Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Nature Communications

Volumn 7, Issue , 2016, Pages

  Ventham, N T ^a   Kennedy, N A ^a   Adams, A T ^a   Kalla, R ^a   Heath, S ^b,c   O'Leary, K R ^a   Drummond, H ^a   Wilson, D C ^a   Gut, I G ^b,c   Nimmo, E R ^a   Satsangi, J ^a   Lauc, Gordan ^d   Campbell, Harry ^a   McGovern, Dermot P B ^e   Annese, Vito ^f   Zoldoš, Vlatka ^g   Permberton, Iain K ^h   Wuhrer, Manfred ^i,j   Kolarich, Daniel ^k   Fernandes, Daryl L ^l   Theorodorou, Evropi ^a   Merrick, Victoria ^a   Spencer, Daniel I ^l   Gardner, Richard A ^l   Doran, Ray ^l   Shubhakar, Archana ^l   Boyapati, Ray ^a   Rudan, Igor ^a   Lionetti, Paolo ^m   Akmačić, Irena Trbojević ^d   Krištić, Jasminka ^d   Vučković, Frano ^d   Štambuk, Jerko ^d   Novokmet, Mislav ^d   Pučić Baković, Maja ^d,g   Gornik, Olga ^g   Andriulli, Angelo ⁿ   Cantoro, Laura ^o   Sturniolo, Giancarlo ^p   Fiorino, Gionata ^q   Manetti, Natalia ^f   Latiano, Anna ⁿ   Kohn, Anna ^o   D'Incà, Renata ^p   Danese, Silvio ^q   Arnott, Ian D ^r   Noble, Colin L ^r   Lees, Charlie W ^r   Shand, Alan G ^r   Ho, Gwo Tzer ^a,r   Dunlop, Malcolm G ^s   Murphy, Lee ^r   Gibson, Jude ^r   Evenden, Louise ^r   Wrobel, Nicola ^r   Gilchrist, Tamara ^r   Fawkes, Angie ^r   Kammeijer, Guinevere S M ⁱ   Clerc, Florent ⁱ   De Haan, Noortje ⁱ   Vojta, Aleksandar ^g   Samaržija, Ivana ^g   Markulin, Dora ^g   Klasić, Marija ^g   Dobrinić, Paula ^g   Aulchenko, Yurii ^t,u   Van Den Heuve, Tim ^v   Jonkers, Daisy ^v   Pierik, Marieke ^v   Vatn, Simen ^w   Ricanek, Petr ^w   Jahnsen, Jørgen ^w   You, Panpan ^w   Sølvernes, Janne ^w   Frengen, Anna B ^x   Tannæs, Tone M ^x   Moen, Aina E F ^x   Dahl, Fredrik A ^x   Lindstrøm, Jonas Christoffer ^x   Ekeland, Gunn S ^x   Detlie, Trond Espen ^x   Keita, Åsa V ^y   Söderholm, Johan D ^y   Hjortswang, Henrik ^z   Halfvarson, Jonas ^aa   Bergemalm, Daniel ^aa   Gomollón, Fernando ^ab   D'Amato, Mauro ^ac,ad   Törkvist, Leif ^ad   Hjelm, Fredrik ^ae   Gullberg, Mats ^ae   Nordberg, Niklas ^ae   Ocklind, Anette ^ae   Pettersson, Erik ^ae   Ekman, Daniel ^ae   Sundell, Mikael ^ae   Modig, Eddie ^ae   Veillard, Anne Clémence ^af   Schoemans, Renaud ^af   Poncelet, Dominique ^af   Sabatel, Céline ^af   Gut, Marta ^b,c   Bayes, Monica ^b,c   Casén, Christina ^ag   Lindahl, Torbjørn ^ag   Ciemniejewska, Ewa ^ag   Vatn, Morten H ^w,x   more..

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^c UNIVERSITAT POMPEU FABRA   (Spain)

^d GENOS GLYCOSCIENCE RESEARCH LABORATORY   (Croatia)

^e CEDARS SINAI MEDICAL CENTER   (United States)

^f CAREGGI UNIVERSITY HOSPITAL   (Italy)

^g UNIVERSITY OF ZAGREB   (Croatia)

^h Photeomix Protein Discovery IP Research Consulting SAS   (France)

ⁱ LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^j VU UNIVERSITY AMSTERDAM   (Netherlands)

^k MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES   (Germany)

^l Culham Science Centre   (United Kingdom)

^m UNIVERSITY OF FLORENCE   (Italy)

ⁿ CSS Hospital   (Italy)

^o SAN CAMILLO FORLANINI HOSPITAL   (Italy)

^p UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^q HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^r WESTERN GENERAL HOSPITAL   (United Kingdom)

^s UNIVERSITY OF EDINBURGH   (United Kingdom)

^t INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

^u NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

^v MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^w AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^x OSLO UNIVERSITY HOSPITAL   (Norway)

^y LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^z Unit of Research and Development in Local Health Care   (Sweden)

^aa Örebro University   (Sweden)

^ab UNIVERSITY OF ZARAGOZA   (Spain)

^ac BIOCRUCES BIZKAIA HEALTH RESEARCH INSTITUTE   (Spain)

^ad KAROLINSKA INSTITUTE   (Sweden)

^ae Uppsala Science Park   (Sweden)

^af Diagenode Sa   (Belgium)

^ag Genetic Analysis AS   (Norway)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CELLS AND CELL COMPONENTS; DIGESTIVE SYSTEM DISORDER; DISEQUILIBRIUM; DNA; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; GENOTYPE; RISK ASSESSMENT;

ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DNA METHYLATION; DNA SEQUENCE; EPIGENETICS; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; GENOTYPE; HUMAN; INFLAMMATORY BOWEL DISEASE; MAJOR CLINICAL STUDY; PROMOTER REGION; QUANTITATIVE TRAIT LOCUS; ADULT; BLOOD; CASE CONTROL STUDY; COHORT ANALYSIS; CROHN DISEASE; FEMALE; GENE EXPRESSION PROFILING; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; MALE; MIDDLE AGED; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS;

MEMBRANE PROTEIN; MICRORNA; MIRN21 MICRORNA, HUMAN; PROTEIN TYROSINE KINASE; TEC PROTEIN-TYROSINE KINASE; VMP1 PROTEIN, HUMAN;

ADULT; CASE-CONTROL STUDIES; COHORT STUDIES; COLITIS, ULCERATIVE; CROHN DISEASE; DNA METHYLATION; EPIGENESIS, GENETIC; EPIGENOMICS; FEMALE; GENE EXPRESSION PROFILING; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MEMBRANE PROTEINS; MICRORNAS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTEIN-TYROSINE KINASES; QUANTITATIVE TRAIT LOCI;

EID: 84998610927     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13507     Document Type: Article

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