메뉴 건너뛰기




Volumn 39, Issue 1, 2017, Pages 47-54

TH9 cells in skin disorders

Author keywords

Allergic contact dermatitis; Atopic dermatitis; Candida albicans; Cutaneous; Cutaneous T cell lymphoma; IL 9; Inflammation; Interleukin 9; Psoriasis; Skin; Skin homing; Skin resident; T helper cell subsets; T helper cells; T helper type 9 cells; Th9 cells

Indexed keywords

ALLERGEN; INTERLEUKIN 9;

EID: 84997817410     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-016-0607-8     Document Type: Review
Times cited : (49)

References (69)
  • 1
    • 84928584195 scopus 로고    scopus 로고
    • The development and in vivo function of T helper 9 cells
    • COI: 1:CAS:528:DC%2BC2MXlvFWqsro%3D, PID: 25848755
    • Kaplan MH, Hufford MM, Olson MR (2015) The development and in vivo function of T helper 9 cells. Nat Rev Immunol 15(5):295–307
    • (2015) Nat Rev Immunol , vol.15 , Issue.5 , pp. 295-307
    • Kaplan, M.H.1    Hufford, M.M.2    Olson, M.R.3
  • 2
    • 84893388714 scopus 로고    scopus 로고
    • Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity
    • PID: 24431112
    • Schlapbach C, Gehad A, Yang C, Watanabe R, Guenova E et al (2014) Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity. Sci Transl Med 6(219):219ra8
    • (2014) Sci Transl Med , vol.6 , Issue.219 , pp. 219ra8
    • Schlapbach, C.1    Gehad, A.2    Yang, C.3    Watanabe, R.4    Guenova, E.5
  • 3
    • 84885831692 scopus 로고    scopus 로고
    • Th9 cells drive host immunity against gastrointestinal worm infection
    • COI: 1:CAS:528:DC%2BC3sXhs1eqt7vN, PID: 24138883
    • Licona-Limon P, Henao-Mejia J, Temann AU, Gagliani N, Licona-Limon I et al (2013) Th9 cells drive host immunity against gastrointestinal worm infection. Immunity 39(4):744–757
    • (2013) Immunity , vol.39 , Issue.4 , pp. 744-757
    • Licona-Limon, P.1    Henao-Mejia, J.2    Temann, A.U.3    Gagliani, N.4    Licona-Limon, I.5
  • 4
    • 78650666947 scopus 로고    scopus 로고
    • Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site
    • COI: 1:CAS:528:DC%2BC3cXhsVaqt7vK, PID: 20971929
    • Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G et al (2010) Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site. J Immunol 185(11):6795–6801
    • (2010) J Immunol , vol.185 , Issue.11 , pp. 6795-6801
    • Tan, C.1    Aziz, M.K.2    Lovaas, J.D.3    Vistica, B.P.4    Shi, G.5
  • 5
    • 84927650199 scopus 로고    scopus 로고
    • The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells
    • COI: 1:CAS:528:DC%2BC2MXlvVejtLk%3D, PID: 25786692
    • Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R et al (2015) The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells. J Immunol 194(8):3567–3582
    • (2015) J Immunol , vol.194 , Issue.8 , pp. 3567-3582
    • Richard, A.C.1    Tan, C.2    Hawley, E.T.3    Gomez-Rodriguez, J.4    Goswami, R.5
  • 6
    • 0036282579 scopus 로고    scopus 로고
    • Elevated expression of interleukin-9 mRNA in the bronchial mucosa of atopic asthmatics and allergen-induced cutaneous late-phase reaction: relationships to eosinophils, mast cells and T lymphocytes
    • COI: 1:CAS:528:DC%2BD38XltlKrsb0%3D, PID: 12047433
    • Ying S, Meng Q, Kay AB, Robinson DS (2002) Elevated expression of interleukin-9 mRNA in the bronchial mucosa of atopic asthmatics and allergen-induced cutaneous late-phase reaction: relationships to eosinophils, mast cells and T lymphocytes. Clin Exp Allergy 32(6):866–871
    • (2002) Clin Exp Allergy , vol.32 , Issue.6 , pp. 866-871
    • Ying, S.1    Meng, Q.2    Kay, A.B.3    Robinson, D.S.4
  • 7
    • 84862615185 scopus 로고    scopus 로고
    • The many lives of IL-9: a question of survival?
