메뉴 건너뛰기




Volumn 115, Issue , 2017, Pages 141-154

A three-dimensional spheroidal cancer model based on PEG-fibrinogen hydrogel microspheres

Author keywords

Cancer tissue engineering; Engineered tumor model; MCF7; Tumor microenvironment; Tumor microsphere; Tumor spheroid

Indexed keywords

BIOMIMETICS; CELL MEMBRANES; CELLS; CYTOLOGY; DISEASES; EMULSIFICATION; EMULSIONS; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGELS; MICROSPHERES; TISSUE ENGINEERING; TUMORS;

EID: 84997525239     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2016.10.052     Document Type: Article
Times cited : (131)

References (59)
  • 1
    • 84861186736 scopus 로고    scopus 로고
    • Jekyll and Hyde: the role of the microenvironment on the progression of cancer
    • [1] Allen, M., Louise Jones, J., Jekyll and Hyde: the role of the microenvironment on the progression of cancer. J. Pathol. 223 (2011), 162–176.
    • (2011) J. Pathol. , vol.223 , pp. 162-176
    • Allen, M.1    Louise Jones, J.2
  • 2
    • 77953066865 scopus 로고    scopus 로고
    • The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D cultures
    • [2] Krause, S., Maffini, M.V., Soto, A.M., Sonnenschein, C., The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D cultures. BMC Cancer, 10, 2010, 263.
    • (2010) BMC Cancer , vol.10 , pp. 263
    • Krause, S.1    Maffini, M.V.2    Soto, A.M.3    Sonnenschein, C.4
  • 3
    • 0036990109 scopus 로고    scopus 로고
    • The organizing principle: microenvironmental influences in the normal and malignant breast
    • [3] Bissell, M.J., Radisky, D.C., Rizki, A., Weaver, V.M., Petersen, O.W., The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation 70 (2002), 537–546.
    • (2002) Differentiation , vol.70 , pp. 537-546
    • Bissell, M.J.1    Radisky, D.C.2    Rizki, A.3    Weaver, V.M.4    Petersen, O.W.5
  • 4
    • 84884709908 scopus 로고    scopus 로고
    • Extracellular matrix components in breast cancer progression and metastasis
    • [4] Oskarsson, T., Extracellular matrix components in breast cancer progression and metastasis. Breast 22:Suppl. 2 (2013), S66–S72.
    • (2013) Breast , vol.22 , pp. S66-S72
    • Oskarsson, T.1
  • 5
    • 0142055892 scopus 로고    scopus 로고
    • The role of fibrinogen and related fragments in tumour angiogenesis and metastasis
    • [5] Staton, C.A., Brown, N.J., Lewis, C.E., The role of fibrinogen and related fragments in tumour angiogenesis and metastasis. Expert Opin. Biol. Ther. 3 (2003), 1105–1120.
    • (2003) Expert Opin. Biol. Ther. , vol.3 , pp. 1105-1120
    • Staton, C.A.1    Brown, N.J.2    Lewis, C.E.3
  • 7
    • 84877759638 scopus 로고    scopus 로고
    • The role of fibrinogen, fibrin and fibrin(ogen) degradation products (FDPs) in tumor progression
    • [7] Kolodziejczyk, J., Ponczek, M.B., The role of fibrinogen, fibrin and fibrin(ogen) degradation products (FDPs) in tumor progression. Contemp. Oncol. 17 (2013), 113–119.
    • (2013) Contemp. Oncol. , vol.17 , pp. 113-119
    • Kolodziejczyk, J.1    Ponczek, M.B.2
  • 8
    • 0034072728 scopus 로고    scopus 로고
    • Fibrinogen assembly, secretion, and deposition into extracellular matrix by MCF-7 human breast carcinoma cells
    • [8] Rybarczyk, B.J., Simpson-Haidaris, P.J., Fibrinogen assembly, secretion, and deposition into extracellular matrix by MCF-7 human breast carcinoma cells. Cancer Res. 60 (2000), 2033–2039.
