Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer

Cell Reports

Volumn 17, Issue 9, 2016, Pages 2195-2209

  Havenar Daughton, Colin ^a,b   Carnathan, Diane G ^b,c   Torrents de la Peña, Alba ^e   Pauthner, Matthias ^b,d   Briney, Bryan ^b,d   Reiss, Samantha M ^a,b   Wood, Jennifer S ^c   Kaushik, Kirti ^a,b   van Gils, Marit J ^e   Rosales, Sandy L ^a   van der Woude, Patricia ^e   Locci, Michela ^a,b   Le, Khoa M ^b,d   de Taeye, Steven W ^e   Sok, Devin ^b,d   Mohammed, Ata Ur Rasheed ^f   Huang, Jessica ^f   Gumber, Sanjeev ^c   Garcia, AnaPatricia ^c   Kasturi, Sudhir P ^c,f   Pulendran, Bali ^b,c,f   Moore, John P ^g   Ahmed, Rafi ^b,f   Seumois, Grégory ^a   Burton, Dennis R ^b,d,i   Sanders, Rogier W ^e,g   Silvestri, Guido ^b,c,f   Crotty, Shane ^a,b,h   more..

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery   (United States)

^c EMORY UNIVERSITY   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

^h UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

ⁱ MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

vaccines

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS ENV TRIMER; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; PROTEIN BINDING;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FINE NEEDLE ASPIRATION BIOPSY; GERMINAL CENTER; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNITY; IMMUNIZATION; LYMPH NODE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; ANIMAL; ANTIBODY PRODUCTION; CELL CLONE; CELL LINEAGE; HELPER CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; PROTEIN MULTIMERIZATION;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODY FORMATION; B-LYMPHOCYTES; BIOPSY, FINE-NEEDLE; CELL LINEAGE; CLONE CELLS; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GERMINAL CENTER; HIV-1; IMMUNIZATION; MACACA MULATTA; PROTEIN BINDING; PROTEIN MULTIMERIZATION; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84996629662     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.10.085     Document Type: Article

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