    • COI: 1:CAS:528:DC%2BC38XovVagtro%3D, PID: 22713829
    • Wilhelm C, Turner JE, Van Snick J, Stockinger B (2012) The many lives of IL-9: a question of survival? Nat Immunol 13(7):637–641
    • (2012) Nat Immunol , vol.13 , Issue.7 , pp. 637-641
    • Wilhelm, C.1    Turner, J.E.2    Van Snick, J.3    Stockinger, B.4
  • 8
    • 84976307978 scopus 로고    scopus 로고
    • The evolution of innate lymphoid cells
    • COI: 1:CAS:528:DC%2BC28XhtVekur7K, PID: 27328009
    • Vivier E, van de Pavert SA, Cooper MD, Belz GT (2016) The evolution of innate lymphoid cells. Nat Immunol 17(7):790–794
    • (2016) Nat Immunol , vol.17 , Issue.7 , pp. 790-794
    • Vivier, E.1    van de Pavert, S.A.2    Cooper, M.D.3    Belz, G.T.4
  • 9
    • 84893707932 scopus 로고    scopus 로고
    • Th9 cells, new players in adaptive immunity
    • COI: 1:CAS:528:DC%2BC3sXhslGmtbbN, PID: 24215739
    • Schmitt E, Klein M, Bopp T (2014) Th9 cells, new players in adaptive immunity. Trends Immunol 35(2):61–68
    • (2014) Trends Immunol , vol.35 , Issue.2 , pp. 61-68
    • Schmitt, E.1    Klein, M.2    Bopp, T.3
  • 10
    • 84864648969 scopus 로고    scopus 로고
    • Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells
    • COI: 1:CAS:528:DC%2BC38XpvFGgtb4%3D, PID: 22772464
    • Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W et al (2012) Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med 18(8):1248–1253
    • (2012) Nat Med , vol.18 , Issue.8 , pp. 1248-1253
    • Purwar, R.1    Schlapbach, C.2    Xiao, S.3    Kang, H.S.4    Elyaman, W.5
  • 11
    • 84994242550 scopus 로고    scopus 로고
    • A high-dimensional atlas of human T cell diversity reveals tissue-specific trafficking and cytokine signatures
    • COI: 1:CAS:528:DC%2BC28XhtlWnsLbN, PID: 27521270
    • Wong MT, Ong DE, Lim FS, Teng KW, McGovern N et al (2016) A high-dimensional atlas of human T cell diversity reveals tissue-specific trafficking and cytokine signatures. Immunity 45(2):442–456
    • (2016) Immunity , vol.45 , Issue.2 , pp. 442-456
    • Wong, M.T.1    Ong, D.E.2    Lim, F.S.3    Teng, K.W.4    McGovern, N.5
  • 12
    • 33646046528 scopus 로고    scopus 로고
    • The vast majority of CLA+ T cells are resident in normal skin
    • COI: 1:CAS:528:DC%2BD28Xis1eqsLo%3D, PID: 16547281
    • Clark RA, Chong B, Mirchandani N, Brinster NK, Yamanaka K et al (2006) The vast majority of CLA+ T cells are resident in normal skin. J Immunol 176(7):4431–4439
    • (2006) J Immunol , vol.176 , Issue.7 , pp. 4431-4439
    • Clark, R.A.1    Chong, B.2    Mirchandani, N.3    Brinster, N.K.4    Yamanaka, K.5
  • 13
    • 84928584525 scopus 로고    scopus 로고
    • IL-9 and its receptor are predominantly involved in the pathogenesis of UC
    • COI: 1:CAS:528:DC%2BC2MXotFKrsb8%3D, PID: 24957265
    • Nalleweg N, Chiriac MT, Podstawa E, Lehmann C, Rau TT et al (2015) IL-9 and its receptor are predominantly involved in the pathogenesis of UC. Gut 64(5):743–755
    • (2015) Gut , vol.64 , Issue.5 , pp. 743-755
    • Nalleweg, N.1    Chiriac, M.T.2    Podstawa, E.3    Lehmann, C.4    Rau, T.T.5
  • 14
    • 84860241847 scopus 로고    scopus 로고
    • Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta
    • COI: 1:CAS:528:DC%2BC38XkvVGrsrY%3D, PID: 22466287
    • Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F et al (2012) Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Nature 484(7395):514–518
    • (2012) Nature , vol.484 , Issue.7395 , pp. 514-518
    • Zielinski, C.E.1    Mele, F.2    Aschenbrenner, D.3    Jarrossay, D.4    Ronchi, F.5
  • 15
    • 77956185307 scopus 로고    scopus 로고
    • Innate immune mechanisms for recognition and uptake of Candida species
    • COI: 1:CAS:528:DC%2BC3cXhtFals7vM, PID: 20705510
    • Netea MG, Marodi L (2010) Innate immune mechanisms for recognition and uptake of Candida species. Trends Immunol 31(9):346–353
    • (2010) Trends Immunol , vol.31 , Issue.9 , pp. 346-353
    • Netea, M.G.1    Marodi, L.2
  • 16
    • 37349015349 scopus 로고    scopus 로고
    • An integrated model of the recognition of Candida albicans by the innate immune system