    • (2000) Cancer Res. , vol.60 , pp. 2033-2039
    • Rybarczyk, B.J.1    Simpson-Haidaris, P.J.2
  • 9
    • 0034548802 scopus 로고    scopus 로고
    • Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation
    • [9] Sahni, A., Francis, C.W., Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation. Blood 96 (2000), 3772–3778.
    • (2000) Blood , vol.96 , pp. 3772-3778
    • Sahni, A.1    Francis, C.W.2
  • 10
    • 37549035033 scopus 로고    scopus 로고
    • Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2)
    • [10] Sahni, A., Simpson-Haidaris, P.J., Sahni, S.K., Vaday, G.G., Francis, C.W., Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2). J. Thromb. Haemost. 6 (2008), 176–183.
    • (2008) J. Thromb. Haemost. , vol.6 , pp. 176-183
    • Sahni, A.1    Simpson-Haidaris, P.J.2    Sahni, S.K.3    Vaday, G.G.4    Francis, C.W.5
  • 11
    • 33845208108 scopus 로고    scopus 로고
    • Life isn't flat: taking cancer biology to the next dimension
    • [11] Smalley, K.S., Lioni, M., Herlyn, M., Life isn't flat: taking cancer biology to the next dimension. In Vitro Cell Dev. Biol. Anim. 42 (2006), 242–247.
    • (2006) In Vitro Cell Dev. Biol. Anim. , vol.42 , pp. 242-247
    • Smalley, K.S.1    Lioni, M.2    Herlyn, M.3
  • 12
    • 59649109230 scopus 로고    scopus 로고
    • Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab
    • [12] Pickl, M., Ries, C.H., Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab. Oncogene 28 (2009), 461–468.
    • (2009) Oncogene , vol.28 , pp. 461-468
    • Pickl, M.1    Ries, C.H.2
  • 13
    • 84867887350 scopus 로고    scopus 로고
    • Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues
    • [13] Baker, B.M., Chen, C.S., Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues. J. Cell Sci. 125 (2012), 3015–3024.
    • (2012) J. Cell Sci. , vol.125 , pp. 3015-3024
    • Baker, B.M.1    Chen, C.S.2
  • 14
    • 34547931078 scopus 로고    scopus 로고
    • Modeling tissue morphogenesis and cancer in 3D
    • [14] Yamada, K.M., Cukierman, E., Modeling tissue morphogenesis and cancer in 3D. Cell 130 (2007), 601–610.
    • (2007) Cell , vol.130 , pp. 601-610
    • Yamada, K.M.1    Cukierman, E.2
  • 15
    • 84954185859 scopus 로고    scopus 로고
    • 3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained
    • [15] Zanoni, M., Piccinini, F., Arienti, C., Zamagni, A., Santi, S., Polico, R., et al. 3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained. Sci. Rep., 6, 2016, 19103.
    • (2016) Sci. Rep. , vol.6 , pp. 19103
    • Zanoni, M.1    Piccinini, F.2    Arienti, C.3    Zamagni, A.4    Santi, S.5    Polico, R.6
  • 16
    • 0037701271 scopus 로고    scopus 로고
    • Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types
    • [16] Kelm, J.M., Timmins, N.E., Brown, C.J., Fussenegger, M., Nielsen, L.K., Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol. Bioeng. 83 (2003), 173–180.
    • (2003) Biotechnol. Bioeng. , vol.83 , pp. 173-180
    • Kelm, J.M.1    Timmins, N.E.2    Brown, C.J.3    Fussenegger, M.4    Nielsen, L.K.5
  • 18
    • 0032796170 scopus 로고    scopus 로고
    • Differential expression of adhesion molecules (CD44, ICAM-1 and LFA-3) in cancer cells grown in monolayer or as multicellular spheroids
    • [18] Rainaldi, G., Calcabrini, A., Arancia, G., Santini, M.T., Differential expression of adhesion molecules (CD44, ICAM-1 and LFA-3) in cancer cells grown in monolayer or as multicellular spheroids. Anticancer Res. 19 (1999), 1769–1778.
