Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways

Cell Death and Disease

Volumn 6, Issue 12, 2015, Pages

  Giordano, L ^a   Deceglie, S ^a   D'Adamo, P ^b,c   Valentino, M L ^d,e   La Morgia, C ^d,e   Fracasso, F ^a   Roberti, M ^a   Cappellari, M ^a   Petrosillo, G ^f   Ciaravolo, S ^g   Parente, D ^g   Giordano, C ^h   Maresca, A ^d,e   Iommarini, L ^d,e   Del Dotto, V ⁱ   Ghelli, A M ⁱ   Salomao, S R ^j   Berezovsky, A ^j   Belfort, R ^j   Sadun, A A ^k   Carelli, V ^d,e   Loguercio Polosa, P ^a   Cantatore, P ^a,f   more..

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^d BELLARIA HOSPITAL   (Italy)

^e UNIVERSITY OF BOLOGNA   (Italy)

^f CNR   (Italy)

^g Vectis Srl   (Italy)

^h SAPIENZA UNIVERSITY OF ROME   (Italy)

ⁱ UNIVERSITY OF BOLOGNA   (Italy)

^j FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^k UNIVERSITY OF CALIFORNIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AROMATIC HYDROCARBON RECEPTOR; CIGARETTE SMOKE CONDENSATE; CYTOCHROME C OXIDASE; GLUCOCORTICOID RECEPTOR; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE M5; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; PEROXIREDOXIN 3; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TOBACCO SMOKE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ARTICLE; BIOENERGY; BRAZILIAN; CELL MUTANT; COHORT ANALYSIS; CONTROLLED STUDY; DETOXIFICATION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; FEMALE; FIBROBLAST; GENE DOSAGE; HUMAN; HUMAN CELL; ITALIAN (CITIZEN); LEBER HEREDITARY OPTIC NEUROPATHY; MALE; MITOCHONDRIAL BIOGENESIS; OXIDATIVE PHOSPHORYLATION; PENETRANCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CARBONYLATION; SMOKING; ADVERSE EFFECTS; GENETICS; METABOLISM; OPTIC ATROPHY, HEREDITARY, LEBER; PATHOLOGY;

DNA, MITOCHONDRIAL; FEMALE; HUMANS; MALE; OPTIC ATROPHY, HEREDITARY, LEBER; OXIDATIVE PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SMOKING;

EID: 84997771399     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.364     Document Type: Article

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