Hu J, Zhao Y, Lu X, Zhang Q, Niu Q (2014) Effects of aluminium on β-Amyloid1-42 and secretases (APP-Cleaving Enzymes) in rat brain. Neurochem Res 39: 1338-1345. doi: 10.1007/s11064-014-1317-z PMID: 24792732
    • (2014) Neurochem Res , vol.39 , pp. 1338-1345
    • Wang, L.1    Hu, J.2    Zhao, Y.3    Lu, X.4    Zhang, Q.5    Niu, Q.6
  • 53
    • 33750731675 scopus 로고    scopus 로고
    • 100 years and counting: Prospects for defeating Alzheimer's disease
    • 17082448
    • Roberson ED, Mucke L (2006) 100 years and counting: prospects for defeating Alzheimer's disease. Science 314:781-784. doi: 10.1126/science.1132813 PMID: 17082448
    • (2006) Science , vol.314 , pp. 781-784
    • Roberson, E.D.1    Mucke, L.2
  • 54
    • 84901813146 scopus 로고    scopus 로고
    • Docosahexaenoic acid ameliorates aluminum induced biochemical and morphological alteration in rat cerebellum
    • 25206046
    • Chaudhary M, Joshi DK, Tripathi S, Kulshrestha S, Mahdi AA (2014) Docosahexaenoic acid ameliorates aluminum induced biochemical and morphological alteration in rat cerebellum. Ann Neurosci 21: 5-9. doi: 10.5214/ans.0972.7531.210103 PMID: 25206046
    • (2014) Ann Neurosci , vol.21 , pp. 5-9
    • Chaudhary, M.1    Joshi, D.K.2    Tripathi, S.3    Kulshrestha, S.4    Mahdi, A.A.5
  • 55
    • 84862840147 scopus 로고    scopus 로고
    • Preventive and curative effect of Trigonella foenum-graecum L.seeds in C57BL/6J models of type 2 diabetes induced by high-fat diet
    • 22633967
    • Hamza N, Berke B, Cheze C, Le Garrec R, Umar A, Agli AN, et al. (2012) Preventive and curative effect of Trigonella foenum-graecum L. seeds in C57BL/6J models of type 2 diabetes induced by high-fat diet. J Ethnopharmacol 142: 516-522. doi: 10.1016/j.jep.2012.05.028 PMID: 22633967
    • (2012) J Ethnopharmacol , vol.142 , pp. 516-522
    • Hamza, N.1    Berke, B.2    Cheze, C.3    Le Garrec, R.4    Umar, A.5    Agli, A.N.6
  • 56
    • 0035369623 scopus 로고    scopus 로고
    • Transcription-dependent and-independent control of neuronal survival by the PI3K-Akt signaling pathway
    • 11399427
    • Brunet A, Datta SR, Greenberg ME (2001) Transcription-dependent and-independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol 11: 297-305. PMID: 11399427
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 297-305
    • Brunet, A.1    Datta, S.R.2    Greenberg, M.E.3
  • 57
    • 33748299477 scopus 로고    scopus 로고
    • The paradoxical pro-and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways
    • 16935409
    • Beurel E, Jope RS (2006) The paradoxical pro-and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol 79: 173-189. doi: 10.1016/j.pneurobio.2006. 07.006 PMID: 16935409
    • (2006) Prog Neurobiol , vol.79 , pp. 173-189
    • Beurel, E.1    Jope, R.S.2
  • 58
    • 34347358646 scopus 로고    scopus 로고
    • JNK signalling: A possible target to prevent neurodegeneration
    • 17584114
    • Borsello T, Forloni G (2007) JNK signalling: a possible target to prevent neurodegeneration. Curr Pharm Des 13: 1875-1886. PMID: 17584114
    • (2007) Curr Pharm des , vol.13 , pp. 1875-1886
    • Borsello, T.1    Forloni, G.2
  • 59
    • 0034655803 scopus 로고    scopus 로고
    • Akt/protein kinase B prevents injury-induced motor neuron death and accelerates axonal regeneration
    • 10751440
    • Namikawa K, Honma M, Abe K, Takeda M, Mansur K, Obata T, et al. (2000) Akt/protein kinase B prevents injury-induced motor neuron death and accelerates axonal regeneration. J. Neurosci 20: 2875-2886. PMID: 10751440
    • (2000) J. Neurosci , vol.20 , pp. 2875-2886
    • Namikawa, K.1    Honma, M.2    Abe, K.3    Takeda, M.4    Mansur, K.5    Obata, T.6
  • 60
    • 33847014888 scopus 로고    scopus 로고
    • Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke
    • 17308356
    • Zhao H, Sapolsky RM, Steinberg GK (2006) Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol 34: 249-270. doi: 10.1385/MN:34:3:249 PMID: 17308356
    • (2006) Mol Neurobiol , vol.34 , pp. 249-270
    • Zhao, H.1    Sapolsky, R.M.2    Steinberg, G.K.3
  • 61
    • 70349106763 scopus 로고    scopus 로고
    • Gelsolin is proteolytically cleaved in the brains of individuals with Alzheimer's disease
    • 19625752 2009
