메뉴 건너뛰기




Volumn 10, Issue 3, 2015, Pages 170-176

Animal models in HIV-1 protection and therapy

Author keywords

HIV 1; humanized mice; Keywords animal models; nonhuman primate; simian immunodeficiency virus (SIV); simian human immunodeficiency virus (SHIV)

Indexed keywords

MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

EID: 84928574709     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0000000000000152     Document Type: Review
Times cited : (44)

References (54)
  • 1
    • 84897382112 scopus 로고    scopus 로고
    • Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques
    • Chahroudi A, Cartwright E, Lee ST, et al. Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques. PLoS Pathogens 2014; 10:e1003958.
    • (2014) PLoS Pathogens , vol.10 , pp. e1003958
    • Chahroudi, A.1    Cartwright, E.2    Lee, S.T.3
  • 2
    • 84858060040 scopus 로고    scopus 로고
    • Natural SIV hosts: Showing AIDS the door
    • Chahroudi A, Bosinger SE, Vanderford TH, et al. Natural SIV hosts: showing AIDS the door. Science 2012; 335:1188-1193.
    • (2012) Science , vol.335 , pp. 1188-1193
    • Chahroudi, A.1    Bosinger, S.E.2    Vanderford, T.H.3
  • 3
    • 84894533767 scopus 로고    scopus 로고
    • HLA-B-57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4 T cell depletion in humanized BLT mice
    • SalgadoM, Swanson MD, Pohlmeyer CW, et al. HLA-B-57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4 T cell depletion in humanized BLT mice. J Virol 2014; 88:3340-3352.
    • (2014) J Virol , vol.88 , pp. 3340-3352
    • Salgado, M.1    Swanson, M.D.2    Pohlmeyer, C.W.3
  • 4
    • 84901933676 scopus 로고    scopus 로고
    • Type i interferon responses in rhesus macaques prevent SIV infection and slow disease progression
    • Sandler NG, Bosinger SE, Estes JD, et al. Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression. Nature 2014; 511:601-605.
    • (2014) Nature , vol.511 , pp. 601-605
    • Sandler, N.G.1    Bosinger, S.E.2    Estes, J.D.3
  • 5
    • 84901255278 scopus 로고    scopus 로고
    • Divergent CD4 T memory stem cell dynamics in pathogenic and nonpathogenic simian immunodeficiency virus infections
    • Cartwright EK, McGary CS, Cervasi B, et al. Divergent CD4 T memory stem cell dynamics in pathogenic and nonpathogenic simian immunodeficiency virus infections. J Immunol 2014; 192:4666-4673.
    • (2014) J Immunol , vol.192 , pp. 4666-4673
    • Cartwright, E.K.1    McGary, C.S.2    Cervasi, B.3
  • 6
    • 84904254930 scopus 로고    scopus 로고
    • Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection
    • Hong JJ, Amancha PK, Rogers KA, et al. Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection. J Immunol 2014; 193:797-806.
    • (2014) J Immunol , vol.193 , pp. 797-806
    • Hong, J.J.1    Amancha, P.K.2    Rogers, K.A.3
  • 7
    • 84892786095 scopus 로고    scopus 로고
    • Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV
    • Roederer M, Keele BF, Schmidt SD, et al. Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. Nature 2014; 505:502-508.
    • (2014) Nature , vol.505 , pp. 502-508
    • Roederer, M.1    Keele, B.F.2    Schmidt, S.D.3
  • 8
    • 84928559014 scopus 로고    scopus 로고
    • Short communication: Viremic control is independent of repeated low-dose SHIVSF162p3 exposures
    • Henning TR, Hanson D, Vishwanathan SA, et al. Short communication: viremic control is independent of repeated low-dose SHIVSF162p3 exposures. AIDS Res Hum Retroviruses 2014; 30:1125-1129.
    • (2014) AIDS Res Hum Retroviruses , vol.30 , pp. 1125-1129
    • Henning, T.R.1    Hanson, D.2    Vishwanathan, S.A.3
  • 9
    • 84925225346 scopus 로고    scopus 로고
    • Nonhuman primate models for cell-associated simian immunodeficiency virus transmission: The need to better understand the complexity of HIV mucosal transmission
    • Bernard-Stoecklin S, Gommet C, CavarelliM, LeGrand R. Nonhuman primate models for cell-associated simian immunodeficiency virus transmission: The need to better understand the complexity of HIV mucosal transmission. J Infect Dis 2014; 210 (Suppl 3):S660-S666.
