CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation-dependent and -independent mechanisms

British Journal of Haematology

Volumn 169, Issue 2, 2015, Pages 286-289

  Hutterer, Evelyn ^a,b   Asslaber, Daniela ^a,b   Caldana, Chiara ^c   Krenn, Peter W ^a,b   Zucchetto, Antonella ^c   Gattei, Valter ^c   Greil, Richard ^a,b   Hartmann, Tanja N ^a,b  

^a PARACELSUS MEDICAL UNIVERSITY   (Austria)

^b Salzburg Cancer Research Institute   (Austria)

^c CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

Chronic lymphocytic leukaemia (CLL); DNA methylation; LFA 1 (CD11A CD18; ITGAL ITGB2); Microenvironment; Proliferation

Indexed keywords

CD18 ANTIGEN; GENOMIC DNA; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ANTIGEN EXPRESSION; CELL ACTIVATION; CELL CLONE; CELL FRACTIONATION; CELL INFILTRATION; CELL MIGRATION; CELL PROLIFERATION; CELL SUBPOPULATION; CHRONIC LYMPHATIC LEUKEMIA; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; HUMAN; IMMUNOREGULATION; LETTER; LEUKEMIA CELL; LYMPHOCYTE HOMING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; TRANSCRIPTION REGULATION; TUMOR MICROENVIRONMENT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ANTIGENS, CD18; DNA METHYLATION; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL;

EID: 84926334027     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.13188     Document Type: Letter

References (10)

1. Agura, E.D., Howard, M. & Collins, S.J. (1992) Identification and sequence analysis of the promoter for the leukocyte integrin beta-subunit (CD18): a retinoic acid-inducible gene. Blood, 79, 602-609.
2. Asslaber, D., Grossinger, E.M., Girbl, T., Hofbauer, S.W., Egle, A., Weiss, L., Greil, R. & Hartmann, T.N. (2013) Mimicking the microenvironment in chronic lymphocytic leukaemia - where does the journey go? British Journal of Haematology, 160, 711-714.
3. Bottinger, E.P., Shelley, C.S., Farokhzad, O.C. & Arnaout, M.A. (1994) The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements. Molecular and Cellular Biology, 14, 2604-2615.
4. Burger, J.A. & Gribben, J.G. (2014) The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: insight into disease biology and new targeted therapies. Seminars in Cancer Biology, 24, 71-81.
5. Cahill, N., Bergh, A.C., Kanduri, M., Goransson-Kultima, H., Mansouri, L., Isaksson, A., Ryan, F., Smedby, K.E., Juliusson, G., Sundstrom, C., Rosen, A. & Rosenquist, R. (2013) 450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments. Leukemia, 27, 150-158.
6. Hartmann, T.N., Grabovsky, V., Wang, W., Desch, P., Rubenzer, G., Wollner, S., Binsky, I., Vallon-Eberhard, A., Sapoznikov, A., Burger, M., Shachar, I., Haran, M., Honczarenko, M., Greil, R. & Alon, R. (2009) Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow. Cancer Research, 69, 3121-3130.
7. Reichardt, P., Patzak, I., Jones, K., Etemire, E., Gunzer, M. & Hogg, N. (2013) A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes. The EMBO Journal, 32, 829-843.
8. Riches, J.C., O'Donovan, C.J., Kingdon, S.J., McClanahan, F., Clear, A.J., Neuberg, D.S., Werner, L., Croce, C.M., Ramsay, A.G., Rassenti, L.Z., Kipps, T.J. & Gribben, J.G. (2014) Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations. Blood, 123, 4101-4110.
9. Tsimberidou, A.M. & Keating, M.J. (2005) Richter syndrome: biology, incidence, and therapeutic strategies. Cancer, 103, 216-228.
10. Zucchetto, A., Caldana, C., Benedetti, D., Tissino, E., Rossi, F.M., Hutterer, E., Pozzo, F., Bomben, R., Dal Bo, M., D'Arena, G., Zaja, F., Pozzato, G., Di Raimondo, F., Hartmann, T.N., Rossi, D., Gaidano, G., Del Poeta, G. & Gattei, V. (2013) CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism. Blood, 122, 3317-3321.