메뉴 건너뛰기




Volumn 20, Issue 9, 2012, Pages 1004-1008

Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes

Author keywords

eQTL; expression; MHC; schizophrenia; SNP

Indexed keywords

ADULT; ARTICLE; C16ORF61 GENE; CHROMOSOME 16; CHROMOSOME 22; CONTROLLED STUDY; CRELD2 GENE; FEMALE; GENE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENOTYPE; HIST1H2BD GENE; HLA DRB3 GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RNF5 GENE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; TRIM26 GENE; TUBB GENE;

EID: 84865268482     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2012.38     Document Type: Article
Times cited : (55)

References (41)
  • 1
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a Complex Trait: Evidence from a Meta-analysis of Twin Studies
    • DOI 10.1001/archpsyc.60.12.1187
    • Sullivan PF, Kendler KS, Neale MC: Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003; 60: 1187-1192. (Pubitemid 37494071)
    • (2003) Archives of General Psychiatry , vol.60 , Issue.12 , pp. 1187-1192
    • Sullivan, P.F.1    Kendler, K.S.2    Neale, M.C.3
  • 2
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • Purcell SM, Wray NR, Stone JL et al: Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009; 460: 748-752.
    • (2009) Nature , vol.460 , pp. 748-752
    • Purcell, S.M.1    Wray, N.R.2    Stone, J.L.3
  • 3
    • 68449096727 scopus 로고    scopus 로고
    • Common variants on chromosome 6p22.1 are associated with schizophrenia
    • Shi J, Levinson DF, Duan J et al: Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 2009; 460: 753-757.
    • (2009) Nature , vol.460 , pp. 753-757
    • Shi, J.1    Levinson, D.F.2    Duan, J.3
  • 4
    • 68449090594 scopus 로고    scopus 로고
    • Common variants conferring risk of schizophrenia
    • Stefansson H, Ophoff RA, Steinberg S et al: Common variants conferring risk of schizophrenia. Nature 2009; 460: 744-747.
    • (2009) Nature , vol.460 , pp. 744-747
    • Stefansson, H.1    Ophoff, R.A.2    Steinberg, S.3
  • 5
    • 49949085933 scopus 로고    scopus 로고
    • Large recurrent microdeletions associated with schizophrenia
    • Stefansson H, Rujescu D, Cichon S et al: Large recurrent microdeletions associated with schizophrenia. Nature 2008; 455: 232-236.
    • (2008) Nature , vol.455 , pp. 232-236
    • Stefansson, H.1    Rujescu, D.2    Cichon, S.3
  • 6
    • 79959938953 scopus 로고    scopus 로고
    • Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients
    • Buizer-Voskamp JE, Muntjewerff JW, Strengman E et al: Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients. Biol Psychiatry 2011; 70: 655-662.
    • (2011) Biol Psychiatry , vol.70 , pp. 655-662
    • Buizer-Voskamp, J.E.1    Muntjewerff, J.W.2    Strengman, E.3
  • 7
    • 53049109352 scopus 로고    scopus 로고
    • Recurrent CNVs disrupt three candidate genes in schizophrenia patients
    • Vrijenhoek T, Buizer-Voskamp JE, van der Stelt I et al: Recurrent CNVs disrupt three candidate genes in schizophrenia patients. Am J Hum Genet 2008; 83: 504-510.
    • (2008) Am J Hum Genet , vol.83 , pp. 504-510
    • Vrijenhoek, T.1    Buizer-Voskamp, J.E.2    Van Der Stelt, I.3
  • 8
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio TA, Collins FS, Cox NJ et al: Finding the missing heritability of complex diseases. Nature 2009; 461: 747-753.
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1    Collins, F.S.2    Cox, N.J.3
  • 9
    • 80053384370 scopus 로고    scopus 로고
    • Genome-wide association study identifies five new schizophrenia loci