    • COI: 1:CAS:528:DC%2BD2sXhsVaqt7jN, PID: 18079743
    • Netea MG, Brown GD, Kullberg BJ, Gow NA (2008) An integrated model of the recognition of Candida albicans by the innate immune system. Nat Rev Microbiol 6(1):67–78
    • (2008) Nat Rev Microbiol , vol.6 , Issue.1 , pp. 67-78
    • Netea, M.G.1    Brown, G.D.2    Kullberg, B.J.3    Gow, N.A.4
  • 17
    • 84938537213 scopus 로고    scopus 로고
    • TH9 cells are required for tissue mast cell accumulation during allergic inflammation
    • COI: 1:CAS:528:DC%2BC2MXjvFCisr0%3D, PID: 25746972, e1
    • Sehra S, Yao W, Nguyen ET, Glosson-Byers NL, Akhtar N et al (2015) TH9 cells are required for tissue mast cell accumulation during allergic inflammation. J Allergy Clin Immunol 136(2):433–440 e1
    • (2015) J Allergy Clin Immunol , vol.136 , Issue.2 , pp. 433-440
    • Sehra, S.1    Yao, W.2    Nguyen, E.T.3    Glosson-Byers, N.L.4    Akhtar, N.5
  • 18
    • 84944682245 scopus 로고    scopus 로고
    • Induction of interleukin-9-producing mucosal mast cells promotes susceptibility to IgE-mediated experimental food allergy
    • COI: 1:CAS:528:DC%2BC2MXhsFert7nN, PID: 26410628
    • Chen CY, Lee JB, Liu B, Ohta S, Wang PY et al (2015) Induction of interleukin-9-producing mucosal mast cells promotes susceptibility to IgE-mediated experimental food allergy. Immunity 43(4):788–802
    • (2015) Immunity , vol.43 , Issue.4 , pp. 788-802
    • Chen, C.Y.1    Lee, J.B.2    Liu, B.3    Ohta, S.4    Wang, P.Y.5
  • 19
    • 84937695151 scopus 로고    scopus 로고
    • IL-17-mediated immunity to the opportunistic fungal pathogen Candida albicans
    • COI: 1:CAS:528:DC%2BC2MXhtFyjtL%2FE, PID: 26188072
    • Conti HR, Gaffen SL (2015) IL-17-mediated immunity to the opportunistic fungal pathogen Candida albicans. J Immunol 195(3):780–788
    • (2015) J Immunol , vol.195 , Issue.3 , pp. 780-788
    • Conti, H.R.1    Gaffen, S.L.2
  • 21
    • 70350513112 scopus 로고    scopus 로고
    • Adverse events associated with common therapy regimens for moderate-to-severe Crohn's disease
    • PID: 19532125
    • Marehbian J, Arrighi HM, Hass S, Tian H, Sandborn WJ (2009) Adverse events associated with common therapy regimens for moderate-to-severe Crohn's disease. Am J Gastroenterol 104(10):2524–2533
    • (2009) Am J Gastroenterol , vol.104 , Issue.10 , pp. 2524-2533
    • Marehbian, J.1    Arrighi, H.M.2    Hass, S.3    Tian, H.4    Sandborn, W.J.5
  • 22
    • 84937801481 scopus 로고    scopus 로고
    • Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells
    • PID: 26192381
    • Lopes JP, Stylianou M, Nilsson G, Urban CF (2015) Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells. Sci Rep 5:12287
    • (2015) Sci Rep , vol.5 , pp. 12287
    • Lopes, J.P.1    Stylianou, M.2    Nilsson, G.3    Urban, C.F.4
  • 23
  • 24
    • 84937549982 scopus 로고    scopus 로고
    • Mast cells kill Candida albicans in the extracellular environment but spare ingested fungi from death
    • COI: 1:CAS:528:DC%2BC2cXhtVKhsbvF, PID: 24950781
    • Trevisan E, Vita F, Medic N, Soranzo MR, Zabucchi G et al (2014) Mast cells kill Candida albicans in the extracellular environment but spare ingested fungi from death. Inflammation 37(6):2174–2189
    • (2014) Inflammation , vol.37 , Issue.6 , pp. 2174-2189
    • Trevisan, E.1    Vita, F.2    Medic, N.3    Soranzo, M.R.4    Zabucchi, G.5
  • 25
    • 76249125167 scopus 로고    scopus 로고
    • Secondary cutaneous candidiasis with eosinophilia
    • PID: 20175854
    • Tsunemi Y, Kadono T, Saeki H, Kikuchi K, Tamaki K et al (2010) Secondary cutaneous candidiasis with eosinophilia. J Dermatol 37(2):175–178
    • (2010) J Dermatol , vol.37 , Issue.2 , pp. 175-178
    • Tsunemi, Y.1    Kadono, T.2    Saeki, H.3    Kikuchi, K.4    Tamaki, K.5
  • 26
    • 39749159156 scopus 로고    scopus 로고
    • T cells specific for Candida albicans antigens and producing type 2 cytokines in lesional mucosa of untreated HIV-infected patients with pseudomembranous oropharyngeal candidiasis
