Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment

Cell Cycle

Volumn 12, Issue 5, 2013, Pages 818-825

  Salem, Ahmed F ^a,b   Al Zoubi, Mazhar Salim ^a,c   Whitaker Menezes, Diana ^a   Martinez Outschoorn, Ubaldo E ^a   Lamb, Rebecca ^d   Hulit, James ^d   Howell, Anthony ^d   Gandara, Ricardo ^d   Sartini, Marina ^e   Galbiati, Ferruccio ^f   Bevilacqua, Generoso ^c   Sotgia, Federica ^a,d   Lisanti, Michael P ^a,d  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b NATIONAL ORGANIZATION FOR DRUG CONTROL AND RESEARCH NODCAR   (Egypt)

^c UNIVERSITY OF PISA   (Italy)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e UNIVERSITY OF GENOA   (Italy)

^f UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagy; Breast cancer; Cancer prevention; Carcinogens; Cigarette smoke; Ketone bodies; Lactate; Microenvironment; Mitochondrial dysfunction; Premature aging; Senescence; Tumor growth

Indexed keywords

CIGARETTE SMOKE; KETONE BODY; LACTIC ACID;

ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BREAST CANCER; CANCER GROWTH; CATABOLISM; CELL AGING; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; EPITHELIUM CELL; EPITHELIUM TUMOR; FIBROBLAST; HOST CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MITOPHAGY; MOUSE; NONHUMAN; PHENOTYPE; PREMATURE AGING; STROMA CELL; TUMOR MICROENVIRONMENT;

EID: 84874601438     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.23722     Document Type: Article

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