    • (1999) Anticancer Res. , vol.19 , pp. 1769-1778
    • Rainaldi, G.1    Calcabrini, A.2    Arancia, G.3    Santini, M.T.4
  • 19
    • 40349103280 scopus 로고    scopus 로고
    • Microfluidic self-assembly of tumor spheroids for anticancer drug discovery
    • [19] Wu, L.Y., Di Carlo, D., Lee, L.P., Microfluidic self-assembly of tumor spheroids for anticancer drug discovery. Biomed. Microdevices 10 (2008), 197–202.
    • (2008) Biomed. Microdevices , vol.10 , pp. 197-202
    • Wu, L.Y.1    Di Carlo, D.2    Lee, L.P.3
  • 20
    • 78650062139 scopus 로고    scopus 로고
    • A review of three-dimensional in vitro tissue models for drug discovery and transport studies
    • [20] Elliott, N.T., Yuan, F., A review of three-dimensional in vitro tissue models for drug discovery and transport studies. J. Pharm. Sci. 100 (2011), 59–74.
    • (2011) J. Pharm. Sci. , vol.100 , pp. 59-74
    • Elliott, N.T.1    Yuan, F.2
  • 21
    • 58749093939 scopus 로고    scopus 로고
    • Recent advances in three-dimensional multicellular spheroid culture for biomedical research
    • [21] Lin, R.Z., Chang, H.Y., Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol. J. 3 (2008), 1172–1184.
    • (2008) Biotechnol. J. , vol.3 , pp. 1172-1184
    • Lin, R.Z.1    Chang, H.Y.2
  • 22
    • 77956188264 scopus 로고    scopus 로고
    • A polymer microstructure array for the formation, culturing, and high throughput drug screening of breast cancer spheroids
    • [22] Markovitz-Bishitz, Y., Tauber, Y., Afrimzon, E., Zurgil, N., Sobolev, M., Shafran, Y., et al. A polymer microstructure array for the formation, culturing, and high throughput drug screening of breast cancer spheroids. Biomaterials 31 (2010), 8436–8444.
    • (2010) Biomaterials , vol.31 , pp. 8436-8444
    • Markovitz-Bishitz, Y.1    Tauber, Y.2    Afrimzon, E.3    Zurgil, N.4    Sobolev, M.5    Shafran, Y.6
  • 23
    • 28344448202 scopus 로고    scopus 로고
    • Fibrinogen and fibrin structure and functions
    • [23] Mosesson, M.W., Fibrinogen and fibrin structure and functions. J. Thromb. Haemost. 3 (2005), 1894–1904.
    • (2005) J. Thromb. Haemost. , vol.3 , pp. 1894-1904
    • Mosesson, M.W.1
  • 24
    • 84898014389 scopus 로고    scopus 로고
    • Dual-phase, surface tension-based fabrication method for generation of tumor millibeads
    • [24] Pradhan, S., Chaudhury, C.S., Lipke, E.A., Dual-phase, surface tension-based fabrication method for generation of tumor millibeads. Langmuir 30 (2014), 3817–3825.
    • (2014) Langmuir , vol.30 , pp. 3817-3825
    • Pradhan, S.1    Chaudhury, C.S.2    Lipke, E.A.3
  • 25
    • 10044290786 scopus 로고    scopus 로고
    • Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures
    • [25] Almany, L., Seliktar, D., Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures. Biomaterials 26 (2005), 2467–2477.
    • (2005) Biomaterials , vol.26 , pp. 2467-2477
    • Almany, L.1    Seliktar, D.2
  • 26
    • 28444482853 scopus 로고    scopus 로고
    • The effect of structural alterations of PEG-fibrinogen hydrogel scaffolds on 3-D cellular morphology and cellular migration
    • [26] Dikovsky, D., Bianco-Peled, H., Seliktar, D., The effect of structural alterations of PEG-fibrinogen hydrogel scaffolds on 3-D cellular morphology and cellular migration. Biomaterials 27 (2006), 1496–1506.
    • (2006) Biomaterials , vol.27 , pp. 1496-1506
    • Dikovsky, D.1    Bianco-Peled, H.2    Seliktar, D.3
  • 27
    • 79961015324 scopus 로고    scopus 로고
    • Development and optimization of a dual-photoinitiator, emulsion-based technique for rapid generation of cell-laden hydrogel microspheres
    • [27] Franco, C.L., Price, J., West, J.L., Development and optimization of a dual-photoinitiator, emulsion-based technique for rapid generation of cell-laden hydrogel microspheres. Acta Biomater. 7 (2011), 3267–3276.
