Brain uptake, retention, and efflux of aluminum and manganese

Environmental Health Perspectives

Volumn 110, Issue SUPPL. 5, 2002, Pages 699-704

  Yokel, Robert A ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Aluminum; b.End5 cells; Blood brain barrier; Brain efflux; Brain endothelial cells; Brain influx; In situ brain perfusion; Manganese; Microdialysis; Rat

Indexed keywords

ALUMINUM; ALUMINUM CITRATE; CARRIER PROTEIN; ERYTHROCYTE BAND 3 PROTEIN; ISOPROTEIN; MANGANESE; MONOCARBOXYLATE TRANSPORTER; SODIUM ION; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANION EXCHANGE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CELL; BRAIN TISSUE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFUSION; ENDOCYTOSIS; ENDOTHELIUM CELL; ERYTHROCYTE; EXTRACELLULAR FLUID; INHIBITION KINETICS; MEMBRANE PERMEABILITY; MICRODIALYSIS; MOLECULAR MECHANICS; NEUROTOXICITY; NONHUMAN; PH; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; RAT; TISSUE DISTRIBUTION; TOXICOKINETICS; TRANSPORT KINETICS;

ANIMALIA; MURINAE;

EID: 0036801988     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.02110s5699     Document Type: Article

References (54)

1. Gerhardsson L, Skerfving S. Concepts on biological markers and biomonitoring for metal toxicity. In: Toxicity of Metals (Chang LW, ed). Boca Raton, FL:CRC Lewis, 1996;81-107.
2. Yokel RA. The toxicology of aluminum in the brain: a review. Neurotoxicology 21:813-828 (2000).
3. Spencer PS. Aluminum and its compounds. In: Experimental and Clinical Neurotoxicology (Spencer PS, Schaumberg HH, eds). New York:Oxford University Press, 2000;142-151.
4. Chu N-S, Huang C-C, Caine DB. Manganese. In: Experimental and Clinical Neurotoxicology (Spencer PS, Schaumburg HH, eds). New York:Oxford University Press, 2000;752-755.
5. Segal A, Sigel H, eds. Metal Ions in Biological Systems. New York:Marcel Dekker, 2000.
6. Berend K, van der Voet G, Boer WH. Acute aluminum encephalopathy in a dialysis center caused by a cement mortar water distribution pipe. Kidney Int 59:746-753 (2001).
7. Crapper DR, Krishnan SS, Dalton AJ. Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration. Science 180:511-513 (1973).
8. U.S. Environmental Protection Agency. Announcement of the drinking water contaminant candidate list. Fed Reg 63:10273-10287 (1998). Available: http://fwebgate1. access.gpo.ogv/cgi-bin/waisgate.cgi?WAISdocID = 4127988281+0+0+0&WAISaction = retrieve [cited 18 June 2002].
9. U.S. Food and Drug Administration. Aluminum in large and small volume parenterals used in total parenteral nutrition. Code of Federal Regulations, vol 21 CFR201.323, 2000. cfr.cgi?TITLE = 21&PART = 201&SECTION = 323&TYPE = TEXT [cited 18 June 2002].
10. Health Canada. Aluminum. Environmental Health Program, 1998. Available: http://www.hc-sc.gc.ca/ehp/ehd/catalogue/bch_pubs/dwgsup_doc/aluminum.pdf [cited 18 June 2002].
11. Hudnell HK. Effects from environmental Mn Exposures: a review of the evidence from non-occupational exposure studies. Neurotoxicology 20:379-397 (1999).
12. Iregen A. Manganese neurotoxicity in industrial exposures: proof of effects, critical exposure level, and sensitive tests. Neurotoxicology 20:315-323 (1999).
13. Copuer J. On the effects of black oxide of manganese when inhaled into the lungs. Br Ann Med Pharm Vital Stat Gen Sci 1:41-42 (1837).
14. Keen CL, Lonnerdal B. Toxicity of essential and beneficial metal ions. In: Handbook of Metal-Ligand Interactions in Biological Fluids, Vol 2 (Berthon G, ed). New York:Marcel Dekker, 1995;683-688.
15. Smith QR. Regulation of brain metal uptake and distribution within the brain. In: Nutrition and the Brain, Vol 8 (Wurtman RJ, Wurtman JJ, eds). New York:Raven Press, 1990;25-74.
16. Aschner M, Vrana KE, Zheng W. Manganese uptake and distribution in the central nervous system (CNS). Neurotoxicology 20:173-180 (1999).
17. Aschner M. Manganese: brain transport and emerging research needs. Environ Health Perspect 108:429-432 (2000).
18. Perl DP, Good PF. Uptake of aluminium into central nervous system along nasal-olfactory pathways. Lancet 1:1028 (1987).
19. Divine KK, Lewis JL, Grant PG, Bench G. Quantitative particle-induced X-ray emission imaging of rat olfactory epithelium applied to the permeability of rat epithelium to inhaled aluminum. Chem Res Toxicol 12:575-581 (1999).
20. Tjälve H, Henriksson J. Uptake of metals in the brain via olfactory pathways. Neurotoxicology 20:1781-195 (1999).
21. 2) to the rat brain: toxicokinetic investigations in a unilateral nasal occlusion model. Toxicol Appl Pharmacol 169:238-248 (2000).
22. Scheibel A. Personal communication.
23. Levin VA. Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem 23:682-684 (1980>
24. Laterra J, Keep R, Betz AL, Goldstein GW. Blood-brain-cerebrospinal fluid barriers. In: Basic Neurochemistry: Molecular, Cellular and Medical Aspects (Siegel GJ, Agranoff BW, eds). Philadelphia:Lippincott-Raven, 1999;671-689.