    • COI: 1:CAS:528:DC%2BD1cXivVOhs7k%3D, PID: 18249024
    • Vultaggio A, Lombardelli L, Giudizi MG, Biagiotti R, Mazzinghi B et al (2008) T cells specific for Candida albicans antigens and producing type 2 cytokines in lesional mucosa of untreated HIV-infected patients with pseudomembranous oropharyngeal candidiasis. Microbes Infect 10(2):166–174
    • (2008) Microbes Infect , vol.10 , Issue.2 , pp. 166-174
    • Vultaggio, A.1    Lombardelli, L.2    Giudizi, M.G.3    Biagiotti, R.4    Mazzinghi, B.5
  • 27
    • 0035865709 scopus 로고    scopus 로고
    • Interleukin 9 promotes influx and local maturation of eosinophils
    • COI: 1:CAS:528:DC%2BD3MXht1Gisr4%3D, PID: 11159534
    • Louahed J, Zhou Y, Maloy WL, Rani PU, Weiss C et al (2001) Interleukin 9 promotes influx and local maturation of eosinophils. Blood 97(4):1035–1042
    • (2001) Blood , vol.97 , Issue.4 , pp. 1035-1042
    • Louahed, J.1    Zhou, Y.2    Maloy, W.L.3    Rani, P.U.4    Weiss, C.5
  • 28
    • 0034665658 scopus 로고    scopus 로고
    • Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils
    • COI: 1:CAS:528:DC%2BD3cXms1ChsLY%3D, PID: 10979962
    • Gounni AS, Gregory B, Nutku E, Aris F, Latifa K et al (2000) Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils. Blood 96(6):2163–2171
    • (2000) Blood , vol.96 , Issue.6 , pp. 2163-2171
    • Gounni, A.S.1    Gregory, B.2    Nutku, E.3    Aris, F.4    Latifa, K.5
  • 29
    • 84929050707 scopus 로고    scopus 로고
    • IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: a plausible mechanism of IL-9R in atopic dermatitis
    • COI: 1:CAS:528:DC%2BC2MXkvVSqu7s%3D, PID: 25840641
    • Hong CH, Chang KL, Wang HJ, Yu HS, Lee CH (2015) IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: a plausible mechanism of IL-9R in atopic dermatitis. J Dermatol Sci 78(3):206–214
    • (2015) J Dermatol Sci , vol.78 , Issue.3 , pp. 206-214
    • Hong, C.H.1    Chang, K.L.2    Wang, H.J.3    Yu, H.S.4    Lee, C.H.5
  • 30
    • 84958184224 scopus 로고    scopus 로고
    • Interactions of fungal pathogens with phagocytes
    • COI: 1:CAS:528:DC%2BC28Xit1Wktrw%3D, PID: 26853116
    • Erwig LP, Gow NA (2016) Interactions of fungal pathogens with phagocytes. Nat Rev Microbiol 14(3):163–176
    • (2016) Nat Rev Microbiol , vol.14 , Issue.3 , pp. 163-176
    • Erwig, L.P.1    Gow, N.A.2
  • 31
    • 84887493396 scopus 로고    scopus 로고
    • Th9 cell development requires a BATF-regulated transcriptional network
    • COI: 1:CAS:528:DC%2BC3sXhslKksLfP, PID: 24216482
    • Jabeen R, Goswami R, Awe O, Kulkarni A, Nguyen ET et al (2013) Th9 cell development requires a BATF-regulated transcriptional network. J Clin Invest 123(11):4641–4653
    • (2013) J Clin Invest , vol.123 , Issue.11 , pp. 4641-4653
    • Jabeen, R.1    Goswami, R.2    Awe, O.3    Kulkarni, A.4    Nguyen, E.T.5
  • 32
    • 77955902281 scopus 로고    scopus 로고
    • Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
    • COI: 1:CAS:528:DC%2BC3cXhtVGitL%2FP, PID: 20674401
    • Staudt V, Bothur E, Klein M, Lingnau K, Reuter S et al (2010) Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 33(2):192–202
    • (2010) Immunity , vol.33 , Issue.2 , pp. 192-202
    • Staudt, V.1    Bothur, E.2    Klein, M.3    Lingnau, K.4    Reuter, S.5
  • 33
    • 84874241774 scopus 로고    scopus 로고
    • Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP
    • COI: 1:CAS:528:DC%2BC3sXhvVGlsLs%3D, PID: 23376058
    • Yao W, Zhang Y, Jabeen R, Nguyen ET, Wilkes DS et al (2013) Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP. Immunity 38(2):360–372
    • (2013) Immunity , vol.38 , Issue.2 , pp. 360-372
    • Yao, W.1    Zhang, Y.2    Jabeen, R.3    Nguyen, E.T.4    Wilkes, D.S.5
  • 34
    • 84907365249 scopus 로고    scopus 로고
    • Nitric oxide enhances Th9 cell differentiation and airway inflammation
    • COI: 1:CAS:528:DC%2BC2MXksVChsrs%3D, PID: 25099390
    • Niedbala W, Besnard AG, Nascimento DC, Donate PB, Sonego F et al (2014) Nitric oxide enhances Th9 cell differentiation and airway inflammation. Nat Commun 5:4575