    • (2014) J Infect Dis , vol.210 , pp. S660-S666
    • Bernard-Stoecklin, S.1    Gommet, C.2    Cavarelli, M.3    Legrand, R.4
  • 10
    • 84886870683 scopus 로고    scopus 로고
    • Defining the interaction of HIV-1 with the mucosal barriers of the female reproductive tract
    • Carias AM, McCoombe S, McRaven M, et al. Defining the interaction of HIV-1 with the mucosal barriers of the female reproductive tract. J Virol 2013; 87:11388-11400.
    • (2013) J Virol , vol.87 , pp. 11388-11400
    • Carias, A.M.1    McCoombe, S.2    McRaven, M.3
  • 11
    • 84907693726 scopus 로고    scopus 로고
    • Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins
    • Del Prete GQ, Ailers B, Moldt B, et al. Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins. Cell Host Microbe 2014; 16:412-418.
    • (2014) Cell Host Microbe , vol.16 , pp. 412-418
    • Del Prete, G.Q.1    Ailers, B.2    Moldt, B.3
  • 12
    • 84912544398 scopus 로고    scopus 로고
    • Infection of monkeys by simianhuman immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes
    • Asmal M, Luedemann C, Lavine CL, et al. Infection of monkeys by simianhuman immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes. Virology 2014; 475C:37-45.
    • (2014) Virology , vol.475 , pp. 37-45
    • Asmal, M.1    Luedemann, C.2    Lavine, C.L.3
  • 13
    • 84869215739 scopus 로고    scopus 로고
    • A species-specific amino acid difference in the macaque CD4 receptor restricts replication by global circulating HIV-1 variants representing viruses from recent infection
    • Humes D, Emery S, Laws E, Overbaugh J. A species-specific amino acid difference in the macaque CD4 receptor restricts replication by global circulating HIV-1 variants representing viruses from recent infection. J Virol 2012; 86:12472-12483.
    • (2012) J Virol , vol.86 , pp. 12472-12483
    • Humes, D.1    Emery, S.2    Laws, E.3    Overbaugh, J.4
  • 14
    • 84920771763 scopus 로고    scopus 로고
    • Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer
    • Boyd DF, Peterson D, Haggarty BS, et al. Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer. J Virol 2015; 89:894-907.
    • (2015) J Virol , vol.89 , pp. 894-907
    • Boyd, D.F.1    Peterson, D.2    Haggarty, B.S.3
  • 15
    • 84905663895 scopus 로고    scopus 로고
    • Nonneutralizing functional antibodies: A new 'old' paradigm for HIV vaccines
    • Excler JL, Ake J, Robb ML, et al. Nonneutralizing functional antibodies: A new 'old' paradigm for HIV vaccines. Clin Vaccine Immunol 2014; 21:1023-1036.
    • (2014) Clin Vaccine Immunol , vol.21 , pp. 1023-1036
    • Excler, J.L.1    Ake, J.2    Robb, M.L.3
  • 16
    • 84920274731 scopus 로고    scopus 로고
    • The role of HIV-specific antibody-dependent cellular cytotoxicity in HIV prevention and the influence of the HIV-1 Vpu protein
    • Kramski M, Stratov I, Kent SJ. The role of HIV-specific antibody-dependent cellular cytotoxicity in HIV prevention and the influence of the HIV-1 Vpu protein. Aids 2015; 29:137-144.
    • (2015) Aids , vol.29 , pp. 137-144
    • Kramski, M.1    Stratov, I.2    Kent, S.J.3
  • 17
    • 84898545740 scopus 로고    scopus 로고
    • Epitope target structures of Fc-mediated effector function during HIV-1 acquisition
    • Lewis GK, Guan Y, Kamin-Lewis R, et al. Epitope target structures of Fc-mediated effector function during HIV-1 acquisition. Curr Opin HIV AIDS 2014; 9:263-270.
    • (2014) Curr Opin HIV AIDS , vol.9 , pp. 263-270
    • Lewis, G.K.1    Guan, Y.2    Kamin-Lewis, R.3
  • 18
    • 34548496893 scopus 로고    scopus 로고
    • Fc receptor but not complement binding is important in antibody protection against HIV
    • Hessell AJ,Hangartner L,HunterM, et al. Fc receptor but not complement binding is important in antibody protection against HIV. Nature 2007; 449:101-104.
    • (2007) Nature , vol.449 , pp. 101-104
    • Hessell, A.J.1    Hangartner, L.2    Hunter, M.3
  • 19
    • 84901262680 scopus 로고    scopus 로고
    • Lack of protection following passive transfer of polyclonal highly functional low-dose nonneutralizing antibodies
    • Dugast AS, Chan Y, Hoffner M, et al. Lack of protection following passive transfer of polyclonal highly functional low-dose nonneutralizing antibodies. PLoS One 2014; 9:e97229.
