Structure-guided redesign increases the propensity of HIV Env to generate highly stable soluble trimers

Journal of Virology

Volumn 90, Issue 6, 2016, Pages 2806-2817

  Guenaga, Javier ^a   Dubrovskaya, Viktoriya ^a   De Val, Natalia ^a   Sharma, Shailendra K ^a   Carrette, Barbara ^a   Ward, Andrew B ^a   Wyatt, Richard T ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; DISULFIDE; GLYCOPROTEIN GP 120; NEUTRALIZING ANTIBODY; VIRUS GLYCOPROTEIN; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; RECOMBINANT PROTEIN; VIRUS ENVELOPE PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; DIFFERENTIAL SCANNING CALORIMETRY; DISULFIDE BOND; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN IMMUNODEFICIENCY VIRUS 1; INTERFEROMETRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; THERMOSTABILITY; CHEMISTRY; GENETICS; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN STABILITY;

DISULFIDES; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV ANTIGENS; HIV-1; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; RECOMBINANT PROTEINS;

EID: 84961124024     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02652-15     Document Type: Article

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