    • (2014) Nat Commun , vol.5 , pp. 4575
    • Niedbala, W.1    Besnard, A.G.2    Nascimento, D.C.3    Donate, P.B.4    Sonego, F.5
  • 35
    • 84902653958 scopus 로고    scopus 로고
    • TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
    • COI: 1:CAS:528:DC%2BC2cXpsVamsL0%3D, PID: 24908389
    • Gerlach K, Hwang Y, Nikolaev A, Atreya R, Dornhoff H et al (2014) TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat Immunol 15(7):676–686
    • (2014) Nat Immunol , vol.15 , Issue.7 , pp. 676-686
    • Gerlach, K.1    Hwang, Y.2    Nikolaev, A.3    Atreya, R.4    Dornhoff, H.5
  • 36
    • 84888008030 scopus 로고    scopus 로고
    • The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin
    • COI: 1:CAS:528:DC%2BC3sXhs1yiu7fO, PID: 24162776
    • Mackay LK, Rahimpour A, Ma JZ, Collins N, Stock AT et al (2013) The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. Nat Immunol 14(12):1294–1301
    • (2013) Nat Immunol , vol.14 , Issue.12 , pp. 1294-1301
    • Mackay, L.K.1    Rahimpour, A.2    Ma, J.Z.3    Collins, N.4    Stock, A.T.5
  • 37
    • 84888013845 scopus 로고    scopus 로고
    • Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells
    • COI: 1:CAS:528:DC%2BC3sXhs1yitLbE, PID: 24162775
    • Skon CN, Lee JY, Anderson KG, Masopust D, Hogquist KA et al (2013) Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells. Nat Immunol 14(12):1285–1293
    • (2013) Nat Immunol , vol.14 , Issue.12 , pp. 1285-1293
    • Skon, C.N.1    Lee, J.Y.2    Anderson, K.G.3    Masopust, D.4    Hogquist, K.A.5
  • 38
    • 56349093347 scopus 로고    scopus 로고
    • IL-4 inhibits TGF-beta-induced Foxp 3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
    • COI: 1:CAS:528:DC%2BD1cXhtlOjsb3O, PID: 18997793
    • Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W et al (2008) IL-4 inhibits TGF-beta-induced Foxp 3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 9(12):1347–1355
    • (2008) Nat Immunol , vol.9 , Issue.12 , pp. 1347-1355
    • Dardalhon, V.1    Awasthi, A.2    Kwon, H.3    Galileos, G.4    Gao, W.5
  • 39
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta ‘reprograms’ the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • COI: 1:CAS:528:DC%2BD1cXhtlOjsbzL, PID: 18931678
    • Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A et al (2008) Transforming growth factor-beta ‘reprograms’ the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 9(12):1341–1346
    • (2008) Nat Immunol , vol.9 , Issue.12 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    van Snick, J.3    Helmby, H.4    Westendorf, A.5
  • 40
    • 84925250971 scopus 로고    scopus 로고
    • Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells
    • PID: 25787765
    • Watanabe R, Gehad A, Yang C, Scott LL, Teague JE et al (2015) Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells. Sci Transl Med 7(279):279ra39
    • (2015) Sci Transl Med , vol.7 , Issue.279 , pp. 279ra39
    • Watanabe, R.1    Gehad, A.2    Yang, C.3    Scott, L.L.4    Teague, J.E.5
  • 41
    • 77956220086 scopus 로고    scopus 로고
    • TGF-beta induces IL-9 production from human Th17 cells
    • COI: 1:CAS:528:DC%2BC3cXns1CqsLs%3D, PID: 20498357
    • Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD et al (2010) TGF-beta induces IL-9 production from human Th17 cells. J Immunol 185(1):46–54
    • (2010) J Immunol , vol.185 , Issue.1 , pp. 46-54
    • Beriou, G.1    Bradshaw, E.M.2    Lozano, E.3    Costantino, C.M.4    Hastings, W.D.5
  • 42
    • 84920747918 scopus 로고    scopus 로고
    • Resident memory T cells in human health and disease
    • PID: 25568072
    • Clark RA (2015) Resident memory T cells in human health and disease. Sci Transl Med 7(269):269rv1
    • (2015) Sci Transl Med , vol.7 , Issue.269 , pp. 269rv1
    • Clark, R.A.1
  • 43
    • 84870294267 scopus 로고    scopus 로고
    • Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis
    • COI: 1:CAS:528:DC%2BC38Xht1OjtrvO, PID: 22951056
    • Gittler JK, Shemer A, Suarez-Farinas M, Fuentes-Duculan J, Gulewicz KJ et al (2012) Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. J Allergy Clin Immunol 130(6):1344–1354