    • (2011) Acta Biomater. , vol.7 , pp. 3267-3276
    • Franco, C.L.1    Price, J.2    West, J.L.3
  • 28
    • 78650474099 scopus 로고    scopus 로고
    • Quantitative characterization of preneoplastic progression using single-cell computed tomography and three-dimensional karyometry
    • [28] Nandakumar, V., Kelbauskas, L., Johnson, R., Meldrum, D., Quantitative characterization of preneoplastic progression using single-cell computed tomography and three-dimensional karyometry. Cytom. Part A 79A (2011), 25–34.
    • (2011) Cytom. Part A , vol.79A , pp. 25-34
    • Nandakumar, V.1    Kelbauskas, L.2    Johnson, R.3    Meldrum, D.4
  • 29
    • 0031018501 scopus 로고    scopus 로고
    • An evaluation of the role of nuclear cytoplasmic ratios and nuclear volume densities as diagnostic indicators in metaplastic, dysplastic and neoplastic lesions of the human cheek
    • [29] White, F.H., Jin, Y., Yang, L., An evaluation of the role of nuclear cytoplasmic ratios and nuclear volume densities as diagnostic indicators in metaplastic, dysplastic and neoplastic lesions of the human cheek. Histol. Histopathol. 12 (1997), 69–77.
    • (1997) Histol. Histopathol. , vol.12 , pp. 69-77
    • White, F.H.1    Jin, Y.2    Yang, L.3
  • 30
    • 38449101699 scopus 로고    scopus 로고
    • Diversity of cell-mediated adhesions in breast cancer spheroids
    • [30] Ivascu, A., Kubbies, M., Diversity of cell-mediated adhesions in breast cancer spheroids. Int. J. Oncol. 31 (2007), 1403–1413.
    • (2007) Int. J. Oncol. , vol.31 , pp. 1403-1413
    • Ivascu, A.1    Kubbies, M.2
  • 31
    • 77956187576 scopus 로고    scopus 로고
    • Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells
    • [31] Loessner, D., Stok, K.S., Lutolf, M.P., Hutmacher, D.W., Clements, J.A., Rizzi, S.C., Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. Biomaterials 31 (2010), 8494–8506.
    • (2010) Biomaterials , vol.31 , pp. 8494-8506
    • Loessner, D.1    Stok, K.S.2    Lutolf, M.P.3    Hutmacher, D.W.4    Clements, J.A.5    Rizzi, S.C.6
  • 32
    • 33845209913 scopus 로고    scopus 로고
    • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    • [32] Neve, R.M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F.L., Fevr, T., et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 10 (2006), 515–527.
    • (2006) Cancer Cell. , vol.10 , pp. 515-527
    • Neve, R.M.1    Chin, K.2    Fridlyand, J.3    Yeh, J.4    Baehner, F.L.5    Fevr, T.6
  • 33
    • 84953227804 scopus 로고    scopus 로고
    • 3D scaffolds in breast cancer research
    • [33] Rijal, G., Li, W., 3D scaffolds in breast cancer research. Biomaterials 81 (2016), 135–156.
    • (2016) Biomaterials , vol.81 , pp. 135-156
    • Rijal, G.1    Li, W.2
  • 34
    • 85011643519 scopus 로고    scopus 로고
    • Polymeric biomaterials for in vitro cancer tissue engineering and drug testing applications
    • [34] Pradhan, S., Hassani, I., Clary, J.M., Lipke, E.A., Polymeric biomaterials for in vitro cancer tissue engineering and drug testing applications. Tissue Eng. Part B, 2016, 10.1089/ten.TEB.2015.0567.
