Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: Decisive role of Bax, Nrf2, NF-κB, Muc5ac, TNF-α and IL-1β

Chemico-Biological Interactions

Volumn 237, Issue , 2015, Pages 151-165

  Kandhare, Amit D ^a   Bodhankar, Subhash L ^a   Mohan, Vishwaraman ^b   Thakurdesai, Prasad A ^b  

^a BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

^b Indus Biotech Private Limited   (India)

Author keywords

Bleomycin; Muc5ac; NF B; Nrf2; Pulmonary fibrosis; Standardized fenugreek seeds extract

Indexed keywords

ALKALINE PHOSPHATASE; BLEOMYCIN; CASPASE 3; COLLAGEN TYPE 1; ENDOTHELIN 1; GLUTATHIONE; GLYCOSIDES BASED STANDARDIZED FENUGREEK SEED EXTRACT; HEME OXYGENASE 1; HISTAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LACTATE DEHYDROGENASE; MALONALDEHYDE; MESSENGER RNA; METHYLPREDNISOLONE; MUCIN 5AC; NITRIC OXIDE; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; SEROTONIN; SMAD3 PROTEIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; BAX PROTEIN, RAT; GLYCOSIDE; MUC5AC PROTEIN, RAT; NFE2L2 PROTEIN, RAT;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; FIBROSING ALVEOLITIS; GENE EXPRESSION; LACTATE DEHYDROGENASE BLOOD LEVEL; LUNG FUNCTION TEST; LUNG LAVAGE; MALE; NONHUMAN; OXYGEN BLOOD LEVEL; PROTECTION; PROTEIN FUNCTION; PROTEIN INDUCTION; RAT; SINGLE DRUG DOSE; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; EMBRYOLOGY; LUNG FIBROSIS; PATHOPHYSIOLOGY; PHYSIOLOGY; PLANT SEED; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; STANDARDS; TRIGONELLA;

RATTUS; RATTUS NORVEGICUS; TRIGONELLA FOENUM-GRAECUM;

ALKALINE PHOSPHATASE; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BLEOMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; GLYCOSIDES; INTERLEUKIN-1BETA; L-LACTATE DEHYDROGENASE; MALE; MUCIN 5AC; NF-E2-RELATED FACTOR 2; NF-KAPPA B; PLANT EXTRACTS; PULMONARY FIBROSIS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEEDS; TRIGONELLA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84935014211     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.06.019     Document Type: Article

References (61)