    • (2012) J Allergy Clin Immunol , vol.130 , Issue.6 , pp. 1344-1354
    • Gittler, J.K.1    Shemer, A.2    Suarez-Farinas, M.3    Fuentes-Duculan, J.4    Gulewicz, K.J.5
  • 44
    • 84888875666 scopus 로고    scopus 로고
    • Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis
    • COI: 1:CAS:528:DC%2BC3sXhvVyjs7zE, PID: 24032555
    • Ma L, Xue HB, Guan XH, Shu CM, Zhang JH et al (2014) Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis. Clin Exp Immunol 175(1):25–31
    • (2014) Clin Exp Immunol , vol.175 , Issue.1 , pp. 25-31
    • Ma, L.1    Xue, H.B.2    Guan, X.H.3    Shu, C.M.4    Zhang, J.H.5
  • 45
    • 84874941248 scopus 로고    scopus 로고
    • Serum interleukin-9 levels are associated with clinical severity in children with atopic dermatitis
    • PID: 22612419
    • Ciprandi G, De Amici M, Giunta V, Marseglia A, Marseglia G (2013) Serum interleukin-9 levels are associated with clinical severity in children with atopic dermatitis. Pediatr Dermatol 30(2):222–225
    • (2013) Pediatr Dermatol , vol.30 , Issue.2 , pp. 222-225
    • Ciprandi, G.1    De Amici, M.2    Giunta, V.3    Marseglia, A.4    Marseglia, G.5
  • 46
    • 84996772746 scopus 로고    scopus 로고
    • Early Activation of Th2/Th22 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions
    • Olivry, T., D. Mayhew, J.S. Paps, K.E. Linder, C. Peredo, et al., Early Activation of Th2/Th22 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions. J Invest Dermatol 2016.
    • (2016) J Invest Dermatol
    • Olivry, T.1    Mayhew, D.2    Paps, J.S.3    Linder, K.E.4    Peredo, C.5
  • 47
    • 79952694948 scopus 로고    scopus 로고
    • An association between IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population
    • COI: 1:CAS:528:DC%2BC3MXjs1yrurY%3D, PID: 21371865
    • Namkung JH, Lee JE, Kim E, Park GT, Yang HS et al (2011) An association between IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population. J Dermatol Sci 62(1):16–21
    • (2011) J Dermatol Sci , vol.62 , Issue.1 , pp. 16-21
    • Namkung, J.H.1    Lee, J.E.2    Kim, E.3    Park, G.T.4    Yang, H.S.5
  • 48
    • 84960154765 scopus 로고    scopus 로고
    • Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
    • COI: 1:CAS:528:DC%2BC28XjsFCjs7Y%3D, PID: 26936133
    • Gomez-Rodriguez J, Meylan F, Handon R, Hayes ET, Anderson SM et al (2016) Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4. Nat Commun 7:10857
    • (2016) Nat Commun , vol.7 , pp. 10857
    • Gomez-Rodriguez, J.1    Meylan, F.2    Handon, R.3    Hayes, E.T.4    Anderson, S.M.5
  • 49
    • 78650193349 scopus 로고    scopus 로고
    • Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases
    • von Bonin A, Rausch A, Mengel A, Hitchcock M, Kruger M et al (2011) Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases. Exp Dermatol 20(1):41–47
    • (2011) Exp Dermatol , vol.20 , Issue.1 , pp. 41-47
    • von Bonin, A.1    Rausch, A.2    Mengel, A.3    Hitchcock, M.4    Kruger, M.5
  • 50
    • 84990851596 scopus 로고    scopus 로고
    • Cellular and molecular immunologic mechanisms in patients with atopic dermatitis
    • COI: 1:CAS:528:DC%2BC28XhtlSlsrvF, PID: 27497276
    • Werfel T, Allam JP, Biedermann T, Eyerich K, Gilles S et al (2016) Cellular and molecular immunologic mechanisms in patients with atopic dermatitis. J Allergy Clin Immunol 138(2):336–349
    • (2016) J Allergy Clin Immunol , vol.138 , Issue.2 , pp. 336-349
    • Werfel, T.1    Allam, J.P.2    Biedermann, T.3    Eyerich, K.4    Gilles, S.5
  • 51
    • 80054927155 scopus 로고    scopus 로고
    • An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation
    • COI: 1:CAS:528:DC%2BC3MXht12iu7jE, PID: 21983833
    • Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M et al (2011) An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 12(11):1071–1077
    • (2011) Nat Immunol , vol.12 , Issue.11 , pp. 1071-1077
    • Wilhelm, C.1    Hirota, K.2    Stieglitz, B.3    Van Snick, J.4    Tolaini, M.5
  • 53