    • Ripke S, Sanders AR, Kendler KS et al: Genome-wide association study identifies five new schizophrenia loci. Nat Genet 2011; 43: 969-976.
    • (2011) Nat Genet , vol.43 , pp. 969-976
    • Ripke, S.1    Sanders, A.R.2    Kendler, K.S.3
  • 11
    • 77950243833 scopus 로고    scopus 로고
    • Multiple common variants for celiac disease influencing immune gene expression
    • Dubois PC, Trynka G, Franke L et al: Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 2010; 42: 295-302.
    • (2010) Nat Genet , vol.42 , pp. 295-302
    • Dubois, P.C.1    Trynka, G.2    Franke, L.3
  • 12
    • 77951439152 scopus 로고    scopus 로고
    • Trait-associated SNPs are more likely to be eQTLs: Annotation to enhance discovery from GWAS
    • Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ: Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet 2010; 6: e1000888.
    • (2010) PLoS Genet , vol.6
    • Nicolae, D.L.1    Gamazon, E.2    Zhang, W.3    Duan, S.4    Dolan, M.E.5    Cox, N.J.6
  • 13
    • 84856228535 scopus 로고    scopus 로고
    • Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain
    • Richards AL, Jones L, Moskvina V et al: Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Mol Psychiatry 2011; 17: 193-201.
    • (2011) Mol Psychiatry , vol.17 , pp. 193-201
    • Richards, A.L.1    Jones, L.2    Moskvina, V.3
  • 14
    • 77953194222 scopus 로고    scopus 로고
    • Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes
    • Zhong H, Beaulaurier J, Lum PY et al: Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet 2010; 6: e1000932.
    • (2010) PLoS Genet , vol.6
    • Zhong, H.1    Beaulaurier, J.2    Lum, P.Y.3
  • 15
    • 77958005855 scopus 로고    scopus 로고
    • Is human blood a good surrogate for brain tissue in transcriptional studies?
    • Cai C, Langfelder P, Fuller TF et al: Is human blood a good surrogate for brain tissue in transcriptional studies? BMC Genomics 2010; 11: 589.
    • (2010) BMC Genomics , vol.11 , pp. 589
    • Cai, C.1    Langfelder, P.2    Fuller, T.F.3
  • 16
    • 70350664635 scopus 로고    scopus 로고
    • Identification of brain transcriptional variation reproduced in peripheral blood: An approach for mapping brain expression traits
    • Jasinska AJ, Service S, Choi OW et al: Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits. Hum Mol Genet 2009; 18: 4415-4427.
    • (2009) Hum Mol Genet , vol.18 , pp. 4415-4427
    • Jasinska, A.J.1    Service, S.2    Choi, O.W.3
  • 18
    • 2042479398 scopus 로고    scopus 로고
    • Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders
    • DOI 10.1038/sj.mp.4001437
    • Iwamoto K, Kakiuchi C, Bundo M, Ikeda K, Kato T: Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Mol Psychiatry 2004; 9: 406-416. (Pubitemid 38534701)
    • (2004) Molecular Psychiatry , vol.9 , Issue.4 , pp. 406-416
    • Iwamoto, K.1    Kakiuchi, C.2    Bundo, M.3    Ikeda, K.4    Kato, T.5
  • 22
    • 68949213816 scopus 로고    scopus 로고
    • Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia
    • Kuzman MR, Medved V, Terzic J, Krainc D: Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia. J Psychiatr Res 2009; 43: 1073-1077.
    • (2009) J Psychiatr Res , vol.43 , pp. 1073-1077
    • Kuzman, M.R.1    Medved, V.2    Terzic, J.3    Krainc, D.4
  • 23
    • 70349570737 scopus 로고    scopus 로고
    • Van Vught PWet al: Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients
    • Saris CG, Horvath S, van Vught PWet al: Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients. BMC Genomics 2009; 10: 405.
    • (2009) BMC Genomics , vol.10 , pp. 405
    • Saris, C.G.1    Horvath, S.2
  • 24
    • 62649155943 scopus 로고    scopus 로고