    • (2014) PLoS One , vol.9 , pp. e97229
    • Dugast, A.S.1    Chan, Y.2    Hoffner, M.3
  • 20
    • 84890899378 scopus 로고    scopus 로고
    • Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques
    • Moog C, Dereuddre-Bosquet N, Teillaud JL, et al. Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques. Mucosal Immunol 2014; 7:46-56.
    • (2014) Mucosal Immunol , vol.7 , pp. 46-56
    • Moog, C.1    Dereuddre-Bosquet, N.2    Teillaud, J.L.3
  • 21
    • 84907983318 scopus 로고    scopus 로고
    • Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
    • Ko SY, Pegu A, Rudicell RS, et al. Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. Nature 2014; 514:642-645.
    • (2014) Nature , vol.514 , pp. 642-645
    • Ko, S.Y.1    Pegu, A.2    Rudicell, R.S.3
  • 23
    • 84908077691 scopus 로고    scopus 로고
    • Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity
    • Bournazos S, Klein F, Pietzsch J, et al. Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. Cell 2014; 158: 1243-1253.
    • (2014) Cell , vol.158 , pp. 1243-1253
    • Bournazos, S.1    Klein, F.2    Pietzsch, J.3
  • 24
    • 79960585840 scopus 로고    scopus 로고
    • Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody
    • Burton DR, Hessell AJ, Keele BF, et al. Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody. Proc Natl Acad Sci USA 2011; 108:11181-11186.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11181-11186
    • Burton, D.R.1    Hessell, A.J.2    Keele, B.F.3
  • 25
    • 84872518803 scopus 로고    scopus 로고
    • Of mice and men: The need for humanized mouse models to study human IgG activity in vivo
    • Lux A, Nimmerjahn F. Of mice and men: The need for humanized mouse models to study human IgG activity in vivo. J Clin Immunol 2013; 33 (Suppl 1):S4-S8.
    • (2013) J Clin Immunol , vol.33 , pp. S4-S8
    • Lux, A.1    Nimmerjahn, F.2
  • 26
    • 84859991126 scopus 로고    scopus 로고
    • Mouse model recapitulating human Fcgamma receptor structural and functional diversity
    • Smith P, DiLillo DJ, Bournazos S, et al. Mouse model recapitulating human Fcgamma receptor structural and functional diversity. Proc Natl Acad Sci USA 2012; 109:6181-6186.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 6181-6186
    • Smith, P.1    Dilillo, D.J.2    Bournazos, S.3
  • 28
    • 84902463140 scopus 로고    scopus 로고
    • Phenotypes and distribution of mucosal memory B-cell populations in the SIV/SHIV rhesus macaque model
    • Demberg T, Mohanram V, Venzon D, Robert-Guroff M. Phenotypes and distribution of mucosal memory B-cell populations in the SIV/SHIV rhesus macaque model. Clin Immunol 2014; 153:264-276.
    • (2014) Clin Immunol , vol.153 , pp. 264-276
    • Demberg, T.1    Mohanram, V.2    Venzon, D.3    Robert-Guroff, M.4
  • 29
    • 84892840924 scopus 로고    scopus 로고
    • Rhesus macaque rectal and duodenal tissues exhibit B-cell sub-populations distinct from peripheral blood that continuously secrete antigen-specific IgA in short-term explant cultures
    • Thomas MA, Demberg T, Vargas-Inchaustegui DA, et al. Rhesus macaque rectal and duodenal tissues exhibit B-cell sub-populations distinct from peripheral blood that continuously secrete antigen-specific IgA in short-term explant cultures. Vaccine 2014; 32:872-880.
    • (2014) Vaccine , vol.32 , pp. 872-880
    • Thomas, M.A.1    Demberg, T.2    Vargas-Inchaustegui, D.A.3
  • 30
    • 77952688015 scopus 로고    scopus 로고
    • Antibody-mediated protection against mucosal simian-human immunodeficiency virus challenge of macaques immunized with alphavirus replicon particles and boosted with trimeric envelope glycoprotein in MF59 adjuvant
    • Barnett SW, Burke B, Sun Y, et al. Antibody-mediated protection against mucosal simian-human immunodeficiency virus challenge of macaques immunized with alphavirus replicon particles and boosted with trimeric envelope glycoprotein in MF59 adjuvant. J Virol 2010; 84:5975-5985.