25. Romero IA, Abbott NJ, Bradbury MWB. The blood-brain barrier in normal CNS and i metal-induced neurotoxicity. In: Toxicology of Metals (Chang LW, Magos L, Suzuki T, eds). Boca Raton, FL:CRC Lewis, 1996;561-585.
26. Society of Toxicology. Guiding Principles in the Use of Animals in Toxicology, Revised March 1999. Available: http://www.toxicology.org/MemberServices/FormsApps/guidingprinciples.pdf
27. Yokel RA, McNamara PJ. Aluminum toxicokinetics: an updated mini-review. Pharmacol Toxicol 88:159-167 (2001),
28. Pardridge WM. CNS drug design based on principles of blood-brain barrier transport. J Neurochem 70:1781-1792 (1998).
29. Davson H, Welch K, Segal MB. The secretion of the cerebrospinal fluid. In: The Physiology and Pathophysiology of the Cerebrospinal Fluid. New York:Churchill Livingstone, 1987;218-221.
30. Rennels ML, Gregory TF, Blaumanis OR, Fujimoto K, Grady PA. Evidence for a "paravascular" fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res 326:47-63 (1985).
31. Akeson MA, Munns DN. Lipid bilayer permeation by neutral aluminum citrate and by three alpha-hydroxy carboxyclic acids. Biochim Biophys Acta 984:200-206 (1989).
32. Crone C. The permeability of capillaries in various organs as determined by use of the indicator diffusion method. Acta Physiol Scand 58:292-305 (1963).
33. Yokel RA, Lidums V, McNamara PJ, Ungerstedt U. Aluminum distribution into brain and liver of rats and rabbits following intravenous aluminum lactate or citrate: a microdialysis study. Toxicol Appl Pharmacol 107:153-163 (1991).
34. Allen DD, Crooks PA, Yokel RA. 4-Trimethylammonium antipyrine: a quaternary ammonium nonradionuclide marker for blood-brain barrier integrity during in vivo microdialysis. J Pharmacol Toxicol Meth 28:129-135 (1992).
35. Yokel RA. Aluminum toxicokinetics at the blood-brain barrier. In: Aluminum and Alzheimer's Disease (Exley C, ed). New York: Elsevier, 2001;233-360.
36. Bradbury MW. Transport of iron in the blood-brain-cerebrospinal fluid system. J Neurochem 69:443-454 (1997).
37. Yokel RA, Wilson M, Harris WR, Halestrap AP. Aluminum citrate uptake by immortalized brain endothelial cells; implications for its blood-brain barrier transport. Brain Res 930:101-110 (2002).
38. Ackley DC, Yokel RA. Aluminum citrates is transported from brain into blood via the monocarboxylic acid transporter located at the blood-brain barrier. Toxicology 120:89-97 (1997).
39. Ackley DC, Yokel RA. Aluminum transport out of brain extracellular fluid is proton dependent and inhibited by mersalyl acid, suggesting mediation by the monocarboxylate trnanporter (MCT1). Toxicology 127:59-67 (1998).
40. Flarend R, Elmore D. Aluminum-26 as a biological tracer using accelerator mass spectrometry. In: Aluminum Toxicity in Infant's Health and Disease (Zatta P, Alfrey AC, eds). Singapore/London:World Scientific, 1998;16-39.
41. 26Al exposure. Toxicol Sci 64:77-82 (2001).
42. Yokel RA, Elmore D, McNamara PJ. Unpublished data.
43. Murphy VA, Wadhwani KC, Smith QR, Rapoport SI. Saturable transport of mangenese (II) across the rat blood-brain barrier. J Neurochem 57:948-954 (1991).
44. Aschner M, Gannon M. Manganese (Mn) transport across that rat blodd-brain barrier: saturable and tranferrin-dependent transport mechanism. Br Res Bull 33:345-349 (1994).
45. Takasato Y, Rapoport SI, Smith QR. An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am J Physiol 247:H484-H493 (1984).
46. Allen DD, Smith QR. Characterization of the blood-brain barrier choline transporter using the in situ rat brain perfusion technique. J Neurochem 73:1032:1041 (2001).
47. 2+ binding to serum transferrin. J Inorg Biochem 54:1-19 (1994).
48. Crossgrove JS, Allen DD, Bukaveckas BL, Rhineheimer SS, Yokel RA. Mangenese distribution across the blood-brain barrier. I: Evidence for carrier-mediated influx of manganese citrate as well as manganese and manganese transferrin. Neuro Toxicology (in press).
49. Triguero D, Buciak J, Pardridge WM. Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J Neurochem 54:1882-1888 (1990).
50. Kakee A, Terasaki T, Sugiyama Y. Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier. J Pharmacol Exp Ther 277:1550-1559 (1996).
51. Kakee A, Terasaki T, Sugiyama Y. Selective brain to blood efflux transport of para-aminohippuric acid accross the blood-brain barrier: in vivo evidence by use of the brain efflux index method. J Pharmacol Exp Ther 283:1018-1025 (1997).
52. Yokel RA, Crossgrove JS, Bukaveckas BL. Manganese distribution accross the blood-brain barrier. II: Manganese efflux from the brain does not appear to be carrier mediated. Neuro Toxicology (in press).
53. Allen DD, Yokel RA. Dissimilar aluminum and gallium permeation of the blood-brain barrier demonstrated by in vivo microdialysis. J Neurochem 58:903-908 (1992).
54. Allen DD, Orvig C, Yokel RA. Evidence for energy-dependent transport of aluminum out of brain extracellular fluid. Toxicology 98:31-39 (1995).