Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway

Inflammatory Bowel Diseases

Volumn 18, Issue 5, 2012, Pages 889-899

  Nimmo, Elaine R ^a   Prendergast, James G ^a   Aldhous, Marian C ^a   Kennedy, Nicholas A ^a   Henderson, Paul ^a,b   Drummond, Hazel E ^a   Ramsahoye, Bernard H ^a   Wilson, David C ^b   Semple, Colin A ^a   Satsangi, Jack ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Children; Crohn's disease; DNA methylation; Epigenetic mechanisms

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 19; INTERLEUKIN 27; TUMOR NECROSIS FACTOR;

ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DNA METHYLATION; EPIGENETICS; FEMALE; GENETIC ASSOCIATION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; TH17 CELL;

ADULT; CASE-CONTROL STUDIES; CROHN DISEASE; DNA; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERLEUKIN-17; MALE; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TH17 CELLS; TUMOR MARKERS, BIOLOGICAL;

EID: 84859795659     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21912     Document Type: Article

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