    • 84872421516 scopus 로고    scopus 로고
    • Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis
    • COI: 1:CAS:528:DC%2BC3sXhsFWqtL4%3D, PID: 23335955
    • Singh TP, Schon MP, Wallbrecht K, Gruber-Wackernagel A, Wang XJ et al (2013) Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis. PLoS One 8(1):e51752
    • (2013) PLoS One , vol.8 , Issue.1
    • Singh, T.P.1    Schon, M.P.2    Wallbrecht, K.3    Gruber-Wackernagel, A.4    Wang, X.J.5
  • 54
    • 84902551403 scopus 로고    scopus 로고
    • IL-9 regulates allergen-specific Th1 responses in allergic contact dermatitis
    • COI: 1:CAS:528:DC%2BC2cXjt1Wmurk%3D, PID: 24487305
    • Liu J, Harberts E, Tammaro A, Girardi N, Filler RB et al (2014) IL-9 regulates allergen-specific Th1 responses in allergic contact dermatitis. J Invest Dermatol 134(7):1903–1911
    • (2014) J Invest Dermatol , vol.134 , Issue.7 , pp. 1903-1911
    • Liu, J.1    Harberts, E.2    Tammaro, A.3    Girardi, N.4    Filler, R.B.5
  • 55
    • 84955598149 scopus 로고    scopus 로고
    • Elevation of IL-9 in extreme patch test reactions suggests it is an inflammatory mediator in allergic contact dermatitis
    • PID: 26756516
    • Gutin L, Tammaro A, Fishelevich R, Gaspari AA (2016) Elevation of IL-9 in extreme patch test reactions suggests it is an inflammatory mediator in allergic contact dermatitis. Dermatitis 27(1):35–36
    • (2016) Dermatitis , vol.27 , Issue.1 , pp. 35-36
    • Gutin, L.1    Tammaro, A.2    Fishelevich, R.3    Gaspari, A.A.4
  • 56
    • 84922393839 scopus 로고    scopus 로고
    • Molecular characterization of human skin response to diphencyprone at peak and resolution phases: therapeutic insights
    • COI: 1:CAS:528:DC%2BC2cXoslCrs7c%3D, PID: 24751728
    • Gulati N, Suarez-Farinas M, Fuentes-Duculan J, Gilleaudeau P, Sullivan-Whalen M et al (2014) Molecular characterization of human skin response to diphencyprone at peak and resolution phases: therapeutic insights. J Invest Dermatol 134(10):2531–2540
    • (2014) J Invest Dermatol , vol.134 , Issue.10 , pp. 2531-2540
    • Gulati, N.1    Suarez-Farinas, M.2    Fuentes-Duculan, J.3    Gilleaudeau, P.4    Sullivan-Whalen, M.5
  • 57
    • 72049108916 scopus 로고    scopus 로고
    • Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals
    • COI: 1:CAS:528:DC%2BD1MXhsFGmsLvN, PID: 19657353
    • Coulter EM, Jenkinson C, Farrell J, Lavergne SN, Pease C et al (2010) Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals. J Invest Dermatol 130(1):161–174
    • (2010) J Invest Dermatol , vol.130 , Issue.1 , pp. 161-174
    • Coulter, E.M.1    Jenkinson, C.2    Farrell, J.3    Lavergne, S.N.4    Pease, C.5
  • 58
    • 0028293650 scopus 로고
    • Thymic lymphomas in interleukin 9 transgenic mice
    • COI: 1:CAS:528:DyaK2cXivFGntL0%3D, PID: 8152793
    • Renauld JC, van der Lugt N, Vink A, van Roon M, Godfraind C et al (1994) Thymic lymphomas in interleukin 9 transgenic mice. Oncogene 9(5):1327–1332
    • (1994) Oncogene , vol.9 , Issue.5 , pp. 1327-1332
    • Renauld, J.C.1    van der Lugt, N.2    Vink, A.3    van Roon, M.4    Godfraind, C.5
  • 59
    • 84883033916 scopus 로고    scopus 로고
    • Overexpression of IL-9 receptor in diffuse large B-cell lymphoma
    • COI: 1:CAS:528:DC%2BC3sXnsVKjtbg%3D, PID: 23638223
    • Lv X, Feng L, Fang X, Jiang Y, Wang X (2013) Overexpression of IL-9 receptor in diffuse large B-cell lymphoma. Int J Clin Exp Pathol 6(5):911–916
    • (2013) Int J Clin Exp Pathol , vol.6 , Issue.5 , pp. 911-916
    • Lv, X.1    Feng, L.2    Fang, X.3    Jiang, Y.4    Wang, X.5
  • 60
    • 84976582998 scopus 로고    scopus 로고
    • Interleukin-9 promotes cell survival and drug resistance in diffuse large B-cell lymphoma
    • PID: 27364124
    • Lv X, Feng L, Ge X, Lu K, Wang X (2016) Interleukin-9 promotes cell survival and drug resistance in diffuse large B-cell lymphoma. J Exp Clin Cancer Res 35(1):106
    • (2016) J Exp Clin Cancer Res , vol.35 , Issue.1 , pp. 106
    • Lv, X.1    Feng, L.2    Ge, X.3    Lu, K.4    Wang, X.5
  • 61
    • 84899509396 scopus 로고    scopus 로고