    • (2016) Tissue Eng. Part B
    • Pradhan, S.1    Hassani, I.2    Clary, J.M.3    Lipke, E.A.4
  • 35
    • 84892368547 scopus 로고    scopus 로고
    • Influence of soluble PEG-OH incorporation in a 3D cell-laden PEG-fibrinogen (PF) hydrogel on smooth muscle cell morphology and growth
    • [35] Lee, B.H., Tin, S.P., Chaw, S.Y., Cao, Y., Xia, Y., Steele, T.W., et al. Influence of soluble PEG-OH incorporation in a 3D cell-laden PEG-fibrinogen (PF) hydrogel on smooth muscle cell morphology and growth. J. Biomater. Sci. Polym. Ed. 25 (2014), 394–409.
    • (2014) J. Biomater. Sci. Polym. Ed. , vol.25 , pp. 394-409
    • Lee, B.H.1    Tin, S.P.2    Chaw, S.Y.3    Cao, Y.4    Xia, Y.5    Steele, T.W.6
  • 36
    • 84896761439 scopus 로고    scopus 로고
    • PlGF-MMP9-engineered iPS cells supported on a PEG-fibrinogen hydrogel scaffold possess an enhanced capacity to repair damaged myocardium
    • [36] Bearzi, C., Gargioli, C., Baci, D., Fortunato, O., Shapira-Schweitzer, K., Kossover, O., et al. PlGF-MMP9-engineered iPS cells supported on a PEG-fibrinogen hydrogel scaffold possess an enhanced capacity to repair damaged myocardium. Cell Death Dis., 5, 2014, e1053.
    • (2014) Cell Death Dis. , vol.5 , pp. e1053
    • Bearzi, C.1    Gargioli, C.2    Baci, D.3    Fortunato, O.4    Shapira-Schweitzer, K.5    Kossover, O.6
  • 37
    • 84891712466 scopus 로고    scopus 로고
    • Time-dependent cellular morphogenesis and matrix stiffening in proteolytically responsive hydrogels
    • [37] Kesselman, D., Kossover, O., Mironi-Harpaz, I., Seliktar, D., Time-dependent cellular morphogenesis and matrix stiffening in proteolytically responsive hydrogels. Acta Biomater. 9 (2013), 7630–7639.
    • (2013) Acta Biomater. , vol.9 , pp. 7630-7639
    • Kesselman, D.1    Kossover, O.2    Mironi-Harpaz, I.3    Seliktar, D.4
  • 38
    • 84923352924 scopus 로고    scopus 로고
    • hiPS-MSCs differentiation towards fibroblasts on a 3D ECM mimicking scaffold
    • [38] Xu, R., Taskin, M.B., Rubert, M., Seliktar, D., Besenbacher, F., Chen, M., hiPS-MSCs differentiation towards fibroblasts on a 3D ECM mimicking scaffold. Sci. Rep., 5, 2015, 8480.
    • (2015) Sci. Rep. , vol.5 , pp. 8480
    • Xu, R.1    Taskin, M.B.2    Rubert, M.3    Seliktar, D.4    Besenbacher, F.5    Chen, M.6
  • 40
    • 84971385394 scopus 로고    scopus 로고
    • Chemokine axes in breast cancer: factors of the tumor microenvironment reshape the CCR7-driven metastatic spread of luminal-A breast tumors
    • [40] Weitzenfeld, P., Kossover, O., Korner, C., Meshel, T., Wiemann, S., Seliktar, D., et al. Chemokine axes in breast cancer: factors of the tumor microenvironment reshape the CCR7-driven metastatic spread of luminal-A breast tumors. J. Leukoc. Biol. 99 (2016), 1009–1025.
    • (2016) J. Leukoc. Biol. , vol.99 , pp. 1009-1025
    • Weitzenfeld, P.1    Kossover, O.2    Korner, C.3    Meshel, T.4    Wiemann, S.5    Seliktar, D.6
  • 41
    • 84900021928 scopus 로고    scopus 로고
    • Quasi-spherical microwells on superhydrophobic substrates for long term culture of multicellular spheroids and high throughput assays
    • [41] Liu, T., Winter, M., Thierry, B., Quasi-spherical microwells on superhydrophobic substrates for long term culture of multicellular spheroids and high throughput assays. Biomaterials 35 (2014), 6060–6068.
