Elevated expression of interleukin-9 mRNA in the bronchial mucosa of atopic asthmatics and allergen-induced cutaneous late-phase reaction: Relationships to eosinophils, mast cells and T lymphocytes

Clinical and Experimental Allergy

Volumn 32, Issue 6, 2002, Pages 866-871

  Ying, S ^a   Meng, Q ^a   Kay, A B ^a   Robinson, D S ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Atopic asthma; Eosinophils; IL 9; Immunohistochemistry; in situ hybridization; Latephase reaction; Mast cells

Indexed keywords

INTERLEUKIN 9; MESSENGER RNA;

ADULT; AIRWAY; ALLERGIC ASTHMA; ALLERGIC REACTION; ARTICLE; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CELL COUNT; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MALE; MAST CELL; PRIORITY JOURNAL; PROVOCATION TEST; SIGNAL TRANSDUCTION; SKIN BIOPSY; T LYMPHOCYTE;

EID: 0036282579     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2002.01376.x     Document Type: Article

References (31)

1. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmatics, in chronic bronchitis, and in emphysema
2. A clinical and pathological study of fatal cases of status asthmatics
3. The pathology of asthma, with special reference to changes in bronchial mucosa
4. The mechanics of airway narrowing in asthma
5. T-helper type 2 cell-directed therapy for asthma
6. Interleukin 5, eosinophils and disease
7. Human interleukin-9: Genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-1-transformed human T cells
8. Alletic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness
9. Interleukin 9 and its receptor: An overview of structure and function
10. Cloning and characterization of a CDNA for a new mouse T cell growth factor (P40)
11. TCGF III/P40 is produced by native murine CD4+ T cells but not a general T cell growth factor
12. Mast cell growth-enhancing activity (MEA) is structurally related and fuctionally identical to the novel mouse T cell growth factor P40/TCGF III (interleukin 9)
13. Intraepithelial infiltration by mast cells with both connective tissue-type and mucosal-type characteristics in gut, trachea, and kidneys of IL-9 transgenic mice
14. Expression of interleukin 9 in the lung of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness
15. Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice
16. Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils
17. IL-9 and its receptor in allergic and nonallergic lung disease: Increased expression in asthma
18. Eosinophil chemokitactic chemokines (eotaxin, eotaxin-2, RANTES, MCP-3, and MCP-4) and CCR3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthma
19. Bronchial mucosal expression of the CC chemokine genes RANTES and MCP-3 in symptomatic atopic and nonatopic asthmatics: Relationship to EG2+ eosinophils and the eosinophil-active cytokines IL-5, GM-CSF and IL-3
20. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: Association of eotaxin with early 6-hour eosinophils, and eotaxin-2 and MCP-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (MCP-3 and RANTES)
21. Cloning and expression of a cDNA for the human homology of mouse T cell and mast cell growth factor P40
22. Murine bone marrow-derived mast cells as potent producers of IL-9: Costimulatory function of IL-10 and kit ligand in the presence of IL-1
23. Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice
24. IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice
25. IL-9 stimulates release of chemotactic factors from human bronchial epithelial cells
26. Interleukin 9 promotes influx and local maturation of eosinophils
27. Phenotype of cells expressing mRNA for TH2-type (IL-4 and IL-5) and THl-type (IL-2 and IFN-γ) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatics and normal control subjects
28. IL-9-deficient mice established fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not for T cell development
29. Antigen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells
30. Interleukin-9 upregulates mucus expression in the airway
31. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response