1. E.S. White, M.H. Lazar, and V.J. Thannickal Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis J. Pathol. 201 2003 343 354
2. D. Schwartz, R. Helmers, J. Galvin, D. Van Fossen, K. Frees, C. Dayton, L. Burmeister, and G. Hunninghake Determinants of survival in idiopathic pulmonary fibrosis Am. J. Respir. Crit. Care Med. 149 1994 450 454
3. A.L. Olson, J.J. Swigris, D.C. Lezotte, J.M. Norris, C.G. Wilson, K.K. Brown, Mortality from pulmonary fibrosis increased in the United States from To 2003 Am. J. Respir. Crit. Care Med. 176 2007 1992 277 284
4. D.A. Zisman, M.P. Keane, J.A. Belperio, R.M. Strieter, and J.P. Lynch III Pulmonary Fibrosis Research 2005 Springer 3 44
5. T. Colby, and A. Churg Patterns of pulmonary fibrosis Pathol. Annu. 21 1985 277 309
6. T.J. Gross, and G.W. Hunninghake Idiopathic pulmonary fibrosis N. Engl. J. Med. 345 2001 517 525
7. A.T. Society, Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement, (2000).
8. W. Dik, R. McAnulty, M. Versnel, B. Naber, L. Zimmermann, G. Laurent, and S. Mutsaers Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats Thorax 58 2003 765 771
9. H.V. Woodcock, T.M. Maher, The treatment of idiopathic pulmonary fibrosis, F1000prime reports, 6 (2014).
10. L. Atzori, F. Chua, S. Dunsmore, D. Willis, M. Barbarisi, R. McAnulty, and G. Laurent Attenuation of bleomycin induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2, 4-bisethylene glycol Thorax 59 2004 217 223
11. H.-D. Wang, M. Yamaya, S. Okinaga, Y.-X. Jia, M. Kamanaka, H. Takahashi, L.-Y. Guo, T. Ohrui, and H. Sasaki Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats Am. J. Respir. Crit. Care Med. 165 2002 406 411
12. A.D. Kandhare, K.S. Raygude, P. Ghosh, T.P. Gosavi, and S.L. Bodhankar Patentability of animal models: India and the globe Int. J. Pharm. Biol. Arch. 2 2011 1024 1032
13. D.S. El-Agamy Nilotinib ameliorates lipopolysaccharide-induced acute lung injury in rats Toxicol. Appl. Pharmacol. 253 2011 153 160
14. S. Kalayarasan, N. Sriram, and G. Sudhandiran Dialyl sulfide attenuates bleomycin-induced pulmonary fibrosis: critical role of iNOS, NF-κB, TNF-α and IL-1β Life Sci. 82 2008 1142 1153
15. W.G. Taylor, H.J. Zulyniak, K.W. Richards, S.N. Acharya, S. Bittman, and J.L. Elder Variation in diosgenin levels among 10 accessions of fenugreek seeds produced in western Canada J. Agric. Food Chem. 50 2002 5994 5997
16. S.P. Patil, P.V. Niphadkar, and M.M. Bapat Allergy to Fenugreek (Trigonella foenum graecum) Ann. Allergy Asthma Immunol. 78 1997 297 300
17. T. Murakami, A. Kishi, H. Matsuda, M. Yoshikawa, Medicinal foodstuffs. XVII. Fenugreek seed. (3): structures of new furostanol-type steroid saponins, trigoneosides Xa, Xb, XIb, XIIa, XIIb, and XIIIa, from the seeds of Egyptian Trigonella foenum-graecum L., Chemical And Pharmaceutical Bulletin (Tokyo), 48 (2000) 994-1000.
18. M. Smith Therapeutic applications of fenugreek Alter. Med. Rev. 8 2003 20 27
19. U. Aswar, S.L. Bodhankar, V. Mohan, and P.A. Thakurdesai Effect of furostanol glycosides from Trigonella foenum-graecum on the reproductive system of male albino rats Phytother. Res. 24 2010 1482 1488
20. A.D. Kandhare, S.L. Bodhankar, V. Mohan, and P.A. Thakurdesai Acute and repeated doses (28 days) oral toxicity study of glycosides based standardized fenugreek seed extract in laboratory mice Regul. Toxicol. Pharmacol. 72 2015 323 334
21. X. Li, and S. Cui The mechanisms and effects of panax notoginside and methylprednisolone in a rat model of pulmonary fibrosis Zhonghua Jie He He Hu Xi Za Zhi 25 2002 520 523
22. J. Cortijo, A. Iranzo, X. Milara, M. Mata, M. Cerdá-Nicolás, A. Ruiz-Saurí, H. Tenor, A. Hatzelmann, and E. Morcillo Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury Br. J. Pharmacol. 156 2009 534 544