    • Serum levels of interleukin-9 correlate with negative prognostic factors in extranodal NK/T-cell lymphoma
    • PID: 24722378
    • Zhang J, Wang WD, Geng QR, Wang L, Chen XQ et al (2014) Serum levels of interleukin-9 correlate with negative prognostic factors in extranodal NK/T-cell lymphoma. PLoS One 9(4):e94637
    • (2014) PLoS One , vol.9 , Issue.4
    • Zhang, J.1    Wang, W.D.2    Geng, Q.R.3    Wang, L.4    Chen, X.Q.5
  • 62
    • 0037473050 scopus 로고    scopus 로고
    • Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice
    • COI: 1:CAS:528:DC%2BD3sXmslGmtQ%3D%3D, PID: 12555065
    • Lange K, Uckert W, Blankenstein T, Nadrowitz R, Bittner C et al (2003) Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice. Oncogene 22(4):517–527
    • (2003) Oncogene , vol.22 , Issue.4 , pp. 517-527
    • Lange, K.1    Uckert, W.2    Blankenstein, T.3    Nadrowitz, R.4    Bittner, C.5
  • 63
    • 84977074370 scopus 로고    scopus 로고
    • STAT3/5-dependent IL9 overexpression contributes to neoplastic cell survival in mycosis fungoides
    • COI: 1:CAS:528:DC%2BC28XhtVyiurbM, PID: 26851186
    • Vieyra-Garcia PA, Wei T, Naym DG, Fredholm S, Fink-Puches R et al (2016) STAT3/5-dependent IL9 overexpression contributes to neoplastic cell survival in mycosis fungoides. Clin Cancer Res 22(13):3328–3339
    • (2016) Clin Cancer Res , vol.22 , Issue.13 , pp. 3328-3339
    • Vieyra-Garcia, P.A.1    Wei, T.2    Naym, D.G.3    Fredholm, S.4    Fink-Puches, R.5
  • 64
    • 84868611628 scopus 로고    scopus 로고
    • Th9 cells promote antitumor immune responses in vivo
    • COI: 1:CAS:528:DC%2BC38Xhs1CisL%2FE, PID: 23064366
    • Lu Y, Hong S, Li H, Park J, Hong B et al (2012) Th9 cells promote antitumor immune responses in vivo. J Clin Invest 122(11):4160–4171
    • (2012) J Clin Invest , vol.122 , Issue.11 , pp. 4160-4171
    • Lu, Y.1    Hong, S.2    Li, H.3    Park, J.4    Hong, B.5
  • 65
    • 84904656835 scopus 로고    scopus 로고
    • The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells
    • COI: 1:CAS:528:DC%2BC2cXhtVKlsrnK, PID: 24973819
    • Vegran F, Berger H, Boidot R, Mignot G, Bruchard M et al (2014) The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells. Nat Immunol 15(8):758–766
    • (2014) Nat Immunol , vol.15 , Issue.8 , pp. 758-766
    • Vegran, F.1    Berger, H.2    Boidot, R.3    Mignot, G.4    Bruchard, M.5
  • 66
    • 84941996879 scopus 로고    scopus 로고
    • The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells
    • COI: 1:CAS:528:DC%2BC2MXhsVWgtL3M, PID: 26322481
    • Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K et al (2015) The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells. Nat Immunol 16(10):1077–1084
    • (2015) Nat Immunol , vol.16 , Issue.10 , pp. 1077-1084
    • Nakatsukasa, H.1    Zhang, D.2    Maruyama, T.3    Chen, H.4    Cui, K.5
  • 67
    • 80053556137 scopus 로고    scopus 로고
    • Serum interleukin 9 levels are increased in patients with systemic sclerosis: association with lower frequency and severity of pulmonary fibrosis
    • COI: 1:CAS:528:DC%2BC3MXhsFSqtb%2FM, PID: 21807780
    • Yanaba K, Yoshizaki A, Asano Y, Kadono T, Sato S (2011) Serum interleukin 9 levels are increased in patients with systemic sclerosis: association with lower frequency and severity of pulmonary fibrosis. J Rheumatol 38(10):2193–2197
    • (2011) J Rheumatol , vol.38 , Issue.10 , pp. 2193-2197
    • Yanaba, K.1    Yoshizaki, A.2    Asano, Y.3    Kadono, T.4    Sato, S.5
  • 68
    • 84953638491 scopus 로고    scopus 로고
    • Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing
    • COI: 1:CAS:528:DC%2BC2MXhtlylsbzJ, PID: 26316095
    • Suarez-Farinas M, Ungar B, Noda S, Shroff A, Mansouri Y et al (2015) Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing. J Allergy Clin Immunol 136(5):1277–1287
    • (2015) J Allergy Clin Immunol , vol.136 , Issue.5 , pp. 1277-1287
    • Suarez-Farinas, M.1    Ungar, B.2    Noda, S.3    Shroff, A.4    Mansouri, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.