    • A unified approach to genotype imputation and haplotypephase inference for large data sets of trios and unrelated individuals
    • Browning BL, Browning SR: A unified approach to genotype imputation and haplotypephase inference for large data sets of trios and unrelated individuals. Am J Hum Genet 2009; 84: 210-223.
    • (2009) Am J Hum Genet , vol.84 , pp. 210-223
    • Browning, B.L.1    Browning, S.R.2
  • 25
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • DOI 10.1093/bioinformatics/19.2.185
    • Bolstad BM, Irizarry RA, Astrand M, Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003; 19: 185-193. (Pubitemid 36181903)
    • (2003) Bioinformatics , vol.19 , Issue.2 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 27
    • 46249088370 scopus 로고    scopus 로고
    • Lumi: A pipeline for processing Illumina microarray
    • DOI 10.1093/bioinformatics/btn224
    • Du P, Kibbe WA, Lin SM: Lumi: a pipeline for processing Illumina microarray. Bioinformatics 2008; 24: 1547-1548. (Pubitemid 351911712)
    • (2008) Bioinformatics , vol.24 , Issue.13 , pp. 1547-1548
    • Du, P.1    Kibbe, W.A.2    Lin, S.M.3
  • 28
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Article3
    • Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3: Article3.
    • (2004) Stat Appl Genet Mol Biol , vol.3
    • Smyth, G.K.1
  • 30
    • 77953223693 scopus 로고    scopus 로고
    • Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
    • Gibbs JR, van der Brug MP, Hernandez DG et al: Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS genetics 2010; 6: e1000952.
    • (2010) PLoS Genetics , vol.6
    • Gibbs, J.R.1    Van Der Brug, M.P.2    Hernandez, D.G.3
  • 36
    • 58149163446 scopus 로고    scopus 로고
    • Tissue-specific genetic control of splicing: Implications for the study of complex traits
    • Heinzen EL, Ge D, Cronin KD et al: Tissue-specific genetic control of splicing: implications for the study of complex traits. PLoS Biol 2008; 6: e1.
    • (2008) PLoS Biol , vol.6
    • Heinzen, E.L.1    Ge, D.2    Cronin, K.D.3
  • 37
    • 70350015386 scopus 로고    scopus 로고
    • The human major histocompatibility complex as a paradigm in genomics research
    • Vandiedonck C, Knight JC: The human major histocompatibility complex as a paradigm in genomics research. Brief Funct Genomic Proteomic 2009; 8: 379-394.
    • (2009) Brief Funct Genomic Proteomic , vol.8 , pp. 379-394
    • Vandiedonck, C.1    Knight, J.C.2
  • 39
    • 77952641170 scopus 로고    scopus 로고
    • Adjuvant aspirin therapy reduces symptoms of schizophrenia spectrum disorders: Results from a randomized, double-blind, placebo-controlled trial
    • Laan W, Grobbee DE, Selten JP, Heijnen CJ, Kahn RS, Burger H: Adjuvant aspirin therapy reduces symptoms of schizophrenia spectrum disorders: results from a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry 2010; 71: 520-527.
    • (2010) J Clin Psychiatry , vol.71 , pp. 520-527
    • Laan, W.1    Grobbee, D.E.2    Selten, J.P.3    Heijnen, C.J.4    Kahn, R.S.5    Burger, H.6
  • 41
    • 34548599766 scopus 로고    scopus 로고
    • Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer
    • DOI 10.1158/0008-5472.CAN-07-0045
    • Bromberg KD, Kluger HM, Delaunay A et al: Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer. Cancer Res 2007; 67: 8172-8179. (Pubitemid 47395153)
    • (2007) Cancer Research , vol.67 , Issue.17 , pp. 8172-8179
    • Bromberg, K.D.1    Kluger, H.M.2    Delaunay, A.3    Abbas, S.4    DiVito, K.A.5    Krajewski, S.6    Ronai, Z.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.