    • Ji L, Chauhan A, Wegiel J, Essa MM, Chauhan V (2009). Gelsolin is proteolytically cleaved in the brains of individuals with Alzheimer's disease. J Alzheimers Dis. 2009; 18:105-11 doi: 10.3233/JAD-2009-1127 PMID: 19625752
    • (2009) J Alzheimers Dis. , vol.18 , pp. 105-111
    • Ji, L.1    Chauhan, A.2    Wegiel, J.3    Essa, M.M.4    Chauhan, V.5
  • 62
    • 0032522924 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
    • 9526010
    • Crowder RJ, Freeman RS (1998) Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J Neurosci 18: 2933-2943. PMID: 9526010
    • (1998) J Neurosci , vol.18 , pp. 2933-2943
    • Crowder, R.J.1    Freeman, R.S.2
  • 63
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • 9346240
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y et al. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 91, 231-241. PMID: 9346240
    • (1997) Cell. , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6
  • 65
    • 0032493729 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway
    • 9685326
    • Pap M, Cooper GM (1998) Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem 273: 19929-19932. PMID: 9685326
    • (1998) J Biol Chem , vol.273 , pp. 19929-19932
    • Pap, M.1    Cooper, G.M.2
  • 66
    • 84877951431 scopus 로고    scopus 로고
    • Molecular mechanisms of environmental enrichment: Impairments in AKT/GSK3β, neurotrophin-3 and CREB signaling
    • 23700479
    • Hu YS, Long N, Pigino G, Brady ST, Lazarov O (2013) Molecular mechanisms of environmental enrichment: impairments in AKT/GSK3β, neurotrophin-3 and CREB signaling. PLoS One. 8: e64460. doi: 10. 1371/journal.pone.0064460 PMID: 23700479
    • (2013) PLoS One. , vol.8
    • Hu, Y.S.1    Long, N.2    Pigino, G.3    Brady, S.T.4    Lazarov, O.5
  • 67
    • 33747425620 scopus 로고    scopus 로고
    • GSK-3 is essential in the pathogenesis of Alzheimer's disease
    • Takashima A (2006) GSK-3 is essential in the pathogenesis of Alzheimer's disease. J Alzheimer's Dis 9: 309-317.
    • (2006) J Alzheimer's Dis , vol.9 , pp. 309-317
    • Takashima, A.1
  • 68
    • 0027515127 scopus 로고
    • Inactivation of glycogen synthase kinase-3 by phosphorylation: New kinase connections in insulin and growth-factor signaling
    • 8250835
    • Sutherland C, Leighton IA, Cohen P (1993) Inactivation of glycogen synthase kinase-3 by phosphorylation: new kinase connections in insulin and growth-factor signaling. Biochem J 296: 15-19. PMID: 8250835
    • (1993) Biochem J , vol.296 , pp. 15-19
    • Sutherland, C.1    Leighton, I.A.2    Cohen, P.3
  • 69
    • 0028176021 scopus 로고
    • Glycogen synthase kinase-3 is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation
    • 7514173
    • Wang QM, Fiol CJ, DePaoli-Roach AA, Roach PJ (1994) Glycogen synthase kinase-3 is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation. J Biol Chem 269: 14566-14574. PMID: 7514173
    • (1994) J Biol Chem , vol.269 , pp. 14566-14574
    • Wang, Q.M.1    Fiol, C.J.2    DePaoli-Roach, A.A.3    Roach, P.J.4
  • 70
    • 84954497911 scopus 로고    scopus 로고
    • Caspase-3 is involved in aluminum-induced impairment of long term potentiation in rats through the Akt/GSK-3β Pathway
    • in press
    • Zhang H, Yang X, Qin X, Niu Q (2016) Caspase-3 is involved in aluminum-induced impairment of long term potentiation in rats through the Akt/GSK-3β Pathway. Neurotox Res (in press).
    • (2016) Neurotox Res
    • Zhang, H.1    Yang, X.2    Qin, X.3    Niu, Q.4
  • 71
    • 84886657375 scopus 로고    scopus 로고
    • Neuroprotective effects of a variety of pomegranate juice extracts against MPTP-induced cytotoxicity and oxidative stress in human primary neurons
    • 24223235
    • Braidy N, Selvaraju S, Essa MM, Vaishnav R, Al-Adawi S, Al-Asmi A, et al. (2013). Neuroprotective effects of a variety of pomegranate juice extracts against MPTP-induced cytotoxicity and oxidative stress in human primary neurons. Oxid Med Cell Longev. 2013:685909 doi: 10.1155/2013/685909 PMID: 24223235
    • (2013) Oxid Med Cell Longev. , vol.2013 , pp. 685909
    • Braidy, N.1    Selvaraju, S.2    Essa, M.M.3    Vaishnav, R.4    Al-Adawi, S.5    Al-Asmi, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.