    • (2014) Biomaterials , vol.35 , pp. 6060-6068
    • Liu, T.1    Winter, M.2    Thierry, B.3
  • 42
    • 79959887793 scopus 로고    scopus 로고
    • The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation
    • [42] Yoshii, Y., Waki, A., Yoshida, K., Kakezuka, A., Kobayashi, M., Namiki, H., et al. The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation. Biomaterials 32 (2011), 6052–6058.
    • (2011) Biomaterials , vol.32 , pp. 6052-6058
    • Yoshii, Y.1    Waki, A.2    Yoshida, K.3    Kakezuka, A.4    Kobayashi, M.5    Namiki, H.6
  • 43
    • 84893648450 scopus 로고    scopus 로고
    • A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics
    • [43] Xu, X., Sabanayagam, C.R., Harrington, D.A., Farach-Carson, M.C., Jia, X.Q., A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics. Biomaterials 35 (2014), 3319–3330.
    • (2014) Biomaterials , vol.35 , pp. 3319-3330
    • Xu, X.1    Sabanayagam, C.R.2    Harrington, D.A.3    Farach-Carson, M.C.4    Jia, X.Q.5
  • 44
    • 83355163224 scopus 로고    scopus 로고
    • The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs
    • [44] Chen, L., Xiao, Z., Meng, Y., Zhao, Y., Han, J., Su, G., et al. The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs. Biomaterials 33 (2012), 1437–1444.
    • (2012) Biomaterials , vol.33 , pp. 1437-1444
    • Chen, L.1    Xiao, Z.2    Meng, Y.3    Zhao, Y.4    Han, J.5    Su, G.6
  • 45
    • 84908102075 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition and cancer stem-like phenotypes within chitosan-hyaluronan membrane-derived 3D tumor spheroids
    • [45] Huang, Y.J., Hsu, S.H., Acquisition of epithelial-mesenchymal transition and cancer stem-like phenotypes within chitosan-hyaluronan membrane-derived 3D tumor spheroids. Biomaterials 35 (2014), 10070–10079.
    • (2014) Biomaterials , vol.35 , pp. 10070-10079
    • Huang, Y.J.1    Hsu, S.H.2
  • 46
    • 84901997778 scopus 로고    scopus 로고
    • Cellular foundations of mammary tubulogenesis
    • [46] Huebner, R.J., Ewald, A.J., Cellular foundations of mammary tubulogenesis. Sem. Cell Dev. Biol. 31 (2014), 124–131.
    • (2014) Sem. Cell Dev. Biol. , vol.31 , pp. 124-131
    • Huebner, R.J.1    Ewald, A.J.2
  • 47
    • 84884990423 scopus 로고    scopus 로고
    • Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells
    • [47] Chen, Q.K., Lee, K., Radisky, D.C., Nelson, C.M., Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Differentiation 86 (2013), 126–132.
    • (2013) Differentiation , vol.86 , pp. 126-132
    • Chen, Q.K.1    Lee, K.2    Radisky, D.C.3    Nelson, C.M.4
  • 48
    • 77954865524 scopus 로고    scopus 로고
    • Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions
    • [48] Godde, N.J., Galea, R.C., Elsum, I.A., Humbert, P.O., Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions. J. Mammary Gland. Biol. 15 (2010), 149–168.
    • (2010) J. Mammary Gland. Biol. , vol.15 , pp. 149-168
    • Godde, N.J.1    Galea, R.C.2    Elsum, I.A.3    Humbert, P.O.4
  • 49
    • 84855387742 scopus 로고    scopus 로고
    • Isotropic 3D nuclear morphometry of normal, fibrocystic and malignant breast epithelial cells reveals new structural alterations
    • [49] Nandakumar, V., Kelbauskas, L., Hernandez, K.F., Lintecum, K.M., Senechal, P., Bussey, K.J., et al. Isotropic 3D nuclear morphometry of normal, fibrocystic and malignant breast epithelial cells reveals new structural alterations. PloS One, 7, 2012, e29230.