    • (2010) J Virol , vol.84 , pp. 5975-5985
    • Barnett, S.W.1    Burke, B.2    Sun, Y.3
  • 31
    • 56349094315 scopus 로고    scopus 로고
    • Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge
    • Bogers WM, Davis D, Baak I, et al. Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge. Virology 2008; 382:217-225.
    • (2008) Virology , vol.382 , pp. 217-225
    • Bogers, W.M.1    Davis, D.2    Baak, I.3
  • 32
    • 77957820631 scopus 로고    scopus 로고
    • Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques
    • Ng CT, Jaworski JP, Jayaraman P, et al. Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques. Nat Med 2010; 16:1117-1119.
    • (2010) Nat Med , vol.16 , pp. 1117-1119
    • Ng, C.T.1    Jaworski, J.P.2    Jayaraman, P.3
  • 33
    • 84885967137 scopus 로고    scopus 로고
    • Neutralizing polyclonal IgGpresent during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques
    • Jaworski JP,Kobie J, Brower Z, et al. Neutralizing polyclonal IgGpresent during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques. J Virol 2013; 87:10447-10459.
    • (2013) J Virol , vol.87 , pp. 10447-10459
    • Jaworski, J.P.1    Kobie, J.2    Brower, Z.3
  • 34
    • 0032947286 scopus 로고    scopus 로고
    • Protection of macaques against pathogenic simian/human immunodeficiency virus 89. 6PD by passive transfer of neutralizing antibodies
    • Mascola JR, Lewis MG, Stiegler G, et al. Protection of macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies. J Virol 1999; 73:4009-4018.
    • (1999) J Virol , vol.73 , pp. 4009-4018
    • Mascola, J.R.1    Lewis, M.G.2    Stiegler, G.3
  • 35
    • 0033952103 scopus 로고    scopus 로고
    • Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection
    • Baba TW, Liska V, Hofmann-Lehmann R, et al. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection. Nat Med 2000; 6:200-206.
    • (2000) Nat Med , vol.6 , pp. 200-206
    • Baba, T.W.1    Liska, V.2    Hofmann-Lehmann, R.3
  • 36
    • 0034864776 scopus 로고    scopus 로고
    • Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro
    • Parren PW, Marx PA, Hessell AJ, et al. Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro. J Virol 2001; 75:8340-8347.
    • (2001) J Virol , vol.75 , pp. 8340-8347
    • Parren, P.W.1    Marx, P.A.2    Hessell, A.J.3
  • 37
    • 68349160853 scopus 로고    scopus 로고
    • Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
    • Hessell AJ, Poignard P, Hunter M, et al. Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques. Nat Med 2009; 15:951-954.
    • (2009) Nat Med , vol.15 , pp. 951-954
    • Hessell, A.J.1    Poignard, P.2    Hunter, M.3
  • 38
    • 67249131966 scopus 로고    scopus 로고
    • Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
    • Hessell AJ, Rakasz EG, Poignard P, et al. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathog 2009; 5:e1000433.
    • (2009) PLoS Pathog , vol.5 , pp. e1000433
    • Hessell, A.J.1    Rakasz, E.G.2    Poignard, P.3
  • 39
    • 0036170921 scopus 로고    scopus 로고
    • Determination of a statistically valid neutralization titer in plasma that confers protection against simian-human immunodeficiency virus challenge following passive transfer of high-titered neutralizing antibodies
    • Nishimura Y, Igarashi T, Haigwood N, et al. Determination of a statistically valid neutralization titer in plasma that confers protection against simian-human immunodeficiency virus challenge following passive transfer of high-titered neutralizing antibodies. J Virol 2002; 76:2123-2130.
    • (2002) J Virol , vol.76 , pp. 2123-2130
    • Nishimura, Y.1    Igarashi, T.2    Haigwood, N.3
  • 40
    • 84863774072 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses
    • Burton DR, Poignard P, Stanfield RL, Wilson IA. Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses. Science 2012; 337:183-186.
    • (2012) Science , vol.337 , pp. 183-186
    • Burton, D.R.1    Poignard, P.2    Stanfield, R.L.3    Wilson, I.A.4
  • 41
    • 84866495323 scopus 로고    scopus 로고
    • Human antibodies that neutralize HIV-1: Identification, structures, and B cell ontogenies
    • Kwong PD, Mascola JR. Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies. Immunity 2012; 37:412-425.