23. A. Delaunois, P. Dedoncker, E. Hanon, and M. Guyaux Repeated assessment of cardiovascular and respiratory functions using combined telemetry and whole-body plethysmography in the rat J. Pharmacol. Toxicol. Methods 60 2009 117 129
24. D. Pilling, D. Roife, M. Wang, S.D. Ronkainen, J.R. Crawford, E.L. Travis, and R.H. Gomer Reduction of bleomycin-induced pulmonary fibrosis by serum amyloid P J. Immunol. 179 2007 4035 4044
25. A.D. Kandhare, S.L. Bodhankar, V. Singh, V. Mohan, and P.A. Thakurdesai Anti-asthmatic effects of type-A procyanidin polyphenols from cinnamon bark in ovalbumin-induced airway hyperresponsiveness in laboratory animals Biomed. Aging Pathol. 3 2013 23 30
26. A.D. Kandhare, P. Ghosh, and S.L. Bodhankar Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats Chem. Biol. Interact. 219C 2014 101 112
27. A.D. Kandhare, K.S. Raygude, P. Ghosh, A.E. Ghule, and S.L. Bodhankar Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy Fitoterapia 83 2012 650 659
28. A.D. Kandhare, V. Shivakumar, A. Rajmane, P. Ghosh, and S.L. Bodhankar Evaluation of the neuroprotective effect of chrysin via modulation of endogenous biomarkers in a rat model of spinal cord injury J. Nat. Med. 2014 1 18
29. T. Ashcroft, J.M. Simpson, and V. Timbrell Simple method of estimating severity of pulmonary fibrosis on a numerical scale J. Clin. Pathol. 41 1988 467 470
30. A. Moeller, K. Ask, D. Warburton, J. Gauldie, and M. Kolb The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int. J. Biochem. Cell Biol. 40 2008 362 382
31. N. Simler, D. Howell, R. Marshall, N. Goldsack, P. Hasleton, G. Laurent, R. Chambers, and J. Egan The rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats Eur. Respir. J. 19 2002 1124 1127
32. N. Sriram, S. Kalayarasan, and G. Sudhandiran Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling Pulm. Pharmacol. Ther. 22 2009 221 236
33. S. Klebanoff, Phagocytic cells: products of oxygen metabolism, inflammation: basic principles and clinical correlates, (1988) 391-444.
34. D.B. Chandler, D.M. Hyde, and S. Giri Morphometric estimates of infiltrative cellular changes during the development of bleomycin-induced pulmonary fibrosis in hamsters Am. J. Pathol. 112 1983 170
35. A. Rao, and C. Shaha Role of glutathione S-transferases in oxidative stress-induced male germ cell apoptosis Free Radical Biol. Med. 29 2000 1015 1027
36. M. Mata, A. Ruiz, M. Cerda, M. Martinez-Losa, J. Cortijo, F. Santangelo, A. Serrano-Mollar, A. Llombart-Bosch, and E. Morcillo Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats Eur. Respir. J. 22 2003 900 905
37. H.-Y. Cho, A.E. Jedlicka, S.P. Reddy, T.W. Kensler, M. Yamamoto, L.-Y. Zhang, and S.R. Kleeberger Role of NRF2 in protection against hyperoxic lung injury in mice Am. J. Respir. Cell Mol. Biol. 26 2002 175 182
38. D.-J. Slebos, S.W. Ryter, and A.M.K. Choi Heme oxygenase-1 and carbon monoxide in pulmonary medicine Respir. Res. 4 2003 7-7
39. A. Sevanian, and P. Hochstein Mechanisms and consequences of lipid peroxidation in biological systems Annu. Rev. Nutr. 5 1985 365 390
40. H. Hao, D.A. Cohen, C.D. Jennings, J.S. Bryson, and A.M. Kaplan Bleomycin-induced pulmonary fibrosis is independent of eosinophils J. Leukoc. Biol. 68 2000 515 521
41. P. Paredi, S.A. Kharitonov, and P.J. Barnes Analysis of expired air for oxidation products Am. J. Respir. Crit. Care Med. 166 2002 31 37
42. H.M. Arafa, M.H. Abdel-Wahab, M.F. El-Shafeey, O.A. Badary, and F. Hamada Anti-fibrotic effect of meloxicam in a murine lung fibrosis model Eur. J. Pharmacol. 564 2007 181 189