    • (2012) PloS One , vol.7 , pp. e29230
    • Nandakumar, V.1    Kelbauskas, L.2    Hernandez, K.F.3    Lintecum, K.M.4    Senechal, P.5    Bussey, K.J.6
  • 50
    • 0026045818 scopus 로고
    • Correlation of nuclear morphometry with progression of breast-cancer
    • [50] Pienta, K.J., Coffey, D.S., Correlation of nuclear morphometry with progression of breast-cancer. Cancer 68 (1991), 2012–2016.
    • (1991) Cancer , vol.68 , pp. 2012-2016
    • Pienta, K.J.1    Coffey, D.S.2
  • 51
    • 0028903826 scopus 로고
    • Quantitative histopathology in ductal carcinoma of the breast - prognostic value of mean nuclear size and mitotic counts
    • [51] Ladekarl, M., Quantitative histopathology in ductal carcinoma of the breast - prognostic value of mean nuclear size and mitotic counts. Cancer 75 (1995), 2114–2122.
    • (1995) Cancer , vol.75 , pp. 2114-2122
    • Ladekarl, M.1
  • 52
    • 0037380791 scopus 로고    scopus 로고
    • Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ
    • [52] Helczynska, K., Kronblad, A., Jogi, A., Nilsson, E., Beckman, S., Landberg, G., et al. Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ. Cancer Res. 63 (2003), 1441–1444.
    • (2003) Cancer Res. , vol.63 , pp. 1441-1444
    • Helczynska, K.1    Kronblad, A.2    Jogi, A.3    Nilsson, E.4    Beckman, S.5    Landberg, G.6
  • 53
    • 84867251505 scopus 로고    scopus 로고
    • The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression
    • [53] Le Bras, G.F., Taubenslag, K.J., Andl, C.D., The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression. Cell Adh. Migr. 6 (2012), 365–373.
    • (2012) Cell Adh. Migr. , vol.6 , pp. 365-373
    • Le Bras, G.F.1    Taubenslag, K.J.2    Andl, C.D.3
  • 54
    • 63249115113 scopus 로고    scopus 로고
    • Loss of tight junction barrier function and its role in cancer metastasis
    • [54] Martin, T.A., Jiang, W.G., Loss of tight junction barrier function and its role in cancer metastasis. Biochim. Biophys. Acta 1788 (2009), 872–891.
    • (2009) Biochim. Biophys. Acta , vol.1788 , pp. 872-891
    • Martin, T.A.1    Jiang, W.G.2
  • 55
    • 0031788894 scopus 로고    scopus 로고
    • Aberrant type I and type III collagen gene expression in human breast cancer in vivo
    • [55] Kauppila, S., Stenbäck, F., Risteli, J., Jukkola, A., Risteli, L., Aberrant type I and type III collagen gene expression in human breast cancer in vivo. J. Pathol. 186 (1998), 262–268.
    • (1998) J. Pathol. , vol.186 , pp. 262-268
    • Kauppila, S.1    Stenbäck, F.2    Risteli, J.3    Jukkola, A.4    Risteli, L.5
  • 56
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: a dynamic niche in cancer progression
    • [56] Lu, P., Weaver, V.M., Werb, Z., The extracellular matrix: a dynamic niche in cancer progression. J. Cell Biol. 196 (2012), 395–406.
    • (2012) J. Cell Biol. , vol.196 , pp. 395-406
    • Lu, P.1    Weaver, V.M.2    Werb, Z.3
  • 58
    • 84922333220 scopus 로고    scopus 로고
    • Remodelling the extracellular matrix in development and disease
    • [58] Bonnans, C., Chou, J., Werb, Z., Remodelling the extracellular matrix in development and disease. Nat. Rev. Mol. Cell Biol. 15 (2014), 786–801.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 786-801
    • Bonnans, C.1    Chou, J.2    Werb, Z.3
  • 59
    • 84928043983 scopus 로고    scopus 로고
    • Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells
    • [59] Wang, K., Andresen Eguiluz, R.C., Wu, F., Seo, B.R., Fischbach, C., Gourdon, D., Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells. Biomaterials 54 (2015), 63–71.
    • (2015) Biomaterials , vol.54 , pp. 63-71
    • Wang, K.1    Andresen Eguiluz, R.C.2    Wu, F.3    Seo, B.R.4    Fischbach, C.5    Gourdon, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.