    • (2012) Immunity , vol.37 , pp. 412-425
    • Kwong, P.D.1    Mascola, J.R.2
  • 42
    • 84869232528 scopus 로고    scopus 로고
    • Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo
    • Moldt B, Rakasz EG, Schultz N, et al. Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo. Proc Natl Acad Sci USA 2012; 109:18921-18925.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 18921-18925
    • Moldt, B.1    Rakasz, E.G.2    Schultz, N.3
  • 43
    • 84907212727 scopus 로고    scopus 로고
    • Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
    • Shingai M, Donau OK, Plishka RJ, et al. Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques. J Exp Med 2014; 211:2061-2074.
    • (2014) J Exp Med , vol.211 , pp. 2061-2074
    • Shingai, M.1    Donau, O.K.2    Plishka, R.J.3
  • 44
    • 84904497424 scopus 로고    scopus 로고
    • Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
    • Pegu A, Yang ZY, Boyington JC, et al. Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor. Sci Transl Med 2014; 6:243ra88.
    • (2014) Sci Transl Med , vol.6 , pp. 243ra88
    • Pegu, A.1    Yang, Z.Y.2    Boyington, J.C.3
  • 45
    • 84907971356 scopus 로고    scopus 로고
    • Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo
    • Rudicell RS, Kwon YD, Ko SY, et al. Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo. J Virol 2014; 88:12669-12682.
    • (2014) J Virol , vol.88 , pp. 12669-12682
    • Rudicell, R.S.1    Kwon, Y.D.2    Ko, S.Y.3
  • 46
    • 84870562234 scopus 로고    scopus 로고
    • HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
    • Klein F, Halper-Stromberg A, Horwitz JA, et al. HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature 2012; 492:118-122.
    • (2012) Nature , vol.492 , pp. 118-122
    • Klein, F.1    Halper-Stromberg, A.2    Horwitz, J.A.3
  • 47
    • 84887626950 scopus 로고    scopus 로고
    • Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
    • Barouch DH, Whitney JB, Moldt B, et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 2013; 503:224-228.
    • (2013) Nature , vol.503 , pp. 224-228
    • Barouch, D.H.1    Whitney, J.B.2    Moldt, B.3
  • 48
    • 84887627657 scopus 로고    scopus 로고
    • Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
    • Shingai M, Nishimura Y, Klein F, et al. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature 2013; 503:277-280.
    • (2013) Nature , vol.503 , pp. 277-280
    • Shingai, M.1    Nishimura, Y.2    Klein, F.3
  • 49
    • 84907379431 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
    • Halper-Stromberg A, Lu CL, Klein F, et al. Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 2014; 158:989-999.
    • (2014) Cell , vol.158 , pp. 989-999
    • Halper-Stromberg, A.1    Lu, C.L.2    Klein, F.3
  • 50
    • 84896120124 scopus 로고    scopus 로고
    • Vectored immunoprophylaxis protects humanized mice frommucosal HIV transmission
    • Balazs AB, Ouyang Y, Hong CM, et al. Vectored immunoprophylaxis protects humanized mice frommucosal HIV transmission. Nat Med 2014; 20:296-300.
    • (2014) Nat Med , vol.20 , pp. 296-300
    • Balazs, A.B.1    Ouyang, Y.2    Hong, C.M.3
  • 51
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010; 329:1168-1174.
    • (2010) Science , vol.329 , pp. 1168-1174
    • Abdool Karim, Q.1    Abdool Karim, S.S.2    Frohlich, J.A.3
  • 52
    • 84897502032 scopus 로고    scopus 로고
    • Postexposure protection of macaques from vaginal SHIV infection by topical integrase inhibitors
    • Dobard C, Sharma S, Parikh UM, et al. Postexposure protection of macaques from vaginal SHIV infection by topical integrase inhibitors. Sci Transl Med 2014; 6:227ra35.
    • (2014) Sci Transl Med , vol.6 , pp. 227ra35
    • Dobard, C.1    Sharma, S.2    Parikh, U.M.3
  • 53
    • 84911947017 scopus 로고    scopus 로고
    • Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants
    • Klein F, Nogueira L, Nishimura Y, et al. Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. J Exp Med 2014; 211:2361-2372.
    • (2014) J Exp Med , vol.211 , pp. 2361-2372
    • Klein, F.1    Nogueira, L.2    Nishimura, Y.3
  • 54
    • 84885669019 scopus 로고    scopus 로고
    • Immune clearance of highly pathogenic SIV infection
    • Hansen SG, Piatak M Jr, Ventura AB, et al. Immune clearance of highly pathogenic SIV infection. Nature 2013; 502:100-104.
    • (2013) Nature , vol.502 , pp. 100-104
    • Hansen, S.G.1    Piatak, M.2    Ventura, A.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.