43. Y. Chen, Y.-C. Nie, Y.-L. Luo, F. Lin, Y.-F. Zheng, G.-H. Cheng, H. Wu, K.-J. Zhang, W.-W. Su, and J.-G. Shen Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice Food Chem. Toxicol. 58 2013 133 140
44. N. Rawson, and J. Peto An overview of prognostic factors in small cell lung cancer. A report from the Subcommittee for the Management of Lung Cancer of the United Kingdom Coordinating Committee on Cancer Research Br. J. Cancer 61 1990 597
45. S. Matusiewicz, I. Williamson, P. Sime, P. Brown, P. Wenham, G. Crompton, and A. Greening Plasma lactate dehydrogenase: a marker of disease activity in cryptogenic fibrosing alveolitis and extrinsic allergic alveolitis? Eur. Respir. J. 6 1993 1282 1286
46. I.A. Leclercq, G.C. Farrell, C. Sempoux, and Y. Horsmans Curcumin inhibits NF-κB activation and reduces the severity of experimental steatohepatitis in mice J. Hepatol. 41 2004 926 934
47. M. Kuroki, Y. Noguchi, M. Shimono, K. Tomono, T. Tashiro, Y. Obata, E. Nakayama, and S. Kohno Repression of bleomycin-induced pneumopathy by TNF J. Immunol. 170 2003 567 574
48. A. Serrano-Mollar, D. Closa, N. Prats, S. Blesa, M. Martinez-Losa, J. Cortijo, J. Estrela, E. Morcillo, and O. Bulbena In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats Br. J. Pharmacol. 138 2003 1037 1048
49. S.H. Phan, and S.L. Kunkel Lung cytokine production in bleomycin-induced pulmonary fibrosis Exp. Lung Res. 18 1992 29 43
50. R.K. Scheule, R.C. Perkins, R. Hamilton, and A. Holian Bleomycin stimulation of cytokine secretion by the human alveolar macrophage Am. J. Physiol. 262 1992 L386 L391
51. M.P. Keane, and R.M. Strieter The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease Respir. Res. 3 2002 133
52. M. Kelly, M. Kolb, P. Bonniaud, and J. Gauldie Re-evaluation of fibrogenic cytokines in lung fibrosis Curr. Pharm. Des. 9 2003 39 49
53. A. Bellocq, E. Azoulay, S. Marullo, A. Flahault, B. Fouqueray, C. Philippe, J. Cadranel, and L. Baud Reactive oxygen and nitrogen intermediates increase transforming growth factor-β 1 release from human epithelial alveolar cells through two different mechanisms Am. J. Respir. Cell Mol. Biol. 21 1999 128 136
54. Y. Gao, J. Lu, Y. Zhang, Y. Chen, Z. Gu, and X. Jiang Baicalein attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of miR-21 Pulm. Pharmacol. Ther. 26 2013 649 654
55. C. Zhou, Y. Shi, J. Li, W. Zhang, C. Fu, Y. Wang, Y. Liu, and J. Liu The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice Pak. J. Pharm. Sci. 26 2013
56. K. Takeyama, K. Dabbagh, J.J. Shim, T. Dao-Pick, I.F. Ueki, and J.A. Nadel Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils J. Immunol. 164 2000 1546 1552
57. V.J. Thannickal, G.B. Toews, E.S. White, J.P. Lynch Iii, and F.J. Martinez Mechanisms of pulmonary fibrosis Annu. Rev. Med. 55 2004 395 417
58. X. Li, and S. Cui [The mechanisms and effects of panax notoginside and methylprednisolone in a rat model of pulmonary fibrosis], Zhonghua jie he he hu xi za zhi= Zhonghua jiehe he huxi zazhi= Chin. J. Tuberc. Resp. Dis. 25 2002 520 523
59. V.Y. Lee, C. Schroedl, J.K. Brunelle, L.J. Buccellato, O.I. Akinci, H. Kaneto, C. Snyder, J. Eisenbart, G.S. Budinger, and N.S. Chandel Bleomycin induces alveolar epithelial cell death through JNK-dependent activation of the mitochondrial death pathway Am. J. Physiol. Lung Cell. Mol. Physiol. 289 2005 L521 L528
60. J. Usuki, and Y. Fukuda Evolution of three patterns of intra-alveolar fibrosis produced by bleomycin in rats Pathol. Int. 45 1995 552 564
61. R. Cruz-Gervis, A.A. Stecenko, R. Dworski, K.B. Lane, J.E. Loyd, R. Pierson, G. King, and K.L. Brigham Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis Respir. Res. 3 2002 17 22